PL378342A1 - Pochodne 2-piperydonu jako agoniści prostaglandyn - Google Patents

Pochodne 2-piperydonu jako agoniści prostaglandyn

Info

Publication number
PL378342A1
PL378342A1 PL378342A PL37834204A PL378342A1 PL 378342 A1 PL378342 A1 PL 378342A1 PL 378342 A PL378342 A PL 378342A PL 37834204 A PL37834204 A PL 37834204A PL 378342 A1 PL378342 A1 PL 378342A1
Authority
PL
Poland
Prior art keywords
prostaglandin agonists
piperidone derivatives
piperidone
derivatives
prostaglandin
Prior art date
Application number
PL378342A
Other languages
English (en)
Inventor
Todd Richard Elworthy
Original Assignee
F. Hoffmann-La Roche Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F. Hoffmann-La Roche Ag filed Critical F. Hoffmann-La Roche Ag
Publication of PL378342A1 publication Critical patent/PL378342A1/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D211/74—Oxygen atoms
    • C07D211/76—Oxygen atoms attached in position 2 or 6
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B55/00—Racemisation; Complete or partial inversion
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
PL378342A 2003-01-10 2004-01-02 Pochodne 2-piperydonu jako agoniści prostaglandyn PL378342A1 (pl)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US43915203P 2003-01-10 2003-01-10

Publications (1)

Publication Number Publication Date
PL378342A1 true PL378342A1 (pl) 2006-03-20

Family

ID=32713441

Family Applications (1)

Application Number Title Priority Date Filing Date
PL378342A PL378342A1 (pl) 2003-01-10 2004-01-02 Pochodne 2-piperydonu jako agoniści prostaglandyn

Country Status (12)

Country Link
US (1) US7271183B2 (pl)
EP (1) EP1585729A1 (pl)
JP (2) JP2006515015A (pl)
KR (1) KR100752891B1 (pl)
CN (1) CN1735597A (pl)
AU (1) AU2004203905A1 (pl)
BR (1) BRPI0406717A (pl)
CA (1) CA2511255C (pl)
MX (1) MXPA05007341A (pl)
PL (1) PL378342A1 (pl)
RU (1) RU2311409C2 (pl)
WO (1) WO2004063158A1 (pl)

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* Cited by examiner, † Cited by third party
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US7053085B2 (en) * 2003-03-26 2006-05-30 Merck & Co. Inc. EP4 receptor agonist, compositions and methods thereof
US6977260B2 (en) 2004-01-22 2005-12-20 Allergan, Inc. Piperidinyl prostaglandin E analogs
US7326716B2 (en) 2003-06-06 2008-02-05 Allergan, Inc. Treatment of inflammatory bowel disease
EP1631355B1 (en) * 2003-06-06 2014-08-13 Allergan, Inc. Piperidinyl prostaglandin e analogs
US7179820B2 (en) * 2003-06-06 2007-02-20 Allergan, Inc. Piperidinyl prostaglandin E analogs
US20080058375A1 (en) * 2004-01-08 2008-03-06 Elworthy Todd R 2-Piperidone derivatives as prostaglandin antagonists
ATE550323T1 (de) * 2004-06-04 2012-04-15 Allergan Inc Piperidinyl-prostaglandinanaloga als den augeninnendruck senkende mittel
WO2006014207A1 (en) 2004-07-02 2006-02-09 Allergan, Inc. Prostaglandin analogs
JP2008518013A (ja) * 2004-10-26 2008-05-29 アラーガン、インコーポレイテッド プロスタグランジンｅｐ４アゴニストによる処置方法およびデリバリー方法
WO2006052630A1 (en) * 2004-11-04 2006-05-18 Allergan, Inc. Therapeutic substituted piperidone compounds
AU2011256895B2 (en) * 2004-11-29 2013-03-14 Allergan, Inc. Treatment of inflammatory bowel disease
JP5014978B2 (ja) * 2005-01-27 2012-08-29 旭化成ファーマ株式会社 ヘテロ６員環化合物及びその用途
US7531533B2 (en) 2005-01-27 2009-05-12 Asahi Kasei Pharma Corporation 6-Membered heterocyclic compound and use thereof
US7754909B1 (en) * 2005-04-06 2010-07-13 The Florida State University Research Foundation, Inc. Compounds and methods of arylmethylation (benzylation) as protection for alcohol groups during chemical synthesis
CA2616604A1 (en) * 2005-08-03 2007-02-08 Merck Frosst Canada Ltd. Ep4 receptor agonist, compositions and methods thereof
US7893107B2 (en) * 2005-11-30 2011-02-22 Allergan, Inc. Therapeutic methods using prostaglandin EP4 agonist components
US20070232660A1 (en) * 2006-04-04 2007-10-04 Allergan, Inc. Therapeutic and delivery methods of prostaglandin ep4 agonists
US8314147B2 (en) 2006-12-15 2012-11-20 Glaxo Group Limited Benzamide derivatives as EP4 receptor agonists
GB2446652A (en) * 2007-02-16 2008-08-20 Inion Ltd Osteogenic compounds
AU2008246579A1 (en) 2007-05-08 2008-11-13 National University Corporation, Hamamatsu University School Of Medicine Cytotoxic T cell activator comprising EP4 agonist
US20130225609A1 (en) * 2010-04-08 2013-08-29 Boehringer Ingelheim International Gmbh Combinations of medicaments, containing pde4-inhibitors and ep4-receptor-antagonists
US8877758B2 (en) 2010-04-08 2014-11-04 Boehringer Ingelheim International Gmbh Combinations of medicaments, containing PDE4-inhibitors and EP4-receptor-antagonists
US20120142684A1 (en) * 2010-12-02 2012-06-07 Allergan, Inc. Compounds and methods for skin repair
ES2559513T3 (es) * 2011-07-04 2016-02-12 Rottapharm Biotech S.R.L. Derivados de amina cíclica como antagonistas del receptor EP4
AR091429A1 (es) 2012-06-29 2015-02-04 Lilly Co Eli Compuestos de fenoxietil piperidina
US9540357B1 (en) 2014-07-31 2017-01-10 Allergan, Inc. 15-aryl prostaglandins as EP4 agonists, and methods of use thereof
PH12020500556A1 (en) 2017-12-25 2021-04-19 Asahi Kasei Pharma Corp Nitrogen-containing six-membered ring compound

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US4113873A (en) 1975-04-26 1978-09-12 Tanabe Seiyaku Co. Ltd. 8-azaprostanoic acid derivatives
NL7604330A (nl) * 1975-04-28 1976-11-01 Syntex Inc Werkwijze voor de bereiding van 8-azaprostaan- zuurderivaten.
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MXPA04000454A (es) * 2001-07-16 2004-03-18 Hoffmann La Roche Derivados de 2-pirrolidona como agonistas de prostanoides.
US7053085B2 (en) * 2003-03-26 2006-05-30 Merck & Co. Inc. EP4 receptor agonist, compositions and methods thereof
US6747037B1 (en) * 2003-06-06 2004-06-08 Allergan, Inc. Piperidinyl prostaglandin E analogs

Also Published As

Publication number Publication date
CN1735597A (zh) 2006-02-15
CA2511255C (en) 2009-04-07
WO2004063158A1 (en) 2004-07-29
JP2010047580A (ja) 2010-03-04
KR20050094837A (ko) 2005-09-28
RU2311409C2 (ru) 2007-11-27
EP1585729A1 (en) 2005-10-19
MXPA05007341A (es) 2005-09-30
US7271183B2 (en) 2007-09-18
BRPI0406717A (pt) 2005-12-20
JP2006515015A (ja) 2006-05-18
CA2511255A1 (en) 2004-07-29
RU2005125284A (ru) 2006-05-27
US20040142969A1 (en) 2004-07-22
KR100752891B1 (ko) 2007-08-28
AU2004203905A1 (en) 2004-07-29

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