PL378342A1 - Pochodne 2-piperydonu jako agoniści prostaglandyn - Google Patents
Pochodne 2-piperydonu jako agoniści prostaglandynInfo
- Publication number
- PL378342A1 PL378342A1 PL378342A PL37834204A PL378342A1 PL 378342 A1 PL378342 A1 PL 378342A1 PL 378342 A PL378342 A PL 378342A PL 37834204 A PL37834204 A PL 37834204A PL 378342 A1 PL378342 A1 PL 378342A1
- Authority
- PL
- Poland
- Prior art keywords
- prostaglandin agonists
- piperidone derivatives
- piperidone
- derivatives
- prostaglandin
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D211/74—Oxygen atoms
- C07D211/76—Oxygen atoms attached in position 2 or 6
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B55/00—Racemisation; Complete or partial inversion
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Physical Education & Sports Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US43915203P | 2003-01-10 | 2003-01-10 |
Publications (1)
Publication Number | Publication Date |
---|---|
PL378342A1 true PL378342A1 (pl) | 2006-03-20 |
Family
ID=32713441
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PL378342A PL378342A1 (pl) | 2003-01-10 | 2004-01-02 | Pochodne 2-piperydonu jako agoniści prostaglandyn |
Country Status (12)
Country | Link |
---|---|
US (1) | US7271183B2 (pl) |
EP (1) | EP1585729A1 (pl) |
JP (2) | JP2006515015A (pl) |
KR (1) | KR100752891B1 (pl) |
CN (1) | CN1735597A (pl) |
AU (1) | AU2004203905A1 (pl) |
BR (1) | BRPI0406717A (pl) |
CA (1) | CA2511255C (pl) |
MX (1) | MXPA05007341A (pl) |
PL (1) | PL378342A1 (pl) |
RU (1) | RU2311409C2 (pl) |
WO (1) | WO2004063158A1 (pl) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7053085B2 (en) | 2003-03-26 | 2006-05-30 | Merck & Co. Inc. | EP4 receptor agonist, compositions and methods thereof |
WO2004108215A1 (en) * | 2003-06-06 | 2004-12-16 | Allergan, Inc. | Piperidinyl prostaglandin e analogs |
US7179820B2 (en) * | 2003-06-06 | 2007-02-20 | Allergan, Inc. | Piperidinyl prostaglandin E analogs |
US7326716B2 (en) * | 2003-06-06 | 2008-02-05 | Allergan, Inc. | Treatment of inflammatory bowel disease |
US6977260B2 (en) | 2004-01-22 | 2005-12-20 | Allergan, Inc. | Piperidinyl prostaglandin E analogs |
US20080058375A1 (en) * | 2004-01-08 | 2008-03-06 | Elworthy Todd R | 2-Piperidone derivatives as prostaglandin antagonists |
ATE550323T1 (de) * | 2004-06-04 | 2012-04-15 | Allergan Inc | Piperidinyl-prostaglandinanaloga als den augeninnendruck senkende mittel |
WO2006014207A1 (en) | 2004-07-02 | 2006-02-09 | Allergan, Inc. | Prostaglandin analogs |
CA2585367A1 (en) * | 2004-10-26 | 2006-05-04 | Allergan, Inc. | Therapeutic and delivery methods of prostaglandin ep4 agonists |
US7994195B2 (en) | 2004-11-04 | 2011-08-09 | Allergan, Inc. | Therapeutic substituted piperidone compounds |
AU2011256895B2 (en) * | 2004-11-29 | 2013-03-14 | Allergan, Inc. | Treatment of inflammatory bowel disease |
CN101133037B (zh) * | 2005-01-27 | 2012-05-09 | 旭化成制药株式会社 | 六元杂环化合物及其用途 |
US7531533B2 (en) | 2005-01-27 | 2009-05-12 | Asahi Kasei Pharma Corporation | 6-Membered heterocyclic compound and use thereof |
US7754909B1 (en) * | 2005-04-06 | 2010-07-13 | The Florida State University Research Foundation, Inc. | Compounds and methods of arylmethylation (benzylation) as protection for alcohol groups during chemical synthesis |
AU2006275270A1 (en) * | 2005-08-03 | 2007-02-08 | Merck Frosst Canada Ltd | EP4 receptor agonist, compositions and methods thereof |
US7893107B2 (en) * | 2005-11-30 | 2011-02-22 | Allergan, Inc. | Therapeutic methods using prostaglandin EP4 agonist components |
US20070232660A1 (en) * | 2006-04-04 | 2007-10-04 | Allergan, Inc. | Therapeutic and delivery methods of prostaglandin ep4 agonists |
BRPI0720254A2 (pt) | 2006-12-15 | 2014-01-07 | Glaxo Group Ltd | Derivados de benzamida como agonistas do receptor ep4 |
GB2446652A (en) * | 2007-02-16 | 2008-08-20 | Inion Ltd | Osteogenic compounds |
EP2147672A4 (en) | 2007-05-08 | 2011-11-02 | Nat University Corp Hamamatsu University School Of Medicine | CYTOTOXIC T CELL ACTIVATOR WITH AN EP4 AGONIST |
WO2011124525A1 (de) * | 2010-04-08 | 2011-10-13 | Boehringer Ingelheim International Gmbh | Arnzeimittelkombinationen enthaltend pde4-inhibitoren und ep4-rezeptor-antagonisten |
WO2011124524A1 (de) | 2010-04-08 | 2011-10-13 | Boehringer Ingelheim International Gmbh | Arzneimittelkombinationen enthaltend pde4-inhibitoren und ep4-rezeptor-antagonisten |
US20120142684A1 (en) * | 2010-12-02 | 2012-06-07 | Allergan, Inc. | Compounds and methods for skin repair |
US9181279B2 (en) * | 2011-07-04 | 2015-11-10 | Rottapharm Biotech S.R.L. | Cyclic amine derivatives as EP4 receptor antagonists |
AR091429A1 (es) * | 2012-06-29 | 2015-02-04 | Lilly Co Eli | Compuestos de fenoxietil piperidina |
US9540357B1 (en) | 2014-07-31 | 2017-01-10 | Allergan, Inc. | 15-aryl prostaglandins as EP4 agonists, and methods of use thereof |
ES2929799T3 (es) | 2017-12-25 | 2022-12-01 | Asahi Kasei Pharma Corp | Compuestos que contienen resto de 2-oxo-1,3,4-tiadiazinan-3-ilo con actividad agonista del receptor EP4 |
Family Cites Families (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1444963A (en) * | 1972-07-24 | 1976-08-04 | American Cyanamid Co | Prostanoic and prostenoic acid derivatives and methods for their preparation |
US3975399A (en) * | 1974-08-06 | 1976-08-17 | E. I. Du Pont De Nemours And Company | 1,5-Disubstituted-2-pyrrolidinones, -3-pyrrolin-2-ones, and -4-pyrrolin-2-ones |
US4113873A (en) * | 1975-04-26 | 1978-09-12 | Tanabe Seiyaku Co. Ltd. | 8-azaprostanoic acid derivatives |
NL7604330A (nl) * | 1975-04-28 | 1976-11-01 | Syntex Inc | Werkwijze voor de bereiding van 8-azaprostaan- zuurderivaten. |
DE2528664A1 (de) | 1975-06-27 | 1977-01-13 | Hoechst Ag | Pyrrolidone und verfahren zu ihrer herstellung |
DE2556326A1 (de) | 1975-12-13 | 1977-06-23 | Hoechst Ag | Neue pyrrolidone und verfahren zu ihrer herstellung |
US4238623A (en) * | 1976-03-29 | 1980-12-09 | Miles Laboratories, Inc. | 5,6-Benzo analogues of prostaglandin |
IL49325A (en) * | 1976-03-31 | 1979-11-30 | Labaz | 8-aza-11-deoxy-pge1 derivatives,their preparation and pharmaceutical compositions containing them |
DE2619638A1 (de) | 1976-05-04 | 1977-11-17 | Hoechst Ag | Pyrrolidone und verfahren zu ihrer herstellung |
US4177346A (en) * | 1976-08-06 | 1979-12-04 | Pfizer Inc. | 1,5-Disubstituted-2-pyrrolidones |
AU512960B2 (en) * | 1977-10-21 | 1980-11-06 | Beecham Group Ltd | Exo-amide prostaglandin analogues |
US4320136A (en) * | 1980-08-11 | 1982-03-16 | E. I. Du Pont De Nemours And Company | 8-Aza-16,16-difluoroprostanoids |
JPS59144756A (ja) * | 1983-04-28 | 1984-08-18 | Tanabe Seiyaku Co Ltd | 8−アザプロスタン酸類化合物及びその製法 |
JPH0643390B2 (ja) * | 1986-04-08 | 1994-06-08 | 久光製薬株式会社 | アザシクロアルカン誘導体 |
US4996199A (en) | 1988-04-08 | 1991-02-26 | Whitby Research, Inc. | Penetration enhancers for transdermal delivery of systemic agents |
CA1334646C (en) | 1988-04-08 | 1995-03-07 | James Vanolden Peck | Transdermal penetration enhancers |
JP2530393B2 (ja) * | 1991-06-28 | 1996-09-04 | 三菱電機株式会社 | キ―ロックスイッチ |
CA2093901A1 (en) | 1991-08-13 | 1993-02-14 | Dane Chang | Composition and method for simultaneous absorption of sulfur dioxide and nitric oxide |
JP3458467B2 (ja) * | 1994-07-28 | 2003-10-20 | 大日本インキ化学工業株式会社 | エポキシ樹脂の製造方法 |
US6034093A (en) * | 1995-06-07 | 2000-03-07 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Substituted sulfonic acid N-[(aminoiminomethyl)phenylalkyl]-azaheterocyclylamide compounds |
US5849587A (en) | 1995-06-09 | 1998-12-15 | Cornell Research Foundation, Inc. | Method of inhibiting viral replication in eukaryotic cells and of inducing apoptosis of virally-infected cells |
AU6427599A (en) | 1998-10-15 | 2000-05-01 | Merck & Co., Inc. | Methods for stimulating bone formation |
WO2000021532A1 (en) | 1998-10-15 | 2000-04-20 | Merck & Co., Inc. | Methods for inhibiting bone resorption |
EE200200355A (et) * | 1999-12-22 | 2003-10-15 | Pfizer Products Inc. | EP4 retseptori selektiivsed agonistid osteoporoosi raviks |
WO2002024647A1 (fr) * | 2000-09-21 | 2002-03-28 | Ono Pharmaceutical Co., Ltd. | Agonistes du recepteur de l'ep4 comprenant comme principe actif des derives de la 8-azaprostaglandine |
US6376533B1 (en) * | 2000-10-20 | 2002-04-23 | Allergan Sales, Inc. | Omega-cycloalkyl 17-heteroaryl prostaglandin E2 analogs as EP2-receptor agonists |
DE60130675T2 (de) * | 2000-11-27 | 2008-01-24 | Pfizer Products Inc., Groton | Selektive agonisten des ep4 rezeptors für die behandlung von osteoporose |
EP1408961B1 (en) * | 2001-07-16 | 2007-07-11 | F. Hoffmann-La Roche Ag | 2 pyrrolidone derivatives as prostanoid agonists |
US7053085B2 (en) * | 2003-03-26 | 2006-05-30 | Merck & Co. Inc. | EP4 receptor agonist, compositions and methods thereof |
US6747037B1 (en) * | 2003-06-06 | 2004-06-08 | Allergan, Inc. | Piperidinyl prostaglandin E analogs |
-
2004
- 2004-01-02 JP JP2005518636A patent/JP2006515015A/ja active Pending
- 2004-01-02 KR KR1020057012774A patent/KR100752891B1/ko not_active IP Right Cessation
- 2004-01-02 WO PCT/EP2004/000008 patent/WO2004063158A1/en active Application Filing
- 2004-01-02 CA CA002511255A patent/CA2511255C/en not_active Expired - Fee Related
- 2004-01-02 PL PL378342A patent/PL378342A1/pl not_active Application Discontinuation
- 2004-01-02 BR BR0406717-7A patent/BRPI0406717A/pt not_active IP Right Cessation
- 2004-01-02 AU AU2004203905A patent/AU2004203905A1/en not_active Abandoned
- 2004-01-02 MX MXPA05007341A patent/MXPA05007341A/es active IP Right Grant
- 2004-01-02 CN CNA200480002071XA patent/CN1735597A/zh active Pending
- 2004-01-02 RU RU2005125284/04A patent/RU2311409C2/ru not_active IP Right Cessation
- 2004-01-02 EP EP04700041A patent/EP1585729A1/en not_active Withdrawn
- 2004-01-08 US US10/754,117 patent/US7271183B2/en not_active Expired - Fee Related
-
2009
- 2009-10-02 JP JP2009230447A patent/JP2010047580A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
BRPI0406717A (pt) | 2005-12-20 |
KR20050094837A (ko) | 2005-09-28 |
CA2511255A1 (en) | 2004-07-29 |
JP2006515015A (ja) | 2006-05-18 |
CN1735597A (zh) | 2006-02-15 |
RU2005125284A (ru) | 2006-05-27 |
JP2010047580A (ja) | 2010-03-04 |
RU2311409C2 (ru) | 2007-11-27 |
EP1585729A1 (en) | 2005-10-19 |
KR100752891B1 (ko) | 2007-08-28 |
MXPA05007341A (es) | 2005-09-30 |
AU2004203905A1 (en) | 2004-07-29 |
CA2511255C (en) | 2009-04-07 |
US7271183B2 (en) | 2007-09-18 |
WO2004063158A1 (en) | 2004-07-29 |
US20040142969A1 (en) | 2004-07-22 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
REFS | Decisions on refusal to grant patents (taken after the publication of the particulars of the applications) |