PL376821A1 - Sposoby zwiększania produkcji polipeptydów - Google Patents
Sposoby zwiększania produkcji polipeptydówInfo
- Publication number
- PL376821A1 PL376821A1 PL376821A PL37682103A PL376821A1 PL 376821 A1 PL376821 A1 PL 376821A1 PL 376821 A PL376821 A PL 376821A PL 37682103 A PL37682103 A PL 37682103A PL 376821 A1 PL376821 A1 PL 376821A1
- Authority
- PL
- Poland
- Prior art keywords
- methods
- polypeptide production
- increasing polypeptide
- increasing
- production
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/67—General methods for enhancing the expression
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0018—Culture media for cell or tissue culture
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
- C12N2500/36—Lipids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/01—Modulators of cAMP or cGMP, e.g. non-hydrolysable analogs, phosphodiesterase inhibitors, cholera toxin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
- C12N2510/02—Cells for production
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36824802P | 2002-03-27 | 2002-03-27 | |
| US36824602P | 2002-03-27 | 2002-03-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL376821A1 true PL376821A1 (pl) | 2006-01-09 |
Family
ID=28678222
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL376821A PL376821A1 (pl) | 2002-03-27 | 2003-03-27 | Sposoby zwiększania produkcji polipeptydów |
Country Status (9)
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050005310A1 (en) * | 1999-07-12 | 2005-01-06 | Genentech, Inc. | Expression vectors and methods |
| PL376821A1 (pl) * | 2002-03-27 | 2006-01-09 | Immunex Corporation | Sposoby zwiększania produkcji polipeptydów |
| JP2006512061A (ja) * | 2002-11-14 | 2006-04-13 | ジェネンテック・インコーポレーテッド | イントロン融合コンストラクトおよび高発現産生細胞系を選択するための使用方法 |
| AU2004234377A1 (en) * | 2003-04-25 | 2004-11-11 | Immunex Corporation | Inducers of recombinant protein expression |
| AU2004266043B2 (en) * | 2003-08-21 | 2007-09-20 | Duchesnay Inc. | Micronutrient supplement |
| JP4520987B2 (ja) * | 2003-08-21 | 2010-08-11 | デュシェネ インク | チャイルドプルーフ微量栄養素サプリメント |
| EP1697414A2 (en) * | 2003-12-23 | 2006-09-06 | Applied Research Systems ARS Holding N.V. | Process for the production of tumor necrosis factor-binding proteins |
| EP1909831A4 (en) | 2005-06-14 | 2013-02-20 | Amgen Inc | PREPARATIONS OF SPONTANEOUS TAMPING PROTEINS |
| WO2007049567A1 (ja) * | 2005-10-24 | 2007-05-03 | Kyowa Hakko Kogyo Co., Ltd. | 物質の製造方法 |
| PL2253644T3 (pl) | 2005-12-20 | 2014-04-30 | Bristol Myers Squibb Co | Kompozycje i sposoby wytwarzania kompozycji |
| AR058568A1 (es) | 2005-12-20 | 2008-02-13 | Bristol Myers Squibb Co | Metodos para producir una composicion con moleculas ctla4-ig a partir de un medio de cultivo |
| WO2008029281A2 (en) * | 2006-02-10 | 2008-03-13 | Invitrogen Corporation | Labeling and detection of post translationally modified proteins |
| US8247187B2 (en) * | 2006-08-14 | 2012-08-21 | Biocontrol Systems, Inc. | Method for detecting pathogens |
| AU2007294731B2 (en) * | 2006-09-13 | 2014-04-17 | Abbvie Inc. | Cell culture improvements |
| US8911964B2 (en) | 2006-09-13 | 2014-12-16 | Abbvie Inc. | Fed-batch method of making human anti-TNF-alpha antibody |
| TW200907062A (en) * | 2007-03-28 | 2009-02-16 | Medarex Inc | Methods of gene amplification and expression |
| TW200902708A (en) * | 2007-04-23 | 2009-01-16 | Wyeth Corp | Methods of protein production using anti-senescence compounds |
| US20090023186A1 (en) * | 2007-07-22 | 2009-01-22 | Excellgene Sa | Use of valproic acid for enhancing production of recombinant proteins in mammalian cells |
| JP2011512877A (ja) * | 2008-03-12 | 2011-04-28 | ワイス・エルエルシー | 組換えタンパク質の大スケール産生に適した細胞を同定する方法 |
| CA2782320A1 (en) * | 2009-12-02 | 2011-06-09 | Acceleron Pharma Inc. | Compositions and methods for increasing serum half-life of fc fusion proteins |
| WO2012043754A1 (ja) | 2010-09-30 | 2012-04-05 | ダイキン工業株式会社 | ドリップ防止剤、並びに、樹脂組成物 |
| RU2615448C2 (ru) * | 2010-12-28 | 2017-04-04 | Чугаи Сейяку Кабусики Кайся | Описание способа культивирования животной клетки |
| WO2012149197A2 (en) | 2011-04-27 | 2012-11-01 | Abbott Laboratories | Methods for controlling the galactosylation profile of recombinantly-expressed proteins |
| US8883982B2 (en) | 2011-06-08 | 2014-11-11 | Acceleron Pharma, Inc. | Compositions and methods for increasing serum half-life |
| CN107988166B (zh) | 2011-07-01 | 2022-03-15 | 美国安进公司 | 哺乳动物细胞培养 |
| EP2653548A1 (de) | 2012-04-17 | 2013-10-23 | Greenovation Biotech GmbH | Verfahren zur Erhöhung der Sekretion rekombinanter Proteine |
| US9067990B2 (en) | 2013-03-14 | 2015-06-30 | Abbvie, Inc. | Protein purification using displacement chromatography |
| US9334319B2 (en) | 2012-04-20 | 2016-05-10 | Abbvie Inc. | Low acidic species compositions |
| WO2013158273A1 (en) | 2012-04-20 | 2013-10-24 | Abbvie Inc. | Methods to modulate c-terminal lysine variant distribution |
| WO2013176754A1 (en) | 2012-05-24 | 2013-11-28 | Abbvie Inc. | Novel purification of antibodies using hydrophobic interaction chromatography |
| US9512214B2 (en) | 2012-09-02 | 2016-12-06 | Abbvie, Inc. | Methods to control protein heterogeneity |
| KR20150043523A (ko) | 2012-09-02 | 2015-04-22 | 애브비 인코포레이티드 | 단백질 불균일성의 제어 방법 |
| SG11201507230PA (en) | 2013-03-12 | 2015-10-29 | Abbvie Inc | Human antibodies that bind human tnf-alpha and methods of preparing the same |
| WO2014159579A1 (en) | 2013-03-14 | 2014-10-02 | Abbvie Inc. | MUTATED ANTI-TNFα ANTIBODIES AND METHODS OF THEIR USE |
| WO2014151878A2 (en) | 2013-03-14 | 2014-09-25 | Abbvie Inc. | Methods for modulating protein glycosylation profiles of recombinant protein therapeutics using monosaccharides and oligosacharides |
| US9017687B1 (en) | 2013-10-18 | 2015-04-28 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same using displacement chromatography |
| CA2904639A1 (en) * | 2013-03-15 | 2014-09-25 | Theocorp Holding Company, Llc | Theobromine compositions useful for increasing fetal weight gain and enhancing bone properties |
| US9598667B2 (en) | 2013-10-04 | 2017-03-21 | Abbvie Inc. | Use of metal ions for modulation of protein glycosylation profiles of recombinant proteins |
| US9181337B2 (en) | 2013-10-18 | 2015-11-10 | Abbvie, Inc. | Modulated lysine variant species compositions and methods for producing and using the same |
| US9085618B2 (en) | 2013-10-18 | 2015-07-21 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same |
| US8946395B1 (en) | 2013-10-18 | 2015-02-03 | Abbvie Inc. | Purification of proteins using hydrophobic interaction chromatography |
| WO2015073884A2 (en) | 2013-11-15 | 2015-05-21 | Abbvie, Inc. | Glycoengineered binding protein compositions |
| BR112019007858A2 (pt) | 2016-10-21 | 2019-07-02 | Amgen Inc | formulações farmacêuticas e métodos para produzir as mesmas |
| KR102190790B1 (ko) * | 2018-10-19 | 2020-12-15 | 주식회사 프로젠 | 변형된 egf 단백질의 생산 방법 |
| US11339197B2 (en) | 2017-10-23 | 2022-05-24 | Progen Co., Ltd. | Modified EGF protein, production method therefor, and use thereof |
| JP2024503239A (ja) | 2020-12-22 | 2024-01-25 | アムジェン インコーポレイテッド | 細胞培養法 |
Family Cites Families (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3824286A (en) | 1970-07-07 | 1974-07-16 | Lever Brothers Ltd | Preparation of polyacetylalkylene diamines |
| DE2961658D1 (en) | 1978-05-17 | 1982-02-18 | Thomae Gmbh Dr K | Process for preparing human interferon |
| US4301249A (en) * | 1980-07-23 | 1981-11-17 | Merck & Co., Inc. | High titer production of hepatitis A virus |
| US4357422A (en) | 1980-08-14 | 1982-11-02 | Massachusetts Institute Of Technology | Method of enhancing interferon production |
| US4416986A (en) * | 1981-01-16 | 1983-11-22 | Merck & Co., Inc. | Methods of producing HBsAg |
| US4473647A (en) | 1981-02-27 | 1984-09-25 | Amf Inc. | Tissue culture medium |
| US6936694B1 (en) | 1982-05-06 | 2005-08-30 | Intermune, Inc. | Manufacture and expression of large structural genes |
| AU588819B2 (en) | 1984-10-29 | 1989-09-28 | Immunex Corporation | Cloning of human granulocyte-macrophage colony stimulating factor gene |
| US4992472A (en) | 1987-06-16 | 1991-02-12 | The United States Of America As Represented By The Department Of Health And Human Services | Chemical differentiating agents |
| US4965195A (en) | 1987-10-26 | 1990-10-23 | Immunex Corp. | Interleukin-7 |
| US4968607A (en) | 1987-11-25 | 1990-11-06 | Immunex Corporation | Interleukin-1 receptors |
| US5075222A (en) | 1988-05-27 | 1991-12-24 | Synergen, Inc. | Interleukin-1 inhibitors |
| WO1990005183A1 (en) | 1988-10-31 | 1990-05-17 | Immunex Corporation | Interleukin-4 receptors |
| US5055608A (en) | 1988-11-14 | 1991-10-08 | Sloan-Kettering Institute For Cancer Research | Novel potent inducers of thermal differentiation and method of use thereof |
| US5330744A (en) | 1988-11-14 | 1994-07-19 | Sloan-Kettering Institute For Cancer Research | Method for increasing sensitivity to chemically induced terminal differentiation |
| ZA899421B (en) | 1988-12-14 | 1990-09-26 | Merrell Dow Pharma | Method of potentiating natural killer cell activity |
| CA2018228C (en) | 1989-06-05 | 1996-02-27 | Nancy L. Parenteau | Cell culture systems and media |
| US5395760A (en) | 1989-09-05 | 1995-03-07 | Immunex Corporation | DNA encoding tumor necrosis factor-α and -β receptors |
| DK0939121T4 (da) | 1989-09-12 | 2008-02-04 | Ahp Mfg B V | TNF-bindende proteiner |
| US6204363B1 (en) | 1989-10-16 | 2001-03-20 | Amgen Inc. | Stem cell factor |
| US5149792A (en) | 1989-12-19 | 1992-09-22 | Amgen Inc. | Platelet-derived growth factor B chain analogs |
| US5272064A (en) | 1989-12-19 | 1993-12-21 | Amgen Inc. | DNA molecules encoding platelet-derived growth factor B chain analogs and method for expression thereof |
| US5272071A (en) | 1989-12-22 | 1993-12-21 | Applied Research Systems Ars Holding N.V. | Method for the modification of the expression characteristics of an endogenous gene of a given cell line |
| US5350683A (en) | 1990-06-05 | 1994-09-27 | Immunex Corporation | DNA encoding type II interleukin-1 receptors |
| WO1991018982A1 (en) | 1990-06-05 | 1991-12-12 | Immunex Corporation | Type ii interleukin-1 receptors |
| US5369108A (en) | 1991-10-04 | 1994-11-29 | Sloan-Kettering Institute For Cancer Research | Potent inducers of terminal differentiation and methods of use thereof |
| DE69332981T2 (de) | 1992-10-23 | 2004-05-19 | Immunex Corp., Seattle | Methoden zur herstellung löslicher, oligomerer proteine |
| US5420019A (en) * | 1993-02-02 | 1995-05-30 | Xoma Corporation | Stable bactericidal/permeability-increasing protein muteins |
| US5554512A (en) | 1993-05-24 | 1996-09-10 | Immunex Corporation | Ligands for flt3 receptors |
| US20010010922A1 (en) | 1994-06-09 | 2001-08-02 | Riccardo Dalla-Favera | Cloning and uses of the genetic locus bcl-6 |
| US5981713A (en) | 1994-10-13 | 1999-11-09 | Applied Research Systems Ars Holding N.V. | Antibodies to intereleukin-1 antagonists |
| US5705364A (en) | 1995-06-06 | 1998-01-06 | Genentech, Inc. | Mammalian cell culture process |
| ES2253753T3 (es) | 1995-06-29 | 2006-06-01 | Immunex Corporation | Citocina que induce apoptosis. |
| JP4306813B2 (ja) | 1995-09-19 | 2009-08-05 | アスビオファーマ株式会社 | 動物細胞の新規培養方法 |
| US6613544B1 (en) | 1995-12-22 | 2003-09-02 | Amgen Inc. | Osteoprotegerin |
| US6096728A (en) | 1996-02-09 | 2000-08-01 | Amgen Inc. | Composition and method for treating inflammatory diseases |
| USRE37234E1 (en) | 1996-11-01 | 2001-06-19 | Nitromed, Inc. | Nitrosated and nitrosylated phosphodiestrase inhibitor compounds, compositions and their uses |
| US6271349B1 (en) | 1996-12-23 | 2001-08-07 | Immunex Corporation | Receptor activator of NF-κB |
| WO1998028010A2 (en) | 1996-12-24 | 1998-07-02 | Hyal Pharmaceutical Corporation | Use of moieties for binding to hyaluronan and icam-1 |
| US6235883B1 (en) | 1997-05-05 | 2001-05-22 | Abgenix, Inc. | Human monoclonal antibodies to epidermal growth factor receptor |
| WO1999032605A1 (en) | 1997-12-19 | 1999-07-01 | Novo Nordisk A/S | Method for producing heterologous proteins in eukaryotic cells on an industrial scale using nucleotide-manipulating agents |
| US6337072B1 (en) | 1998-04-03 | 2002-01-08 | Hyseq, Inc. | Interleukin-1 receptor antagonist and recombinant production thereof |
| EP1117778A2 (en) | 1998-10-02 | 2001-07-25 | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES | Methods and compositions for inducing differentiation and apoptosis in cells that overexpress the notch protein |
| US6660843B1 (en) | 1998-10-23 | 2003-12-09 | Amgen Inc. | Modified peptides as therapeutic agents |
| EP1171615B1 (en) | 1999-04-26 | 2006-12-13 | Genentech, Inc. | Cell culture process for glycoproteins |
| ES2252070T3 (es) | 1999-10-13 | 2006-05-16 | Immunex Corporation | Vectores y procedimientos para la expresion de proteinas recombinantes. |
| AU1920301A (en) | 1999-11-17 | 2001-05-30 | Immunex Corporation | Receptor activator of nf-kappa b |
| AU2001259432B2 (en) | 2000-05-03 | 2005-04-21 | Amgen Inc. | Modified peptides, comprising an FC domain, as therapeutic agents |
| PL376821A1 (pl) * | 2002-03-27 | 2006-01-09 | Immunex Corporation | Sposoby zwiększania produkcji polipeptydów |
-
2003
- 2003-03-27 PL PL376821A patent/PL376821A1/pl unknown
- 2003-03-27 ES ES03716840.8T patent/ES2557741T3/es not_active Expired - Lifetime
- 2003-03-27 EP EP03716840.8A patent/EP1497444B1/en not_active Expired - Lifetime
- 2003-03-27 CA CA2480121A patent/CA2480121C/en not_active Expired - Fee Related
- 2003-03-27 US US10/400,334 patent/US6872549B2/en not_active Expired - Lifetime
- 2003-03-27 WO PCT/US2003/009266 patent/WO2003083066A2/en active IP Right Grant
- 2003-03-27 JP JP2003580502A patent/JP2005521401A/ja active Pending
- 2003-03-27 MX MXPA04009381A patent/MXPA04009381A/es active IP Right Grant
- 2003-03-27 AU AU2003220529A patent/AU2003220529B2/en not_active Expired
-
2005
- 2005-02-04 US US11/051,149 patent/US7452695B2/en active Active
-
2008
- 2008-02-04 JP JP2008024395A patent/JP4414466B2/ja not_active Expired - Lifetime
- 2008-11-26 JP JP2008301520A patent/JP4414472B2/ja not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| ES2557741T3 (es) | 2016-01-28 |
| CA2480121C (en) | 2012-02-28 |
| US20030211579A1 (en) | 2003-11-13 |
| WO2003083066A3 (en) | 2004-02-26 |
| JP4414472B2 (ja) | 2010-02-10 |
| CA2480121A1 (en) | 2003-10-09 |
| AU2003220529B2 (en) | 2006-09-07 |
| EP1497444B1 (en) | 2015-11-04 |
| MXPA04009381A (es) | 2005-01-25 |
| US7452695B2 (en) | 2008-11-18 |
| WO2003083066A2 (en) | 2003-10-09 |
| JP4414466B2 (ja) | 2010-02-10 |
| EP1497444A2 (en) | 2005-01-19 |
| US20050233415A1 (en) | 2005-10-20 |
| JP2005521401A (ja) | 2005-07-21 |
| EP1497444A4 (en) | 2006-08-30 |
| AU2003220529A1 (en) | 2003-10-13 |
| US6872549B2 (en) | 2005-03-29 |
| JP2008167760A (ja) | 2008-07-24 |
| JP2009082138A (ja) | 2009-04-23 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PL376821A1 (pl) | Sposoby zwiększania produkcji polipeptydów | |
| HUS1500016I1 (hu) | Tiacumicin elõállítása | |
| AU2003283174A8 (en) | Method for protein production | |
| AU2003206684A8 (en) | Plant polypeptide production | |
| PL377943A1 (pl) | Sposób wytwarzania benzofenonów | |
| IL162780A0 (en) | Method for producing modified peptide | |
| GB0201505D0 (en) | Process | |
| EP1539982A4 (en) | glutathione | |
| PL372214A1 (en) | Novel process | |
| EP1614695A4 (en) | POLYPEPTIDE | |
| GB0218977D0 (en) | Polypeptide | |
| HK1082000A1 (en) | Method for producing cephalexin | |
| GB0201378D0 (en) | Process | |
| GB0202563D0 (en) | Process | |
| GB0223193D0 (en) | Polypeptide | |
| GB0229967D0 (en) | Protein production | |
| GB0218030D0 (en) | Multi-submit protein production system | |
| GB0208925D0 (en) | Polypeptide | |
| PL374000A1 (en) | Improved process for hydroxyazapirones | |
| GB0229476D0 (en) | Novel process | |
| GB0206655D0 (en) | Novel process | |
| EP1477559A4 (en) | NEW POLYPEPTIDE | |
| GB0202221D0 (en) | Novel polypeptide | |
| PL377523A1 (pl) | Sposób wytwarzania zrekombinowanej heterokarpiny | |
| GB0222616D0 (en) | Novel method |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| DISC | Decisions on discontinuance of the proceedings (taken after the publication of the particulars of the applications) |