PL375980A1 - Nowe związki imidazolowe jako inhibitory transformującego czynnika wzrostowego (TGF) - Google Patents

Nowe związki imidazolowe jako inhibitory transformującego czynnika wzrostowego (TGF)

Info

Publication number
PL375980A1
PL375980A1 PL03375980A PL37598003A PL375980A1 PL 375980 A1 PL375980 A1 PL 375980A1 PL 03375980 A PL03375980 A PL 03375980A PL 37598003 A PL37598003 A PL 37598003A PL 375980 A1 PL375980 A1 PL 375980A1
Authority
PL
Poland
Prior art keywords
tgf
inhibitors
growth factor
transforming growth
imidazole compounds
Prior art date
Application number
PL03375980A
Other languages
English (en)
Inventor
Laura Cook Blumberg
Michael John Munchhof
Original Assignee
Pfizer Products Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Products Inc. filed Critical Pfizer Products Inc.
Publication of PL375980A1 publication Critical patent/PL375980A1/pl

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
PL03375980A 2002-09-18 2003-09-08 Nowe związki imidazolowe jako inhibitory transformującego czynnika wzrostowego (TGF) PL375980A1 (pl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US41189402P 2002-09-18 2002-09-18
US48452203P 2003-07-02 2003-07-02

Publications (1)

Publication Number Publication Date
PL375980A1 true PL375980A1 (pl) 2005-12-12

Family

ID=32033577

Family Applications (1)

Application Number Title Priority Date Filing Date
PL03375980A PL375980A1 (pl) 2002-09-18 2003-09-08 Nowe związki imidazolowe jako inhibitory transformującego czynnika wzrostowego (TGF)

Country Status (28)

Country Link
US (2) US7153872B2 (pl)
EP (1) EP1542990B1 (pl)
JP (1) JP4547271B2 (pl)
KR (1) KR20050057392A (pl)
CN (1) CN1681805A (pl)
AP (1) AP2005003264A0 (pl)
AR (1) AR041274A1 (pl)
AT (1) ATE433968T1 (pl)
AU (1) AU2003263404A1 (pl)
BR (1) BR0314372A (pl)
CA (1) CA2498047C (pl)
CO (1) CO5550453A2 (pl)
DE (1) DE60328028D1 (pl)
EA (1) EA200500378A1 (pl)
EC (1) ECSP055680A (pl)
ES (1) ES2325687T3 (pl)
HR (1) HRP20050252A2 (pl)
IS (1) IS7712A (pl)
MA (1) MA27441A1 (pl)
MX (1) MXPA05002981A (pl)
NO (1) NO20051008L (pl)
OA (1) OA12928A (pl)
PA (1) PA8583301A1 (pl)
PE (1) PE20050072A1 (pl)
PL (1) PL375980A1 (pl)
TW (1) TW200404793A (pl)
UY (1) UY27982A1 (pl)
WO (1) WO2004026859A1 (pl)

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AU2005280168A1 (en) * 2004-08-31 2006-03-09 Biogen Idec Ma Inc. Pyrimidinylimidazoles as TGF-beta inhibitors
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US8865732B2 (en) 2008-03-21 2014-10-21 Novartis Ag Heterocyclic compounds and uses thereof
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WO2010149755A1 (en) 2009-06-26 2010-12-29 Novartis Ag 1, 3-disubstituted imidazolidin-2-one derivatives as inhibitors of cyp 17
DE102009043260A1 (de) 2009-09-28 2011-04-28 Merck Patent Gmbh Pyridinyl-imidazolonderivate
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US8080568B1 (en) * 2010-06-29 2011-12-20 Ewha University - Industry Collaboration Foundation 2-pyridyl substituted imidazoles as therapeutic ALK5 and/or ALK4 inhibitors
USRE47141E1 (en) 2010-06-29 2018-11-27 EWHA University—Industry Collaboration Foundation Methods of treating fibrosis, cancer and vascular injuries
DE102010049595A1 (de) 2010-10-26 2012-04-26 Merck Patent Gmbh Chinazolinderivate
US9242969B2 (en) 2013-03-14 2016-01-26 Novartis Ag Biaryl amide compounds as kinase inhibitors
CN109045032A (zh) 2014-01-01 2018-12-21 麦迪威森技术有限责任公司 氨基吡啶类化合物和使用方法
UY36294A (es) 2014-09-12 2016-04-29 Novartis Ag Compuestos y composiciones como inhibidores de quinasa
AU2017329090B9 (en) 2016-09-19 2019-09-05 Novartis Ag Therapeutic combinations comprising a RAF inhibitor and a ERK inhibitor
WO2018132279A1 (en) * 2017-01-05 2018-07-19 Bristol-Myers Squibb Company Tgf beta receptor antagonists
US11266653B2 (en) 2017-05-02 2022-03-08 Novartis Ag Combination therapy
AU2019396360A1 (en) 2018-12-11 2021-05-27 Theravance Biopharma R&D Ip, Llc Naphthyridine and quinoline derivatives useful as ALK5 inhibitors
CA3138123A1 (en) 2019-05-13 2020-11-19 Novartis Ag New crystalline forms of n-(3-(2-(2-hydroxyethoxy)-6-morpholinopyridin-4-yl)-4-methvlphenyl)-2 (trifluoromethyl)isonicotinamide as raf inhibitors for the treatment of cancer
CN114728941A (zh) * 2019-11-22 2022-07-08 施万生物制药研发Ip有限责任公司 作为alk5抑制剂的经取代的1,5-萘啶或喹啉
KR102539660B1 (ko) 2020-08-20 2023-06-02 가천대학교 산학협력단 베타-폴리비닐리덴 플루오라이드 코팅층이 형성된 아연 음극 및 상기 음극을 포함하는 수계 아연 이온 전지
KR102733584B1 (ko) 2020-09-04 2024-11-21 고려대학교 세종산학협력단 전기화학적 및 광전기화학적 수소 생산용 황화니켈 나노결정 촉매 및 이의 제조방법
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Also Published As

Publication number Publication date
US7635702B2 (en) 2009-12-22
CN1681805A (zh) 2005-10-12
ATE433968T1 (de) 2009-07-15
UY27982A1 (es) 2004-04-30
MXPA05002981A (es) 2005-06-22
CA2498047C (en) 2009-05-19
NO20051008L (no) 2005-06-07
CA2498047A1 (en) 2004-04-01
US20040106608A1 (en) 2004-06-03
HRP20050252A2 (en) 2005-10-31
CO5550453A2 (es) 2005-08-31
TW200404793A (en) 2004-04-01
AR041274A1 (es) 2005-05-11
AP2005003264A0 (en) 2005-03-31
OA12928A (en) 2006-10-13
US20070088037A1 (en) 2007-04-19
US7153872B2 (en) 2006-12-26
ECSP055680A (es) 2005-05-30
AU2003263404A1 (en) 2004-04-08
IS7712A (is) 2005-02-24
PE20050072A1 (es) 2005-03-01
BR0314372A (pt) 2005-07-19
EP1542990A1 (en) 2005-06-22
EP1542990B1 (en) 2009-06-17
DE60328028D1 (de) 2009-07-30
JP2006502237A (ja) 2006-01-19
KR20050057392A (ko) 2005-06-16
MA27441A1 (fr) 2005-07-01
JP4547271B2 (ja) 2010-09-22
WO2004026859A1 (en) 2004-04-01
EA200500378A1 (ru) 2005-08-25
PA8583301A1 (es) 2004-09-16
ES2325687T3 (es) 2009-09-14

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