PA8583301A1 - Nuevos compuestos de imidazol como inhibidores del factor de crecimiento transformante (tgf) - Google Patents

Nuevos compuestos de imidazol como inhibidores del factor de crecimiento transformante (tgf)

Info

Publication number
PA8583301A1
PA8583301A1 PA20038583301A PA8583301A PA8583301A1 PA 8583301 A1 PA8583301 A1 PA 8583301A1 PA 20038583301 A PA20038583301 A PA 20038583301A PA 8583301 A PA8583301 A PA 8583301A PA 8583301 A1 PA8583301 A1 PA 8583301A1
Authority
PA
Panama
Prior art keywords
tgf
growth factor
transforming growth
inhibitors
compounds
Prior art date
Application number
PA20038583301A
Other languages
English (en)
Inventor
Laura Cook Blumberg
Michael John Munchhof
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of PA8583301A1 publication Critical patent/PA8583301A1/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Abstract

SE DESCRIBEN NUEVOS COMPUESTOS DE IMIDAZOL, INCLUYENDO SUS DERIVADOS INTERMEDIOS PARA SU PREPARACION, COMPOSICIONES FARMACEUTICAS QUE LOS CONTIENEN Y SU USO MEDICINAL. LOS COMPUESTOS DE LA PRESENTE INVENCION SON INHIBIDORES POTENTES DE RUTA DE SEÑALIZACION DEL FACTOR DEL CRECIMIENTO TRANSFORMANTE ("TGF)-ß. SON DE UTILIDAD EN EL TRATAMIENTO DE DIVERSOS ESTADOS DE ENFERMEDAD RELACIONADOS CON TGF INCLUYENDO POR EJEMPLO CANCER Y ENFERMEDADES FIBROTICAS.
PA20038583301A 2002-09-18 2003-09-17 Nuevos compuestos de imidazol como inhibidores del factor de crecimiento transformante (tgf) PA8583301A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US41189402P 2002-09-18 2002-09-18
US48452203P 2003-07-02 2003-07-02

Publications (1)

Publication Number Publication Date
PA8583301A1 true PA8583301A1 (es) 2004-09-16

Family

ID=32033577

Family Applications (1)

Application Number Title Priority Date Filing Date
PA20038583301A PA8583301A1 (es) 2002-09-18 2003-09-17 Nuevos compuestos de imidazol como inhibidores del factor de crecimiento transformante (tgf)

Country Status (28)

Country Link
US (2) US7153872B2 (es)
EP (1) EP1542990B1 (es)
JP (1) JP4547271B2 (es)
KR (1) KR20050057392A (es)
CN (1) CN1681805A (es)
AP (1) AP2005003264A0 (es)
AR (1) AR041274A1 (es)
AT (1) ATE433968T1 (es)
AU (1) AU2003263404A1 (es)
BR (1) BR0314372A (es)
CA (1) CA2498047C (es)
CO (1) CO5550453A2 (es)
DE (1) DE60328028D1 (es)
EA (1) EA200500378A1 (es)
EC (1) ECSP055680A (es)
ES (1) ES2325687T3 (es)
HR (1) HRP20050252A2 (es)
IS (1) IS7712A (es)
MA (1) MA27441A1 (es)
MX (1) MXPA05002981A (es)
NO (1) NO20051008L (es)
OA (1) OA12928A (es)
PA (1) PA8583301A1 (es)
PE (1) PE20050072A1 (es)
PL (1) PL375980A1 (es)
TW (1) TW200404793A (es)
UY (1) UY27982A1 (es)
WO (1) WO2004026859A1 (es)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR039241A1 (es) * 2002-04-04 2005-02-16 Biogen Inc Heteroarilos trisustituidos y metodos para su produccion y uso de los mismos
UA80295C2 (en) * 2002-09-06 2007-09-10 Biogen Inc Pyrazolopyridines and using the same
AP2005003264A0 (en) * 2002-09-18 2005-03-31 Pfizer Prod Inc Novel imidazole compounds as transforming growth factor (TGD) inhibitors.
AU2003259475A1 (en) * 2002-09-18 2004-04-08 Pfizer Products Inc. Pyrazole derivatives as transforming growth factor (TGF) inhibitors
KR20050057415A (ko) 2002-09-18 2005-06-16 화이자 프로덕츠 인코포레이티드 전환성장인자(ｔｇｆ) 억제제로서의 신규한 싸이아졸 및 옥사졸 화합물
PA8595001A1 (es) * 2003-03-04 2004-09-28 Pfizer Prod Inc Nuevos compuestos heteroaromaticos condensados que son inhibidores del factor de crecimiento transforante (tgf)
US20080319012A1 (en) * 2004-04-21 2008-12-25 In2Gen Co., Ltd. 2-Pyridyl substituted imidazoles as ALK5 and/or ALK4 inhibitors
KR100749566B1 (ko) 2004-04-21 2007-08-16 이화여자대학교 산학협력단 Ａｌｋ5 및/또는 ａｌｋ4 억제제로 유효한 2-피리딜이치환된 이미다졸 유도체
EP1765789B1 (en) * 2004-06-18 2013-02-27 Novartis AG N-(1-(1-benzyl-4-phenyl-1h-imidazol-2-yl)-2,2-dimethylpropyl)benzamide derivatives and related compounds as kinesin spindle protein (ksp) inhibitors for the treatment of cancer
CA2578630A1 (en) * 2004-08-31 2006-03-09 Wen-Cherng Lee Pyrimidinylimidazoles as tgf-beta inhibitors
EP1798229A4 (en) * 2004-09-07 2009-07-29 Sankyo Co SUBSTITUTED BIPHENYL DERIVATIVE
PE20070335A1 (es) * 2005-08-30 2007-04-21 Novartis Ag Benzimidazoles sustituidos y metodos para su preparacion
CN101330914A (zh) * 2005-12-16 2008-12-24 爱尔康公司 使用alk5调节剂控制眼内压
CN1990473B (zh) * 2005-12-30 2013-07-10 中国人民解放军军事医学科学院毒物药物研究所 三取代1h-咪唑类化合物、其制备方法、药物组合物及其制药用途
WO2008094556A2 (en) * 2007-01-30 2008-08-07 Biogen Idec Ma Inc. Imidazolone compounds as tgf-beta family type i receptors, alk5 and/or alk4 antagonists
JP2010529031A (ja) * 2007-05-29 2010-08-26 グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー Ｐｉ３キナーゼ阻害剤としてのナフチリジン誘導体
WO2009047163A1 (en) * 2007-10-10 2009-04-16 F. Hoffmann-La Roche Ag Methods of treating inflammatory diseases
US8865732B2 (en) 2008-03-21 2014-10-21 Novartis Ag Heterocyclic compounds and uses thereof
BRPI0908906A2 (pt) * 2008-03-21 2019-09-24 Novartis Ag compostos heterocíclicos e usos dos mesmos
US8324241B2 (en) 2008-04-11 2012-12-04 Bristol-Myers Squibb Company Triazolo compounds useful as DGAT1 inhibitors
US8394823B2 (en) 2008-04-11 2013-03-12 Bristol-Myers Squibb Company Triazolopyridine compounds useful as DGAT1 inhibitors
WO2009155388A1 (en) 2008-06-20 2009-12-23 Bristol-Myers Squibb Company Imidazopyridine and imidazopyrazine compounds useful as kinase inhibitors
AU2010264698C1 (en) 2009-06-26 2013-05-16 Novartis Ag 1, 3-disubstituted imidazolidin-2-one derivatives as inhibitors of CYP 17
DE102009043260A1 (de) 2009-09-28 2011-04-28 Merck Patent Gmbh Pyridinyl-imidazolonderivate
DE102009049679A1 (de) 2009-10-19 2011-04-21 Merck Patent Gmbh Pyrazolopyrimidinderivate
USRE47141E1 (en) 2010-06-29 2018-11-27 EWHA University—Industry Collaboration Foundation Methods of treating fibrosis, cancer and vascular injuries
US8080568B1 (en) * 2010-06-29 2011-12-20 Ewha University - Industry Collaboration Foundation 2-pyridyl substituted imidazoles as therapeutic ALK5 and/or ALK4 inhibitors
DE102010049595A1 (de) 2010-10-26 2012-04-26 Merck Patent Gmbh Chinazolinderivate
US9242969B2 (en) 2013-03-14 2016-01-26 Novartis Ag Biaryl amide compounds as kinase inhibitors
ES2813875T3 (es) 2014-01-01 2021-03-25 Medivation Tech Llc Compuestos y procedimientos de uso
UY36294A (es) 2014-09-12 2016-04-29 Novartis Ag Compuestos y composiciones como inhibidores de quinasa
US10961239B2 (en) 2017-01-05 2021-03-30 Bristol-Myers Squibb Company TGF beta receptor antagonists
AU2019396360A1 (en) 2018-12-11 2021-05-27 Theravance Biopharma R&D Ip, Llc Naphthyridine and quinoline derivatives useful as ALK5 inhibitors
EP4061809A1 (en) 2019-11-22 2022-09-28 Theravance Biopharma R&D IP, LLC Substituted 1,5-naphthyridines or quinolines as alk5 inhibitors
KR102539660B1 (ko) 2020-08-20 2023-06-02 가천대학교 산학협력단 베타-폴리비닐리덴 플루오라이드 코팅층이 형성된 아연 음극 및 상기 음극을 포함하는 수계 아연 이온 전지
KR20220031386A (ko) 2020-09-04 2022-03-11 고려대학교 세종산학협력단 전기화학적 및 광전기화학적 수소 생산용 황화니켈 나노결정 촉매 및 이의 제조방법
US20230089180A1 (en) * 2021-08-13 2023-03-23 Bisichem Co., Ltd. Fused ring heteroaryl compounds and use thereof
CN115466260B (zh) * 2022-09-06 2023-10-13 延边大学 含氨基酸结构的咪唑和噻唑类衍生物及其制备方法和应用

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3707475A (en) 1970-11-16 1972-12-26 Pfizer Antiinflammatory imidazoles
IL83467A0 (en) * 1986-08-15 1988-01-31 Fujisawa Pharmaceutical Co Imidazole derivatives,processes for their preparation and pharmaceutical compositions containing the same
US5656644A (en) * 1994-07-20 1997-08-12 Smithkline Beecham Corporation Pyridyl imidazoles
US6087381A (en) 1997-05-22 2000-07-11 G. D. Searle & Company Pyrazole derivatives as p38 kinase inhibitors
US6514977B1 (en) 1997-05-22 2003-02-04 G.D. Searle & Company Substituted pyrazoles as p38 kinase inhibitors
IL132736A0 (en) 1997-05-22 2001-03-19 Searle & Co 3(5)-Heteroaryl substituted pyrazoles as p38 kinase inhibitors
ES2187473T3 (es) * 1999-04-09 2003-06-16 Smithkline Beecham Corp Triarylimidazoles.
AR029803A1 (es) * 2000-02-21 2003-07-16 Smithkline Beecham Plc Imidazoles sustituidos con piridilo y composiciones farmaceuticas que las comprenden
GB0007405D0 (en) * 2000-03-27 2000-05-17 Smithkline Beecham Corp Compounds
PE20020506A1 (es) 2000-08-22 2002-07-09 Glaxo Group Ltd Derivados de pirazol fusionados como inhibidores de la proteina cinasa
GB0027987D0 (en) * 2000-11-16 2001-01-03 Smithkline Beecham Plc Compounds
EP1349851A4 (en) 2000-11-16 2004-09-08 Smithkline Beecham Corp COMPOUNDS
GB0100762D0 (en) 2001-01-11 2001-02-21 Smithkline Beecham Plc Novel use
WO2002066462A1 (en) 2001-02-02 2002-08-29 Glaxo Group Limited Pyrazole derivatives against tgf overexpression
GB0102672D0 (en) 2001-02-02 2001-03-21 Glaxo Group Ltd Compounds
JP2004521901A (ja) 2001-02-02 2004-07-22 グラクソ　グループ　リミテッド Ｔｇｆ阻害剤としてのピラゾール
CA2440211A1 (en) * 2001-03-09 2002-09-19 Pfizer Products Inc. Benzimidazole anti-inflammatory compounds
AR039241A1 (es) * 2002-04-04 2005-02-16 Biogen Inc Heteroarilos trisustituidos y metodos para su produccion y uso de los mismos
JP2005539000A (ja) 2002-07-31 2005-12-22 スミスクライン・ビーチャム・コーポレイション Ａｌｋ５阻害剤としての２−フェニルピリジン−４−イル誘導体
AP2005003264A0 (en) 2002-09-18 2005-03-31 Pfizer Prod Inc Novel imidazole compounds as transforming growth factor (TGD) inhibitors.
KR20050057415A (ko) 2002-09-18 2005-06-16 화이자 프로덕츠 인코포레이티드 전환성장인자(ｔｇｆ) 억제제로서의 신규한 싸이아졸 및 옥사졸 화합물
PL375973A1 (en) 2002-09-18 2005-12-12 Pfizer Products Inc. Novel isothiazole and isoxazole compounds as transforming growth factor (tgf) inhibitors
CA2497971A1 (en) 2002-09-18 2004-04-01 Pfizer Products Inc. Triazole derivatives as transforming growth factor (tgf) inhibitors
AU2003259475A1 (en) 2002-09-18 2004-04-08 Pfizer Products Inc. Pyrazole derivatives as transforming growth factor (TGF) inhibitors
PA8595001A1 (es) 2003-03-04 2004-09-28 Pfizer Prod Inc Nuevos compuestos heteroaromaticos condensados que son inhibidores del factor de crecimiento transforante (tgf)

Also Published As

Publication number Publication date
US20040106608A1 (en) 2004-06-03
EP1542990A1 (en) 2005-06-22
OA12928A (en) 2006-10-13
ECSP055680A (es) 2005-05-30
HRP20050252A2 (en) 2005-10-31
MA27441A1 (fr) 2005-07-01
MXPA05002981A (es) 2005-06-22
PE20050072A1 (es) 2005-03-01
US7153872B2 (en) 2006-12-26
US7635702B2 (en) 2009-12-22
ATE433968T1 (de) 2009-07-15
EA200500378A1 (ru) 2005-08-25
DE60328028D1 (de) 2009-07-30
JP4547271B2 (ja) 2010-09-22
CO5550453A2 (es) 2005-08-31
IS7712A (is) 2005-02-24
CA2498047A1 (en) 2004-04-01
TW200404793A (en) 2004-04-01
KR20050057392A (ko) 2005-06-16
BR0314372A (pt) 2005-07-19
PL375980A1 (en) 2005-12-12
JP2006502237A (ja) 2006-01-19
NO20051008L (no) 2005-06-07
AU2003263404A1 (en) 2004-04-08
EP1542990B1 (en) 2009-06-17
US20070088037A1 (en) 2007-04-19
CA2498047C (en) 2009-05-19
AP2005003264A0 (en) 2005-03-31
WO2004026859A1 (en) 2004-04-01
CN1681805A (zh) 2005-10-12
AR041274A1 (es) 2005-05-11
UY27982A1 (es) 2004-04-30
ES2325687T3 (es) 2009-09-14

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