PL357533A1 - Sposób oczyszczania lowastatyny i simwastatyny prowadzący do zmniejszonych poziomów zanieczyszczeń dimerycznych - Google Patents
Sposób oczyszczania lowastatyny i simwastatyny prowadzący do zmniejszonych poziomów zanieczyszczeń dimerycznychInfo
- Publication number
- PL357533A1 PL357533A1 PL01357533A PL35753301A PL357533A1 PL 357533 A1 PL357533 A1 PL 357533A1 PL 01357533 A PL01357533 A PL 01357533A PL 35753301 A PL35753301 A PL 35753301A PL 357533 A1 PL357533 A1 PL 357533A1
- Authority
- PL
- Poland
- Prior art keywords
- simvastatin
- reduced levels
- dimeric impurities
- lovastatin
- purifying
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/30—Oxygen atoms, e.g. delta-lactones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pyrane Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US18686800P | 2000-03-03 | 2000-03-03 | |
PCT/US2001/006334 WO2001066538A1 (en) | 2000-03-03 | 2001-02-27 | A process for purifying lovastatin and simvastatin with reduced levels of dimeric impurities |
Publications (1)
Publication Number | Publication Date |
---|---|
PL357533A1 true PL357533A1 (pl) | 2004-07-26 |
Family
ID=22686591
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PL01357533A PL357533A1 (pl) | 2000-03-03 | 2001-02-27 | Sposób oczyszczania lowastatyny i simwastatyny prowadzący do zmniejszonych poziomów zanieczyszczeń dimerycznych |
Country Status (18)
Country | Link |
---|---|
US (1) | US6521762B2 (pl) |
EP (1) | EP1265884A4 (pl) |
JP (1) | JP2003525935A (pl) |
KR (1) | KR20030069790A (pl) |
CN (1) | CN1443182A (pl) |
AU (1) | AU4183301A (pl) |
CA (1) | CA2402061A1 (pl) |
CZ (1) | CZ20023201A3 (pl) |
DE (1) | DE01913139T1 (pl) |
HR (1) | HRP20020730A2 (pl) |
HU (1) | HUP0301214A2 (pl) |
IL (1) | IL151583A0 (pl) |
IS (1) | IS6533A (pl) |
PL (1) | PL357533A1 (pl) |
SK (1) | SK13782002A3 (pl) |
TR (1) | TR200403001T3 (pl) |
WO (1) | WO2001066538A1 (pl) |
ZA (1) | ZA200207023B (pl) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100435078B1 (ko) * | 2002-02-08 | 2004-06-09 | 종근당바이오 주식회사 | 심바스타틴의 정제방법 |
AU2003286417A1 (en) * | 2003-12-05 | 2005-06-24 | Biocon Limited | Process for the purification of macrolides |
US20050282883A1 (en) * | 2004-04-29 | 2005-12-22 | John Griffin | Compositions and treatments for inhibiting kinase and/or HMG-CoA reductase |
US7199126B2 (en) * | 2004-04-29 | 2007-04-03 | Pharmix Corporation | Compositions and treatments for inhibiting kinase and/or HMG-CoA reductase |
US20050272770A1 (en) * | 2004-04-29 | 2005-12-08 | John Griffin | Compositions and treatments for inhibiting kinase and/or HMG-CoA reductase |
US7183285B2 (en) * | 2004-04-29 | 2007-02-27 | Pharmix Corp. | Compositions and treatments for inhibiting kinase and/or HMG-CoA reductase |
US8012498B2 (en) | 2004-07-12 | 2011-09-06 | Sandhya Goyal | Topical gel formulation comprising organophosphate insecticide and preparation thereof |
US8158139B2 (en) * | 2004-07-12 | 2012-04-17 | Taro Pharmaceuticals North America, Inc. | Topical gel formulation comprising organophosphate insecticide and preparation thereof |
US20070015779A1 (en) * | 2005-04-29 | 2007-01-18 | John Griffin | Compositions and treatments for inhibiting kinase and/or hmg-coa reductase |
US7560445B2 (en) | 2005-07-06 | 2009-07-14 | Taro Pharmaceuticals North America, Inc. | Process for preparing malathion for pharmaceutical use |
US20090111997A1 (en) * | 2005-11-23 | 2009-04-30 | Aaron Cote | Method of Generating Amorphous Solid for Water-Insoluble Pharmaceuticals |
US8481084B2 (en) | 2007-05-23 | 2013-07-09 | Amcol International Corporation | Cholesterol-interacting layered phyllosilicates and methods of reducing hypercholesteremia in a mammal |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5925599B2 (ja) | 1979-02-20 | 1984-06-19 | 三共株式会社 | 新生理活性物質モナコリンkおよびその製造法 |
US4294926A (en) | 1979-06-15 | 1981-10-13 | Merck & Co., Inc. | Hypocholesteremic fermentation products and process of preparation |
US4319039A (en) | 1979-06-15 | 1982-03-09 | Merck & Co., Inc. | Preparation of ammonium salt of hypocholesteremic fermentation product |
US4294846A (en) | 1979-09-21 | 1981-10-13 | Merck & Co., Inc. | Hypocholesteremic fermentation products and products of preparation |
US4342767A (en) | 1980-01-23 | 1982-08-03 | Merck & Co., Inc. | Hypocholesteremic fermentation products |
US4444784A (en) | 1980-08-05 | 1984-04-24 | Merck & Co., Inc. | Antihypercholesterolemic compounds |
US4420491A (en) | 1980-05-28 | 1983-12-13 | Merck & Co., Inc. | Hypocholesteremic fermentation products and process of preparation |
US4582915A (en) | 1983-10-11 | 1986-04-15 | Merck & Co., Inc. | Process for C-methylation of 2-methylbutyrates |
US4820850A (en) | 1987-07-10 | 1989-04-11 | Merck & Co., Inc. | Process for α-C-alkylation of the 8-acyl group on mevinolin and analogs thereof |
US4916239A (en) | 1988-07-19 | 1990-04-10 | Merck & Co., Inc. | Process for the lactonization of mevinic acids and analogs thereof |
US5202029A (en) * | 1991-03-13 | 1993-04-13 | Caron Kabushiki Kaisha | Process for purification of hmg-coa reductase inhibitors |
HU210867B (en) * | 1992-11-04 | 1995-10-30 | Biogal Gyogyszergyar | Method for extraction and purification of mevinolin from culture medium |
SI9300047A (en) | 1993-01-29 | 1994-09-30 | Krka | Microbiological method for preparation of lovostatin and/or mevinoline acid |
US5409820A (en) | 1993-08-06 | 1995-04-25 | Apotex, Inc. | Process for the production of lovastatin using Coniothyrium fuckelii |
WO1997020834A1 (en) | 1995-12-06 | 1997-06-12 | Antibiotic Co. | Method of production of lovastatin |
IN186880B (pl) | 1997-10-28 | 2001-12-01 | Ranbaxy Lab Ltd | |
IN186879B (pl) | 1997-10-28 | 2001-12-01 | Ranbaxy Lab Ltd | |
SI9800046A (sl) | 1998-02-18 | 1999-08-31 | LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. | Postopek za pridobivanje inhibitorjev HMG-CoA reduktaze visoke čistosti |
SI20072A (sl) * | 1998-09-18 | 2000-04-30 | LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. | Postopek za pridobivanje inhibitorjev HMG-CoA reduktaze |
EP1228057A2 (en) | 1999-10-27 | 2002-08-07 | Merck & Co., Inc. | Lactonization process |
-
2001
- 2001-02-27 JP JP2001565354A patent/JP2003525935A/ja active Pending
- 2001-02-27 IL IL15158301A patent/IL151583A0/xx unknown
- 2001-02-27 CN CN01808689A patent/CN1443182A/zh active Pending
- 2001-02-27 CZ CZ20023201A patent/CZ20023201A3/cs unknown
- 2001-02-27 DE DE01913139T patent/DE01913139T1/de active Pending
- 2001-02-27 KR KR1020027011541A patent/KR20030069790A/ko not_active Application Discontinuation
- 2001-02-27 AU AU4183301A patent/AU4183301A/xx active Pending
- 2001-02-27 WO PCT/US2001/006334 patent/WO2001066538A1/en not_active Application Discontinuation
- 2001-02-27 PL PL01357533A patent/PL357533A1/pl not_active Application Discontinuation
- 2001-02-27 TR TR2004/03001T patent/TR200403001T3/xx unknown
- 2001-02-27 CA CA002402061A patent/CA2402061A1/en not_active Abandoned
- 2001-02-27 HU HU0301214A patent/HUP0301214A2/hu unknown
- 2001-02-27 EP EP01913139A patent/EP1265884A4/en not_active Withdrawn
- 2001-02-27 US US09/793,946 patent/US6521762B2/en not_active Expired - Fee Related
- 2001-02-27 SK SK1378-2002A patent/SK13782002A3/sk not_active Application Discontinuation
-
2002
- 2002-08-29 IS IS6533A patent/IS6533A/is unknown
- 2002-09-02 ZA ZA200207023A patent/ZA200207023B/en unknown
- 2002-09-05 HR HRP20020730 patent/HRP20020730A2/hr not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
AU4183301A (en) | 2001-09-17 |
EP1265884A1 (en) | 2002-12-18 |
JP2003525935A (ja) | 2003-09-02 |
IS6533A (is) | 2002-08-29 |
HRP20020730A2 (en) | 2004-12-31 |
CN1443182A (zh) | 2003-09-17 |
US20020002288A1 (en) | 2002-01-03 |
HUP0301214A2 (hu) | 2003-08-28 |
EP1265884A4 (en) | 2003-05-21 |
US6521762B2 (en) | 2003-02-18 |
DE01913139T1 (de) | 2005-03-31 |
TR200403001T3 (tr) | 2005-02-21 |
SK13782002A3 (sk) | 2004-02-03 |
IL151583A0 (en) | 2003-04-10 |
ZA200207023B (en) | 2003-09-02 |
CZ20023201A3 (cs) | 2003-09-17 |
WO2001066538A1 (en) | 2001-09-13 |
CA2402061A1 (en) | 2001-09-13 |
KR20030069790A (ko) | 2003-08-27 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
REFS | Decisions on refusal to grant patents (taken after the publication of the particulars of the applications) |