PL3554681T3 - Sposób na matryce sensorowe koron białkowych do wczesnego wykrywania chorób - Google Patents

Sposób na matryce sensorowe koron białkowych do wczesnego wykrywania chorób

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Publication number
PL3554681T3
PL3554681T3 PL17881767T PL17881767T PL3554681T3 PL 3554681 T3 PL3554681 T3 PL 3554681T3 PL 17881767 T PL17881767 T PL 17881767T PL 17881767 T PL17881767 T PL 17881767T PL 3554681 T3 PL3554681 T3 PL 3554681T3
Authority
PL
Poland
Prior art keywords
diseases
sensor array
early detection
protein corona
corona sensor
Prior art date
Application number
PL17881767T
Other languages
English (en)
Inventor
Omid Farokhzad
Morteza Mahmoudi
Claudia Corbo
Original Assignee
The Brigham And Women's Hospital, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=62559844&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL3554681(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by The Brigham And Women's Hospital, Inc. filed Critical The Brigham And Women's Hospital, Inc.
Publication of PL3554681T3 publication Critical patent/PL3554681T3/pl

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/40—Concentrating samples
    • G01N1/405—Concentrating samples by adsorption or absorption
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G—PHYSICS
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    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G01N33/57488—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds identifable in body fluids
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    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6842—Proteomic analysis of subsets of protein mixtures with reduced complexity, e.g. membrane proteins, phosphoproteins, organelle proteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6845—Methods of identifying protein-protein interactions in protein mixtures
    • G—PHYSICS
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    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
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    • G—PHYSICS
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G—PHYSICS
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    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
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    • B82Y15/00—Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
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    • G01N15/02—Investigating particle size or size distribution
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    • G01N2800/7023—(Hyper)proliferation
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Biophysics (AREA)
  • Medical Informatics (AREA)
  • Data Mining & Analysis (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Evolutionary Biology (AREA)
  • Theoretical Computer Science (AREA)
  • Evolutionary Computation (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Bioethics (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Software Systems (AREA)
  • Databases & Information Systems (AREA)
  • Artificial Intelligence (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Nanotechnology (AREA)
PL17881767T 2016-12-16 2017-12-18 Sposób na matryce sensorowe koron białkowych do wczesnego wykrywania chorób PL3554681T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662435409P 2016-12-16 2016-12-16
EP17881767.2A EP3554681B1 (en) 2016-12-16 2017-12-18 Method for protein corona sensor array for early detection of diseases
PCT/US2017/067013 WO2018112460A1 (en) 2016-12-16 2017-12-18 System and method for protein corona sensor array for early detection of diseases

Publications (1)

Publication Number Publication Date
PL3554681T3 true PL3554681T3 (pl) 2022-05-16

Family

ID=62559844

Family Applications (2)

Application Number Title Priority Date Filing Date
PL21216039.4T PL4056263T3 (pl) 2016-12-16 2017-12-18 System i sposób na matryce sensorowe koron białkowych do wczesnego wykrywania chorób
PL17881767T PL3554681T3 (pl) 2016-12-16 2017-12-18 Sposób na matryce sensorowe koron białkowych do wczesnego wykrywania chorób

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PL21216039.4T PL4056263T3 (pl) 2016-12-16 2017-12-18 System i sposób na matryce sensorowe koron białkowych do wczesnego wykrywania chorób

Country Status (14)

Country Link
US (3) US10866242B2 (pl)
EP (3) EP4056263B1 (pl)
JP (4) JP7069170B2 (pl)
CN (5) CN114441747B (pl)
AU (2) AU2017375496B2 (pl)
CA (1) CA3046540A1 (pl)
DE (4) DE202017007366U1 (pl)
DK (1) DK3554681T3 (pl)
ES (2) ES2993503T3 (pl)
GB (1) GB2561940A (pl)
MX (2) MX391457B (pl)
PL (2) PL4056263T3 (pl)
PT (1) PT3554681T (pl)
WO (1) WO2018112460A1 (pl)

Families Citing this family (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201615128D0 (en) * 2016-09-06 2016-10-19 Univ Manchester Methods
US20210072255A1 (en) 2016-12-16 2021-03-11 The Brigham And Women's Hospital, Inc. System and method for protein corona sensor array for early detection of diseases
CN114441747B (zh) 2016-12-16 2023-06-23 布里格姆及妇女医院股份有限公司 用于疾病的早期检测的蛋白质冠传感器阵列的系统和方法
EP3895605A1 (en) * 2016-12-21 2021-10-20 Emory University Methods and systems for determining abnormal cardiac activity
JP7404253B2 (ja) * 2017-11-27 2023-12-25 レティスペック インコーポレイテッド アルツハイマー病の病状のためのハイパースペクトル画像誘導ラマン眼球撮像装置
CN108760700A (zh) * 2018-05-29 2018-11-06 云南健牛生物科技有限公司 一种荧光金纳米簇的制备及用于四环素及铜荧光探针
EP3877400A4 (en) * 2018-11-07 2022-09-07 Seer, Inc. Compositions, methods and systems for protein corona analysis and uses thereof
CN109212217B (zh) * 2018-11-07 2021-09-10 李玉民 基于amy1a蛋白胃癌检测试剂盒及其使用方法
CN109599177B (zh) * 2018-11-27 2023-04-11 华侨大学 一种基于病历的深度学习预测医疗轨迹的方法
CN109734792B (zh) * 2019-01-17 2022-05-24 武汉明德生物科技股份有限公司 人cntn1抗原、人cntn1抗体检测试剂盒及其制备方法与应用
GB201903054D0 (en) * 2019-03-07 2019-04-24 Univ Bristol Sensor
KR102829707B1 (ko) * 2019-03-26 2025-07-04 시어 인코퍼레이티드 생체 유체로부터의 단백질 코로나 분석을 위한 조성물, 방법 및 시스템 및 그것들의 용도
CN110385427B (zh) * 2019-07-31 2021-10-19 东南大学 一种水溶性纳米粒子及其制备方法和应用
KR20240137114A (ko) 2019-08-05 2024-09-19 시어 인코퍼레이티드 샘플 제조, 데이터 생성, 및 단백질 코로나 분석을 위한 시스템 및 방법
CN112578125B (zh) * 2019-09-27 2022-10-25 成都中医药大学 检测粪钙卫蛋白含量的试剂在制备卵巢病变筛查试剂盒中的用途
WO2021087407A1 (en) * 2019-11-02 2021-05-06 Seer, Inc. Systems for protein corona analysis
CN111292801A (zh) * 2020-01-21 2020-06-16 西湖大学 蛋白质质谱结合深度学习评估甲状腺结节的方法
WO2021154893A1 (en) * 2020-01-30 2021-08-05 Prognomiq Inc Lung biomarkers and methods of use thereof
DE102020202262A1 (de) 2020-02-21 2021-08-26 Robert Bosch Gesellschaft mit beschränkter Haftung Verfahren zur Herstellung einer nanoskaligen Kanalstruktur
US12379329B2 (en) * 2020-04-24 2025-08-05 Nokomis, Inc. RF rapid diagnostics of infection and contamination
US20210350897A1 (en) * 2020-05-06 2021-11-11 Janssen Pharmaceuticals, Inc. Aggregating and analyzing drug administration data
FR3110698B1 (fr) * 2020-05-25 2025-02-07 Centre Nat Rech Scient Méthode pronostique d’hémopathies
WO2021243285A1 (en) * 2020-05-29 2021-12-02 Seer, Inc. Systems and methods for rapid identification of proteins
GB202008287D0 (en) * 2020-06-02 2020-07-15 Kostarelos Kostas Methods of determining cancer
WO2022020272A1 (en) * 2020-07-20 2022-01-27 Seer, Inc. Particles and methods of assaying
GB202012433D0 (en) * 2020-08-10 2020-09-23 Univ Manchester Nanoparticle-enabled analysis of cell-free nucleic acid in complex biological fluids
GB202012434D0 (en) * 2020-08-10 2020-09-23 Univ Manchester Multiomic analysis of nanoparticle-coronas
JP2023540904A (ja) 2020-08-25 2023-09-27 シアー， インコーポレイテッド タンパク質および核酸をアッセイするための組成物および方法
CN112034182A (zh) * 2020-09-01 2020-12-04 复旦大学附属中山医院 一种结肠癌转移预测方法和系统
US11250723B1 (en) * 2020-11-04 2022-02-15 King Abdulaziz University Visuospatial disorders detection in dementia using a computer-generated environment based on voting approach of machine learning algorithms
US20220260559A1 (en) * 2020-11-04 2022-08-18 Seer, Inc. Biomarkers for diagnosing alzheimer's disease
IT202000031139A1 (it) * 2020-12-16 2022-06-16 Univ Degli Studi Roma La Sapienza Test sierologico per coadiuvare la diagnosi e il monitoraggio del glioblastoma multiforme
CN112730692B (zh) * 2021-01-08 2022-11-29 首都医科大学附属北京朝阳医院 用于预测胎膜早破的生物标记物和方法
US20220227890A1 (en) 2021-01-21 2022-07-21 Nautilus Biotechnology, Inc. Systems and methods for biomolecule preparation
GB202102399D0 (en) * 2021-02-19 2021-04-07 Univ Manchester Methods of determining alzheimer's disease
CN112951321B (zh) * 2021-03-01 2023-10-24 湖南大学 一种基于张量分解的miRNA-疾病关联预测方法及系统
EP4056271A1 (en) 2021-03-10 2022-09-14 Cline Scientific AB Quantification of cell migration and metastatic potential of tumor cells
US20220328134A1 (en) 2021-03-31 2022-10-13 PrognomIQ, Inc. Multi-omic assessment
US11735303B2 (en) * 2021-06-22 2023-08-22 David Haase Apparatus and method for determining a composition of a replacement therapy treatment
CN113409335B (zh) * 2021-06-22 2023-04-07 西安邮电大学 基于强弱联合半监督直觉模糊聚类的图像分割方法
CN113470739B (zh) * 2021-07-03 2023-04-18 中国科学院新疆理化技术研究所 一种基于混合隶属度随机块模型的蛋白质相互作用预测方法和系统
WO2023039479A1 (en) 2021-09-10 2023-03-16 PrognomIQ, Inc. Direct classification of raw biomolecule measurement data
WO2023039579A1 (en) 2021-09-13 2023-03-16 PrognomIQ, Inc. Enhanced detection and quantitation of biomolecules
CN114019042B (zh) * 2021-10-29 2023-06-20 浙江工商大学 基于石墨烯的黄颡鱼蛋白酶抑制剂含量测定方法及装置
US12431235B1 (en) 2021-12-21 2025-09-30 United Services Automobile Association (Usaa) Automatic identification of, and responding to, cognition impairment
EP4466538A2 (en) * 2022-01-20 2024-11-27 Seer, Inc. Particles and methods of assaying
CN114879565B (zh) * 2022-05-17 2024-12-13 中建八局南方建设有限公司 一种基于大数据分析的智慧楼宇调控管理系统
CN115901706B (zh) * 2022-11-23 2025-07-29 广东石油化工学院 基于N,S-GQDs-Fe3O4@rGO构建低密度脂蛋白检测的荧光适配体传感器
CN116578053B (zh) * 2023-06-20 2025-08-29 天津中医药大学 一种基于数字孪生技术的中药智能水液提取系统及方法
US12368503B2 (en) 2023-12-27 2025-07-22 Quantum Generative Materials Llc Intent-based satellite transmit management based on preexisting historical location and machine learning
CN117593306B (zh) * 2024-01-19 2024-05-03 数据空间研究院 一种功能磁共振大脑皮层的分区方法及系统
CN118001254B (zh) * 2024-04-09 2024-07-26 北京悦康科创医药科技股份有限公司 靶向抗原呈递细胞的脂质组合物及其应用
JP7760671B1 (ja) * 2024-08-09 2025-10-27 住友化学株式会社 情報処理方法、情報処理装置及びコンピュータプログラム
CN119475061A (zh) * 2025-01-15 2025-02-18 国科大杭州高等研究院 生物分子冠拉曼光谱信号数据的分析识别系统

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5143854A (en) 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US6361944B1 (en) 1996-07-29 2002-03-26 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
AU1725200A (en) 1998-11-16 2000-06-05 California Institute Of Technology Simultaneous determination of equilibrium and kinetic properties
DE19852928C1 (de) 1998-11-17 2000-08-03 Steffen Panzner Strukturen in Form von Hohlkugeln
US6969615B2 (en) 1999-07-26 2005-11-29 20/20 Genesystems, Inc. Methods, devices, arrays and kits for detecting and analyzing biomolecules
US6780602B2 (en) 2001-11-01 2004-08-24 Microbiosystems, Limited Partnership Taxonomic identification of pathogenic microorganisms and their toxic proteins
EP2226316B1 (en) 2002-05-30 2016-01-13 The Scripps Research Institute Copper-catalysed ligation of azides and acetylenes
CN1832763A (zh) * 2003-06-05 2006-09-13 森特利昂公司 编码纤维母细胞生长因子的质粒用于治疗与高胆固醇血症或糖尿病相关的血管生成缺陷
DE102004051785B4 (de) 2004-10-25 2008-04-24 Bruker Daltonik Gmbh Proteinprofile mit Luft-MALDI
US9002652B1 (en) 2005-01-27 2015-04-07 Institute For Systems Biology Methods for identifying and using organ-specific proteins in blood
JP2009524828A (ja) * 2006-01-27 2009-07-02 ジョージ メーソン ユニバーシティー 眼の流体のマーカー
ES2448426T3 (es) 2007-10-12 2014-03-13 Pronota Nv Uso de aptámeros en proteómica
US8021891B2 (en) 2007-11-28 2011-09-20 University Of Massachusetts Methods and compositions for protein detection using nanoparticle-fluorescent polymer complexes
KR101039629B1 (ko) * 2008-05-22 2011-06-08 성균관대학교산학협력단 생체물질의 검출방법, 생체물질 검출용 칩의 제조방법 및생물질 검출용 칩
EP2401619A1 (en) * 2009-02-26 2012-01-04 University College Dublin National University Of Ireland, Dublin A method for the selective concentration of a specific low abundance biomolecule
WO2010148365A2 (en) 2009-06-19 2010-12-23 The Arizona Board Of Regents, A Body Corporate Of The State Of Arizona For And On Behalf Of Arizona State University Compound arrays for sample profiling
EP2524219A4 (en) 2010-01-14 2013-08-07 Univ Central Florida Res Found PROCESS FOR DETECTION AND ANALYSIS OF BIOMOLECULES AND BIOMOLECULAR COMPLEXES AND THEIR APPLICATION FOR MEDICAL RESEARCH AND DIAGNOSIS
JP6114035B2 (ja) 2010-02-10 2017-04-12 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 肺癌検出用唾液バイオマーカー
US9329176B2 (en) 2010-11-18 2016-05-03 Academia Sinica Glycopeptide-functionalized nanoparticles arrays for capturing and detecting biomolecules
WO2012106385A2 (en) * 2011-01-31 2012-08-09 Apprise Bio, Inc. Methods of identifying multiple epitopes in cells
GB201103726D0 (en) 2011-03-04 2011-04-20 Immunovia Ab Method, array and use thereof
WO2012170711A1 (en) * 2011-06-07 2012-12-13 Caris Life Sciences Luxembourg Holdings, S.A.R.L Circulating biomarkers for cancer
US20130058923A1 (en) * 2011-08-03 2013-03-07 Qun Huo Biomolecular interactions and interaction products as biomarkers for detection, diagnosis, prognosis and predicting therapeutic responses of human diseases
CN103874770A (zh) * 2011-08-08 2014-06-18 卡里斯生命科学卢森堡控股有限责任公司 生物标志物组合物和方法
KR20140068087A (ko) * 2011-08-23 2014-06-05 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 펩티드 나노입자 및 이의 용도
US20150168421A1 (en) * 2012-04-05 2015-06-18 Integrated Diagnostics, Inc. Srm methods in alzheimer's disease and neurological disease assays
US20140296096A1 (en) * 2013-03-27 2014-10-02 Oslo Universitetssykehus Hf Prostate cancer markers and uses thereof
CN103869080B (zh) * 2014-03-06 2016-01-27 中国农业大学 慢性神经退行性疾病早期诊断标志物及应用
US10900975B2 (en) 2015-05-12 2021-01-26 Arizona Board Of Regents On Behalf Of Arizona State University Systems and methods of epitope binning and antibody profiling
WO2017091631A1 (en) 2015-11-23 2017-06-01 Massachusetts Institute Of Technology Protein corona phase molecular recognition
GB201615128D0 (en) 2016-09-06 2016-10-19 Univ Manchester Methods
CN114441747B (zh) 2016-12-16 2023-06-23 布里格姆及妇女医院股份有限公司 用于疾病的早期检测的蛋白质冠传感器阵列的系统和方法

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