PL3465214T3 - Sposoby przewidywania korzyści terapeutycznej terapii anty-cd19 u pacjentów - Google Patents

Sposoby przewidywania korzyści terapeutycznej terapii anty-cd19 u pacjentów

Info

Publication number
PL3465214T3
PL3465214T3 PL17728484T PL17728484T PL3465214T3 PL 3465214 T3 PL3465214 T3 PL 3465214T3 PL 17728484 T PL17728484 T PL 17728484T PL 17728484 T PL17728484 T PL 17728484T PL 3465214 T3 PL3465214 T3 PL 3465214T3
Authority
PL
Poland
Prior art keywords
predicting
therapy
patients
methods
therapeutic benefits
Prior art date
Application number
PL17728484T
Other languages
English (en)
Polish (pl)
Inventor
Jan Endell
Mark Winderlich
Rainer Boxhammer
Original Assignee
Morphosys Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Morphosys Ag filed Critical Morphosys Ag
Publication of PL3465214T3 publication Critical patent/PL3465214T3/pl

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407Specifically defined cancers
    • G01N33/57426Specifically defined cancers leukemia
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G01N33/57492Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds localized on the membrane of tumor or cancer cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70503Immunoglobulin superfamily, e.g. VCAMs, PECAM, LFA-3
    • G01N2333/70535Fc-receptors, e.g. CD16, CD32, CD64 (CD2314/705F)
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/52Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Organic Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
PL17728484T 2016-05-30 2017-05-30 Sposoby przewidywania korzyści terapeutycznej terapii anty-cd19 u pacjentów PL3465214T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP16171885 2016-05-30
PCT/EP2017/063045 WO2017207574A1 (en) 2016-05-30 2017-05-30 Methods for predicting therapeutic benefit of anti-cd19 therapy in patients
EP17728484.1A EP3465214B1 (en) 2016-05-30 2017-05-30 Methods for predicting therapeutic benefit of anti-cd19 therapy in patients

Publications (1)

Publication Number Publication Date
PL3465214T3 true PL3465214T3 (pl) 2021-12-20

Family

ID=56116221

Family Applications (2)

Application Number Title Priority Date Filing Date
PL21170716.1T PL3916392T3 (pl) 2016-05-30 2017-05-30 Sposoby przewidywania korzyści terapeutycznej terapii anty-cd19 u pacjentów
PL17728484T PL3465214T3 (pl) 2016-05-30 2017-05-30 Sposoby przewidywania korzyści terapeutycznej terapii anty-cd19 u pacjentów

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PL21170716.1T PL3916392T3 (pl) 2016-05-30 2017-05-30 Sposoby przewidywania korzyści terapeutycznej terapii anty-cd19 u pacjentów

Country Status (27)

Country Link
US (2) US20190195879A1 (OSRAM)
EP (2) EP3916392B1 (OSRAM)
JP (2) JP7066639B2 (OSRAM)
KR (1) KR102416144B1 (OSRAM)
CN (2) CN115932265A (OSRAM)
AU (1) AU2017272608B2 (OSRAM)
BR (1) BR112018074603A2 (OSRAM)
CY (1) CY1124768T1 (OSRAM)
DK (2) DK3916392T3 (OSRAM)
EA (1) EA201892542A1 (OSRAM)
ES (2) ES2981046T3 (OSRAM)
FI (1) FI3916392T3 (OSRAM)
HR (2) HRP20210938T1 (OSRAM)
HU (2) HUE067450T2 (OSRAM)
IL (1) IL263103B2 (OSRAM)
LT (2) LT3916392T (OSRAM)
MA (2) MA45124B1 (OSRAM)
MD (2) MD3916392T2 (OSRAM)
MX (2) MX388502B (OSRAM)
PL (2) PL3916392T3 (OSRAM)
PT (2) PT3916392T (OSRAM)
RS (2) RS62155B1 (OSRAM)
SG (2) SG11201810159TA (OSRAM)
SI (2) SI3916392T1 (OSRAM)
SM (2) SMT202100291T1 (OSRAM)
WO (1) WO2017207574A1 (OSRAM)
ZA (2) ZA201808647B (OSRAM)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017032679A1 (en) 2015-08-21 2017-03-02 Morphosys Ag Combinations and uses thereof
AU2017348624B2 (en) 2016-10-28 2024-09-26 Incyte Corporation Combination of anti CD19 antibody with a BCL-2 inhibitor and uses thereof
KR20200030337A (ko) 2018-09-12 2020-03-20 주식회사 녹십자랩셀 종양 치료를 위한 항-cd 19 항체 및 자연살해세포를 포함하는 약학적 조합물
JP2022532519A (ja) 2019-05-03 2022-07-15 モルフォシス・アーゲー 限られた数のnk細胞を有する患者における抗cd19療法
PH12022551021A1 (en) * 2019-10-31 2023-03-06 Morphosys Ag Sequential anti-cd19 therapy
IL292181A (en) * 2019-10-31 2022-06-01 Morphosys Ag Anti-cd19 therapy in combination with lenalidomide for the treatment of leukemia or lymphoma
IL303384A (en) * 2020-12-04 2023-08-01 Morphosys Ag Anti-CD19 combination therapy

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HK1041221A1 (zh) * 1998-08-11 2002-07-05 Idec药物公司 包括施用抗-cd20抗体的b-细胞淋巴瘤联合疗法
US7320991B2 (en) 2001-02-27 2008-01-22 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services, National Institutes Of Health Analogs of thalidomide as potential angiogenesis inhibitors
WO2005016326A2 (en) 2003-07-11 2005-02-24 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Analogs of thalidomide as potential angiogenesis inhibitors
US7109304B2 (en) 2003-07-31 2006-09-19 Immunomedics, Inc. Humanized anti-CD19 antibodies
US7902338B2 (en) 2003-07-31 2011-03-08 Immunomedics, Inc. Anti-CD19 antibodies
CA2597924C (en) * 2005-02-15 2018-10-02 Duke University Anti-cd19 antibodies and uses in oncology
JP5215180B2 (ja) 2005-06-20 2013-06-19 メダレックス インコーポレーティッド Cd19抗体およびその使用法
ATE509954T1 (de) 2005-12-30 2011-06-15 Merck Patent Gmbh Anti-cd19-antikörper mit reduzierter immunogenität
ES2402591T3 (es) 2006-08-14 2013-05-07 Xencor Inc. Anticuerpos optimizados que seleccionan como diana CD19
US8323653B2 (en) 2006-09-08 2012-12-04 Medimmune, Llc Humanized anti-CD19 antibodies and their use in treatment of oncology, transplantation and autoimmune disease
WO2008032217A2 (fr) * 2006-09-13 2008-03-20 Glycode Methode d'investigation de la reponse a un traitement par un anticorps monoclonal
ES2659517T3 (es) 2007-05-30 2018-03-16 Xencor, Inc. Métodos y composiciones para inhibir células que expresan CD32B
SI2211904T1 (sl) 2007-10-19 2016-12-30 Seattle Genetics, Inc. CD19 vezavna sredstva in njihove uporabe
CN102421800A (zh) 2009-02-23 2012-04-18 格兰马克药品股份有限公司 结合cd19的人源化抗体及其用途
WO2011147834A1 (en) 2010-05-26 2011-12-01 Roche Glycart Ag Antibodies against cd19 and uses thereof
EP2409712A1 (en) 2010-07-19 2012-01-25 International-Drug-Development-Biotech Anti-CD19 antibody having ADCC and CDC functions and improved glycosylation profile
EP2409993A1 (en) 2010-07-19 2012-01-25 International-Drug-Development-Biotech Anti-CD19 antibody having ADCC function with improved glycosylation profile
CA2817842A1 (en) * 2010-11-15 2012-05-24 Medimmune, Llc Combination therapy for b cell lymphomas
EP2524929A1 (en) 2011-05-17 2012-11-21 Sanofi Use of anti-CD19 maytansinoid immunoconjugate antibody for the treatment of CD19+ B-cell malignancies syptoms
PT2744826T (pt) * 2011-08-16 2022-05-19 Morphosys Ag Terapia de combinação com um anticorpo anti-cd19 e um análogo de purina
KR20140064873A (ko) * 2011-08-16 2014-05-28 모르포시스 아게 항-cd19 항체 및 질소 머스타드를 사용한 조합 요법
CA2858906A1 (en) * 2011-12-12 2013-06-20 Pikamab, Inc Predicting responsiveness to antibody maintenance therapy
CN106029098A (zh) * 2014-02-25 2016-10-12 免疫医疗公司 人源化rfb4抗cd22抗体
US20170137516A1 (en) 2014-06-16 2017-05-18 Xencor, Inc. Treatment for chronic lymphocytic leukemia (cll)
JP6805137B2 (ja) * 2014-07-11 2020-12-23 アンセルム(アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル) 血液学的癌を診断するための方法

Also Published As

Publication number Publication date
KR102416144B1 (ko) 2022-07-04
CN109313194A (zh) 2019-02-05
SMT202100291T1 (it) 2021-07-12
MD3916392T2 (ro) 2024-10-31
ES2878156T3 (es) 2021-11-18
MA45124B1 (fr) 2021-05-31
KR20190013980A (ko) 2019-02-11
PT3916392T (pt) 2024-06-04
DK3465214T3 (da) 2021-05-31
EP3916392B1 (en) 2024-05-01
CY1124768T1 (el) 2022-11-25
ZA201808647B (en) 2021-05-26
SG10201911958SA (en) 2020-02-27
PT3465214T (pt) 2021-06-30
HUE067450T2 (hu) 2024-10-28
MX388502B (es) 2025-03-20
WO2017207574A1 (en) 2017-12-07
MD3465214T2 (ro) 2021-09-30
ZA202100296B (en) 2025-05-28
EP3916392A1 (en) 2021-12-01
MA45124A (fr) 2017-12-07
US20190195879A1 (en) 2019-06-27
JP2019519770A (ja) 2019-07-11
LT3916392T (lt) 2024-08-26
IL263103A (en) 2018-12-31
IL263103B2 (en) 2023-10-01
MX2018014702A (es) 2019-10-02
SG11201810159TA (en) 2018-12-28
CA3025823A1 (en) 2017-12-07
CN115932265A (zh) 2023-04-07
JP7066639B2 (ja) 2022-05-13
EA201892542A1 (ru) 2019-06-28
BR112018074603A2 (pt) 2019-03-19
HRP20240670T1 (hr) 2024-09-27
SI3916392T1 (sl) 2024-10-30
LT3465214T (lt) 2021-10-11
AU2017272608B2 (en) 2023-08-10
NZ748468A (en) 2025-05-30
IL263103B1 (en) 2023-06-01
RS62155B1 (sr) 2021-08-31
HUE054860T2 (hu) 2021-10-28
DK3916392T3 (da) 2024-05-21
JP7511806B2 (ja) 2024-07-08
EP3465214A1 (en) 2019-04-10
HRP20210938T1 (hr) 2021-09-03
MA57021B1 (fr) 2024-05-31
EP3465214B1 (en) 2021-04-28
AU2017272608A1 (en) 2018-12-06
US20220283166A1 (en) 2022-09-08
SMT202400204T1 (it) 2024-09-16
MX2021014963A (es) 2022-02-24
SI3465214T1 (sl) 2021-12-31
RS65540B1 (sr) 2024-06-28
ES2981046T3 (es) 2024-10-07
FI3916392T3 (fi) 2024-06-03
CN109313194B (zh) 2022-11-04
PL3916392T3 (pl) 2024-09-23
JP2022119764A (ja) 2022-08-17

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