PL3464309T3 - Pochodne nukleozydu fosforoamidynianowego jako środki przeciwnowotworowe - Google Patents

Pochodne nukleozydu fosforoamidynianowego jako środki przeciwnowotworowe

Info

Publication number
PL3464309T3
PL3464309T3 PL17728596T PL17728596T PL3464309T3 PL 3464309 T3 PL3464309 T3 PL 3464309T3 PL 17728596 T PL17728596 T PL 17728596T PL 17728596 T PL17728596 T PL 17728596T PL 3464309 T3 PL3464309 T3 PL 3464309T3
Authority
PL
Poland
Prior art keywords
anticancer agents
nucleoside derivatives
phosphoramidate nucleoside
phosphoramidate
derivatives
Prior art date
Application number
PL17728596T
Other languages
English (en)
Inventor
Hugh GRIFFITH
Michaela Serpi
Magdalena Slusarczyk
Original Assignee
NuCana plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by NuCana plc filed Critical NuCana plc
Publication of PL3464309T3 publication Critical patent/PL3464309T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/173—Purine radicals with 2-deoxyribosyl as the saccharide radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C07H19/207—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids the phosphoric or polyphosphoric acids being esterified by a further hydroxylic compound, e.g. flavine adenine dinucleotide or nicotinamide-adenine dinucleotide

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
PL17728596T 2016-06-01 2017-05-31 Pochodne nukleozydu fosforoamidynianowego jako środki przeciwnowotworowe PL3464309T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1609601.8A GB201609601D0 (en) 2016-06-01 2016-06-01 Phosphoramidate compounds
EP17728596.2A EP3464309B1 (en) 2016-06-01 2017-05-31 Phosphoramidate nucleoside derivatives as anticancer agents
PCT/GB2017/051549 WO2017207986A1 (en) 2016-06-01 2017-05-31 Phosphoramidate nucleoside derivatives as anticancer agents

Publications (1)

Publication Number Publication Date
PL3464309T3 true PL3464309T3 (pl) 2020-10-19

Family

ID=56410850

Family Applications (1)

Application Number Title Priority Date Filing Date
PL17728596T PL3464309T3 (pl) 2016-06-01 2017-05-31 Pochodne nukleozydu fosforoamidynianowego jako środki przeciwnowotworowe

Country Status (26)

Country Link
US (2) US10906929B2 (pl)
EP (1) EP3464309B1 (pl)
JP (2) JP7025351B2 (pl)
KR (1) KR20190015353A (pl)
CN (1) CN109195981A (pl)
AU (1) AU2017273117B2 (pl)
BR (1) BR112018074961A2 (pl)
CA (1) CA3025440A1 (pl)
CL (1) CL2018003404A1 (pl)
DK (1) DK3464309T3 (pl)
EA (1) EA036409B1 (pl)
ES (1) ES2801448T3 (pl)
GB (1) GB201609601D0 (pl)
HR (1) HRP20200983T1 (pl)
HU (1) HUE051335T2 (pl)
IL (1) IL263121B (pl)
MX (1) MX378839B (pl)
MY (1) MY198880A (pl)
PH (1) PH12018502606A1 (pl)
PL (1) PL3464309T3 (pl)
PT (1) PT3464309T (pl)
SA (1) SA518400552B1 (pl)
SG (1) SG11201810018TA (pl)
SI (1) SI3464309T1 (pl)
WO (1) WO2017207986A1 (pl)
ZA (1) ZA201807652B (pl)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201421083D0 (en) 2014-11-27 2015-01-14 Kalvista Pharmaceuticals Ltd Enzyme inhibitors
KR102548806B1 (ko) 2014-11-28 2023-06-27 뉴카나 피엘씨 항암제로서 새로운 2' 및/또는 5' 아미노산 에스테르 포스포르아미데이트 3'-디옥시아데노신 유도체
HUE049918T2 (hu) 2016-05-31 2020-11-30 Kalvista Pharmaceuticals Ltd Pirazol-származékok mint plazma kallikrein inhibitorok
GB201609603D0 (en) 2016-06-01 2016-07-13 Kalvista Pharmaceuticals Ltd Polymorphs of N-[(6-cyano-2-fluoro-3-methoxyphenyl)Methyl]-3-(methoxymethyl)-1-({4-[(2-ox opyridin-1-YL)Methyl]phenyl}methyl)pyrazole-4-carboxamide
GB201609601D0 (en) 2016-06-01 2016-07-13 Nucana Biomed Ltd Phosphoramidate compounds
GB201609607D0 (en) 2016-06-01 2016-07-13 Kalvista Pharmaceuticals Ltd Polymorphs of N-(3-Fluoro-4-methoxypyridin-2-yl)methyl)-3-(methoxymethyl)-1-({4-((2-oxopy ridin-1-yl)methyl)phenyl}methyl)pyrazole-4-carboxamide and salts
GB201709471D0 (en) 2017-06-14 2017-07-26 Nucana Biomed Ltd Diastereoselective synthesis of hosphate derivatives
LT3716952T (lt) 2017-11-29 2022-04-11 Kalvista Pharmaceuticals Limited Vaisto formos, apimančios plazmos kalikreino inhibitorių
GB201719881D0 (en) 2017-11-29 2018-01-10 Kalvista Pharmaceuticals Ltd Solid forms of plasma kallikrein inhibitor and salts thereof
GB201720279D0 (en) 2017-12-05 2018-01-17 Nucana Biomed Ltd Anticancer compounds
JP7337855B2 (ja) * 2018-03-09 2023-09-04 メディヴィル・アクチエボラーグ （２，２－ビスヒドロキシメチル）メチレンシクロプロパンヌクレオチドを用いたがんの治療
CN114206852A (zh) 2019-08-09 2022-03-18 卡尔维斯塔制药有限公司 血浆激肽释放酶抑制剂
CN110845560B (zh) * 2019-11-21 2021-08-24 广东中科药物研究有限公司 苯丙氨酸酰胺化的核苷酸衍生物及其制备方法与应用

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2415368A1 (en) * 2000-07-13 2002-01-31 Yi Jin Synthesis and antiviral evaluation of nucleic acid based (nab) libraries
CA2589935A1 (en) 2004-12-09 2006-06-15 Regents Of The University Of Minnesota Nucleosides with antiviral and anticancer activity
GB0505781D0 (en) 2005-03-21 2005-04-27 Univ Cardiff Chemical compounds
CA2749394A1 (en) 2009-01-09 2010-07-15 University College Of Cardiff Consultants Limited Phosphoramidate derivatives of guanosine nucleoside compounds for treatment of viral infections
US20120070411A1 (en) 2010-09-22 2012-03-22 Alios Biopharma, Inc. Substituted nucleotide analogs
US9156874B2 (en) 2011-01-03 2015-10-13 Nanjing Molecular Research, Inc. Double-liver-targeting phosphoramidate and phosphonoamidate prodrugs
HRP20160346T1 (hr) 2011-03-01 2016-05-06 Nucana Biomed Limited Fosforoamidatni derivati 5-fluoro-2'-deoksiuridina za upotrebu u tretmanu raka
WO2012142075A1 (en) * 2011-04-13 2012-10-18 Merck Sharp & Dohme Corp. 2'-azido substituted nucleoside derivatives and methods of use thereof for the treatment of viral diseases
ES2927955T3 (es) 2013-09-11 2022-11-14 Univ Emory Composiciones de nucleótidos y nucleósidos y sus usos
KR20160099090A (ko) 2013-11-27 2016-08-19 아이데닉스 파마슈티칼스 엘엘씨 간암의 치료를 위한 뉴클레오티드
CA2947939A1 (en) 2014-05-28 2015-12-03 Idenix Pharmaceuticals Llc Nucleoside derivatives for the treatment of cancer
DK3119794T3 (en) 2014-06-25 2018-01-22 NuCana plc FORMULA CONTAINING A GEMCITABIN PRODRUG
KR102548806B1 (ko) * 2014-11-28 2023-06-27 뉴카나 피엘씨 항암제로서 새로운 2' 및/또는 5' 아미노산 에스테르 포스포르아미데이트 3'-디옥시아데노신 유도체
AU2016276316B2 (en) 2015-06-09 2020-01-23 Abbvie Inc. Nuclear receptor modulators
GB201609601D0 (en) 2016-06-01 2016-07-13 Nucana Biomed Ltd Phosphoramidate compounds
GB201609600D0 (en) * 2016-06-01 2016-07-13 Nucuna Biomed Ltd Cancer treatments

Also Published As

Publication number Publication date
IL263121A (en) 2018-12-31
GB201609601D0 (en) 2016-07-13
EA201892745A1 (ru) 2019-05-31
IL263121B (en) 2021-10-31
ZA201807652B (en) 2021-05-26
HRP20200983T1 (hr) 2020-12-11
CN109195981A (zh) 2019-01-11
EA036409B1 (ru) 2020-11-06
CA3025440A1 (en) 2017-12-07
SG11201810018TA (en) 2018-12-28
AU2017273117B2 (en) 2021-02-04
ES2801448T3 (es) 2021-01-11
PT3464309T (pt) 2020-06-23
BR112018074961A2 (pt) 2019-03-12
MY198880A (en) 2023-10-02
EP3464309B1 (en) 2020-06-10
JP7025351B2 (ja) 2022-02-24
CL2018003404A1 (es) 2019-04-05
PH12018502606A1 (en) 2019-10-21
US10906929B2 (en) 2021-02-02
US20210130387A1 (en) 2021-05-06
KR20190015353A (ko) 2019-02-13
EP3464309A1 (en) 2019-04-10
US20190375779A1 (en) 2019-12-12
MX2018014859A (es) 2019-03-07
MX378839B (es) 2025-03-11
JP2019517510A (ja) 2019-06-24
HUE051335T2 (hu) 2021-03-01
WO2017207986A1 (en) 2017-12-07
SI3464309T1 (sl) 2020-10-30
JP2022051936A (ja) 2022-04-01
DK3464309T3 (da) 2020-06-29
SA518400552B1 (ar) 2021-12-08
AU2017273117A1 (en) 2018-12-06

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