PL3464260T3 - Związki zawierające motyw mocznika i ich pochodne jako leki antybakteryjne - Google Patents
Związki zawierające motyw mocznika i ich pochodne jako leki antybakteryjneInfo
- Publication number
- PL3464260T3 PL3464260T3 PL17728481T PL17728481T PL3464260T3 PL 3464260 T3 PL3464260 T3 PL 3464260T3 PL 17728481 T PL17728481 T PL 17728481T PL 17728481 T PL17728481 T PL 17728481T PL 3464260 T3 PL3464260 T3 PL 3464260T3
- Authority
- PL
- Poland
- Prior art keywords
- derivatives
- containing compounds
- antibacterial drugs
- motif containing
- urea
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
- A01N47/28—Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N<
- A01N47/30—Derivatives containing the group >N—CO—N aryl or >N—CS—N—aryl
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
- A61K31/36—Compounds containing methylenedioxyphenyl groups, e.g. sesamin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C275/32—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms
- C07C275/34—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms having nitrogen atoms of urea groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C275/38—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by doubly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C275/42—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
- C07D317/66—Nitrogen atoms not forming part of a nitro radical
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Emergency Medicine (AREA)
- Dentistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16171906 | 2016-05-30 | ||
| PCT/EP2017/063014 WO2017207556A2 (en) | 2016-05-30 | 2017-05-30 | Urea motif containing compounds and derivatives thereof as antibacterial drugs |
| EP17728481.7A EP3464260B8 (en) | 2016-05-30 | 2017-05-30 | Urea motif containing compounds and derivatives thereof as antibacterial drugs |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL3464260T3 true PL3464260T3 (pl) | 2022-01-31 |
Family
ID=56087197
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL17728481T PL3464260T3 (pl) | 2016-05-30 | 2017-05-30 | Związki zawierające motyw mocznika i ich pochodne jako leki antybakteryjne |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US12187696B2 (pl) |
| EP (1) | EP3464260B8 (pl) |
| JP (1) | JP7129085B2 (pl) |
| CN (1) | CN109890804B (pl) |
| CA (1) | CA3023040A1 (pl) |
| DK (1) | DK3464260T3 (pl) |
| ES (1) | ES2901164T3 (pl) |
| HU (1) | HUE057798T2 (pl) |
| PL (1) | PL3464260T3 (pl) |
| SG (1) | SG11201809537VA (pl) |
| WO (1) | WO2017207556A2 (pl) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017028745A1 (en) * | 2015-08-17 | 2017-02-23 | Chung-Wai Shiau | Substituted malonamides and their use as antibacterial drugs |
| CN108785306B (zh) * | 2018-09-09 | 2021-02-19 | 东北农业大学 | 索拉非尼在制备抑菌及干预致病菌生物被膜的药物中的用途 |
| CN109456261A (zh) * | 2018-12-05 | 2019-03-12 | 西安交通大学 | 一种基于vegfr-2抑制剂索拉菲尼的光亲合探针分子及其制备方法 |
| CN113061126A (zh) * | 2021-03-16 | 2021-07-02 | 无锡海伦生物科技有限公司 | 基于卤素中间体的索拉非尼光亲和探针分子的制备方法及应用 |
| US11648248B1 (en) | 2022-01-12 | 2023-05-16 | King Abdulaziz University | Potent antimicrobial compounds with a pyridazine nucleus |
| TW202339708A (zh) * | 2022-04-13 | 2023-10-16 | 國立臺灣大學 | 抗微生物組合物、醫藥組合物及其用途 |
| EP4554576A2 (en) * | 2022-07-15 | 2025-05-21 | University of Southern California | Bifunctional photocrosslinking probes for covalent capture of protein-nucleic acid complexes in cells |
| CN117180254A (zh) * | 2023-08-25 | 2023-12-08 | 华中科技大学协和深圳医院 | Sc-43用于制备抗革兰氏阳性细菌感染药物中的应用 |
| WO2025083280A1 (en) * | 2023-10-19 | 2025-04-24 | Universitat De Barcelona | Sorafenib analogs for use in the treatment of cancer |
| EP4674846A1 (en) | 2024-07-02 | 2026-01-07 | Technische Universität München | Urea motif containing compounds as antibacterial drugs against multiresistant mycobacteria |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL254871A (pl) * | 1959-08-14 | |||
| US3579578A (en) * | 1966-07-08 | 1971-05-18 | Givaudan Corp | 3,4-dihalo-3' and 4'-lower alkylcarbanilides |
| US3503886A (en) * | 1967-10-27 | 1970-03-31 | Mary C Noel | Antiseptic compositions |
| WO1989000563A1 (en) | 1987-07-17 | 1989-01-26 | The Nutrasweet Company | High potency sweetening agents |
| JPH10109912A (ja) * | 1996-10-04 | 1998-04-28 | Akio Suganuma | 抗菌組成物 |
| US6207679B1 (en) * | 1997-06-19 | 2001-03-27 | Sepracor, Inc. | Antimicrobial agents uses and compositions related thereto |
| US6093742A (en) * | 1997-06-27 | 2000-07-25 | Vertex Pharmaceuticals, Inc. | Inhibitors of p38 |
| US7517880B2 (en) | 1997-12-22 | 2009-04-14 | Bayer Pharmaceuticals Corporation | Inhibition of p38 kinase using symmetrical and unsymmetrical diphenyl ureas |
| AU757777B2 (en) * | 1998-12-04 | 2003-03-06 | Influx, Inc. | Inhibitors of multidrug transporters |
| AU2002243439A1 (en) | 2000-11-17 | 2002-07-24 | Smithkline Beecham Corporation | Fatty acid synthase inhibitors |
| KR20030080509A (ko) * | 2002-04-09 | 2003-10-17 | 주식회사 엘지생명과학 | 우레아, 티오우레아 및 설파마이드 유도체를 함유하는항균제 조성물 |
| EP1656341A1 (en) * | 2003-07-09 | 2006-05-17 | Paratek Pharmaceuticals, Inc. | Prodrugs of 9-aminomethyl tetracycline compounds |
| AU2005302669A1 (en) * | 2004-10-27 | 2006-05-11 | Neurogen Corporation | Diaryl ureas as CB1 antagonists |
| WO2007101710A1 (en) | 2006-03-09 | 2007-09-13 | Cenix Bioscience Gmbh | Use of inhibitors of scavenger receptor class proteins for the treatment of infectious diseases |
| FR2901792A1 (fr) * | 2006-06-06 | 2007-12-07 | Negma Lerads Soc Par Actions S | DERIVES ACTIVATEURS DE PPARs, PROCEDE DE PREPARATION ET APPLICATION EN THERAPEUTIQUE |
| EP2152260A1 (en) | 2007-05-31 | 2010-02-17 | Syntopix Group plc | An antibacterial formulation comprising a dialkyl sulphosuccinate and a carbanilide antibacterial agent |
| WO2009035951A2 (en) | 2007-09-11 | 2009-03-19 | Arete Therapeutics, Inc. | Soluble epoxide hydrolase inhibitors |
| KR20100096101A (ko) | 2007-10-19 | 2010-09-01 | 더 보드 오브 리전츠 오브 더 유니버시티 오브 텍사스 시스템 | 박테리아 독성을 억제하는 방법 및 이에 대한 화합물 |
| EP2385831A4 (en) | 2009-01-09 | 2014-03-26 | Uab Research Foundation | SMALL MOLECULAR HEMMER OF NADS, NAMNAT AND NMNAT |
| CN103130686B (zh) | 2011-12-02 | 2016-09-14 | 天津市国际生物医药联合研究院 | N,n′-不对称二芳基取代脲类化合物及其制备方法和用途 |
| WO2013142628A2 (en) | 2012-03-20 | 2013-09-26 | Fred Hutchinson Cancer Research Center | Antibiotic compounds and compositions, and methods for identification thereof |
| US9951097B2 (en) | 2012-12-04 | 2018-04-24 | The Board Of Trustees Of The University Of Illinois | Antibacterial compounds targeting isoprenoid biosynthesis |
| WO2015051149A1 (en) | 2013-10-04 | 2015-04-09 | The Trustees Of Columbia University In The City Of New York | Sorafenib analogs and uses thereof |
| US9387186B2 (en) | 2014-05-22 | 2016-07-12 | Muhammad Iqbal Choudhary | Thiourea derivatives |
-
2017
- 2017-05-30 WO PCT/EP2017/063014 patent/WO2017207556A2/en not_active Ceased
- 2017-05-30 PL PL17728481T patent/PL3464260T3/pl unknown
- 2017-05-30 CN CN201780034569.1A patent/CN109890804B/zh active Active
- 2017-05-30 ES ES17728481T patent/ES2901164T3/es active Active
- 2017-05-30 SG SG11201809537VA patent/SG11201809537VA/en unknown
- 2017-05-30 US US16/304,521 patent/US12187696B2/en active Active
- 2017-05-30 HU HUE17728481A patent/HUE057798T2/hu unknown
- 2017-05-30 EP EP17728481.7A patent/EP3464260B8/en active Active
- 2017-05-30 DK DK17728481.7T patent/DK3464260T3/da active
- 2017-05-30 CA CA3023040A patent/CA3023040A1/en active Pending
- 2017-05-30 JP JP2018562297A patent/JP7129085B2/ja active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP3464260A2 (en) | 2019-04-10 |
| JP2019524644A (ja) | 2019-09-05 |
| US20210009550A1 (en) | 2021-01-14 |
| DK3464260T3 (da) | 2021-12-20 |
| CA3023040A1 (en) | 2017-12-07 |
| SG11201809537VA (en) | 2018-12-28 |
| CN109890804B (zh) | 2026-02-24 |
| ES2901164T3 (es) | 2022-03-21 |
| CN109890804A (zh) | 2019-06-14 |
| US12187696B2 (en) | 2025-01-07 |
| EP3464260B8 (en) | 2022-02-16 |
| HUE057798T2 (hu) | 2022-06-28 |
| EP3464260B1 (en) | 2021-10-27 |
| WO2017207556A2 (en) | 2017-12-07 |
| WO2017207556A3 (en) | 2018-01-11 |
| WO2017207556A4 (en) | 2018-03-22 |
| JP7129085B2 (ja) | 2022-09-01 |
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