PL3447056T3 - Związek będący inhibitorem wielu kinaz oraz jego postać krystaliczna i zastosowanie - Google Patents
Związek będący inhibitorem wielu kinaz oraz jego postać krystaliczna i zastosowanieInfo
- Publication number
- PL3447056T3 PL3447056T3 PL17879808.8T PL17879808T PL3447056T3 PL 3447056 T3 PL3447056 T3 PL 3447056T3 PL 17879808 T PL17879808 T PL 17879808T PL 3447056 T3 PL3447056 T3 PL 3447056T3
- Authority
- PL
- Poland
- Prior art keywords
- crystal form
- kinase inhibitor
- inhibitor compound
- compound
- kinase
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
- A61K31/5517—1,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611174146 | 2016-12-13 | ||
| CN201710426594 | 2017-06-08 | ||
| CN201710593933 | 2017-07-20 | ||
| PCT/CN2017/115698 WO2018108079A1 (zh) | 2016-12-13 | 2017-12-12 | 多激酶抑制剂化合物、其晶型及用途 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL3447056T3 true PL3447056T3 (pl) | 2025-09-01 |
Family
ID=62557952
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL17879808.8T PL3447056T3 (pl) | 2016-12-13 | 2017-12-12 | Związek będący inhibitorem wielu kinaz oraz jego postać krystaliczna i zastosowanie |
Country Status (21)
| Country | Link |
|---|---|
| US (3) | US10208042B1 (pl) |
| EP (1) | EP3447056B1 (pl) |
| JP (1) | JP6594571B2 (pl) |
| KR (1) | KR102373577B1 (pl) |
| CN (1) | CN108218868B (pl) |
| AU (1) | AU2017376353B2 (pl) |
| BR (1) | BR112019008295B1 (pl) |
| CA (1) | CA3041155C (pl) |
| DK (1) | DK3447056T3 (pl) |
| ES (1) | ES3033634T3 (pl) |
| FI (1) | FI3447056T3 (pl) |
| HR (1) | HRP20250730T1 (pl) |
| HU (1) | HUE071671T2 (pl) |
| LT (1) | LT3447056T (pl) |
| PL (1) | PL3447056T3 (pl) |
| PT (1) | PT3447056T (pl) |
| RS (1) | RS66947B1 (pl) |
| RU (1) | RU2723985C9 (pl) |
| SI (1) | SI3447056T1 (pl) |
| SM (1) | SMT202500245T1 (pl) |
| WO (1) | WO2018108079A1 (pl) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL3447056T3 (pl) | 2016-12-13 | 2025-09-01 | Transthera Sciences (Nanjing), Inc. | Związek będący inhibitorem wielu kinaz oraz jego postać krystaliczna i zastosowanie |
| KR102195348B1 (ko) | 2018-11-15 | 2020-12-24 | 에이치케이이노엔 주식회사 | 단백질 키나제 억제제로서의 신규 화합물 및 이를 포함하는 약제학적 조성물 |
| JP7738335B2 (ja) * | 2020-02-24 | 2025-09-12 | 薬捷安康（南京）科技股▲分▼有限公司 | マルチキナーゼ阻害剤の新規用途 |
| KR20230008792A (ko) | 2020-05-08 | 2023-01-16 | 트랜스테라 사이언시즈 (난징), 인크. | 항종양 화합물의 합성방법 및 그 중간체 |
| EP4310086A4 (en) * | 2021-03-16 | 2025-07-02 | Hk Inno N Corp | CRYSTALLINE FORM OF A HETEROCYCLIC COMPOUND AS A PROTEIN KINASE INHIBITOR |
| US20250082650A1 (en) * | 2021-03-29 | 2025-03-13 | Transthera Sciences (Nanjing), Inc. | Combined use of multikinase inhibitor |
| EP4338741A1 (en) | 2021-05-10 | 2024-03-20 | Transthera Sciences (Nanjing), Inc. | Pharmaceutical composition and use of multi-kinase inhibitor |
| TW202320760A (zh) | 2021-11-27 | 2023-06-01 | 大陸商藥捷安康(南京)科技股份有限公司 | 激酶抑制劑的新用途 |
| WO2023104074A1 (zh) * | 2021-12-07 | 2023-06-15 | 药捷安康(南京)科技股份有限公司 | 激酶抑制剂的新用途 |
| CN119302963A (zh) * | 2023-07-14 | 2025-01-14 | 药捷安康(南京)科技股份有限公司 | 药物组合物及其用途 |
| CN119970748A (zh) * | 2023-11-13 | 2025-05-13 | 药捷安康(南京)科技股份有限公司 | 药物组合物及其用途 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6350786B1 (en) * | 1998-09-22 | 2002-02-26 | Hoffmann-La Roche Inc. | Stable complexes of poorly soluble compounds in ionic polymers |
| US6440959B1 (en) * | 1999-04-21 | 2002-08-27 | Hoffman-La Roche Inc. | Pyrazolobenzodiazepines |
| CA2582985A1 (en) * | 2004-10-13 | 2006-04-20 | Jin-Jun Liu | Disubstituted pyrazolobenzodiazepines useful as inhibitors for cdk2 and angiogesis, and for the treatment of breast, colon, lung and prostate cancer |
| CN102603743B (zh) * | 2012-02-24 | 2014-05-28 | 南京天易生物科技有限公司 | 抗肿瘤的氮杂苯并[f]薁衍生物其制备方法及其用途 |
| PL3447056T3 (pl) | 2016-12-13 | 2025-09-01 | Transthera Sciences (Nanjing), Inc. | Związek będący inhibitorem wielu kinaz oraz jego postać krystaliczna i zastosowanie |
-
2017
- 2017-12-12 PL PL17879808.8T patent/PL3447056T3/pl unknown
- 2017-12-12 HU HUE17879808A patent/HUE071671T2/hu unknown
- 2017-12-12 FI FIEP17879808.8T patent/FI3447056T3/fi active
- 2017-12-12 SI SI201731611T patent/SI3447056T1/sl unknown
- 2017-12-12 CA CA3041155A patent/CA3041155C/en active Active
- 2017-12-12 KR KR1020197015517A patent/KR102373577B1/ko active Active
- 2017-12-12 RU RU2019115518A patent/RU2723985C9/ru active
- 2017-12-12 PT PT178798088T patent/PT3447056T/pt unknown
- 2017-12-12 WO PCT/CN2017/115698 patent/WO2018108079A1/zh not_active Ceased
- 2017-12-12 ES ES17879808T patent/ES3033634T3/es active Active
- 2017-12-12 JP JP2018567899A patent/JP6594571B2/ja active Active
- 2017-12-12 BR BR112019008295-6A patent/BR112019008295B1/pt active IP Right Grant
- 2017-12-12 DK DK17879808.8T patent/DK3447056T3/da active
- 2017-12-12 SM SM20250245T patent/SMT202500245T1/it unknown
- 2017-12-12 RS RS20250631A patent/RS66947B1/sr unknown
- 2017-12-12 LT LTEPPCT/CN2017/115698T patent/LT3447056T/lt unknown
- 2017-12-12 CN CN201711317321.4A patent/CN108218868B/zh active Active
- 2017-12-12 AU AU2017376353A patent/AU2017376353B2/en active Active
- 2017-12-12 EP EP17879808.8A patent/EP3447056B1/en active Active
- 2017-12-12 HR HRP20250730TT patent/HRP20250730T1/hr unknown
-
2018
- 2018-10-10 US US16/156,371 patent/US10208042B1/en active Active
-
2019
- 2019-01-25 US US16/257,342 patent/US10889586B2/en active Active
-
2020
- 2020-12-31 US US17/139,452 patent/US11718620B2/en active Active
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