PL343435A1 - Glycine transport inhibitors - Google Patents

Glycine transport inhibitors

Info

Publication number
PL343435A1
PL343435A1 PL99343435A PL34343599A PL343435A1 PL 343435 A1 PL343435 A1 PL 343435A1 PL 99343435 A PL99343435 A PL 99343435A PL 34343599 A PL34343599 A PL 34343599A PL 343435 A1 PL343435 A1 PL 343435A1
Authority
PL
Poland
Prior art keywords
transport inhibitors
glycine transport
glycine
inhibitors
transport
Prior art date
Application number
PL99343435A
Other languages
English (en)
Inventor
Walter Herman Maria Lou Luyten
Frans Eduard Janssens
Ludo Edmond Josephine Kennis
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of PL343435A1 publication Critical patent/PL343435A1/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
PL99343435A 1998-03-06 1999-02-26 Glycine transport inhibitors PL343435A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP98200701 1998-03-06
PCT/EP1999/001309 WO1999044596A2 (en) 1998-03-06 1999-02-26 Glycine transport inhibitors

Publications (1)

Publication Number Publication Date
PL343435A1 true PL343435A1 (en) 2001-08-13

Family

ID=8233444

Family Applications (1)

Application Number Title Priority Date Filing Date
PL99343435A PL343435A1 (en) 1998-03-06 1999-02-26 Glycine transport inhibitors

Country Status (17)

Country Link
EP (1) EP1059922A2 (ja)
JP (1) JP2002505277A (ja)
KR (1) KR20010032968A (ja)
CN (1) CN1292698A (ja)
AU (1) AU3408999A (ja)
BG (1) BG104685A (ja)
BR (1) BR9907951A (ja)
CA (1) CA2322164A1 (ja)
EE (1) EE200000482A (ja)
HR (1) HRP20000523A2 (ja)
HU (1) HUP0101048A2 (ja)
IL (1) IL138228A0 (ja)
NO (1) NO20004431L (ja)
PL (1) PL343435A1 (ja)
SK (1) SK13082000A3 (ja)
TR (1) TR200002567T2 (ja)
WO (1) WO1999044596A2 (ja)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2215670T3 (es) * 1999-06-28 2004-10-16 Janssen Pharmaceutica N.V. Inhibidores de la replicacion del virus sincitial respiratorio.
UA73749C2 (en) * 1999-11-01 2005-09-15 Diarylenines
AU2001254546A1 (en) * 2000-04-20 2001-11-07 Nps Allelix Corp. Aminopiperidines
DE10040016A1 (de) * 2000-08-16 2002-02-28 Boehringer Ingelheim Pharma Neue beta-Amyloid Inhibitoren, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel
JP2004508312A (ja) 2000-09-08 2004-03-18 グリアテック　インコーポレイテッド 置換ヒドラジン誘導体
AU2001290786A1 (en) * 2000-09-14 2002-03-26 Gliatech, Inc. Nitrogen-containing compounds and their use as glycine transport inhibitors
AR032653A1 (es) 2001-02-09 2003-11-19 Telik Inc Inhibidores heterociclicos del trasportador de glicina 2 composiciones farmaceuticas, uso y metodos.
US7030150B2 (en) 2001-05-11 2006-04-18 Trimeris, Inc. Benzimidazole compounds and antiviral uses thereof
NZ545454A (en) * 2003-09-09 2009-11-27 Hoffmann La Roche 1-(2-amino-benzoyl)-piperazine derivatives as glycine uptake inhibitors for the treatment of psychoses
BRPI0413536B8 (pt) 2003-09-09 2021-05-25 Hoffmann La Roche derivados de 1-benzoil-piperazina, seu uso e medicamento que os compreende
WO2005058885A2 (en) * 2003-12-18 2005-06-30 Glaxo Group Limited Piperidine derivatives and their use as glycine transporter inhibitors
TW200630337A (en) 2004-10-14 2006-09-01 Euro Celtique Sa Piperidinyl compounds and the use thereof
ATE430142T1 (de) * 2004-12-09 2009-05-15 Hoffmann La Roche Phenylpiperazin-methanon-derivate
ATE457989T1 (de) 2004-12-15 2010-03-15 Hoffmann La Roche Bi- und trizyklische substituierte phenyl- methanone als inhibitoren von glycin-i (glyt-1)- transportern zur behandlung der alzheimer- krankheit
PE20061156A1 (es) 2004-12-23 2006-12-16 Glaxo Group Ltd Derivados de benzamida como agentes inhibidores del transportador de glicina
GB0428233D0 (en) * 2004-12-23 2005-01-26 Glaxo Group Ltd Compounds
US7485637B2 (en) 2005-01-04 2009-02-03 Hoffmann-La Roche Inc. Benzoyl-tetrahydropiperidine derivatives
CN101356163A (zh) * 2005-01-06 2009-01-28 弗·哈夫曼-拉罗切有限公司 作为甘氨酸转运体1(GlyT-1)抑制剂用于治疗神经学和神经精神病学障碍的硫烷基取代的苯甲酮化合物
ATE472327T1 (de) * 2005-01-07 2010-07-15 Hoffmann La Roche Ä4-(heteroaryl)piperazin-1-ylü-(2,5-substituier e phenyl)methanon-derivate als glycin-transporter 1 (glyt-1) hemmer zur behandlung von neurologischen und neuropsychiatrischen erkrankungen
AU2006207650B2 (en) * 2005-01-18 2011-01-27 F. Hoffmann-La Roche Ag 2, 5-disubstituted phenyl methanone derivatives as glycine transporter 1 (GlyT-I) inhibitors for the treatment of neurological and neuropsychiatry disorders
AU2006208547B2 (en) 2005-01-26 2011-02-10 F. Hoffmann-La Roche Ag Phenyl methanone derivatives and their use as glycine transporter 1 inhibitors
ES2334578T3 (es) * 2005-02-07 2010-03-12 F. Hoffmann-La Roche Ag Fenil-metanonas sustituidas por heterociclo como inhibidores del transportador 1 de la glicina.
CN100341871C (zh) * 2005-06-03 2007-10-10 复旦大学 含哌啶结构的有机硫化合物，制备方法和应用
WO2007110449A1 (en) 2006-03-29 2007-10-04 Euro-Celtique S.A. Benzenesulfonamide compounds and their use
WO2007118854A1 (en) 2006-04-13 2007-10-25 Euro-Celtique S.A. Benzenesulfonamide compounds and the use thereof
US8791264B2 (en) 2006-04-13 2014-07-29 Purdue Pharma L.P. Benzenesulfonamide compounds and their use as blockers of calcium channels
EA017471B1 (ru) 2006-11-01 2012-12-28 Пэдью Фарма Л.П. Фенилпропионамидные соединения и их применение
FR2910321B1 (fr) 2006-12-21 2009-07-10 Galderma Res & Dev S N C Snc Gel creme comprenant au moins un retinoide et du peroxyde de benzole
FR2910320B1 (fr) * 2006-12-21 2009-02-13 Galderma Res & Dev S N C Snc Emulsion comprenant au moins un retinoide et du peroxyde de benzole
WO2008124118A1 (en) 2007-04-09 2008-10-16 Purdue Pharma L.P. Benzenesulfonyl compounds and the use therof
WO2009040659A2 (en) 2007-09-28 2009-04-02 Purdue Pharma L.P. Benzenesulfonamide compounds and the use thereof
US8258306B2 (en) * 2007-12-12 2012-09-04 Amgen Inc. Glycine transporter-1 inhibitors

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4219559A (en) * 1979-01-10 1980-08-26 Janssen Pharmaceutica N.V. N-Heterocyclyl-4-piperidinamines
CA1140119A (en) * 1978-04-03 1983-01-25 Joseph Torremans N-heterocyclyl-4-piperidinamines
PH23995A (en) * 1984-01-09 1990-02-09 Janssen Pharmaceutica Nv 4((bicycle heterocyclyl)-methyl and hetero)piperidines
US4695575A (en) * 1984-11-13 1987-09-22 Janssen Pharmaceutica, N.V. 4-[(bicycle heterocyclyl)-methyl and -hetero]-piperidines
WO1999025353A1 (en) * 1997-11-13 1999-05-27 Merck Sharp & Dohme Limited Therapeutic uses of triazolo-pyridazine derivatives

Also Published As

Publication number Publication date
EE200000482A (et) 2002-02-15
EP1059922A2 (en) 2000-12-20
KR20010032968A (ko) 2001-04-25
CN1292698A (zh) 2001-04-25
WO1999044596A3 (en) 2000-02-17
CA2322164A1 (en) 1999-09-10
BR9907951A (pt) 2001-01-30
BG104685A (en) 2001-04-30
IL138228A0 (en) 2001-10-31
JP2002505277A (ja) 2002-02-19
TR200002567T2 (tr) 2000-11-21
HRP20000523A2 (en) 2001-02-28
HUP0101048A2 (hu) 2001-10-28
SK13082000A3 (sk) 2001-03-12
AU3408999A (en) 1999-09-20
NO20004431L (no) 2000-10-30
NO20004431D0 (no) 2000-09-05
WO1999044596A2 (en) 1999-09-10

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Legal Events

Date Code Title Description
REFS Decisions on refusal to grant patents (taken after the publication of the particulars of the applications)