PL3365321T3 - Jon obojnaczy solabegronu i jego zastosowania - Google Patents

Jon obojnaczy solabegronu i jego zastosowania

Info

Publication number
PL3365321T3
PL3365321T3 PL16858451.4T PL16858451T PL3365321T3 PL 3365321 T3 PL3365321 T3 PL 3365321T3 PL 16858451 T PL16858451 T PL 16858451T PL 3365321 T3 PL3365321 T3 PL 3365321T3
Authority
PL
Poland
Prior art keywords
solabegron zwitterion
solabegron
zwitterion
Prior art date
Application number
PL16858451.4T
Other languages
English (en)
Inventor
Raymond E. STEVENS
Dalian Zhao
Bingidimi Itute MOBELE
Original Assignee
B3Ar Therapeutics, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by B3Ar Therapeutics, Inc. filed Critical B3Ar Therapeutics, Inc.
Publication of PL3365321T3 publication Critical patent/PL3365321T3/pl

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/52Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/195Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/196Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/08Drugs for disorders of the urinary system of the prostate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/10Drugs for disorders of the urinary system of the bladder
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/16Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions not involving the amino or carboxyl groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/20Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D233/26Radicals substituted by carbon atoms having three bonds to hetero atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D498/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
PL16858451.4T 2015-10-23 2016-10-24 Jon obojnaczy solabegronu i jego zastosowania PL3365321T3 (pl)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201562245656P 2015-10-23 2015-10-23
US201562245670P 2015-10-23 2015-10-23
US201662345574P 2016-06-03 2016-06-03
US201662345357P 2016-06-03 2016-06-03
US201662345327P 2016-06-03 2016-06-03
PCT/US2016/058516 WO2017070689A2 (en) 2015-10-23 2016-10-24 Solabegron zwitterion and uses thereof

Publications (1)

Publication Number Publication Date
PL3365321T3 true PL3365321T3 (pl) 2024-03-25

Family

ID=58557973

Family Applications (1)

Application Number Title Priority Date Filing Date
PL16858451.4T PL3365321T3 (pl) 2015-10-23 2016-10-24 Jon obojnaczy solabegronu i jego zastosowania

Country Status (11)

Country Link
US (5) US10065922B2 (pl)
EP (1) EP3365321B1 (pl)
CN (2) CN108290824B (pl)
CA (1) CA3001850A1 (pl)
DK (1) DK3365321T3 (pl)
ES (1) ES2967863T3 (pl)
FI (1) FI3365321T3 (pl)
IL (2) IL258856B2 (pl)
PL (1) PL3365321T3 (pl)
PT (1) PT3365321T (pl)
WO (1) WO2017070689A2 (pl)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9907767B2 (en) 2010-08-03 2018-03-06 Velicept Therapeutics, Inc. Pharmaceutical compositions and the treatment of overactive bladder
AU2015358378A1 (en) 2014-12-03 2017-06-29 Velicept Therapeutics, Inc. Compositions and methods of using modified release solabegron for lower urinary tract symptoms
IL258856B2 (en) 2015-10-23 2024-07-01 Velicept Therapeutics Inc Solabegron zwitterion and uses thereof
US10298650B2 (en) * 2016-04-20 2019-05-21 Vasona Networks, Inc. Maximum sustainable encoding bit rates for video downloads
JP7682605B2 (ja) 2017-06-06 2025-05-26 ウロバント サイエンシズ ゲゼルシャフト ミット ベシュレンクター ハフトゥング 過活動膀胱を治療するためのビベグロンの使用
TW202438077A (zh) 2018-12-05 2024-10-01 瑞士商優洛凡特科學公司 維貝隆(vibegron)於治療患有良性前列腺增生之男性中膀胱過動症症狀之用途
CN111925294A (zh) * 2020-07-06 2020-11-13 济南大学 一种托特罗定帕莫酸盐及其制备方法
CN117529310A (zh) * 2021-03-31 2024-02-06 B3Ar治疗股份有限公司 微粒化的索拉贝隆的组合物及其使用方法

Family Cites Families (74)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL267508A (pl) 1960-07-26
EP0006735B1 (en) 1978-06-28 1983-06-15 Beecham Group Plc Secondary amines, their preparation, pharmaceutical compositions containing them and their use
GB8519154D0 (en) 1985-07-30 1985-09-04 Ici Plc Aromatic ethers
DE3934436A1 (de) 1989-06-01 1991-04-18 Thomae Gmbh Dr K 2-hydroxy-n-propylamine, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
US5061727A (en) 1990-05-04 1991-10-29 American Cyanamid Company Substituted 5-(2-((2-aryl-2-hydroxyethyl)amino)propyl)-1,3-benzodioxoles
NO179246C (no) 1991-11-20 1996-09-04 Sankyo Co Aromatiske amino-alkoholderivater og mellomprodukter til fremstilling derav
AU2737295A (en) 1994-06-09 1996-01-04 Glaxo Group Limited Phenethanolamine derivatives and their use as atypical beta-adrenoceptor agonists
US5677346A (en) 1995-01-31 1997-10-14 Sepracor, Inc. Treating urinary incontinence using (S)-desethyloxybutynin
CZ126598A3 (cs) 1995-10-26 1998-09-16 Mitsubishi-Tokyo Pharmaceuticals, Inc. Fenylethanolaminové sloučeniny, způsob jejich výroby a farmaceutické prostředky s jejich obsahem
US6123961A (en) 1996-09-25 2000-09-26 Bridge Pharma, Inc. Treating urinary incontinence with (R)-desethyloxybutynin and (R)-oxybutynin
GB9812709D0 (en) 1998-06-13 1998-08-12 Glaxo Group Ltd Chemical compounds
US20060240105A1 (en) 1998-11-02 2006-10-26 Elan Corporation, Plc Multiparticulate modified release composition
EP2020229A1 (en) 1998-11-02 2009-02-04 Elan Pharma International Limited Multiparticulate modified release composition
DE19856167C1 (de) 1998-12-05 2000-05-04 Vetter & Co Apotheker Nadelschutzanordnung für Spritzen, Karpulen und dergleichen Injektionsinstrumente
GB9929297D0 (en) 1999-12-11 2000-02-02 Glaxo Group Ltd Process
WO2001054728A1 (fr) 2000-01-28 2001-08-02 Asahi Kasei Kabushiki Kaisha NOUVEAUX REMEDES ET UTILISATION D'UN AGONISTE β3
US6395762B1 (en) 2000-07-17 2002-05-28 American Home Products Corporation Phenyl amino squarate and thiadiazole dioxide beta-3 adrenergic receptor agonists
US6525202B2 (en) 2000-07-17 2003-02-25 Wyeth Cyclic amine phenyl beta-3 adrenergic receptor agonists
US6444685B1 (en) 2000-07-17 2002-09-03 Wyeth N-(4-sulfonylaryl)Cyclylamine 2-hydroxyethylamines as beta-3 adrenergic receptor agonists
US6451814B1 (en) 2000-07-17 2002-09-17 Wyeth Heterocyclic β-3 adrenergic receptor agonists
US7709677B2 (en) 2001-01-31 2010-05-04 Glaxosmithkline Llc Process of preparing arylethanoldiamines
US7034053B2 (en) 2001-01-31 2006-04-25 Smithkline Beecham Corporation Phenethanolamine derivatives, compositions, and their use as agonists at atypical beta-adrenoreceptors
GB0102407D0 (en) * 2001-01-31 2001-03-14 Glaxo Group Ltd Process
JP2004529902A (ja) 2001-03-13 2004-09-30 ペンウェスト ファーマシューティカルズ カンパニー グルココルチコステロイドを含有する時間治療(chronotherapeutic)投与形態
WO2003024483A1 (fr) 2001-09-11 2003-03-27 Fujisawa Pharmaceutical Co., Ltd. Potentialisateur d'effets inhibiteurs sur la frequence des mictions et l'incontinence urinaire
TW200800953A (en) 2002-10-30 2008-01-01 Theravance Inc Intermediates for preparing substituted 4-amino-1-(pyridylmethyl) piperidine
EP1424079A1 (en) 2002-11-27 2004-06-02 Boehringer Ingelheim International GmbH Combination of a beta-3-receptor agonist and of a reuptake inhibitor of serotonin and/or norepinephrine
JP2007509896A (ja) 2003-11-03 2007-04-19 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング β−3−アドレノセプターアゴニスト及びαアンタゴニスト及び/又は5−αレダクターゼインヒビターを含有する医薬組成物
DE10352132A1 (de) 2003-11-04 2005-06-09 Boehringer Ingelheim Pharma Gmbh & Co. Kg Pharmazeutische Zusammensetzung aus einem Beta-3-Adrenozeptor-Agonisten und einem Alpha Agonisten
ES2329583T3 (es) 2003-11-27 2009-11-27 Develogen Aktiengesellschaft Metodo para prevenir y tratar la diabetes con neurturina.
KR101071748B1 (ko) * 2003-12-23 2011-10-11 아스텔라스세이야쿠 가부시키가이샤 아미노알콜 유도체
US20050152974A1 (en) 2003-12-31 2005-07-14 Garth Boehm Atomoxetine formulations
EP1550447A1 (en) 2004-01-02 2005-07-06 Schering Aktiengesellschaft Menstrual cycle control and improvement of conception rates in females
WO2005077364A1 (ja) 2004-02-18 2005-08-25 Yamanouchi Pharmaceutical Co., Ltd. ソリフェナシンの経皮投与製剤およびその経皮透過改善方法
JP2008516909A (ja) 2004-10-18 2008-05-22 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 前立腺及び下部泌尿生殖路の病気を治療するためのβ−3アゴニストの使用
TW200716204A (en) 2005-04-19 2007-05-01 Smithkline Beecham Cork Ltd Pharmaceutical composition
EP1769792A1 (de) 2005-09-30 2007-04-04 Boehringer Ingelheim Pharma GmbH & Co.KG Verwendung eines beta-3-Adrenozeptor-Agonisten zur Behandlung von Nieren- und Blasenbeschwerden
ITMI20061581A1 (it) 2006-08-04 2008-02-05 Univ Bari Ligandi del recettore beta-3 adrenergico e loro uso in terapia
EP1967202A1 (en) 2007-03-05 2008-09-10 AEterna Zentaris GmbH Use of LHRH Antagonists for the Treatment of Lower Urinary Tract Symptoms, in particular Overactive Bladder and/or Detrusor Overactivity
CA2681749A1 (en) 2007-03-29 2008-10-09 Merck & Co., Inc. Combination therapy for the treatment-of lower urinary tract symptoms
EP2064222B1 (en) 2007-04-02 2014-05-07 Theracos, Inc. Benzylic glycoside derivatives and methods of use
GB0714790D0 (en) 2007-07-30 2007-09-12 Jagotec Ag Improvements in or relating to organic compounds
SI2216021T1 (sl) 2007-11-02 2013-01-31 Astellas Pharma Inc. Farmacevtski sestavek za zdravljenje prekomerno aktivnega sečnega mehurja
WO2009123870A1 (en) 2008-04-04 2009-10-08 Merck & Co., Inc. Hydroxymethyl pyrrolidines as beta 3 adrenergic receptor agonists
PE20091825A1 (es) 2008-04-04 2009-12-04 Merck & Co Inc Hidroximetil pirrolidinas como agonistas del receptor adrenergico beta 3
EP2181707A1 (en) 2008-11-04 2010-05-05 Astellas Ireland Co., Ltd. Combined use of an alpha-adrenergic receptor antagonist and an anti-muscarinic agent
US8778998B2 (en) 2009-04-10 2014-07-15 Auspex Pharmaceuticals, Inc. Biphenyl-3-carboxylic acid modulators of beta-3-adrenoreceptor
US8828953B2 (en) 2009-04-20 2014-09-09 NaZura BioHealth, Inc. Chemosensory receptor ligand-based therapies
US8618144B2 (en) 2009-05-08 2013-12-31 Merck Sharp & Dohme Corp Pyrrolidine-derived beta 3 adrenergic receptor agonists
US8586760B2 (en) 2009-06-15 2013-11-19 Auspex Pharmaceuticals, Inc. Aminothiazole modulators of beta-3-adrenoreceptor
EP2470021B1 (en) 2009-08-27 2014-10-22 Merck Sharp & Dohme Corp. Novel pyrrolidine derived beta 3 adrenergic receptor agonists
IN2012DN00971A (pl) 2009-08-27 2015-04-10 Merck Sharp & Dohme
MX2012004134A (es) 2009-10-07 2012-05-08 Merck Sharp & Dohme Terapia de combinacion usando un agonista del receptor adrenergico beta 3 y un agente antimuscarinico.
HUE033199T2 (en) 2009-12-15 2017-11-28 Octeta Therapeutics Llc PPAR-friendly thiazolidinediones and combinations for the treatment of neurodegenerative diseases
KR20120092714A (ko) 2009-12-15 2012-08-21 메타볼릭 솔루션스 디벨롭먼트 컴퍼니, 엘엘씨 비만 및 다른 대사성 질환의 치료를 위한 ppar 절약형 티아졸리딘디온 및 복합제
EP2512471A1 (en) 2009-12-15 2012-10-24 Metabolic Solutions Development Company LLC Ppar-sparing thiazolidinediones and combinations for the treatment of diabetes mellitus and other metabolic diseases
US8748433B2 (en) 2010-04-30 2014-06-10 Merck Sharp & Dohme Corp. β3 adrenergic receptor agonists
KR101927068B1 (ko) 2010-05-05 2018-12-10 베링거 인겔하임 인터내셔날 게엠베하 체중 감소 치료에 후속하는 dpp-4 억제제에 의한 순차적 병용 요법
WO2016004056A1 (en) 2014-07-03 2016-01-07 Velicept Therapeutics, Inc. Pharmaceutical combinations
US9522129B2 (en) 2010-08-03 2016-12-20 Velicept Therapeutics, Inc. Pharmaceutical Combination
US9907767B2 (en) 2010-08-03 2018-03-06 Velicept Therapeutics, Inc. Pharmaceutical compositions and the treatment of overactive bladder
KR20130135239A (ko) * 2010-08-03 2013-12-10 앨씨알엑스, 인크. 과민성 방광 치료를 위한 베타-3 아드레날린 수용체 작용제 및 무스카린 수용체 길항제의 약학적 배합제
WO2012154770A1 (en) 2011-05-10 2012-11-15 Theravida, Inc. Combinations of tolterodine and salivary stimulants for the treatment of overactive bladder
KR20150020160A (ko) 2012-02-09 2015-02-25 앨씨알엑스, 인크. 과민성 방광의 치료를 위한 무스카린 수용체 길항제 및 베타―3 아드레날린 수용체 작용제의 조합물
ES2394349B1 (es) 2012-08-29 2013-11-04 Fundación Centro Nacional De Investigaciones Cardiovasculares Carlos Iii Uso de agonistas selectivos de receptores beta-3 adrenérgicos para el tratamiento de hipertensión pulmonar
BR112015004244A2 (pt) 2012-08-31 2017-07-04 Astellas Pharma Inc composição médica oralmente administrada
US20150306170A1 (en) 2012-11-21 2015-10-29 Ferring B.V. Composition for immediate and extended release
EP2961730A2 (en) * 2013-02-26 2016-01-06 XenoPort, Inc. Method of making 1-(acyloxy)-alkyl carbamate compounds
US10166183B2 (en) * 2014-02-07 2019-01-01 Auspex Pharmaceuticals, Inc. Pharmaceutical formulations
AU2015358378A1 (en) * 2014-12-03 2017-06-29 Velicept Therapeutics, Inc. Compositions and methods of using modified release solabegron for lower urinary tract symptoms
IL258856B2 (en) 2015-10-23 2024-07-01 Velicept Therapeutics Inc Solabegron zwitterion and uses thereof
WO2017210696A1 (en) 2016-06-03 2017-12-07 Velicept Therapeutics, Inc. Dosing regimens for beta-3 adrenoceptor agonists and anti-muscarinic agents for the treatment and prevention of lower urinary tract symptoms and overactive bladder
WO2017210700A1 (en) 2016-06-03 2017-12-07 Velicept Therapeutics, Inc. Compositions and methods of using modified release solabegron for lower urinary tract symptoms
CN117529310A (zh) 2021-03-31 2024-02-06 B3Ar治疗股份有限公司 微粒化的索拉贝隆的组合物及其使用方法

Also Published As

Publication number Publication date
ES2967863T3 (es) 2024-05-06
IL258856B2 (en) 2024-07-01
CN114230477A (zh) 2022-03-25
US20180370902A1 (en) 2018-12-27
IL310527A (en) 2024-03-01
US20170114005A1 (en) 2017-04-27
IL258856B1 (en) 2024-03-01
US11691944B2 (en) 2023-07-04
WO2017070689A3 (en) 2017-07-20
EP3365321A4 (en) 2019-06-05
US10065922B2 (en) 2018-09-04
CN108290824A (zh) 2018-07-17
EP3365321B1 (en) 2023-12-13
WO2017070689A2 (en) 2017-04-27
US12435026B2 (en) 2025-10-07
PT3365321T (pt) 2024-01-12
EP3365321A2 (en) 2018-08-29
US20190185414A1 (en) 2019-06-20
FI3365321T3 (fi) 2024-01-02
IL258856A (en) 2018-06-28
CA3001850A1 (en) 2017-04-27
HK1258038A1 (en) 2019-11-01
US20210317073A1 (en) 2021-10-14
US20240124391A1 (en) 2024-04-18
US10221126B2 (en) 2019-03-05
CN108290824B (zh) 2022-03-11
DK3365321T3 (da) 2024-01-15
US10844004B2 (en) 2020-11-24

Similar Documents

Publication Publication Date Title
IL283321A (en) Antibodies against muc16 and their uses
IL258284A (en) Anti-Lag 3 antibodies and their uses
IL255577B (en) Binding materials - tigit and their uses
IL258248A (en) Attraction Oligonucleotide Conjugates and Their Uses
ZA201800536B (en) Il-8-binding antibodies and uses thereof
IL257263A (en) Antibodies against angptl8 and their use
IL253433A0 (en) Binders - tnfrsf and their uses
IL259367B (en) Promoters and their uses
IL254955B (en) Anti-pacap antibodies and their uses
SG10202008304TA (en) Antibodies against ox40 and uses thereof
IL247014A0 (en) 6-heteroaryloxy and 6-aryloxy-quinoline-2-carboxamides and their use
HUE044571T2 (hu) Módosított ciklopentapeptidek és alkalmazásaik
ZA201801549B (en) Acetamide thienotriazoldiazepines and uses thereof
SG11201708624YA (en) Therapeutic antibodies and uses thereof
PL3365321T3 (pl) Jon obojnaczy solabegronu i jego zastosowania
PT3292154T (pt) Anticorpos anti-her3 humano e seus usos
GB201503387D0 (en) Anti-carbapenem antibodies and uses thereof
ZA201801052B (en) Combinations and uses thereof
IL264473A (en) GPR156 variants and their uses
SG11201705748SA (en) Anti-glycoprotein antibodies and uses thereof
IL254241A0 (en) Etv2 and its uses
PL3307080T3 (pl) Środek słodzący oraz jego zastosowanie
GB2545167B (en) Cloches and use thereof