PL330897A1 - Inhibitors of matrix metaloproteinase - Google Patents
Inhibitors of matrix metaloproteinaseInfo
- Publication number
- PL330897A1 PL330897A1 PL97330897A PL33089797A PL330897A1 PL 330897 A1 PL330897 A1 PL 330897A1 PL 97330897 A PL97330897 A PL 97330897A PL 33089797 A PL33089797 A PL 33089797A PL 330897 A1 PL330897 A1 PL 330897A1
- Authority
- PL
- Poland
- Prior art keywords
- inhibitors
- matrix metaloproteinase
- metaloproteinase
- matrix
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/40—Acylated substituent nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
- C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
- C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
- C07D317/66—Nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9613547.0A GB9613547D0 (en) | 1996-06-27 | 1996-06-27 | Matrix metalloproteinase inhibitors |
| PCT/EP1997/003251 WO1997049674A1 (en) | 1996-06-27 | 1997-06-20 | Matrix metalloproteinase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL330897A1 true PL330897A1 (en) | 1999-06-07 |
Family
ID=10796022
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL97330897A PL330897A1 (en) | 1996-06-27 | 1997-06-20 | Inhibitors of matrix metaloproteinase |
Country Status (18)
| Country | Link |
|---|---|
| EP (1) | EP0920414A1 (xx) |
| JP (1) | JP2000514043A (xx) |
| KR (1) | KR20000022534A (xx) |
| AR (1) | AR008621A1 (xx) |
| AU (1) | AU733938B2 (xx) |
| BR (1) | BR9709902A (xx) |
| CA (1) | CA2257404A1 (xx) |
| CZ (1) | CZ430398A3 (xx) |
| EA (1) | EA001432B1 (xx) |
| GB (1) | GB9613547D0 (xx) |
| ID (1) | ID17792A (xx) |
| IL (1) | IL127262A0 (xx) |
| NO (1) | NO986049L (xx) |
| NZ (1) | NZ333550A (xx) |
| PL (1) | PL330897A1 (xx) |
| TW (1) | TW460441B (xx) |
| WO (1) | WO1997049674A1 (xx) |
| ZA (1) | ZA975631B (xx) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19719817A1 (de) * | 1997-05-13 | 1998-11-19 | Hoechst Ag | Substituierte 6- und 7-Aminotetrahydroisochinolincarbonsäuren |
| NZ503945A (en) | 1997-07-31 | 2002-11-26 | Procter & Gamble | Metalloprotease-inhibiting amide derivatives |
| GB9803005D0 (en) * | 1998-02-12 | 1998-04-08 | British Biotech Pharm | Anti-inflammatory agents |
| GB9804777D0 (en) * | 1998-03-07 | 1998-04-29 | British Biotech Pharm | Anti-inflammatory agents |
| US6335324B1 (en) | 1998-06-25 | 2002-01-01 | Bristol-Myers Squibb Co. | Beta lactam compounds and their use as inhibitors of tryptase |
| GB9901863D0 (en) | 1999-01-29 | 1999-03-17 | British Biotech Pharm | Antibacterial agents |
| AU764051B2 (en) | 1999-03-03 | 2003-08-07 | Procter & Gamble Company, The | Alkenyl- and alkynyl-containing metalloprotease inhibitors |
| AU2268401A (en) * | 1999-12-17 | 2001-06-25 | Versicor Inc | Novel succinate compounds, compositions and methods of use and preparation |
| GB9930754D0 (en) * | 1999-12-29 | 2000-02-16 | Smithkline Beecham Plc | Novel compounds |
| AU2001271068A1 (en) * | 2000-07-18 | 2002-01-30 | Chugai Seiyaku Kabushiki Kaisha | Matrix metalloprotease inhibitors |
| AR036053A1 (es) | 2001-06-15 | 2004-08-04 | Versicor Inc | Compuestos de n-formil-hidroxilamina, un proceso para su preparacion y composiciones farmaceuticas |
| ES2283589T3 (es) | 2001-06-15 | 2007-11-01 | Vicuron Pharmaceuticals, Inc. | Compuestos biciclicos de pirrolidina. |
| US20110230479A1 (en) * | 2005-04-15 | 2011-09-22 | Longo Frank M | Neurotrophin mimetics and uses thereof |
| KR20060116552A (ko) * | 2005-05-10 | 2006-11-15 | 연세대학교 산학협력단 | 매트릭스 메탈로프로테이나제 저해제로서 엔-포르밀히드록실아민 유도체 |
| FR2949463B1 (fr) * | 2009-08-26 | 2011-09-16 | Commissariat Energie Atomique | Inhibiteurs de mmp |
| CN108383804A (zh) | 2009-11-12 | 2018-08-10 | 特罗菲克斯制药股份有限公司 | 神经营养蛋白模拟化合物及其盐的晶型 |
| US10273219B2 (en) | 2009-11-12 | 2019-04-30 | Pharmatrophix, Inc. | Crystalline forms of neurotrophin mimetic compounds and their salts |
| BR112021006407A8 (pt) | 2018-10-04 | 2022-12-06 | Inst Nat Sante Rech Med | uso de inibidores do egfr para ceratodermas |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4599361A (en) * | 1985-09-10 | 1986-07-08 | G. D. Searle & Co. | Hydroxamic acid based collagenase inhibitors |
| DK77487A (da) * | 1986-03-11 | 1987-09-12 | Hoffmann La Roche | Hydroxylaminderivater |
| KR927003520A (ko) * | 1990-12-03 | 1992-12-18 | 죤 에드워드 베리만 | 펩티딜(peptidyl) 유도체 |
| CA2058797A1 (en) * | 1991-02-01 | 1992-08-02 | Michael John Broadhurst | Amino acid derivatives |
| EP0520573A1 (en) * | 1991-06-27 | 1992-12-30 | Glaxo Inc. | Cyclic imide derivatives |
-
1996
- 1996-06-27 GB GBGB9613547.0A patent/GB9613547D0/en active Pending
-
1997
- 1997-06-18 TW TW086108613A patent/TW460441B/zh active
- 1997-06-20 IL IL12726297A patent/IL127262A0/xx unknown
- 1997-06-20 BR BR9709902A patent/BR9709902A/pt unknown
- 1997-06-20 WO PCT/EP1997/003251 patent/WO1997049674A1/en not_active Application Discontinuation
- 1997-06-20 JP JP10502322A patent/JP2000514043A/ja active Pending
- 1997-06-20 KR KR1019980710980A patent/KR20000022534A/ko not_active Application Discontinuation
- 1997-06-20 EA EA199900057A patent/EA001432B1/ru not_active IP Right Cessation
- 1997-06-20 CA CA002257404A patent/CA2257404A1/en not_active Abandoned
- 1997-06-20 EP EP97929242A patent/EP0920414A1/en not_active Withdrawn
- 1997-06-20 CZ CZ984303A patent/CZ430398A3/cs unknown
- 1997-06-20 PL PL97330897A patent/PL330897A1/xx unknown
- 1997-06-20 NZ NZ333550A patent/NZ333550A/xx unknown
- 1997-06-20 AU AU33422/97A patent/AU733938B2/en not_active Ceased
- 1997-06-25 ZA ZA9705631A patent/ZA975631B/xx unknown
- 1997-06-26 AR ARP970102813A patent/AR008621A1/es unknown
- 1997-06-26 ID IDP972218A patent/ID17792A/id unknown
-
1998
- 1998-12-22 NO NO986049A patent/NO986049L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| KR20000022534A (ko) | 2000-04-25 |
| CZ430398A3 (cs) | 1999-08-11 |
| IL127262A0 (en) | 1999-09-22 |
| GB9613547D0 (en) | 1996-08-28 |
| AU3342297A (en) | 1998-01-14 |
| NO986049D0 (no) | 1998-12-22 |
| CA2257404A1 (en) | 1997-12-31 |
| BR9709902A (pt) | 1999-08-10 |
| EA001432B1 (ru) | 2001-02-26 |
| ID17792A (id) | 1998-01-29 |
| NO986049L (no) | 1999-03-01 |
| TW460441B (en) | 2001-10-21 |
| NZ333550A (en) | 2000-07-28 |
| EA199900057A1 (ru) | 1999-06-24 |
| EP0920414A1 (en) | 1999-06-09 |
| AR008621A1 (es) | 2000-02-09 |
| ZA975631B (en) | 1998-01-30 |
| AU733938B2 (en) | 2001-05-31 |
| WO1997049674A1 (en) | 1997-12-31 |
| JP2000514043A (ja) | 2000-10-24 |
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