IL127262A0 - Matrix metalloproteinase inhibitors - Google Patents
Matrix metalloproteinase inhibitorsInfo
- Publication number
- IL127262A0 IL127262A0 IL12726297A IL12726297A IL127262A0 IL 127262 A0 IL127262 A0 IL 127262A0 IL 12726297 A IL12726297 A IL 12726297A IL 12726297 A IL12726297 A IL 12726297A IL 127262 A0 IL127262 A0 IL 127262A0
- Authority
- IL
- Israel
- Prior art keywords
- matrix metalloproteinase
- metalloproteinase inhibitors
- inhibitors
- matrix
- metalloproteinase
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/40—Acylated substituent nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
- C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
- C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
- C07D317/66—Nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyridine Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9613547.0A GB9613547D0 (en) | 1996-06-27 | 1996-06-27 | Matrix metalloproteinase inhibitors |
| PCT/EP1997/003251 WO1997049674A1 (en) | 1996-06-27 | 1997-06-20 | Matrix metalloproteinase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL127262A0 true IL127262A0 (en) | 1999-09-22 |
Family
ID=10796022
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL12726297A IL127262A0 (en) | 1996-06-27 | 1997-06-20 | Matrix metalloproteinase inhibitors |
Country Status (18)
| Country | Link |
|---|---|
| EP (1) | EP0920414A1 (en) |
| JP (1) | JP2000514043A (en) |
| KR (1) | KR20000022534A (en) |
| AR (1) | AR008621A1 (en) |
| AU (1) | AU733938B2 (en) |
| BR (1) | BR9709902A (en) |
| CA (1) | CA2257404A1 (en) |
| CZ (1) | CZ430398A3 (en) |
| EA (1) | EA001432B1 (en) |
| GB (1) | GB9613547D0 (en) |
| ID (1) | ID17792A (en) |
| IL (1) | IL127262A0 (en) |
| NO (1) | NO986049L (en) |
| NZ (1) | NZ333550A (en) |
| PL (1) | PL330897A1 (en) |
| TW (1) | TW460441B (en) |
| WO (1) | WO1997049674A1 (en) |
| ZA (1) | ZA975631B (en) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19719817A1 (en) * | 1997-05-13 | 1998-11-19 | Hoechst Ag | Substituted 6- and 7-aminotetrahydroisoquinoline carboxylic acids |
| IL134273A0 (en) * | 1997-07-31 | 2001-04-30 | Procter & Gamble | Acyclic metalloprotease inhibitors |
| GB9803005D0 (en) | 1998-02-12 | 1998-04-08 | British Biotech Pharm | Anti-inflammatory agents |
| GB9804777D0 (en) * | 1998-03-07 | 1998-04-29 | British Biotech Pharm | Anti-inflammatory agents |
| US6335324B1 (en) | 1998-06-25 | 2002-01-01 | Bristol-Myers Squibb Co. | Beta lactam compounds and their use as inhibitors of tryptase |
| GB9901863D0 (en) * | 1999-01-29 | 1999-03-17 | British Biotech Pharm | Antibacterial agents |
| WO2000051975A1 (en) | 1999-03-03 | 2000-09-08 | The Procter & Gamble Company | Alkenyl- and alkynyl-containing metalloprotease inhibitors |
| CA2393825A1 (en) * | 1999-12-17 | 2001-06-21 | Versicor, Inc. | Novel succinate compounds, compositions and methods of use and preparation |
| GB9930754D0 (en) * | 1999-12-29 | 2000-02-16 | Smithkline Beecham Plc | Novel compounds |
| AU2001271068A1 (en) * | 2000-07-18 | 2002-01-30 | Chugai Seiyaku Kabushiki Kaisha | Matrix metalloprotease inhibitors |
| WO2002102791A1 (en) | 2001-06-15 | 2002-12-27 | Vicuron Pharmaceuticals Inc. | Pyrrolidine bicyclic compounds |
| AR036053A1 (en) | 2001-06-15 | 2004-08-04 | Versicor Inc | N-FORMIL-HYDROXYLAMINE COMPOUNDS, A PROCESS FOR PREPARATION AND PHARMACEUTICAL COMPOSITIONS |
| US20110230479A1 (en) * | 2005-04-15 | 2011-09-22 | Longo Frank M | Neurotrophin mimetics and uses thereof |
| KR20060116552A (en) * | 2005-05-10 | 2006-11-15 | 연세대학교 산학협력단 | N-formyl hydroxylamine derivatives as matrix metalloproteinase inhibitors |
| FR2949463B1 (en) * | 2009-08-26 | 2011-09-16 | Commissariat Energie Atomique | MMP INHIBITORS |
| US10273219B2 (en) | 2009-11-12 | 2019-04-30 | Pharmatrophix, Inc. | Crystalline forms of neurotrophin mimetic compounds and their salts |
| EP2498782B1 (en) | 2009-11-12 | 2019-01-09 | Pharmatrophix Inc. | Crystalline forms of neurotrophin mimetic compounds and their salts |
| US20210393632A1 (en) | 2018-10-04 | 2021-12-23 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Egfr inhibitors for treating keratodermas |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4599361A (en) * | 1985-09-10 | 1986-07-08 | G. D. Searle & Co. | Hydroxamic acid based collagenase inhibitors |
| DK77487A (en) * | 1986-03-11 | 1987-09-12 | Hoffmann La Roche | hydroxylamine |
| EP0489579B1 (en) * | 1990-12-03 | 1995-03-29 | Celltech Therapeutics Limited | Peptidyl derivatives |
| CA2058797A1 (en) * | 1991-02-01 | 1992-08-02 | Michael John Broadhurst | Amino acid derivatives |
| EP0520573A1 (en) * | 1991-06-27 | 1992-12-30 | Glaxo Inc. | Cyclic imide derivatives |
-
1996
- 1996-06-27 GB GBGB9613547.0A patent/GB9613547D0/en active Pending
-
1997
- 1997-06-18 TW TW086108613A patent/TW460441B/en active
- 1997-06-20 EP EP97929242A patent/EP0920414A1/en not_active Withdrawn
- 1997-06-20 WO PCT/EP1997/003251 patent/WO1997049674A1/en not_active Application Discontinuation
- 1997-06-20 CZ CZ984303A patent/CZ430398A3/en unknown
- 1997-06-20 IL IL12726297A patent/IL127262A0/en unknown
- 1997-06-20 EA EA199900057A patent/EA001432B1/en not_active IP Right Cessation
- 1997-06-20 CA CA002257404A patent/CA2257404A1/en not_active Abandoned
- 1997-06-20 JP JP10502322A patent/JP2000514043A/en active Pending
- 1997-06-20 KR KR1019980710980A patent/KR20000022534A/en not_active Application Discontinuation
- 1997-06-20 AU AU33422/97A patent/AU733938B2/en not_active Ceased
- 1997-06-20 NZ NZ333550A patent/NZ333550A/en unknown
- 1997-06-20 BR BR9709902A patent/BR9709902A/en unknown
- 1997-06-20 PL PL97330897A patent/PL330897A1/en unknown
- 1997-06-25 ZA ZA9705631A patent/ZA975631B/en unknown
- 1997-06-26 AR ARP970102813A patent/AR008621A1/en unknown
- 1997-06-26 ID IDP972218A patent/ID17792A/en unknown
-
1998
- 1998-12-22 NO NO986049A patent/NO986049L/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| NO986049D0 (en) | 1998-12-22 |
| CZ430398A3 (en) | 1999-08-11 |
| AU733938B2 (en) | 2001-05-31 |
| EA199900057A1 (en) | 1999-06-24 |
| ZA975631B (en) | 1998-01-30 |
| EA001432B1 (en) | 2001-02-26 |
| EP0920414A1 (en) | 1999-06-09 |
| TW460441B (en) | 2001-10-21 |
| WO1997049674A1 (en) | 1997-12-31 |
| BR9709902A (en) | 1999-08-10 |
| CA2257404A1 (en) | 1997-12-31 |
| JP2000514043A (en) | 2000-10-24 |
| AU3342297A (en) | 1998-01-14 |
| NZ333550A (en) | 2000-07-28 |
| PL330897A1 (en) | 1999-06-07 |
| KR20000022534A (en) | 2000-04-25 |
| GB9613547D0 (en) | 1996-08-28 |
| ID17792A (en) | 1998-01-29 |
| NO986049L (en) | 1999-03-01 |
| AR008621A1 (en) | 2000-02-09 |
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