PL3200786T3 - Zastosowanie pochodnych pirydylowych o skondensowanym układzie bicyklicznym jako inhibitorów fgfr4 - Google Patents
Zastosowanie pochodnych pirydylowych o skondensowanym układzie bicyklicznym jako inhibitorów fgfr4Info
- Publication number
- PL3200786T3 PL3200786T3 PL15781518T PL15781518T PL3200786T3 PL 3200786 T3 PL3200786 T3 PL 3200786T3 PL 15781518 T PL15781518 T PL 15781518T PL 15781518 T PL15781518 T PL 15781518T PL 3200786 T3 PL3200786 T3 PL 3200786T3
- Authority
- PL
- Poland
- Prior art keywords
- ring
- fused bicyclic
- pyridyl derivatives
- fgfr4 inhibitors
- bicyclic pyridyl
- Prior art date
Links
- 101150082429 FGFR4 gene Proteins 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2014088094 | 2014-10-03 | ||
| PCT/US2015/053677 WO2016054483A1 (en) | 2014-10-03 | 2015-10-02 | Use of ring-fused bicyclic pyridyl derivatives as fgfr4 inhibitors |
| EP15781518.4A EP3200786B1 (en) | 2014-10-03 | 2015-10-02 | Use of ring-fused bicyclic pyridyl derivatives as fgfr4 inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL3200786T3 true PL3200786T3 (pl) | 2020-03-31 |
Family
ID=54330059
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL15781518T PL3200786T3 (pl) | 2014-10-03 | 2015-10-02 | Zastosowanie pochodnych pirydylowych o skondensowanym układzie bicyklicznym jako inhibitorów fgfr4 |
Country Status (6)
| Country | Link |
|---|---|
| US (3) | US20180185341A1 (en:Method) |
| EP (1) | EP3200786B1 (en:Method) |
| JP (2) | JP6585167B2 (en:Method) |
| ES (1) | ES2756748T3 (en:Method) |
| PL (1) | PL3200786T3 (en:Method) |
| WO (1) | WO2016054483A1 (en:Method) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016054483A1 (en) * | 2014-10-03 | 2016-04-07 | Novartis Ag | Use of ring-fused bicyclic pyridyl derivatives as fgfr4 inhibitors |
| WO2017198149A1 (zh) * | 2016-05-20 | 2017-11-23 | 江苏豪森药业集团有限公司 | Fgfr4抑制剂、其制备方法和应用 |
| WO2018055503A1 (en) | 2016-09-20 | 2018-03-29 | Novartis Ag | Combination comprising a pd-1 antagonist and an fgfr4 inhibitor |
| MX387222B (es) | 2016-11-02 | 2025-03-18 | Novartis Ag | Combinaciones de inhibidores de fgfr4 y secuestrantes de ácido biliar. |
| TWI723480B (zh) * | 2018-07-27 | 2021-04-01 | 大陸商北京加科思新藥研發有限公司 | 用作fgfr4抑制劑的稠環衍生物 |
| EP3942045A1 (en) | 2019-03-21 | 2022-01-26 | Onxeo | A dbait molecule in combination with kinase inhibitor for the treatment of cancer |
| JP2023500906A (ja) | 2019-11-08 | 2023-01-11 | インサーム（インスティテュ ナシオナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシェ メディカル） | キナーゼ阻害剤に対する獲得抵抗性を有するがんの処置方法 |
| WO2021148581A1 (en) | 2020-01-22 | 2021-07-29 | Onxeo | Novel dbait molecule and its use |
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| CA2927252C (en) * | 2013-10-25 | 2021-09-28 | Novartis Ag | Ring-fused bicyclic pyridyl derivatives as fgfr4 inhibitors |
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| WO2016054483A1 (en) * | 2014-10-03 | 2016-04-07 | Novartis Ag | Use of ring-fused bicyclic pyridyl derivatives as fgfr4 inhibitors |
| US9802917B2 (en) * | 2015-03-25 | 2017-10-31 | Novartis Ag | Particles of N-(5-cyano-4-((2-methoxyethyl)amino)pyridin-2-yl)-7-formyl-6-((4-methyl-2-oxopiperazin-1-yl)methyl)-3,4-dihydro-1,8-naphthyridine-1(2H)-carboxamide |
| JP2018509448A (ja) * | 2015-03-25 | 2018-04-05 | ノバルティス アーゲー | 組合せ医薬 |
| MX387222B (es) | 2016-11-02 | 2025-03-18 | Novartis Ag | Combinaciones de inhibidores de fgfr4 y secuestrantes de ácido biliar. |
-
2015
- 2015-10-02 WO PCT/US2015/053677 patent/WO2016054483A1/en not_active Ceased
- 2015-10-02 US US15/516,443 patent/US20180185341A1/en not_active Abandoned
- 2015-10-02 ES ES15781518T patent/ES2756748T3/es active Active
- 2015-10-02 EP EP15781518.4A patent/EP3200786B1/en active Active
- 2015-10-02 PL PL15781518T patent/PL3200786T3/pl unknown
- 2015-10-02 JP JP2017517705A patent/JP6585167B2/ja active Active
-
2018
- 2018-11-13 US US16/190,087 patent/US10463653B2/en active Active
-
2019
- 2019-02-28 US US16/289,612 patent/US10507201B2/en active Active
- 2019-09-04 JP JP2019161051A patent/JP6794514B2/ja active Active
Also Published As
| Publication number | Publication date |
|---|---|
| JP2019218398A (ja) | 2019-12-26 |
| US20190076412A1 (en) | 2019-03-14 |
| WO2016054483A1 (en) | 2016-04-07 |
| EP3200786B1 (en) | 2019-08-28 |
| US10507201B2 (en) | 2019-12-17 |
| ES2756748T3 (es) | 2020-04-27 |
| US20190231760A1 (en) | 2019-08-01 |
| US20180185341A1 (en) | 2018-07-05 |
| EP3200786A1 (en) | 2017-08-09 |
| JP6794514B2 (ja) | 2020-12-02 |
| JP2017530154A (ja) | 2017-10-12 |
| JP6585167B2 (ja) | 2019-10-02 |
| US10463653B2 (en) | 2019-11-05 |
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