PL3194405T4 - Makrocykliczne inhibitory kinazy lrrk2 - Google Patents
Makrocykliczne inhibitory kinazy lrrk2Info
- Publication number
- PL3194405T4 PL3194405T4 PL15766801T PL15766801T PL3194405T4 PL 3194405 T4 PL3194405 T4 PL 3194405T4 PL 15766801 T PL15766801 T PL 15766801T PL 15766801 T PL15766801 T PL 15766801T PL 3194405 T4 PL3194405 T4 PL 3194405T4
- Authority
- PL
- Poland
- Prior art keywords
- kinase inhibitors
- lrrk2 kinase
- macrocyclic
- macrocyclic lrrk2
- inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/529—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim forming part of bridged ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14290279 | 2014-09-17 | ||
| PCT/EP2015/071349 WO2016042089A1 (en) | 2014-09-17 | 2015-09-17 | Macrocyclic lrrk2 kinase inhibitors |
| EP15766801.3A EP3194405B1 (en) | 2014-09-17 | 2015-09-17 | Macrocyclic lrrk2 kinase inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PL3194405T4 true PL3194405T4 (pl) | 2019-07-31 |
| PL3194405T3 PL3194405T3 (pl) | 2019-07-31 |
Family
ID=51752058
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL15766801T PL3194405T3 (pl) | 2014-09-17 | 2015-09-17 | Makrocykliczne inhibitory kinazy lrrk2 |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US10377772B2 (pl) |
| EP (1) | EP3194405B1 (pl) |
| JP (1) | JP2017529365A (pl) |
| KR (1) | KR20170048599A (pl) |
| CN (1) | CN107108641A (pl) |
| AU (1) | AU2015316801B2 (pl) |
| BR (1) | BR112017005299A2 (pl) |
| CA (1) | CA2960777A1 (pl) |
| DK (1) | DK3194405T3 (pl) |
| EA (1) | EA032838B1 (pl) |
| ES (1) | ES2717510T3 (pl) |
| HU (1) | HUE043972T2 (pl) |
| IL (1) | IL251054B (pl) |
| MX (1) | MX2017003470A (pl) |
| PL (1) | PL3194405T3 (pl) |
| SG (1) | SG11201701936WA (pl) |
| TR (1) | TR201904514T4 (pl) |
| TW (1) | TW201625639A (pl) |
| WO (1) | WO2016042089A1 (pl) |
| ZA (1) | ZA201701841B (pl) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111221514B (zh) * | 2020-01-13 | 2023-03-03 | 陕西心像信息科技有限公司 | 基于OsgEarth的三维可视化组件实现方法及系统 |
| CN115698020A (zh) * | 2020-01-31 | 2023-02-03 | 昂科迪塞恩精密医药公司(Opm) | 大环rip2-激酶抑制剂 |
| BR112022022511A2 (pt) | 2020-05-06 | 2022-12-13 | Servier Lab | Inibidores macrocíclicos de lrrk2 quinase |
| MX2023010910A (es) | 2021-03-18 | 2023-09-27 | Servier Lab | Nuevos inhibidores macrociclicos de la quinasa de lrrk2. |
| EP4416133A1 (en) * | 2021-10-11 | 2024-08-21 | Baylor College of Medicine | G-protein-coupled receptor regulators and methods of use thereof |
| AR127470A1 (es) | 2021-10-27 | 2024-01-31 | H Lundbeck As | Inhibidores de lrrk2 |
| CN117425660A (zh) * | 2022-05-18 | 2024-01-19 | 上海翊石医药科技有限公司 | 一种芳杂环类化合物及其中间体、药物组合物和用途 |
| US11958865B1 (en) | 2022-09-15 | 2024-04-16 | H. Lundbeck A/S | Leucine-rich repeat kinase 2 (LRRK2) inhibitors |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IS2334B (is) | 1992-09-08 | 2008-02-15 | Vertex Pharmaceuticals Inc., (A Massachusetts Corporation) | Aspartyl próteasi hemjari af nýjum flokki súlfonamíða |
| DE69429357T2 (de) | 1993-10-01 | 2002-08-14 | Astrazeneca Ab, Soedertaelje | Verfahren i |
| EP0729758A3 (en) | 1995-03-02 | 1997-10-29 | Pfizer | Pyrazolopyrimidines and pyrrolopyrimidines to treat neuronal disorders and other diseases |
| US6043358A (en) | 1995-11-01 | 2000-03-28 | Merck & Co., Inc. | Hexahydro-5-imino-1,4-heteroazepine derivatives as inhibitors of nitric oxide synthases |
| DK0915880T3 (da) | 1996-07-24 | 2008-02-11 | Bristol Myers Squibb Pharma Co | Azolotriaziner og pyrimidiner |
| GB9718913D0 (en) | 1997-09-05 | 1997-11-12 | Glaxo Group Ltd | Substituted oxindole derivatives |
| US6194410B1 (en) | 1998-03-11 | 2001-02-27 | Hoffman-La Roche Inc. | Pyrazolopyrimidine and pyrazolines and process for preparation thereof |
| US6369087B1 (en) | 1999-08-26 | 2002-04-09 | Robert R. Whittle | Alkoxy substituted benzimidazole compounds, pharmaceutical preparations containing the same, and methods of using the same |
| CA2432148C (en) | 2000-12-28 | 2011-01-18 | Ono Pharmaceutical Co., Ltd. | Tri-heterocyclic compounds and a pharmaceutical comprising them as an active ingredient |
| US7067507B2 (en) * | 2001-06-12 | 2006-06-27 | Pharmacia & Upjohn Company | Macrocycles useful in the treatment of Alzheimer's disease |
| EP1802749B1 (en) | 2004-10-21 | 2012-08-22 | Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) | Kaspp (lrrk2) gene, its production and use for the detection and treatment of neurodegenerative disorders |
| NO323175B1 (no) | 2004-12-23 | 2007-01-15 | Jan O Aasly | Framgangsmate for a pavise en mutasjon som forarsaker arvelig parkinsonisme |
| FI123725B (fi) | 2005-08-01 | 2013-10-15 | Reijo Viljanen | Menetelmä sahalaitteen terän jännittämiseksi ja ohjaamiseksi sekä ohjaus- ja jännityslaitteet |
| KR101576159B1 (ko) | 2005-11-16 | 2015-12-09 | 에스*바이오 피티이 리미티드 | 헤테로알킬이 결합된 피리미딘 유도체 |
| WO2009127642A2 (en) | 2008-04-15 | 2009-10-22 | Cellzome Limited | Use of lrrk2 inhibitors for neurodegenerative diseases |
| JP5752691B2 (ja) | 2009-09-29 | 2015-07-22 | グラクソ グループ リミテッドＧｌａｘｏ Ｇｒｏｕｐ Ｌｉｍｉｔｅｄ | 新規化合物 |
| KR101852169B1 (ko) * | 2010-05-20 | 2018-04-26 | 어레이 바이오파마 인크. | Trk 키나제 저해제로서의 매크로시클릭 화합물 |
| WO2013001310A1 (en) * | 2011-06-30 | 2013-01-03 | Centro Nacional De Investigaciones Oncológicas (Cnio) | Macrocyclic compounds and their use as cdk8 inhibitors |
| CN103930427B (zh) * | 2011-09-30 | 2016-03-09 | 昂科迪塞恩股份有限公司 | 大环flt3激酶抑制剂 |
| MX342177B (es) * | 2011-09-30 | 2016-09-20 | Ipsen Pharma Sas | Inhibidores de cinasa 2 de repeticion rica en leucina (lrrk2) macrociclica. |
-
2015
- 2015-09-17 WO PCT/EP2015/071349 patent/WO2016042089A1/en active Application Filing
- 2015-09-17 AU AU2015316801A patent/AU2015316801B2/en not_active Ceased
- 2015-09-17 EP EP15766801.3A patent/EP3194405B1/en active Active
- 2015-09-17 DK DK15766801.3T patent/DK3194405T3/en active
- 2015-09-17 TR TR2019/04514T patent/TR201904514T4/tr unknown
- 2015-09-17 MX MX2017003470A patent/MX2017003470A/es unknown
- 2015-09-17 SG SG11201701936WA patent/SG11201701936WA/en unknown
- 2015-09-17 EA EA201790626A patent/EA032838B1/ru not_active IP Right Cessation
- 2015-09-17 US US15/511,879 patent/US10377772B2/en not_active Expired - Fee Related
- 2015-09-17 KR KR1020177010322A patent/KR20170048599A/ko unknown
- 2015-09-17 JP JP2017515823A patent/JP2017529365A/ja active Pending
- 2015-09-17 ES ES15766801T patent/ES2717510T3/es active Active
- 2015-09-17 TW TW104130753A patent/TW201625639A/zh unknown
- 2015-09-17 PL PL15766801T patent/PL3194405T3/pl unknown
- 2015-09-17 CA CA2960777A patent/CA2960777A1/en not_active Abandoned
- 2015-09-17 HU HUE15766801A patent/HUE043972T2/hu unknown
- 2015-09-17 BR BR112017005299A patent/BR112017005299A2/pt not_active IP Right Cessation
- 2015-09-17 CN CN201580061216.1A patent/CN107108641A/zh active Pending
-
2017
- 2017-03-09 IL IL251054A patent/IL251054B/en not_active IP Right Cessation
- 2017-03-15 ZA ZA2017/01841A patent/ZA201701841B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP3194405B1 (en) | 2018-12-26 |
| HUE043972T2 (hu) | 2019-09-30 |
| MX2017003470A (es) | 2017-08-07 |
| TR201904514T4 (tr) | 2019-04-22 |
| CN107108641A (zh) | 2017-08-29 |
| ES2717510T3 (es) | 2019-06-21 |
| EA032838B1 (ru) | 2019-07-31 |
| DK3194405T3 (en) | 2019-04-15 |
| AU2015316801A1 (en) | 2017-04-27 |
| IL251054A0 (en) | 2017-04-30 |
| ZA201701841B (en) | 2019-08-28 |
| BR112017005299A2 (pt) | 2017-12-12 |
| US20170240565A1 (en) | 2017-08-24 |
| WO2016042089A1 (en) | 2016-03-24 |
| EA201790626A1 (ru) | 2017-07-31 |
| US10377772B2 (en) | 2019-08-13 |
| EP3194405A1 (en) | 2017-07-26 |
| AU2015316801B2 (en) | 2019-03-07 |
| KR20170048599A (ko) | 2017-05-08 |
| TW201625639A (zh) | 2016-07-16 |
| JP2017529365A (ja) | 2017-10-05 |
| CA2960777A1 (en) | 2016-03-24 |
| PL3194405T3 (pl) | 2019-07-31 |
| IL251054B (en) | 2019-03-31 |
| SG11201701936WA (en) | 2017-04-27 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL287113A (en) | smyd inhibitors | |
| ZA201901034B (en) | Macrocycle kinase inhibitors | |
| HRP20181899T1 (hr) | Biaril inhibitori kinaze | |
| EP3172213A4 (en) | Macrocyclic kinase inhibitors and uses thereof | |
| HK1243415A1 (zh) | 溴結構域抑制劑 | |
| EP3131900A4 (en) | Heterocyclic kinase inhibitors | |
| IL248895A0 (en) | Phosphatidylinositol 3-kinase inhibitors | |
| GB201615282D0 (en) | Tankyrase inhibitors | |
| ZA201701841B (en) | Macrocyclic lrrk2 kinase inhibitors | |
| SG11201609350XA (en) | Methods for inhibiting necroptosis | |
| HK1219481A1 (zh) | 大環的 激酶抑制劑 | |
| EP3102571A4 (en) | SUBSTITUTED PYRIMIDINES USEFUL AS EGFR-T790M KINASE INHIBITORS | |
| IL258438B (en) | 2-Aminoquinoline derivatives as p70s6 kinase inhibitors | |
| ZA201701331B (en) | Macrocyclic rip2 kinase inhibitors | |
| GB201414116D0 (en) | Benzodiazepine derivatives | |
| EP3201181A4 (en) | Sphingosine kinase inhibitors | |
| GB201404570D0 (en) | Macrocyclic kinase inhibitors | |
| GB201404555D0 (en) | Macrocyclic kinase inhibitors | |
| GB201519382D0 (en) | Kinase inhibitors | |
| GB201519381D0 (en) | Kinase inhibitors | |
| GB201614783D0 (en) | Kinases inhibitors | |
| AU2014903812A0 (en) | Novel kinase inhibitors i | |
| GB201418154D0 (en) | Inhibitors | |
| GB201409661D0 (en) | Novel compounds and their use as kinase inhibitors | |
| GB201405532D0 (en) | Novel compounds and their use as Kinase inhibitors |