MX2022009285A - Inhibidores macrocíclicos de la quinasa rip2. - Google Patents
Inhibidores macrocíclicos de la quinasa rip2.Info
- Publication number
- MX2022009285A MX2022009285A MX2022009285A MX2022009285A MX2022009285A MX 2022009285 A MX2022009285 A MX 2022009285A MX 2022009285 A MX2022009285 A MX 2022009285A MX 2022009285 A MX2022009285 A MX 2022009285A MX 2022009285 A MX2022009285 A MX 2022009285A
- Authority
- MX
- Mexico
- Prior art keywords
- rip2
- kinase inhibitors
- kinase
- macrocyclic
- compounds
- Prior art date
Links
- 229940043355 kinase inhibitor Drugs 0.000 title abstract 2
- 239000003757 phosphotransferase inhibitor Substances 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 238000003745 diagnosis Methods 0.000 abstract 1
- 239000000032 diagnostic agent Substances 0.000 abstract 1
- 229940039227 diagnostic agent Drugs 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 150000002678 macrocyclic compounds Chemical class 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/0834—Compounds having one or more O-Si linkage
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/05—Isotopically modified compounds, e.g. labelled
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
La presente invención se refiere a compuestos macrocíclicos y composiciones que contienen dichos compuestos que actúan como inhibidores de cinasa, en particular como inhibidores de cinasa RIP2, y/o mutantes de la misma, para su uso en el diagnóstico, prevención y/o tratamiento de enfermedades asociadas a cinasa RIP2. Además, la presente invención proporciona métodos para utilizar dichos compuestos, por ejemplo, como medicamento o agente de diagnóstico.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP20154852 | 2020-01-31 | ||
| PCT/EP2021/052255 WO2021152165A1 (en) | 2020-01-31 | 2021-02-01 | Macrocyclic rip2-kinase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2022009285A true MX2022009285A (es) | 2022-11-09 |
Family
ID=69423151
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2022009285A MX2022009285A (es) | 2020-01-31 | 2021-02-01 | Inhibidores macrocíclicos de la quinasa rip2. |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US20230126352A1 (es) |
| EP (1) | EP4097110A1 (es) |
| JP (1) | JP2023516551A (es) |
| KR (1) | KR20230005117A (es) |
| CN (1) | CN115698020A (es) |
| AR (1) | AR124556A1 (es) |
| AU (1) | AU2021214866A1 (es) |
| BR (1) | BR112022014925B1 (es) |
| CA (1) | CA3168814A1 (es) |
| IL (1) | IL295196A (es) |
| MX (1) | MX2022009285A (es) |
| TW (1) | TW202140499A (es) |
| UY (1) | UY39061A (es) |
| WO (1) | WO2021152165A1 (es) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114874221A (zh) * | 2022-05-12 | 2022-08-09 | 广州佳途科技股份有限公司 | 一种rip2激酶抑制剂中间体及其合成方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2016510797A (ja) * | 2013-03-15 | 2016-04-11 | オンコデザイン エス．ア． | 大環状塩誘導性キナーゼ阻害剤 |
| SG11201506357RA (en) * | 2013-03-15 | 2015-09-29 | Ipsen Pharma Sas | Macrocyclic lrrk2 kinase inhibitors |
| KR20150133765A (ko) * | 2013-03-15 | 2015-11-30 | 온코디자인 에스.에이. | 거대고리 rip2 키나제 억제제 |
| WO2015136073A1 (en) * | 2014-03-14 | 2015-09-17 | Oncodesign Sa | Macrocyclic tgf-br2 kinase inhibitors |
| JP6736545B2 (ja) * | 2014-09-17 | 2020-08-05 | オンコデザイン エス．ア． | 大環状ｒｉｐ２キナーゼ阻害剤 |
| WO2016042089A1 (en) * | 2014-09-17 | 2016-03-24 | Oncodesign S.A. | Macrocyclic lrrk2 kinase inhibitors |
-
2021
- 2021-02-01 AU AU2021214866A patent/AU2021214866A1/en active Pending
- 2021-02-01 WO PCT/EP2021/052255 patent/WO2021152165A1/en active Application Filing
- 2021-02-01 JP JP2022546542A patent/JP2023516551A/ja active Pending
- 2021-02-01 IL IL295196A patent/IL295196A/en unknown
- 2021-02-01 AR ARP210100265A patent/AR124556A1/es unknown
- 2021-02-01 TW TW110103705A patent/TW202140499A/zh unknown
- 2021-02-01 BR BR112022014925-5A patent/BR112022014925B1/pt active IP Right Grant
- 2021-02-01 EP EP21702985.9A patent/EP4097110A1/en active Pending
- 2021-02-01 KR KR1020227028996A patent/KR20230005117A/ko active Search and Examination
- 2021-02-01 CN CN202180023037.4A patent/CN115698020A/zh active Pending
- 2021-02-01 UY UY0001039061A patent/UY39061A/es unknown
- 2021-02-01 US US17/759,644 patent/US20230126352A1/en active Pending
- 2021-02-01 CA CA3168814A patent/CA3168814A1/en active Pending
- 2021-02-01 MX MX2022009285A patent/MX2022009285A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| BR112022014925B1 (pt) | 2023-12-19 |
| KR20230005117A (ko) | 2023-01-09 |
| TW202140499A (zh) | 2021-11-01 |
| CN115698020A (zh) | 2023-02-03 |
| CA3168814A1 (en) | 2021-08-05 |
| AR124556A1 (es) | 2023-04-12 |
| WO2021152165A1 (en) | 2021-08-05 |
| BR112022014925A2 (pt) | 2022-09-20 |
| US20230126352A1 (en) | 2023-04-27 |
| AU2021214866A1 (en) | 2022-09-22 |
| EP4097110A1 (en) | 2022-12-07 |
| UY39061A (es) | 2022-01-31 |
| BR112022014925A8 (pt) | 2023-05-09 |
| IL295196A (en) | 2022-09-01 |
| JP2023516551A (ja) | 2023-04-20 |
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