PL3177723T3 - Aptamery do zastosowania przeciwko chorobom związanym z autoprzeciwciałem - Google Patents
Aptamery do zastosowania przeciwko chorobom związanym z autoprzeciwciałemInfo
- Publication number
- PL3177723T3 PL3177723T3 PL15744602T PL15744602T PL3177723T3 PL 3177723 T3 PL3177723 T3 PL 3177723T3 PL 15744602 T PL15744602 T PL 15744602T PL 15744602 T PL15744602 T PL 15744602T PL 3177723 T3 PL3177723 T3 PL 3177723T3
- Authority
- PL
- Poland
- Prior art keywords
- aptamers
- associated diseases
- use against
- against autoantibody
- autoantibody
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/115—Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6854—Immunoglobulins
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B99/00—Subject matter not provided for in other groups of this subclass
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/16—Aptamers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2330/00—Production
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A90/00—Technologies having an indirect contribution to adaptation to climate change
- Y02A90/10—Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Physics & Mathematics (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Pain & Pain Management (AREA)
- Microbiology (AREA)
- Hematology (AREA)
- Biochemistry (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Dermatology (AREA)
- Bioinformatics & Computational Biology (AREA)
- Evolutionary Biology (AREA)
- Medical Informatics (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14179715.9A EP2982756A1 (en) | 2014-08-04 | 2014-08-04 | Aptamers for use against autoantibody-associated diseases |
| EP15744602.2A EP3177723B1 (en) | 2014-08-04 | 2015-08-04 | Aptamers for use against autoantibody-associated diseases |
| PCT/EP2015/067951 WO2016020377A1 (en) | 2014-08-04 | 2015-08-04 | Aptamers for use against autoantibody-associated diseases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL3177723T3 true PL3177723T3 (pl) | 2018-05-30 |
Family
ID=51302898
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL15744602T PL3177723T3 (pl) | 2014-08-04 | 2015-08-04 | Aptamery do zastosowania przeciwko chorobom związanym z autoprzeciwciałem |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20170226513A1 (pl) |
| EP (2) | EP2982756A1 (pl) |
| JP (4) | JP6630356B2 (pl) |
| CN (3) | CN106795516A (pl) |
| AU (1) | AU2015299059B2 (pl) |
| BR (1) | BR112017002270B1 (pl) |
| CA (1) | CA2956877C (pl) |
| DK (1) | DK3177723T3 (pl) |
| ES (1) | ES2658492T3 (pl) |
| PL (1) | PL3177723T3 (pl) |
| WO (1) | WO2016020377A1 (pl) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2572915T3 (es) | 2011-06-02 | 2016-06-03 | The University Of Louisville Research Foundation, Inc. | Nanopartículas conjugadas a un agente antinucleolina |
| EP2982756A1 (en) * | 2014-08-04 | 2016-02-10 | Berlin Cures Holding AG | Aptamers for use against autoantibody-associated diseases |
| WO2017214378A1 (en) | 2016-06-08 | 2017-12-14 | President And Fellows Of Harvard College | Engineered viral vector reduces induction of inflammatory and immune responses |
| EP3707262A1 (en) | 2017-11-08 | 2020-09-16 | President and Fellows of Harvard College | Compositions and methods for inhibiting viral vector-induced inflammatory responses |
| US20200133979A1 (en) * | 2018-10-24 | 2020-04-30 | Scivera LLC | Computer-implemented method for quantifying chemical hazard assessment |
| EP3715375A1 (en) | 2019-03-23 | 2020-09-30 | Ablevia biotech GmbH | Compound for the prevention or treatment of pre-eclampsia |
| EP3715376A1 (en) | 2019-03-23 | 2020-09-30 | Ablevia biotech GmbH | Compound for the prevention or treatment of myasthenia gravis |
| EP3715374A1 (en) | 2019-03-23 | 2020-09-30 | Ablevia biotech GmbH | Compound for the sequestration of undesirable antibodies in a patient |
| US11986536B2 (en) | 2019-03-23 | 2024-05-21 | Ablevia Biotech Gmbh | Compound for the sequestration of undesirable antibodies in a patient |
| AU2021347583A1 (en) | 2020-09-23 | 2023-05-25 | Ablevia Biotech Gmbh | Compound for increasing efficacy of viral vectors |
| WO2022063879A1 (en) | 2020-09-23 | 2022-03-31 | Ablevia Biotech Gmbh | Compound for the sequestration of undesirable antibodies in a patient |
| JP2023542388A (ja) | 2020-09-23 | 2023-10-06 | アブレヴィア バイオテック ゲーエムベーハー | 第ｖｉｉｉ因子補充療法の有効性を増加させるための化合物 |
| CA3192740A1 (en) | 2020-09-23 | 2022-03-31 | Oskar SMRZKA | Compound for the prevention or treatment of autoantibody-mediated conditions |
| TW202228784A (zh) | 2020-09-23 | 2022-08-01 | 奧地利商艾柏力維亞生技有限公司 | 用以於一患者中螯合非預期的抗ｐｅｇ抗體的化合物 |
| CN116710143A (zh) | 2020-09-24 | 2023-09-05 | 艾柏力维亚生技有限公司 | 用于预防或治疗重症肌无力的化合物 |
| CN113588937A (zh) * | 2021-07-19 | 2021-11-02 | 刘艳 | 一种心肌细胞m3受体的检测方法 |
| CN114533889B (zh) * | 2022-02-25 | 2023-05-26 | 中南大学 | 一种DNA功能化PBNPs纳米酶制备方法和在靶向光热治疗剂制备中的应用 |
| WO2023180502A1 (en) | 2022-03-24 | 2023-09-28 | Ablevia Biotech Gmbh | Compound for increasing efficacy of oncolytic viruses |
| WO2024038918A1 (ja) * | 2022-08-19 | 2024-02-22 | 国立大学法人東京農工大学 | 一本鎖抗体結合アプタマー |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69902887T2 (de) * | 1998-02-19 | 2003-08-07 | Ortho-Mcneil Pharmaceutical, Inc. | Azole peptidomimetische verbindungen als thrombin rezeptor antagoniste |
| WO1999065928A2 (en) * | 1998-06-19 | 1999-12-23 | Genzyme Corporation | Polynucleotide population isolated from non-metastatic and metastatic breast tumor tissues |
| CA2370000A1 (en) * | 1999-04-08 | 2000-10-19 | Uab Research Foundation | Antiproliferative activity of g-righ oligonucleotides and method of using same to bind to nucleolin |
| JP2005500253A (ja) * | 2001-02-23 | 2005-01-06 | オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド | トロンビン受容体アンタゴニストとしてのアミノメチルピロロキナゾリン化合物 |
| WO2005037323A2 (en) | 2003-10-10 | 2005-04-28 | University Of Louisville Research Foundation, Inc. | Use of gro to treat or prevent inflammation |
| EA200800667A1 (ru) | 2005-08-26 | 2008-08-29 | Аркемикс Корп. | Аптамеры, связывающие тромбин с высокой аффинностью |
| US20090131351A1 (en) * | 2007-11-16 | 2009-05-21 | Antisoma Research Limited | Methods, compositions, and kits for modulating tumor cell proliferation |
| WO2011133142A1 (en) * | 2010-04-20 | 2011-10-27 | University Of Louisville | Treatment of vhl-negative tumors |
| EP2402016A1 (en) | 2010-06-29 | 2012-01-04 | Charité - Universitätsmedizin Berlin | Aptamers that inhibit interaction between antibody and 1st or 2nd extracellular loop of human beta-1-adrenergic receptor |
| EP2497828A1 (en) | 2011-03-07 | 2012-09-12 | Charité - Universitätsmedizin Berlin | Use of aptamers in therapy and/or diagnosis of autoimmune diseases |
| EP2982756A1 (en) * | 2014-08-04 | 2016-02-10 | Berlin Cures Holding AG | Aptamers for use against autoantibody-associated diseases |
-
2014
- 2014-08-04 EP EP14179715.9A patent/EP2982756A1/en not_active Withdrawn
-
2015
- 2015-08-04 WO PCT/EP2015/067951 patent/WO2016020377A1/en active Application Filing
- 2015-08-04 JP JP2017526761A patent/JP6630356B2/ja active Active
- 2015-08-04 CN CN201580050998.9A patent/CN106795516A/zh active Pending
- 2015-08-04 BR BR112017002270-2A patent/BR112017002270B1/pt active IP Right Grant
- 2015-08-04 ES ES15744602.2T patent/ES2658492T3/es active Active
- 2015-08-04 CN CN202311224599.2A patent/CN117247941A/zh active Pending
- 2015-08-04 EP EP15744602.2A patent/EP3177723B1/en active Active
- 2015-08-04 CA CA2956877A patent/CA2956877C/en active Active
- 2015-08-04 PL PL15744602T patent/PL3177723T3/pl unknown
- 2015-08-04 US US15/501,238 patent/US20170226513A1/en active Pending
- 2015-08-04 DK DK15744602.2T patent/DK3177723T3/en active
- 2015-08-04 CN CN202311225061.3A patent/CN117230073A/zh active Pending
- 2015-08-04 AU AU2015299059A patent/AU2015299059B2/en active Active
-
2018
- 2018-07-05 JP JP2018128622A patent/JP7267689B2/ja active Active
-
2020
- 2020-10-16 JP JP2020174859A patent/JP2021035369A/ja active Pending
-
2022
- 2022-11-28 JP JP2022189180A patent/JP2023022189A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JP2021035369A (ja) | 2021-03-04 |
| AU2015299059A1 (en) | 2017-03-02 |
| CA2956877A1 (en) | 2016-02-11 |
| EP2982756A1 (en) | 2016-02-10 |
| JP2017529872A (ja) | 2017-10-12 |
| ES2658492T3 (es) | 2018-03-12 |
| CN117247941A (zh) | 2023-12-19 |
| BR112017002270B1 (pt) | 2020-11-24 |
| AU2015299059B2 (en) | 2017-08-03 |
| DK3177723T3 (en) | 2018-02-12 |
| CA2956877C (en) | 2019-06-25 |
| US20170226513A1 (en) | 2017-08-10 |
| WO2016020377A1 (en) | 2016-02-11 |
| JP7267689B2 (ja) | 2023-05-02 |
| JP6630356B2 (ja) | 2020-01-15 |
| CN117230073A (zh) | 2023-12-15 |
| JP2023022189A (ja) | 2023-02-14 |
| BR112017002270A2 (pt) | 2018-01-16 |
| EP3177723B1 (en) | 2017-12-06 |
| CN106795516A (zh) | 2017-05-31 |
| JP2018171070A (ja) | 2018-11-08 |
| EP3177723A1 (en) | 2017-06-14 |
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