PL307333A1 - Improved antiandrogens - Google Patents

Improved antiandrogens

Info

Publication number
PL307333A1
PL307333A1 PL93307333A PL30733393A PL307333A1 PL 307333 A1 PL307333 A1 PL 307333A1 PL 93307333 A PL93307333 A PL 93307333A PL 30733393 A PL30733393 A PL 30733393A PL 307333 A1 PL307333 A1 PL 307333A1
Authority
PL
Poland
Prior art keywords
antiandrogens
androgen
improved
treatment
dependent diseases
Prior art date
Application number
PL93307333A
Other languages
English (en)
Inventor
Fernand Labrie
Yves Merand
Shankar M Singh
Original Assignee
Endorecherche Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Endorecherche Inc filed Critical Endorecherche Inc
Publication of PL307333A1 publication Critical patent/PL307333A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
    • C07J73/001—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom
    • C07J73/005—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom by nitrogen as hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/28—Antiandrogens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0033—Androstane derivatives substituted in position 17 alfa and 17 beta
    • C07J1/0037—Androstane derivatives substituted in position 17 alfa and 17 beta the substituent in position 17 alfa being a saturated hydrocarbon group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0033—Androstane derivatives substituted in position 17 alfa and 17 beta
    • C07J1/004—Androstane derivatives substituted in position 17 alfa and 17 beta the substituent in position 17 alfa being an unsaturated hydrocarbon group
    • C07J1/0044—Alkenyl derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0033—Androstane derivatives substituted in position 17 alfa and 17 beta
    • C07J1/004—Androstane derivatives substituted in position 17 alfa and 17 beta the substituent in position 17 alfa being an unsaturated hydrocarbon group
    • C07J1/0048—Alkynyl derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J21/005—Ketals
    • C07J21/006—Ketals at position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/006—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton spiro-condensed

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
PL93307333A 1993-05-17 1993-05-20 Improved antiandrogens PL307333A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US6061293A 1993-05-17 1993-05-17

Publications (1)

Publication Number Publication Date
PL307333A1 true PL307333A1 (en) 1995-05-15

Family

ID=22030624

Family Applications (1)

Application Number Title Priority Date Filing Date
PL93307333A PL307333A1 (en) 1993-05-17 1993-05-20 Improved antiandrogens

Country Status (14)

Country Link
EP (1) EP0650495B1 (OSRAM)
JP (1) JP2741286B2 (OSRAM)
KR (1) KR100241228B1 (OSRAM)
AT (1) ATE197458T1 (OSRAM)
CA (1) CA2136303A1 (OSRAM)
CZ (2) CZ285893B6 (OSRAM)
DE (1) DE69329649D1 (OSRAM)
FI (1) FI945458L (OSRAM)
HU (1) HUT69408A (OSRAM)
PL (1) PL307333A1 (OSRAM)
RU (1) RU2141966C1 (OSRAM)
SK (1) SK139194A3 (OSRAM)
TW (1) TW259791B (OSRAM)
WO (1) WO1994026767A1 (OSRAM)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5879711A (en) * 1997-11-07 1999-03-09 Sequeira; Joel A. Stable antiandrogenic gel composition
BR9908592A (pt) 1998-03-11 2001-04-24 Endorech Inc Processo para inibir a atividade de 17ß-hidroxiesteróide desidrogenase tipo 5, composição farmacêutica, inibidor de 17ß-hidroxiesteróide desidrogenase tipo 5, processo para inibir 17ß-hidroxiesteróide desidrogenase tipo 3, inibidor de 17ß-hidroxiesteróide desidrogenase tipo 3, processos para tratar, ou reduzir o risco de desenvolver, câncer da próstata, hiperplasia prostática benigna, acne, seborréia, hirsutismo ou alopécia androgênica, sìndrome de ovário policìstico, câncer de mama, endometriose ou leiomioma, para inibir as secreções hormonais testiculares, para tratar puberdade precoce, e, kit
WO2002089802A2 (en) 2001-05-08 2002-11-14 Schering Corporation Use of neurokinin receptor antagonists to treat androgen-dependent diseases
KR100991616B1 (ko) 2001-09-06 2010-11-04 쉐링 코포레이션 안드로겐 의존성 질환 치료용 17β-하이드록시스테로이드데하이드로게나제 유형 3 억제제
PE20030705A1 (es) 2001-10-17 2003-08-21 Schering Corp Inhibidores de la 17beta-hidroxiesteroide deshidrogenasa tipo 3 para el tratamiento de enfermedades androgeno-dependientes
AU2003219656B2 (en) * 2002-01-15 2007-05-17 Merck Sharp & Dohme Corp. 17-hydroxy-4-aza-androstan-3-ones as androgen receptor modulators
US7074795B2 (en) 2002-11-18 2006-07-11 Schering Corporation 17β-hydroxysteroid dehydrogenase type 3 inhibitors for the treatment of androgen dependent diseases
CA2509758A1 (en) 2002-12-17 2004-07-22 Schering Corporation 17 beta-hydroxysteroid dehydrogenase type 3 inhibitors for the treatment of androgen dependent diseases
GB0513702D0 (en) 2005-07-04 2005-08-10 Sterix Ltd Compound
GB0722779D0 (en) 2007-11-20 2008-01-02 Sterix Ltd Compound

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1081494A (en) * 1965-09-14 1967-08-31 British Drug Houses Ltd 17ª‡-(alka-1',3'-diynyl)-steroids
US3875188A (en) * 1968-04-10 1975-04-01 Eugene E Galantay 17-Beta-alpha-lower alkyl allene-substituted steroids
JPS5513273A (en) * 1978-07-13 1980-01-30 Kanebo Ltd Readily absorbable thiazolidine prodrug of anti- inflammatory corticosteroid and its drug composition
FR2430952A1 (fr) * 1978-07-13 1980-02-08 Roussel Uclaf Nouveaux derives acetyleniques de l'androst 4-ene, leur procede de preparation et leur application comme medicament
WO1991000732A1 (en) * 1989-07-07 1991-01-24 Endorecherche Inc. Androgen derivatives for use in the inhibition of sex steroid activity

Also Published As

Publication number Publication date
DE69329649D1 (de) 2000-12-14
RU2141966C1 (ru) 1999-11-27
HUT69408A (en) 1995-09-28
ATE197458T1 (de) 2000-11-11
EP0650495B1 (en) 2000-11-08
JP2741286B2 (ja) 1998-04-15
CA2136303A1 (en) 1994-11-24
SK139194A3 (en) 1995-07-11
WO1994026767A1 (en) 1994-11-24
CZ282494A3 (en) 1995-12-13
CZ285893B6 (cs) 1999-11-17
RU94046463A (ru) 1997-02-27
EP0650495A1 (en) 1995-05-03
KR100241228B1 (ko) 2000-02-01
JPH08510988A (ja) 1996-11-19
FI945458A0 (fi) 1994-11-21
FI945458A7 (fi) 1995-01-16
TW259791B (OSRAM) 1995-10-11
FI945458L (fi) 1995-01-16
CZ287991B6 (cs) 2001-03-14

Similar Documents

Publication Publication Date Title
BG102600A (en) Carbamoyloxy derivatives of mutilin and their use as bactericides
CA2148928A1 (en) Pharmacologically active pyridine derivatives and processes for the preparation thereof
MY102986A (en) Benzo (5,6) cycloheptapyridines, compositions and methods of use
WO1996032003A3 (en) Tetrahydroimidazopyridoindolediones and their use as medicaments
MY111201A (en) New imidazopyridines
SE9604786D0 (sv) New compounds
HK1056181A1 (zh) 作為抗炎劑的17β-硫代羧酸酯17α-芳基羰氧基氧雄甾烷衍生物
NZ233735A (en) Heterocyclic substituted aminophenol derivatives
MY114393A (en) 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1, 3-propanediol derivatives
HU9301197D0 (en) Medical preparatives containing quinoline and quinazoline derivatives as well as new quinoline and quinazoline derivatives
TW259791B (OSRAM)
JO1704B1 (en) New potent compounds
GB2380939B (en) Treatment or prevention of auto-immune diseases
MD502G2 (ro) Derivaţi noi ai adenozinei, procedee de preparare a lor, compoziţii farmaceutice ce le conţin
AU2351095A (en) Benzimidazole derivatives having dopaminergic activity
NO940777D0 (no) Anvendelse av et pregnanderivat
MY132057A (en) Quinoxalinones, a process for their preparation and their use
ES2174113T3 (es) Nuevos derivados de ((3-alcoxi-fenoxi)-etil)-dialquilamina y su utilizacion como anestesicos locales.
UA41880C2 (uk) Серотонінергічні похідні ерголіну і фармацевтична композиція
YU5893A (sh) Sulfonilkarbamid i postupak za njegovo dobijanje
EP0198271A3 (en) Peptides
CA1271748C (en) BENZAZEPINE DERIVATIVES
BG103271A (en) Derivatives of n-(benzothiazol-2-yl) piperidine-1-ethaneamines, method for their preparation and application as therapeutical means
HUT71513A (en) 2-substituted-(3-chlorophenyl)-3,6-diazahexanoic acid derivatives for producing alkil-trazodone derivatives and process for producing them
NZ219083A (en) N-substituted erythromyclylamines and pharmaceutical compositions