PL3007687T3 - Kombinacja pentacyklicznych triterpenów i hydroksytyrozolu oraz jego pochodnych - Google Patents

Kombinacja pentacyklicznych triterpenów i hydroksytyrozolu oraz jego pochodnych

Info

Publication number
PL3007687T3
PL3007687T3 PL14730844.9T PL14730844T PL3007687T3 PL 3007687 T3 PL3007687 T3 PL 3007687T3 PL 14730844 T PL14730844 T PL 14730844T PL 3007687 T3 PL3007687 T3 PL 3007687T3
Authority
PL
Poland
Prior art keywords
pentacyclical
hydroxytyrosol
triterpenes
derivatives
combination
Prior art date
Application number
PL14730844.9T
Other languages
English (en)
Inventor
José Carlos Quintela Fernández
Esther DE LA FUENTE GARCÍA
Marco Pugliese
Pilar Mancera Aroca
Javier Bustos Santafé
Juan Francisco Espinosa Parrilla
Noemí Virgili Treserres
Blanca WAPPENHANS BATTESTINI
Original Assignee
Natac Biotech, S.L.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Natac Biotech, S.L. filed Critical Natac Biotech, S.L.
Publication of PL3007687T3 publication Critical patent/PL3007687T3/pl

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/045Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/047Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/045Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05Phenols
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/075Ethers or acetals
    • A61K31/085Ethers or acetals having an ether linkage to aromatic ring nuclear carbon
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/191Carboxylic acids, e.g. valproic acid having two or more hydroxy groups, e.g. gluconic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02Muscle relaxants, e.g. for tetanus or cramps
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/08Antiepileptics; Anticonvulsants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Nutrition Science (AREA)
  • Food Science & Technology (AREA)
  • Mycology (AREA)
  • Polymers & Plastics (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Physiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
PL14730844.9T 2013-06-13 2014-06-12 Kombinacja pentacyklicznych triterpenów i hydroksytyrozolu oraz jego pochodnych PL3007687T3 (pl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP13171906.4A EP2813221A1 (en) 2013-06-13 2013-06-13 Combination of pentacyclic triterpenes and hydroxytyrosol and derivatives thereof
PCT/EP2014/062269 WO2014198842A1 (en) 2013-06-13 2014-06-12 Combination of pentacyclic triterpenes and hydroxytyrosol and derivatives thereof

Publications (1)

Publication Number Publication Date
PL3007687T3 true PL3007687T3 (pl) 2024-04-08

Family

ID=48607145

Family Applications (1)

Application Number Title Priority Date Filing Date
PL14730844.9T PL3007687T3 (pl) 2013-06-13 2014-06-12 Kombinacja pentacyklicznych triterpenów i hydroksytyrozolu oraz jego pochodnych

Country Status (10)

Country Link
US (1) US10376529B2 (pl)
EP (2) EP2813221A1 (pl)
JP (1) JP6441908B2 (pl)
CN (1) CN105530922B (pl)
CA (1) CA2915164A1 (pl)
ES (1) ES2970405T3 (pl)
HU (1) HUE065124T2 (pl)
PL (1) PL3007687T3 (pl)
RS (1) RS65176B1 (pl)
WO (1) WO2014198842A1 (pl)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106581006B (zh) * 2015-10-16 2019-11-29 香港理工大学深圳研究院 三萜类化合物在制备治疗帕金森药物中的应用
JP2017178914A (ja) * 2016-03-31 2017-10-05 株式会社ニュートリション・アクト 脳機能改善及び向上のための組成物
CN106138016A (zh) * 2016-06-28 2016-11-23 西安交通大学 羟基酪醇在制备防治阿尔茨海默病的药物中的应用
CN106420765A (zh) * 2016-09-10 2017-02-22 浙江大学 山楂酸在制备治疗和预防中枢神经系统疾病药物中的用途
KR102665310B1 (ko) * 2016-10-27 2024-05-10 주식회사 엘지생활건강 베어바스코사이드를 포함하는 구강질환 예방 또는 치료용 조성물
KR101895554B1 (ko) * 2017-02-28 2018-09-05 경희대학교 산학협력단 올레아놀릭산을 포함하는 신경발달장애 또는 강박장애의 예방, 개선 또는 치료용 조성물
MX2020002884A (es) * 2017-09-14 2020-10-05 Phoenix Biotechnology Inc Método y composición neuroprotectora mejorada para tratar afecciones neurológicas.
JP7356710B2 (ja) * 2017-10-17 2023-10-05 国立大学法人富山大学 ペリオスチン及びpkm2の分泌促進剤
CN110693893B (zh) * 2018-07-10 2023-11-03 香港大学 来自地黄的提取物作为多发性硬化症的治疗剂
CN109503695B (zh) * 2018-09-07 2020-05-22 南昌大学第一附属医院 熊果酸锂及其合成方法与在预防和治疗阿尔茨海默病中的应用
CN109303786B (zh) * 2018-11-27 2024-09-20 山东省药学科学院 一种耐缺氧的组合物及其应用
WO2020249117A1 (zh) * 2019-06-12 2020-12-17 华东理工大学 抗高血压的多元醇化合物及其衍生物
CN112521286B (zh) * 2019-09-17 2021-12-28 西安交通大学 化合物3-羟基-3’,4’-二羟基-丁酸苯乙酯的制备方法和用途
US10995053B1 (en) * 2020-03-20 2021-05-04 Shaanxi University Of Science And Technology Hydroxytyrosol ursolic acid ester with antioxidant activity and methods of preparing the same
CN115361877B (zh) * 2020-03-31 2024-10-29 卢斯塔公司 饲料添加剂

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2111498B1 (es) 1996-07-25 1998-09-01 Univ Granada Procedimiento de aprovechamiento industrial de los acidos oleanolico y maslinico contenidos en los subproductos de la molturacion de la aceituna.
JP2001181198A (ja) * 1999-10-14 2001-07-03 Nisshin Oil Mills Ltd:The 美肌剤、皮膚の抗老化剤、美白剤および皮膚外用剤
AU768306B2 (en) 1999-10-14 2003-12-04 Nisshin Oil Mills, Ltd., The Skin-care agents, skin antiaging agents, whitening agents and external skin preparations
WO2003082259A1 (en) 2002-04-03 2003-10-09 Puleva Biotech, S.A. Natural phenolic products and derivatives thereof for protection against neurodegenerative diseases
ES2261088B1 (es) 2005-04-27 2007-12-01 Laboratorios Alcala Farma, S.L. Uso de hidroxitirosol en la prevencion y tratamiento del ictus cerebral isquemico.
ES2301336B1 (es) * 2006-02-22 2009-05-01 Universidad De Granada Extracto de aceituna como pronutriente en alimentacion animal.
ES2286953B1 (es) 2006-05-18 2008-12-16 Universidad De Granada Formulacion de triterpenos naturales y biofenoles obtenidos del genero olea en liposomas.
US8841264B2 (en) * 2006-07-14 2014-09-23 Dsm Ip Assets B.V. Compositions
DE102006062566A1 (de) * 2006-12-29 2008-07-03 Henkel Kgaa Kosmetische und dermatologische Zusammensetzungen gegen unreine Haut und/oder Akne
ES2311394B2 (es) * 2007-02-22 2009-10-21 Universidad De Granada Alimento funcional obtenido por reincorporacion de ingredientes naturales de la aceituna al aceite de oliva.
EP1982707A1 (en) 2007-04-18 2008-10-22 DSMIP Assets B.V. Use of hydroxytyrosol as anti-aging agent
ES2326065B1 (es) 2008-03-28 2010-07-08 Consejo Superior De Investigaciones Cientificas (Csic) Utilizacion de un triterpeno pentaciclico para la preparacion de una composicion farmaceutica destinada al tratamiento de la esclerosis multiple.
ES2333638B2 (es) 2009-07-29 2010-10-21 Universidad De Granada Uso del acido maslinico para el tratamiento de dolores de naturaleza nociceptiva, inflamatoria y neurogenica.
ES2395317B1 (es) * 2011-07-08 2014-04-16 Consejo Superior De Investigaciones Cientificas (Csic) Procedimiento para la obtención de extracto de hidroxitirosol, extracto mezcla de hidroxitirosol y 3,4-dihidroxifenilglicol, y extracto de acetato de hidroxitirosilo, a partir de subproductos del olivo y su purificación.

Also Published As

Publication number Publication date
ES2970405T3 (es) 2024-05-28
RS65176B1 (sr) 2024-03-29
EP2813221A1 (en) 2014-12-17
WO2014198842A1 (en) 2014-12-18
EP3007687B1 (en) 2023-11-15
CA2915164A1 (en) 2014-12-18
EP3007687C0 (en) 2023-11-15
JP2016521717A (ja) 2016-07-25
CN105530922B (zh) 2018-07-03
JP6441908B2 (ja) 2018-12-19
US20160143930A1 (en) 2016-05-26
EP3007687A1 (en) 2016-04-20
HUE065124T2 (hu) 2024-05-28
CN105530922A (zh) 2016-04-27
US10376529B2 (en) 2019-08-13

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