PL2991983T3 - Pochodne 2-fenylo lub 2-hetaryloimidazolo[1,2-a]pirydyny - Google Patents
Pochodne 2-fenylo lub 2-hetaryloimidazolo[1,2-a]pirydynyInfo
- Publication number
- PL2991983T3 PL2991983T3 PL14719326T PL14719326T PL2991983T3 PL 2991983 T3 PL2991983 T3 PL 2991983T3 PL 14719326 T PL14719326 T PL 14719326T PL 14719326 T PL14719326 T PL 14719326T PL 2991983 T3 PL2991983 T3 PL 2991983T3
- Authority
- PL
- Poland
- Prior art keywords
- hetaryl
- imidazol
- phenyl
- pyridine derivatives
- pyridine
- Prior art date
Links
- VNHBYKHXBCYPBJ-UHFFFAOYSA-N 5-ethynylimidazo[1,2-a]pyridine Chemical class C#CC1=CC=CC2=NC=CN12 VNHBYKHXBCYPBJ-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/0002—General or multifunctional contrast agents, e.g. chelated agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Cardiology (AREA)
- Hospice & Palliative Care (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychiatry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13165676 | 2013-04-29 | ||
| EP14719326.2A EP2991983B1 (en) | 2013-04-29 | 2014-04-25 | 2-phenyl or 2-hetaryl imidazol[1,2-a]pyridine derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2991983T3 true PL2991983T3 (pl) | 2017-07-31 |
Family
ID=48190297
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL14719326T PL2991983T3 (pl) | 2013-04-29 | 2014-04-25 | Pochodne 2-fenylo lub 2-hetaryloimidazolo[1,2-a]pirydyny |
Country Status (18)
| Country | Link |
|---|---|
| US (3) | US10138234B2 (pl) |
| EP (1) | EP2991983B1 (pl) |
| JP (1) | JP6212628B2 (pl) |
| KR (2) | KR20170094001A (pl) |
| CN (1) | CN105164125B (pl) |
| AR (1) | AR096119A1 (pl) |
| AU (1) | AU2014261628A1 (pl) |
| BR (1) | BR112015027015A2 (pl) |
| CA (1) | CA2910368A1 (pl) |
| DK (1) | DK2991983T3 (pl) |
| ES (1) | ES2624453T3 (pl) |
| MX (1) | MX2015014353A (pl) |
| PL (1) | PL2991983T3 (pl) |
| RU (1) | RU2015147450A (pl) |
| SG (1) | SG11201508912YA (pl) |
| SI (1) | SI2991983T1 (pl) |
| WO (1) | WO2014177458A1 (pl) |
| ZA (1) | ZA201507389B (pl) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20170094001A (ko) * | 2013-04-29 | 2017-08-16 | 에프. 호프만-라 로슈 아게 | 2-페닐 또는 2-헤트아릴 이미다졸[1,2-a]피리딘 유도체 |
| MX2015015893A (es) * | 2013-05-23 | 2016-03-04 | Hoffmann La Roche | 2-fenilimidazo[1,2-a]pirimidinas como agentes formadores de imagen. |
| JP6182668B2 (ja) | 2013-09-26 | 2017-08-16 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | 画像化ツールとしてのイミダゾ［１，２−ａ］ピリジン−７−アミン |
| BR112018006005A2 (pt) * | 2015-09-29 | 2018-10-30 | Oncotherapy Science Inc | composto bicíclico e uso do mesmo para inibição de suv39h2 |
| EP3487545A1 (en) | 2016-07-22 | 2019-05-29 | AC Immune S.A. | Compounds for imaging tau protein aggregates |
| CN115650982A (zh) | 2016-07-22 | 2023-01-31 | Ac免疫有限公司 | 用于成像tau蛋白聚集体的化合物 |
| WO2018165112A1 (en) * | 2017-03-09 | 2018-09-13 | Oncotherapy Science, Inc. | Bicyclic compound and use thereof for inhibiting histone methyltransferase |
| EP3743423A1 (en) | 2018-01-24 | 2020-12-02 | AC Immune SA | Gamma-carboline compounds for the detection of tau aggregates |
| EP3743426A1 (en) | 2018-01-24 | 2020-12-02 | AC Immune SA | Azacarboline compounds for the detection of tau aggregates |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5654436A (en) * | 1995-06-07 | 1997-08-05 | American Home Products Corporation | 2-substituted benzimidazole derivatives |
| CA2444214A1 (en) | 2001-04-23 | 2002-10-31 | The Trustees Of The University Of Pennsylvania | Amyloid plaque aggregation inhibitors and diagnostic imaging agents |
| EP1432453B1 (en) | 2001-08-27 | 2013-08-14 | The Trustees of The University of Pennsylvania | Stilbene derivatives and their use for binding and imaging amyloid plaques |
| JP4738419B2 (ja) * | 2005-11-30 | 2011-08-03 | 富士フイルムＲｉファーマ株式会社 | アミロイドの凝集及び／又は沈着に起因する疾患の診断薬及び治療薬 |
| JP4913157B2 (ja) * | 2006-01-17 | 2012-04-11 | エフ．ホフマン−ラ ロシュ アーゲー | ＧＡＢＡレセプター経由でのアルツハイマー病の処置に有用なアリール−イソオキサゾール−４−イル−イミダゾ［１，２−ａ］ピリジン誘導体 |
| EP2023919A4 (en) * | 2006-05-08 | 2010-12-22 | Molecular Neuroimaging Llc | COMPOUNDS AND AMYLOID PROBES FOR THERAPY AND IMAGING USES |
| CA2655826A1 (en) * | 2006-06-21 | 2007-12-27 | Nihon Medi-Physics Co., Ltd. | Novel compound having affinity for amyloid |
| CN101535309A (zh) * | 2006-11-17 | 2009-09-16 | 日本医事物理股份有限公司 | 对淀粉状蛋白具有亲和性的新化合物 |
| AU2008208091A1 (en) * | 2007-01-22 | 2008-07-31 | Astrazeneca Ab | Novel heteroaryl substituted imidazo [1,2 -a] pyridine derivatives |
| US20150377123A1 (en) | 2007-08-01 | 2015-12-31 | United Technologies Corporation | Turbine section of high bypass turbofan |
| CN102702195A (zh) * | 2007-10-30 | 2012-10-03 | 日本医事物理股份有限公司 | 对淀粉样蛋白具有亲和性的新化合物的应用及制备方法 |
| JP5667058B2 (ja) | 2008-09-23 | 2015-02-12 | ウィスタ ラボラトリーズ リミテッド | 凝集したタウ分子に対するリガンド |
| PE20121438A1 (es) * | 2009-09-24 | 2012-10-26 | Hoffmann La Roche | Derivados de imidazopiridina o imidazopirimidina como inhibidores de fosfodiesterasa 10a |
| US8703768B2 (en) * | 2010-06-09 | 2014-04-22 | Hoffmann-La Roche Inc. | Nitrogen containing heteroaryl compounds |
| KR20170094001A (ko) | 2013-04-29 | 2017-08-16 | 에프. 호프만-라 로슈 아게 | 2-페닐 또는 2-헤트아릴 이미다졸[1,2-a]피리딘 유도체 |
| JP6182668B2 (ja) * | 2013-09-26 | 2017-08-16 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | 画像化ツールとしてのイミダゾ［１，２−ａ］ピリジン−７−アミン |
-
2014
- 2014-04-25 KR KR1020177021836A patent/KR20170094001A/ko not_active Withdrawn
- 2014-04-25 DK DK14719326.2T patent/DK2991983T3/en active
- 2014-04-25 JP JP2016511013A patent/JP6212628B2/ja active Active
- 2014-04-25 ES ES14719326.2T patent/ES2624453T3/es active Active
- 2014-04-25 WO PCT/EP2014/058415 patent/WO2014177458A1/en not_active Ceased
- 2014-04-25 BR BR112015027015A patent/BR112015027015A2/pt not_active IP Right Cessation
- 2014-04-25 KR KR1020157033882A patent/KR20160003173A/ko not_active Abandoned
- 2014-04-25 CA CA2910368A patent/CA2910368A1/en not_active Abandoned
- 2014-04-25 RU RU2015147450A patent/RU2015147450A/ru not_active Application Discontinuation
- 2014-04-25 AU AU2014261628A patent/AU2014261628A1/en not_active Abandoned
- 2014-04-25 SG SG11201508912YA patent/SG11201508912YA/en unknown
- 2014-04-25 EP EP14719326.2A patent/EP2991983B1/en active Active
- 2014-04-25 CN CN201480024056.9A patent/CN105164125B/zh active Active
- 2014-04-25 PL PL14719326T patent/PL2991983T3/pl unknown
- 2014-04-25 SI SI201430205A patent/SI2991983T1/sl unknown
- 2014-04-25 MX MX2015014353A patent/MX2015014353A/es unknown
- 2014-04-28 AR ARP140101744A patent/AR096119A1/es unknown
-
2015
- 2015-10-06 ZA ZA2015/07389A patent/ZA201507389B/en unknown
- 2015-10-28 US US14/925,574 patent/US10138234B2/en active Active
-
2018
- 2018-10-16 US US16/161,299 patent/US11358962B2/en active Active
- 2018-10-16 US US16/161,306 patent/US10975073B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US20190048003A1 (en) | 2019-02-14 |
| ZA201507389B (en) | 2017-01-25 |
| HK1213555A1 (zh) | 2016-07-08 |
| EP2991983A1 (en) | 2016-03-09 |
| KR20170094001A (ko) | 2017-08-16 |
| JP2016520046A (ja) | 2016-07-11 |
| JP6212628B2 (ja) | 2017-10-11 |
| CN105164125A (zh) | 2015-12-16 |
| CN105164125B (zh) | 2017-10-13 |
| CA2910368A1 (en) | 2014-11-06 |
| BR112015027015A2 (pt) | 2017-07-25 |
| WO2014177458A1 (en) | 2014-11-06 |
| ES2624453T3 (es) | 2017-07-14 |
| SG11201508912YA (en) | 2015-11-27 |
| US10138234B2 (en) | 2018-11-27 |
| AU2014261628A1 (en) | 2015-10-22 |
| RU2015147450A (ru) | 2017-06-05 |
| KR20160003173A (ko) | 2016-01-08 |
| US20160244441A1 (en) | 2016-08-25 |
| SI2991983T1 (sl) | 2017-06-30 |
| AR096119A1 (es) | 2015-12-09 |
| MX2015014353A (es) | 2016-04-07 |
| DK2991983T3 (en) | 2017-05-08 |
| US11358962B2 (en) | 2022-06-14 |
| EP2991983B1 (en) | 2017-03-01 |
| US10975073B2 (en) | 2021-04-13 |
| US20190048002A1 (en) | 2019-02-14 |
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