PL2953938T3 - Funkcjonalizowane związki benzopiranowe i ich zastosowanie - Google Patents
Funkcjonalizowane związki benzopiranowe i ich zastosowanieInfo
- Publication number
- PL2953938T3 PL2953938T3 PL15746211T PL15746211T PL2953938T3 PL 2953938 T3 PL2953938 T3 PL 2953938T3 PL 15746211 T PL15746211 T PL 15746211T PL 15746211 T PL15746211 T PL 15746211T PL 2953938 T3 PL2953938 T3 PL 2953938T3
- Authority
- PL
- Poland
- Prior art keywords
- functionalised
- benzopyran compounds
- benzopyran
- compounds
- functionalised benzopyran
- Prior art date
Links
- 150000001562 benzopyrans Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
- C07D311/08—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring
- C07D311/16—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring substituted in position 7
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing aromatic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrane Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461937368P | 2014-02-07 | 2014-02-07 | |
| US201461987323P | 2014-05-01 | 2014-05-01 | |
| PCT/AU2015/050040 WO2015117202A1 (en) | 2014-02-07 | 2015-02-05 | Functionalised benzopyran compounds and use thereof |
| EP15746211.0A EP2953938B1 (en) | 2014-02-07 | 2015-02-05 | Functionalised benzopyran compounds and use thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2953938T3 true PL2953938T3 (pl) | 2017-12-29 |
Family
ID=53777071
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL15746211T PL2953938T3 (pl) | 2014-02-07 | 2015-02-05 | Funkcjonalizowane związki benzopiranowe i ich zastosowanie |
Country Status (24)
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK2953938T3 (en) * | 2014-02-07 | 2017-10-02 | Novogen ltd | Functionalized benzopyran compounds and their use |
| US10980774B2 (en) | 2015-02-02 | 2021-04-20 | Mei Pharma, Inc. | Combination therapies |
| US10265294B2 (en) | 2016-03-31 | 2019-04-23 | Yale University | Compositions and methods for treating epithelial cancer |
| WO2017173496A1 (en) * | 2016-04-06 | 2017-10-12 | Noxopharm Limited | Radiotherapy improvements |
| US11559510B2 (en) | 2016-04-06 | 2023-01-24 | Noxopharm Limited | Isoflavonoid composition with improved pharmacokinetics |
| CN109700798A (zh) * | 2017-03-01 | 2019-05-03 | 浙江大学 | 苯并吡喃黄酮结构类型雄激素受体拮抗剂及其应用 |
| JP2023519990A (ja) | 2020-03-30 | 2023-05-15 | ノクソファーム リミティド | 感染に関連する炎症の治療のための方法 |
| CA3181730A1 (en) * | 2020-06-11 | 2021-12-16 | Daniel P. Gold | Combination therapies |
| WO2023235929A1 (en) * | 2022-06-08 | 2023-12-14 | Noxopharm Limited | Functionalised benzopyran compounds and uses thereof |
| CN118005594B (zh) * | 2023-05-24 | 2024-10-29 | 内蒙古大学 | 3-羟基苯并二氢吡喃衍生物的合成及其抗肿瘤活性 |
Family Cites Families (62)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3340276A (en) | 1964-04-01 | 1967-09-05 | Ciba Geigy Corp | 3, 4-diphenyl-chromans |
| US3822287A (en) | 1969-04-17 | 1974-07-02 | Rexall Drug Chemical | Process for preparation of substituted 3,4-(diphenyl)chromans |
| US4447622A (en) | 1981-09-22 | 1984-05-08 | Council Of Scientific And Industrial Research Rafi Marg | Preparation of l- and d-isomers of dl-3,4-trans-2,2-disubstituted-3,4-diarylchromans and derivatives thereof |
| BE891562A (fr) | 1981-12-21 | 1982-04-16 | Council Scient Ind Res | Isomeres 1 et d de d1-3, 4-trans-3, 4-diarylchromanes 2, 2-disubstitues et leurs derives, leur preparation et leur utilisation |
| US5451603A (en) | 1993-03-11 | 1995-09-19 | Zymogenetics, Inc. | 3,4-diarylchromans for treatment of dermatitis |
| US5280040A (en) | 1993-03-11 | 1994-01-18 | Zymogenetics, Inc. | Methods for reducing bone loss using centchroman derivatives |
| CN1168097A (zh) | 1995-01-13 | 1997-12-17 | 诺沃挪第克公司 | 3，4-二苯基苯并二氢吡喃在制备治疗或预防自发性或生理性男子女性型乳房药物组合物中的用途 |
| HUP9800521A3 (en) | 1995-01-13 | 1999-12-28 | Novo Nordisk As | Use of 3,4-diphenyl chromans for the manufacture of a pharmaceutical composition for the treatment or propylaxis of hyperlipoproteinaemia, hypertriglyceridaemia, hyperlipidaemia or hypercholesterolaemia or arteriosclerosis |
| HUP9702244A3 (en) | 1995-01-13 | 1999-12-28 | Novo Nordisk As | Use of 3,4-diphenyl chromans for manufacture of a pharmaceutical composition for treatment or prophylaxis of gynaecological disorders |
| CZ212097A3 (en) | 1995-01-20 | 1997-11-12 | Novo Nordisk As | Use of 3,4-diphenylchromans for preparing a medicament intended for treating or prophylaxis of cerebral degenerative diseases |
| HUP9800297A3 (en) | 1995-01-20 | 1999-12-28 | Novo Nordisk As | Use of 3,4-diphenyl chromans for the manufacture of a vasodilatory pharmaceutical composition |
| TW448046B (en) | 1995-01-20 | 2001-08-01 | Novo Nordisk As | Use of 3,4-diphenyl chromans for the manufacture of a pharmaceutical composition for the treatment or prophylaxis of obesity |
| US5726202A (en) | 1996-01-11 | 1998-03-10 | Novo Nordisk A/S | Benign prostatic hypertrophy |
| JP2000506505A (ja) | 1996-01-11 | 2000-05-30 | ノボ ノルディスク アクティーゼルスカブ | 閉経期の症状の治療又は予防のための医薬組成物の製造のための３，４―ジフェニルクロマンの使用 |
| US5883118A (en) | 1996-01-11 | 1999-03-16 | Nova Nordisk A/S | Prostatic carcinoma |
| US5747059A (en) | 1996-01-11 | 1998-05-05 | Novo Nordisk A/S | Atrophy of skin/mucous membrane |
| CN1207038A (zh) | 1996-01-11 | 1999-02-03 | 诺沃挪第克公司 | 3,4－二苯基苯并二氢吡喃在生产预防或治疗绝经症状的药物组合物中的应用 |
| US5756539A (en) | 1996-07-11 | 1998-05-26 | Novo Nordis A/S | 3, 4-diphenyl chromans for inhibiting one or more psychiatric disorders |
| US5780502A (en) | 1996-07-12 | 1998-07-14 | Novo Nordisk A/S | Use of 3,4-diphenyl chromans for the manufacture of a pharmaceutical composition for inhibiting one or more symptoms of premenstrual syndrome |
| US5919817A (en) | 1996-10-28 | 1999-07-06 | Novo Nordisk A/S | Cis-3, 4-chroman derivatives useful in the prevention or treatment of estrogen related diseases or syndromes |
| ZA979642B (en) | 1996-10-28 | 1998-04-28 | Novo Nordisk As | Heterocyclic compounds, compositions and uses. |
| IL129625A0 (en) | 1996-10-28 | 2000-02-29 | Novo Nordisk As | Novel (-)-enantionmers of CIS-3,4-chroman derivatives useful in the prevention or treatment of estrogen related diseases or syndromes |
| US5925771A (en) | 1996-10-28 | 1999-07-20 | Novo Nordisk A/S | Process for the preparation of (-)-3,4-trans-diarylchromans |
| US6043269A (en) | 1996-10-28 | 2000-03-28 | Novo Nordisk A/S | cis-3,4-chroman derivatives useful in the prevention or treatment of estrogen related diseases or syndromes |
| WO1998033500A1 (en) | 1997-01-29 | 1998-08-06 | Novo Nordisk A/S | Use of 3,4-diphenyl chromans for the manufacture of a pharmaceutical composition for inhibiting senescence-associated motor impairment |
| AU5550298A (en) | 1997-01-29 | 1998-08-25 | Novo Nordisk A/S | Use of 3,4-diphenyl chromans for the manufacture of a pharmaceutical compositionfor increasing libido in post-menopausal women |
| US6184005B1 (en) | 1998-04-28 | 2001-02-06 | Novo Nordisk A/S | Enzymatic resolvation for obtaining a (−)-3,4-trans-diarylchroman |
| EP1115398B1 (en) * | 1998-09-23 | 2010-05-05 | Research Development Foundation | Tocopherols, tocotrienols, other chroman and side chain derivatives and uses thereof |
| WO2001007031A1 (en) | 1999-07-26 | 2001-02-01 | Shionogi & Co., Ltd. | Benzene derivatives and immunopotentiating compositions or drug-sensitivity restoring agents containing the same |
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| WO2002074307A1 (en) | 2001-03-16 | 2002-09-26 | Novogen Research Pty Ltd | Treatment of restenosis |
| US20050119301A1 (en) | 2001-03-16 | 2005-06-02 | Alan Husband | Treatment of restenosis |
| JP2005524630A (ja) | 2002-01-14 | 2005-08-18 | ノルディック・ビオサイエンス・エー／エス | エストロゲン受容体を介する軟骨破壊の抑制 |
| US20040167165A1 (en) | 2003-01-16 | 2004-08-26 | Geetha Shankar | Methods of treating conditions associated with an Edg-7 receptor |
| US20060141591A1 (en) | 2003-06-04 | 2006-06-29 | Youichi Kyuuko | Method for producing optically active chroman-carboxylate |
| MXPA06005697A (es) * | 2003-11-19 | 2006-08-17 | Novogen Res Pty Ltd | Composiciones y metodos para radioterapia y quimioterapia en combinacion. |
| US8080675B2 (en) | 2004-09-21 | 2011-12-20 | Marshall Edwards, Inc. | Chroman derivatives, medicaments and use in therapy |
| ES2516067T3 (es) * | 2004-09-21 | 2014-10-30 | Mei Pharma, Inc. | Derivados de cromano sustituidos, medicamentos y utilización en terapia |
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| CN102153535A (zh) | 2011-03-04 | 2011-08-17 | 中国海洋大学 | 一种抗肿瘤多药耐药抑制剂苯并吡喃-3-醇酯化衍生物及其制备方法和应用 |
| US20120251630A1 (en) * | 2011-03-29 | 2012-10-04 | Marshall Edwards, Inc. | Remission therapy of cancer with isoflavonoids |
| WO2013026942A1 (en) * | 2011-08-25 | 2013-02-28 | The Provost, Fellows, Foundation Scholars, And The Other Members Of Board, Of The College Of The Holy And Undivided Trinity Of Queen Elizabeth, Near Dublin | Tubulin binding agents |
| EP3409666A3 (en) | 2012-06-07 | 2019-01-02 | Georgia State University Research Foundation, Inc. | Seca inhibitors and methods of making and using thereof |
| CN103408528B (zh) | 2013-08-13 | 2015-04-29 | 浙江大学 | 一种色满化合物及其制备方法和应用 |
| CN103450142B (zh) | 2013-09-04 | 2015-03-25 | 浙江大学 | 一种色满化合物及其提取方法和应用 |
| CN103585145A (zh) | 2013-11-28 | 2014-02-19 | 常州科立信医疗器械有限公司 | Artoxanthochromane在治疗前列腺癌药物中的应用 |
| CN103638008B (zh) | 2013-12-02 | 2015-09-16 | 刘艳娇 | Artoxanthochromane在治疗皮肤癌药物中的应用 |
| CN103690525A (zh) | 2013-12-02 | 2014-04-02 | 常州科立信医疗器械有限公司 | Artoxanthochromane在治疗舌癌药物中的应用 |
| CN103705503A (zh) | 2013-12-04 | 2014-04-09 | 常州科立信医疗器械有限公司 | Artoxanthochromane在治疗乳腺癌药物中的应用 |
| DK2953938T3 (en) * | 2014-02-07 | 2017-10-02 | Novogen ltd | Functionalized benzopyran compounds and their use |
-
2015
- 2015-02-05 DK DK15746211.0T patent/DK2953938T3/en active
- 2015-02-05 PL PL15746211T patent/PL2953938T3/pl unknown
- 2015-02-05 AU AU2015213484A patent/AU2015213484B2/en active Active
- 2015-02-05 CN CN201810378034.2A patent/CN108484559A/zh active Pending
- 2015-02-05 PT PT157462110T patent/PT2953938T/pt unknown
- 2015-02-05 CN CN201580002687.5A patent/CN105980372B/zh active Active
- 2015-02-05 WO PCT/AU2015/050040 patent/WO2015117202A1/en not_active Ceased
- 2015-02-05 SG SG11201604490SA patent/SG11201604490SA/en unknown
- 2015-02-05 RU RU2016133731A patent/RU2676766C2/ru active
- 2015-02-05 KR KR1020167021722A patent/KR102395543B1/ko active Active
- 2015-02-05 US US14/771,440 patent/US9701655B2/en active Active
- 2015-02-05 NZ NZ711603A patent/NZ711603A/en unknown
- 2015-02-05 JP JP2016568089A patent/JP6570042B2/ja active Active
- 2015-02-05 MY MYPI2016702471A patent/MY195739A/en unknown
- 2015-02-05 ES ES15746211.0T patent/ES2643407T3/es active Active
- 2015-02-05 CA CA2936012A patent/CA2936012C/en active Active
- 2015-02-05 SG SG11201506988TA patent/SG11201506988TA/en unknown
- 2015-02-05 LT LTEP15746211.0T patent/LT2953938T/lt unknown
- 2015-02-05 BR BR112016018099A patent/BR112016018099B8/pt active IP Right Grant
- 2015-02-05 SI SI201530099T patent/SI2953938T1/en unknown
- 2015-02-05 MX MX2016010137A patent/MX368063B/es active IP Right Grant
- 2015-02-05 EP EP15746211.0A patent/EP2953938B1/en active Active
- 2015-09-10 IL IL241515A patent/IL241515B/en active IP Right Grant
-
2016
- 2016-07-19 PH PH12016501422A patent/PH12016501422B1/en unknown
- 2016-07-31 SA SA516371583A patent/SA516371583B1/ar unknown
- 2016-08-01 CL CL2016001937A patent/CL2016001937A1/es unknown
-
2017
- 2017-06-05 US US15/613,711 patent/US10370349B2/en active Active
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