PL2921500T3 - Genetycznie zmodyfikowane ludzkie linie komórkowe naturalni zabójcy - Google Patents

Genetycznie zmodyfikowane ludzkie linie komórkowe naturalni zabójcy

Info

Publication number
PL2921500T3
PL2921500T3 PL15150984.1T PL15150984T PL2921500T3 PL 2921500 T3 PL2921500 T3 PL 2921500T3 PL 15150984 T PL15150984 T PL 15150984T PL 2921500 T3 PL2921500 T3 PL 2921500T3
Authority
PL
Poland
Prior art keywords
cell lines
genetically modified
natural killer
killer cell
modified human
Prior art date
Application number
PL15150984.1T
Other languages
English (en)
Inventor
Kerry S. Cambell
Original Assignee
The Institute For Cancer Research
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35968029&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL2921500(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by The Institute For Cancer Research filed Critical The Institute For Cancer Research
Publication of PL2921500T3 publication Critical patent/PL2921500T3/pl

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/461—Cellular immunotherapy characterised by the cell type used
    • A61K39/4613—Natural-killer cells [NK or NK-T]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/4643—Vertebrate antigens
    • A61K39/4644—Cancer antigens
    • A61K39/464402—Receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70535—Fc-receptors, e.g. CD16, CD32, CD64 (CD2314/705F)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/283—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against Fc-receptors, e.g. CD16, CD32, CD64
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0646—Natural killers cells [NK], NKT cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5011—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5047—Cells of the immune system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/23—Interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2503/00—Use of cells in diagnostics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2503/00—Use of cells in diagnostics
    • C12N2503/02—Drug screening
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Urology & Nephrology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Oncology (AREA)
  • Mycology (AREA)
  • Wood Science & Technology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • General Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
PL15150984.1T 2004-07-10 2005-07-08 Genetycznie zmodyfikowane ludzkie linie komórkowe naturalni zabójcy PL2921500T3 (pl)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US58658104P 2004-07-10 2004-07-10

Publications (1)

Publication Number Publication Date
PL2921500T3 true PL2921500T3 (pl) 2024-02-05

Family

ID=35968029

Family Applications (1)

Application Number Title Priority Date Filing Date
PL15150984.1T PL2921500T3 (pl) 2004-07-10 2005-07-08 Genetycznie zmodyfikowane ludzkie linie komórkowe naturalni zabójcy

Country Status (12)

Country Link
US (8) US7618817B2 (pl)
EP (5) EP3406631B1 (pl)
AT (1) ATE443084T1 (pl)
AU (1) AU2005277831B2 (pl)
CA (2) CA3052445C (pl)
DE (1) DE602005016683D1 (pl)
DK (4) DK3406631T3 (pl)
ES (3) ES2925912T3 (pl)
HK (2) HK1203975A1 (pl)
PL (1) PL2921500T3 (pl)
PT (1) PT2921500T (pl)
WO (1) WO2006023148A2 (pl)

Families Citing this family (99)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006023148A2 (en) * 2004-07-10 2006-03-02 Fox Chase Cancer Center Genetically modified human natural killer cell lines
US7994298B2 (en) 2004-09-24 2011-08-09 Trustees Of Dartmouth College Chimeric NK receptor and methods for treating cancer
RU2495882C2 (ru) 2006-09-08 2013-10-20 Медиммун, Ллк. Гуманизированные антитела к cd19 и их применение для лечения онкологического, связанного с трансплантацией и аутоиммунного заболевания
RU2549701C2 (ru) 2007-05-07 2015-04-27 Медиммун, Ллк Анти-icos антитела и их применение в лечении онкологических, связанных с трансплантацией и аутоиммунных заболеваний
JP5282040B2 (ja) * 2007-09-28 2013-09-04 オリンパス株式会社 Ｆｃ受容体遺伝子導入ＮＫ細胞を用いた抗体依存性細胞傷害のアッセイ方法
US8092804B2 (en) 2007-12-21 2012-01-10 Medimmune Limited Binding members for interleukin-4 receptor alpha (IL-4Rα)-173
ES2518415T3 (es) 2007-12-21 2014-11-05 Medimmune Limited Elementos de unión para receptor alfa de interleucina-4 (IL-4Ralfa)
EP2161339A1 (en) * 2008-08-29 2010-03-10 F. Hoffmann-La Roche Ag ADCC with modified NK92 cells
EP2358392B1 (en) 2008-11-12 2019-01-09 MedImmune, LLC Antibody formulation
US9273283B2 (en) 2009-10-29 2016-03-01 The Trustees Of Dartmouth College Method of producing T cell receptor-deficient T cells expressing a chimeric receptor
US9181527B2 (en) 2009-10-29 2015-11-10 The Trustees Of Dartmouth College T cell receptor-deficient T cell compositions
WO2013033626A2 (en) 2011-08-31 2013-03-07 Trustees Of Dartmouth College Nkp30 receptor targeted therapeutics
CN110511278B (zh) 2012-05-07 2024-08-09 达特茅斯大学理事会 抗b7-h6抗体、融合蛋白及其使用方法
BR112016006999B1 (pt) 2013-10-02 2023-11-14 Medimmune, Llc Anticorpos neutralizantes antiinfluenza a seus usos, seu método de produção, composição que os compreendem, ácido nucleico e vetor
KR20220147705A (ko) 2013-11-01 2022-11-03 이뮤너티바이오, 인크. 종양세포 치사활성 및 항균성 조성물 및 방법
US8986691B1 (en) 2014-07-15 2015-03-24 Kymab Limited Method of treating atopic dermatitis or asthma using antibody to IL4RA
US8980273B1 (en) 2014-07-15 2015-03-17 Kymab Limited Method of treating atopic dermatitis or asthma using antibody to IL4RA
US10464989B2 (en) 2014-03-28 2019-11-05 Regents Of The University Of Minnesota Polypeptides, cells, and methods involving engineered CD16
DK3143134T3 (da) 2014-05-15 2021-01-04 Nat Univ Singapore Modificerede, naturlige dræberceller og anvendelser deraf
WO2015179710A1 (en) 2014-05-22 2015-11-26 Conkwest, Inc. Treating solid tumours with nk-92 cells applied by microcatheter
US20170151283A1 (en) * 2014-05-23 2017-06-01 The Trustees Of The University Of Pennsylvania Compositions and methods for treating antibody resistance
CA2951355C (en) 2014-06-18 2023-10-31 Chemotherapeutisches Forschungsinstitut Georg-Speyer-Haus Car-expressing nk-92 cells as cell therapeutic agents
WO2016057345A1 (en) * 2014-10-06 2016-04-14 Nantkwest, Inc. Treating viral hemorrhagic fever with nk-92 cells
GB201501175D0 (en) * 2015-01-23 2015-03-11 Univ Oslo Hf A universal T-cell for personalised medicine
AU2016243120B2 (en) * 2015-03-27 2021-09-30 Immunitybio, Inc. Genetically modified NK-92 cells and monoclonal antibodies for the treatment of cancer
US20170304364A1 (en) * 2015-03-27 2017-10-26 Nantkwest, Inc. Nk-92 cells in combination therapy with cancer drugs
AU2016256367A1 (en) 2015-04-25 2017-12-07 The General Hospital Corporation Anti-fugetactic agent and anti-cancer agent combination therapy and compositions for the treatment of cancer
RS62446B1 (sr) 2015-06-01 2021-11-30 Medimmune Llc Neutrališući vezujući molekuli protiv gripa i njihova primena
CA2987290C (en) * 2015-06-10 2023-10-03 Nantkwest, Inc. Modified nk-92 cells for treating cancer
EP3421590B1 (en) 2015-07-29 2021-07-14 ONK Therapeutics Limited Modified natural killer cells and natural killer cell lines having increased cytotoxicity
US10906951B2 (en) 2015-07-29 2021-02-02 Onk Therapeutics Limited Modified natural killer cells and natural killer cell lines having increased cytotoxicity
US11890348B2 (en) 2015-09-18 2024-02-06 The General Hospital Corporation Localized delivery of anti-fugetactic agent for treatment of cancer
US10533157B1 (en) 2015-12-03 2020-01-14 Nantbio, Inc. Recombinant NK cells expressing co-stimulatory molecules
WO2017120501A1 (en) 2016-01-07 2017-07-13 Mayo Foundation For Medical Education And Research Methods of treating cancer with interferon
WO2017132202A1 (en) * 2016-01-25 2017-08-03 Nant Holdings Ip, Llc Nk cells with altered cxcl12/cxcr4 signaling
WO2017184534A1 (en) * 2016-04-18 2017-10-26 The Gorlin Companies Methods and compositions for improving safety and efficacy of natural killer cell immunotherapy
WO2017201432A2 (en) 2016-05-19 2017-11-23 Jounaidi Youssef Tethered interleukin-2 to its receptor il-2rbeta, a platform to enhance natural killer and regulatory t cell activity
WO2018053270A1 (en) * 2016-09-16 2018-03-22 The General Hospital Corporation Modified natural killer cells for the treatment of cancer
EP3519562A4 (en) 2016-09-29 2020-03-25 Nantkwest, Inc. NK-92 HLA CLASS I DEFICIENT CELLS WITH REDUCED IMMUNOGENICITY
US11752172B2 (en) 2017-01-04 2023-09-12 Nova Southeastern University Natural killer (NK) cells expressing an antigen-specific functional T cell receptor (TCR) complex, methods for production thereof, and methods for therapeutic use thereof
CN110168078B (zh) 2017-01-06 2024-05-14 免疫生物公司 具有降低的cd96/tigit表达的遗传修饰的nk-92细胞
EP3576791A4 (en) * 2017-02-01 2020-11-25 Nant Holdings IP, LLC CALRETICULIN-MEDIATION CANCER TREATMENT
CN110612119A (zh) 2017-02-07 2019-12-24 西雅图儿童医院（Dba西雅图儿童研究所） 磷脂醚(ple)car t细胞肿瘤靶向(ctct)剂
EP3580341A4 (en) * 2017-02-09 2020-11-04 Indapta Therapeutics, Inc. MANIPULATED NATURAL KILLER (NK) CELLS AND COMPOSITIONS AND METHOD FOR THEREFORE
WO2018160622A1 (en) 2017-02-28 2018-09-07 Endocyte, Inc. Compositions and methods for car t cell therapy
KR20240010558A (ko) 2017-03-08 2024-01-23 이뮤너티바이오, 인크. 임상용 변형된 NK-92 haNK003 세포
MX2019011324A (es) 2017-03-23 2020-01-21 Massachusetts Gen Hospital Bloqueo de cxcr4/cxcr7 y tratamiento de enfermedad asociada con el virus del papiloma humano.
SG11201908337VA (en) 2017-03-27 2019-10-30 Nat Univ Singapore Stimulatory cell lines for ex vivo expansion and activation of natural killer cells
JP2020511981A (ja) * 2017-03-27 2020-04-23 ナントセル，インコーポレイテッド ａＮＫ及びＩＬ−１２組成物及び方法
KR20240057444A (ko) 2017-03-27 2024-05-02 내셔널 유니버시티 오브 싱가포르 절단된 nkg2d 키메라 수용체 및 자연 살해 세포 면역요법에서의 그의 용도
CN110996975A (zh) * 2017-04-13 2020-04-10 森迪生物科学公司 组合癌症免疫疗法
JP2020534252A (ja) 2017-08-04 2020-11-26 ナントクエスト インコーポレイテッド Ｎｋ−９２細胞を用いた白血病の治療と抑制
US20200283501A1 (en) * 2017-10-26 2020-09-10 Regents Of The University Of Minnesota Recombinant immune cells, methods of making, and methods of use
WO2019084284A1 (en) 2017-10-27 2019-05-02 Coneksis, Inc. NK CELLS FOR USE IN THE TREATMENT OF CANCER IN DOGS
US20210187024A1 (en) 2017-11-01 2021-06-24 Nantkwest, Inc. NK-92 Cells to Stimulate Anti-Cancer Vaccine
US11311576B2 (en) 2018-01-22 2022-04-26 Seattle Children's Hospital Methods of use for CAR T cells
WO2019152513A1 (en) 2018-01-31 2019-08-08 Nantkwest, Inc. Use of 5% human albumin in wash and harvest media
CA3091224A1 (en) 2018-03-12 2019-09-19 Nantkwest, Inc. Use of cd33car modified high affinity nk cells (t-hank) to reduce myeloid-derived suppressor cells suppressor activity (or reduce negative impact on nk cell activity)
WO2019201629A1 (en) * 2018-04-19 2019-10-24 Onkimmune Limited Nk cells for use with antibodies in cancer therapy
US20210187025A1 (en) * 2018-05-14 2021-06-24 Indapta Therapeutics, Inc. Subsets of human natural killer cells with enhanced antibody-directed immune responses
KR20210011977A (ko) 2018-05-22 2021-02-02 난트케이웨스트, 인크. Nk-92 세포를 성장시키기 위한 기초 배지
JP2021525073A (ja) * 2018-05-22 2021-09-24 ナントケーウエスト，インコーポレイテッド ＦｃイプシロンＣＡＲ
AU2019272583B2 (en) 2018-05-22 2022-01-06 Immunitybio, Inc. Optimization of NK-92 cell growth using poloxamer
US20210163868A1 (en) 2018-05-22 2021-06-03 Nantkwest, Inc. Methods and systems for cell bed formation during bioprocessing
US20210267190A1 (en) 2018-07-10 2021-09-02 Nantkwest, Inc. Cryopreservation
WO2020028654A1 (en) 2018-08-01 2020-02-06 Nantkwest, Inc. Combined invasion and cytotoxicity assay using chemokine secreting target cells
IL314189A (en) 2018-08-01 2024-09-01 Immunitybio Inc A quadricistronic system containing a receptor or cytokine and a chimeric antigen receptor for genetic modification of immunotherapies
IL296408A (en) * 2018-10-31 2022-11-01 Immunitybio Inc Elimination of PD-11-positive malignancies by NK cells expressing a chimeric antigen receptor for PD-11
KR20200119892A (ko) 2018-10-31 2020-10-20 난트퀘스트, 인크. Cd19-car 발현 nk 세포에 의한 cd19-양성 림프성 악성종양의 제거(elimination of cd19-positive lymphoid malignancies by cd19-car expressing nk cells)
CA3092305A1 (en) 2018-11-06 2020-05-14 Nantkwest, Inc. Chimeric antigen receptor-modified nk-92 cells
US12109238B2 (en) 2018-11-06 2024-10-08 Immunitybio, Inc. Chimeric antigen receptor-modified NK-92 cells
AU2019388876A1 (en) 2018-11-26 2021-05-20 Immunitybio, Inc. IL-2 Dependent NK-92 cells with stable Fc receptor expression
CA3123225A1 (en) * 2018-12-20 2020-06-25 Kleo Pharmaceuticals, Inc. Combination therapy of arms and natural killer cells
US20220073878A1 (en) * 2019-01-18 2022-03-10 Acepodia Biotechnologies Ltd. A novel cd16+ natural killer cell and a method of culturing cd16+ natural killer cell
AU2020243623A1 (en) * 2019-03-19 2021-11-04 Ramot At Tel-Aviv University Ltd. T cell expressing an FC gamma receptor and methods of use thereof
EP3712257A1 (en) 2019-03-21 2020-09-23 ONK Therapeutics Limited Modified natural killer cells with increased resistance to cell death
JP2022526504A (ja) 2019-03-21 2022-05-25 オーエヌケー セラピューティクス リミテッド 細胞死に対する耐性が増大した改変免疫エフェクター細胞
BR112021021060A2 (pt) 2019-04-23 2021-12-14 Sanofi Sa Anticorpos anti-cd38 e formulações
US11655302B2 (en) 2019-06-10 2023-05-23 Sanofi Anti-CD38 antibodies and formulations
IL314722A (en) * 2019-08-01 2024-10-01 Immunitybio Inc NK-92 cells modified with a chimeric anti-B7-H4 antigen receptor
JP7375163B2 (ja) 2019-08-15 2023-11-07 ナントバイオ，インコーポレイテッド Ｔｇｆ－ベータトラップ
EP4061385A4 (en) * 2019-11-19 2024-08-14 Acibadem Mehmet Ali Aydinlar Ueniversitesi METHOD FOR REDESIGNING AND EXPANDING NK92 CELLS FOR USE IN IMMUNOTHERAPY
AU2020387167A1 (en) * 2019-11-20 2022-04-21 Immunitybio, Inc. Cell-mediated transient delivery of immune-enhancing molecules into the tumor microenvironment
WO2021116913A1 (en) * 2019-12-09 2021-06-17 Nantkwest, Inc. Screening of cell clones expressing polygenic transgenes through non-antibiotic dependent positive selection
US11230699B2 (en) 2020-01-28 2022-01-25 Immunitybio, Inc. Chimeric antigen receptor-modified NK-92 cells targeting EGFR super-family receptors
CN115315510A (zh) * 2020-01-28 2022-11-08 免疫生物公司 靶向egfr超家族受体的嵌合抗原受体修饰的nk-92细胞
US11857620B2 (en) 2020-03-11 2024-01-02 Immunitybio, Inc. Method of inducing immunity against SARS-CoV-2 using spike (s) and nucleocapsid (N)-ETSD immunogens delivered by a replication-defective adenovirus
US20210284716A1 (en) 2020-03-11 2021-09-16 Immunitybio, Inc. ACE2-Fc Trap
CN113603787B (zh) * 2020-05-04 2023-05-23 英诺康生物医药科技(广州)有限公司 一种非分泌型的人白细胞介素15及应用
CA3186887A1 (en) 2020-06-22 2021-12-30 Ramot At Tel-Aviv University Ltd. Multi subunit protein modules, cells expressing same and uses thereof
TW202216771A (zh) 2020-06-26 2022-05-01 德商拜耳廠股份有限公司 用於治療應用之ccr8抗體
US11661459B2 (en) 2020-12-03 2023-05-30 Century Therapeutics, Inc. Artificial cell death polypeptide for chimeric antigen receptor and uses thereof
CN116635064A (zh) 2020-12-18 2023-08-22 世纪治疗股份有限公司 具有适应性受体特异性的嵌合抗原受体系统
WO2022153212A1 (en) 2021-01-13 2022-07-21 Axon Neuroscience Se Antibodies neutralizing sars-cov-2
EP4108247A1 (en) 2021-06-23 2022-12-28 Ostravska univerzita Urine progenitor cells for use in cancer therapy
WO2023081163A1 (en) 2021-11-02 2023-05-11 Immunitybio, Inc. Natural killer cells for chordoma therapy
EP4180049A1 (en) 2021-11-16 2023-05-17 Ostravska univerzita Therapeutic composition for cancer treatment
WO2023114901A2 (en) * 2021-12-15 2023-06-22 Oxford Biomedica Solutions Llc Methods and compositions for the production of adeno-associated virus
WO2024154122A1 (en) 2023-01-18 2024-07-25 Gilboa Therapeutics LTD Immune cells expressing a complement receptor and uses thereof

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3773919A (en) 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
US3733919A (en) * 1971-09-20 1973-05-22 Adjustable eccentric bearing mountings background
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US4676980A (en) 1985-09-23 1987-06-30 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Target specific cross-linked heteroantibodies
DE68929256T2 (de) * 1988-05-27 2001-05-17 Applied Research Systems Ars Holding N.V., Curacao Humaner Rezeptor Fc(gamma)RIII
US5767077A (en) * 1988-05-27 1998-06-16 Applied Research Systems Ars Holding N.V. Human Fc-γ receptor III
WO1991000360A1 (en) 1989-06-29 1991-01-10 Medarex, Inc. Bispecific reagents for aids therapy
US7038031B1 (en) * 1989-07-28 2006-05-02 Sloan-Kettering Institute For Cancer Research DNA encoding FcγR receptor protein on NK cells
US5661016A (en) 1990-08-29 1997-08-26 Genpharm International Inc. Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
US5625126A (en) 1990-08-29 1997-04-29 Genpharm International, Inc. Transgenic non-human animals for producing heterologous antibodies
US5633425A (en) * 1990-08-29 1997-05-27 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
EP0586505A1 (en) 1991-05-14 1994-03-16 Repligen Corporation Heteroconjugate antibodies for treatment of hiv infection
EP0758394B1 (en) 1994-05-02 2002-11-20 Bernd Groner Bifunctional protein, preparation and use
KR100343214B1 (ko) * 1995-03-28 2002-11-13 삼성에스디아이 주식회사 전계방출소자의제조방법
US5830725A (en) 1995-04-28 1998-11-03 The Board Of Trustees For The Leland Stanford Junior University Rapid, stable high-titre production of recombing retrovirus
AU2582897A (en) 1996-03-15 1997-10-01 Millennium Pharmaceuticals, Inc. Compositions and methods for the diagnosis, prevention, and treatment of neoplastic cell growth and proliferation
DE69834257T2 (de) * 1997-04-30 2007-01-04 Klingemann, Hans Natürliche killerzelllinien und verfahren zu ihrer verwendung
US20030026780A1 (en) * 2001-07-18 2003-02-06 Hood Leroy E. Innate immunity mediated methods of treating pathological conditions
AU2003236019A1 (en) * 2002-04-09 2003-10-20 Kyowa Hakko Kirin Co., Ltd. Drug containing antibody composition appropriate for patient suffering from Fc Gamma RIIIa polymorphism
US7618617B2 (en) * 2002-05-31 2009-11-17 L'oreal Aqueous hair treatment compositions, thickened with an amphiphilic linear block copolymer
EP1639013B1 (en) 2003-07-02 2012-09-12 Innate Pharma Pan-kir2dl NK-receptor antibodies and their use in diagnostic and therapy
PL2287195T3 (pl) 2004-07-01 2019-10-31 Novo Nordisk As Przeciwciała pan-kir2dl receptora nk i ich zastosowanie w diagnostyce i terapii
WO2006023148A2 (en) 2004-07-10 2006-03-02 Fox Chase Cancer Center Genetically modified human natural killer cell lines
PL1836225T3 (pl) 2005-01-06 2012-05-31 Novo Nordisk As Czynniki wiążące kir i sposoby ich stosowania

Also Published As

Publication number Publication date
EP2112162A1 (en) 2009-10-28
HK1215269A1 (zh) 2016-08-19
US20230372545A1 (en) 2023-11-23
ES2955952T3 (es) 2023-12-11
EP2801583B1 (en) 2018-04-25
CA2572938A1 (en) 2006-03-02
CA3052445A1 (en) 2006-03-02
DK2112162T3 (da) 2015-02-23
DE602005016683D1 (de) 2009-10-29
EP3406631B1 (en) 2022-06-29
WO2006023148A8 (en) 2006-05-04
US8313943B2 (en) 2012-11-20
PT2921500T (pt) 2023-09-25
US20240016957A1 (en) 2024-01-18
EP2801583A1 (en) 2014-11-12
US20160067356A1 (en) 2016-03-10
ES2678094T3 (es) 2018-08-08
US9181322B2 (en) 2015-11-10
DK2921500T3 (da) 2023-09-18
US20100086486A1 (en) 2010-04-08
US20130040386A1 (en) 2013-02-14
EP3406631A1 (en) 2018-11-28
EP1771471A2 (en) 2007-04-11
AU2005277831A2 (en) 2009-03-12
DK3406631T3 (da) 2022-08-29
EP2112162B1 (en) 2015-01-14
WO2006023148A3 (en) 2006-08-03
CA3052445C (en) 2023-08-22
WO2006023148A2 (en) 2006-03-02
US20080247990A1 (en) 2008-10-09
DK2801583T3 (en) 2018-07-16
EP1771471B1 (en) 2009-09-16
EP2921500B1 (en) 2023-08-30
EP2921500A1 (en) 2015-09-23
AU2005277831B2 (en) 2012-11-22
CA2572938C (en) 2019-10-15
ATE443084T1 (de) 2009-10-15
ES2925912T3 (es) 2022-10-20
HK1203975A1 (en) 2015-11-06
US20060292156A1 (en) 2006-12-28
US7618817B2 (en) 2009-11-17
US9150636B2 (en) 2015-10-06
AU2005277831A1 (en) 2006-03-02
US20100086996A1 (en) 2010-04-08

Similar Documents

Publication Publication Date Title
PL2921500T3 (pl) Genetycznie zmodyfikowane ludzkie linie komórkowe naturalni zabójcy
IL250316A0 (en) Tissue tumor suppression using human placental perfusate and intermediate natural killer cells derived from human placenta
GB0615687D0 (en) Stems Cells
EP1809740A4 (en) CARDIAC STEM CELLS
HK1075423A1 (en) Human nosecock
EP1658723A4 (en) TECHNIQUES FOR RECORDING CONTENT
EP1997884A4 (en) NEW HUMAN T-CELL POPULATION
EP1778267A4 (en) COMPOSITIONS AND METHODS ASSOCIATED WITH HEART FAILURE
AU303644S (en) Sofa
ZAA200500514S (en) Chairs
ZAA200500260S (en) Chairs
GB0419527D0 (en) Pylon power
ZA200702966B (en) Cryopreservation of cells
EP1589099A4 (en) IMMORTALIZED NATURAL KILLER CELL LINE
PL1948305T3 (pl) Konstrukcja łopatki do defibrylacji
GB0411182D0 (en) Fish refuge
GB0421135D0 (en) Power pylon
GB0406296D0 (en) Polypeptide expression in plants
GB2418841B (en) Convertible armchair
GB0506070D0 (en) Pad pod ie swinging chair
GB0424204D0 (en) POD material
HU0400860D0 (en) Solar arrangements
IL183352A (en) Structure to grow isolated human mesenchymal cells that are differentiated and various aspects associated with this structure
HU0400140V0 (en) Beehive
HU0400135V0 (en) Beehive