PL2877479T3 - Sposób oczyszczania saponin - Google Patents

Sposób oczyszczania saponin

Info

Publication number
PL2877479T3
PL2877479T3 PL13742207T PL13742207T PL2877479T3 PL 2877479 T3 PL2877479 T3 PL 2877479T3 PL 13742207 T PL13742207 T PL 13742207T PL 13742207 T PL13742207 T PL 13742207T PL 2877479 T3 PL2877479 T3 PL 2877479T3
Authority
PL
Poland
Prior art keywords
saponins
purification
Prior art date
Application number
PL13742207T
Other languages
English (en)
Inventor
Juan Jose DIAZ GARCIA
Margit Theresia HOLZER
Original Assignee
Glaxosmithkline Biologicals S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxosmithkline Biologicals S.A. filed Critical Glaxosmithkline Biologicals S.A.
Publication of PL2877479T3 publication Critical patent/PL2877479T3/pl

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J71/00Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0036Nitrogen-containing hetero ring
    • C07J71/0042Nitrogen only
    • C07J71/0052Nitrogen only at position 16(17)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00Processes for the preparation of sugar derivatives
    • C07H1/06Separation; Purification
    • C07H1/08Separation; Purification from natural products
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20Carbocyclic rings
    • C07H15/24Condensed ring systems having three or more rings
    • C07H15/256Polyterpene radicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
PL13742207T 2012-07-27 2013-07-25 Sposób oczyszczania saponin PL2877479T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1213364.1A GB201213364D0 (en) 2012-07-27 2012-07-27 Purification process
EP13742207.7A EP2877479B1 (en) 2012-07-27 2013-07-25 Process for the purification of saponins
PCT/EP2013/065708 WO2014016374A1 (en) 2012-07-27 2013-07-25 Process for the purification of saponins

Publications (1)

Publication Number Publication Date
PL2877479T3 true PL2877479T3 (pl) 2019-06-28

Family

ID=46881236

Family Applications (1)

Application Number Title Priority Date Filing Date
PL13742207T PL2877479T3 (pl) 2012-07-27 2013-07-25 Sposób oczyszczania saponin

Country Status (18)

Country Link
US (1) US9540416B2 (pl)
EP (1) EP2877479B1 (pl)
JP (1) JP6360830B2 (pl)
CN (1) CN104662031B (pl)
BR (1) BR112015001655B1 (pl)
CA (1) CA2879709C (pl)
CY (1) CY1121304T1 (pl)
DK (1) DK2877479T3 (pl)
ES (1) ES2708783T3 (pl)
GB (1) GB201213364D0 (pl)
HR (1) HRP20190123T1 (pl)
HU (1) HUE042179T2 (pl)
LT (1) LT2877479T (pl)
PL (1) PL2877479T3 (pl)
PT (1) PT2877479T (pl)
SI (1) SI2877479T1 (pl)
TR (1) TR201901100T4 (pl)
WO (1) WO2014016374A1 (pl)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110822822B (zh) * 2014-06-09 2021-08-24 泰尔茂比司特公司 冻干法
WO2017088080A1 (es) 2015-11-25 2017-06-01 Natural Response S.A. Método para la obtención de saponinas a partir de plantas
EP3515179A4 (en) 2016-09-26 2020-05-06 Natural Response, S.A. MANUFACTURE OF BIOMASS IN ULTRA HIGH DENSITY PLANTATIONS
MX2020005481A (es) * 2017-12-01 2020-12-07 Glaxosmithkline Biologicals Sa Purificacion de saponina.
BR112020010635A2 (pt) * 2017-12-01 2020-11-10 Glaxosmithkline Biologicals S.A. extração de saponina
WO2020245207A1 (en) 2019-06-05 2020-12-10 Glaxosmithkline Biologicals Sa Saponin purification
CN110404113A (zh) * 2019-08-29 2019-11-05 上海白衣缘生物工程有限公司 一种制备无细胞医用植入材料的方法
CA3188708A1 (en) 2020-08-07 2022-02-10 Access To Advanced Health Institute Purified saponins and chromatographic process for purification of same
EP4259814A2 (en) 2020-12-09 2023-10-18 GlaxoSmithKline Biologicals SA Modification of saponins
WO2023242187A1 (en) 2022-06-15 2023-12-21 Glaxosmithkline Biologicals Sa Enzymatic modification of saponins

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5057540A (en) 1987-05-29 1991-10-15 Cambridge Biotech Corporation Saponin adjuvant
US4912094B1 (en) 1988-06-29 1994-02-15 Ribi Immunochem Research Inc. Modified lipopolysaccharides and process of preparation
GB9106048D0 (en) 1991-03-21 1991-05-08 Smithkline Beecham Biolog Vaccines
UA56132C2 (uk) 1995-04-25 2003-05-15 Смітклайн Бічем Байолоджікалс С.А. Композиція вакцини (варіанти), спосіб стабілізації qs21 відносно гідролізу (варіанти), спосіб приготування композиції вакцини
ES2297841T3 (es) * 1996-12-02 2008-05-01 Antigenics Inc. Nuevas composiciones de saponina y usos de las mismas.
US6231859B1 (en) * 1996-12-02 2001-05-15 Aquila Biopharmaceuticals, Inc. Saponin adjuvant compositions
WO1998056415A1 (en) * 1997-06-11 1998-12-17 Aquila Biopharmaceuticals, Inc. Purified saponins as oral adjuvants
US6231858B1 (en) 1998-01-09 2001-05-15 Mochida Corporation Bolus for radiotherapy
EP1071441A1 (en) 1998-04-17 2001-01-31 Her Majesty The Queen in Right of Canada, as represented by The Minister of Agriculture and Agri-Food Canada Process for recovery and purification of saponins and sapogenins from quinoa (chenopodium quinoa)
GB2373743B (en) * 2001-03-27 2004-11-03 Membrane Extraction Tech Ltd Solvent exchange process
TWI457133B (zh) 2005-12-13 2014-10-21 Glaxosmithkline Biolog Sa 新穎組合物
GB0525321D0 (en) * 2005-12-13 2006-01-18 Glaxosmithkline Biolog Sa Novel compositions
CN102462718A (zh) 2010-11-19 2012-05-23 苏州宝泽堂医药科技有限公司 一种青阳参皂苷的提取方法
CN102232977A (zh) 2011-05-06 2011-11-09 南京泽朗医药科技有限公司 一种从商陆中提取总皂苷的方法
CN102351938B (zh) 2011-09-01 2012-09-26 安徽农业大学 一种高纯度茶皂素的制备方法

Also Published As

Publication number Publication date
EP2877479A1 (en) 2015-06-03
EP2877479B1 (en) 2018-11-14
WO2014016374A1 (en) 2014-01-30
PT2877479T (pt) 2019-01-28
TR201901100T4 (tr) 2019-02-21
BR112015001655A2 (pt) 2017-07-04
LT2877479T (lt) 2019-01-10
US20140030318A1 (en) 2014-01-30
GB201213364D0 (en) 2012-09-12
CN104662031B (zh) 2017-11-03
HUE042179T2 (hu) 2019-06-28
CA2879709C (en) 2020-10-06
DK2877479T3 (en) 2019-02-25
CY1121304T1 (el) 2020-05-29
BR112015001655B1 (pt) 2021-08-17
JP2015522643A (ja) 2015-08-06
US9540416B2 (en) 2017-01-10
CA2879709A1 (en) 2014-01-30
CN104662031A (zh) 2015-05-27
ES2708783T3 (es) 2019-04-11
SI2877479T1 (sl) 2019-03-29
HRP20190123T1 (hr) 2019-03-08
JP6360830B2 (ja) 2018-07-18

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