LT2877479T - Saponinų gryninimo būdas - Google Patents

Saponinų gryninimo būdas

Info

Publication number
LT2877479T
LT2877479T LTEP13742207.7T LT13742207T LT2877479T LT 2877479 T LT2877479 T LT 2877479T LT 13742207 T LT13742207 T LT 13742207T LT 2877479 T LT2877479 T LT 2877479T
Authority
LT
Lithuania
Prior art keywords
saponins
purification
Prior art date
Application number
LTEP13742207.7T
Other languages
English (en)
Inventor
Juan Jose DIAZ GARCIA
Margit Theresia HOLZER
Original Assignee
Glaxosmithkline Biologicals S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxosmithkline Biologicals S.A. filed Critical Glaxosmithkline Biologicals S.A.
Publication of LT2877479T publication Critical patent/LT2877479T/lt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J71/00Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0036Nitrogen-containing hetero ring
    • C07J71/0042Nitrogen only
    • C07J71/0052Nitrogen only at position 16(17)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00Processes for the preparation of sugar derivatives
    • C07H1/06Separation; Purification
    • C07H1/08Separation; Purification from natural products
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20Carbocyclic rings
    • C07H15/24Condensed ring systems having three or more rings
    • C07H15/256Polyterpene radicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
LTEP13742207.7T 2012-07-27 2013-07-25 Saponinų gryninimo būdas LT2877479T (lt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1213364.1A GB201213364D0 (en) 2012-07-27 2012-07-27 Purification process
PCT/EP2013/065708 WO2014016374A1 (en) 2012-07-27 2013-07-25 Process for the purification of saponins

Publications (1)

Publication Number Publication Date
LT2877479T true LT2877479T (lt) 2019-01-10

Family

ID=46881236

Family Applications (1)

Application Number Title Priority Date Filing Date
LTEP13742207.7T LT2877479T (lt) 2012-07-27 2013-07-25 Saponinų gryninimo būdas

Country Status (18)

Country Link
US (1) US9540416B2 (lt)
EP (1) EP2877479B1 (lt)
JP (1) JP6360830B2 (lt)
CN (1) CN104662031B (lt)
BR (1) BR112015001655B1 (lt)
CA (1) CA2879709C (lt)
CY (1) CY1121304T1 (lt)
DK (1) DK2877479T3 (lt)
ES (1) ES2708783T3 (lt)
GB (1) GB201213364D0 (lt)
HR (1) HRP20190123T1 (lt)
HU (1) HUE042179T2 (lt)
LT (1) LT2877479T (lt)
PL (1) PL2877479T3 (lt)
PT (1) PT2877479T (lt)
SI (1) SI2877479T1 (lt)
TR (1) TR201901100T4 (lt)
WO (1) WO2014016374A1 (lt)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3769618A1 (en) * 2014-06-09 2021-01-27 Terumo BCT, Inc. Lyophilization container
WO2017088080A1 (es) 2015-11-25 2017-06-01 Natural Response S.A. Método para la obtención de saponinas a partir de plantas
WO2018057031A1 (en) 2016-09-26 2018-03-29 Natural Response, S.A. Production of biomass in ultra high density plantations
JP2021504429A (ja) * 2017-12-01 2021-02-15 グラクソスミスクライン バイオロジカルズ ソシエテ アノニム サポニン抽出
US11591364B2 (en) 2017-12-01 2023-02-28 Glaxosmithkline Biologicals Sa Saponin purification
JP2022535091A (ja) 2019-06-05 2022-08-04 グラクソスミスクライン バイオロジカルズ ソシエテ アノニム サポニン精製
CN110404113A (zh) * 2019-08-29 2019-11-05 上海白衣缘生物工程有限公司 一种制备无细胞医用植入材料的方法
MX2023001586A (es) 2020-08-07 2023-05-03 Access To Advanced Health Inst Saponinas purificadas y proceso cromatografico para purificacion de las mismas.
EP4259814A2 (en) 2020-12-09 2023-10-18 GlaxoSmithKline Biologicals SA Modification of saponins
WO2023242187A1 (en) 2022-06-15 2023-12-21 Glaxosmithkline Biologicals Sa Enzymatic modification of saponins

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5057540A (en) 1987-05-29 1991-10-15 Cambridge Biotech Corporation Saponin adjuvant
US4912094B1 (en) 1988-06-29 1994-02-15 Ribi Immunochem Research Inc. Modified lipopolysaccharides and process of preparation
GB9106048D0 (en) 1991-03-21 1991-05-08 Smithkline Beecham Biolog Vaccines
UA56132C2 (uk) 1995-04-25 2003-05-15 Смітклайн Бічем Байолоджікалс С.А. Композиція вакцини (варіанти), спосіб стабілізації qs21 відносно гідролізу (варіанти), спосіб приготування композиції вакцини
US6231859B1 (en) * 1996-12-02 2001-05-15 Aquila Biopharmaceuticals, Inc. Saponin adjuvant compositions
DK0952771T3 (da) * 1996-12-02 2008-05-19 Antigenics Inc Hidtil ukendte saponinpræparater og anvendelser deraf
WO1998056415A1 (en) * 1997-06-11 1998-12-17 Aquila Biopharmaceuticals, Inc. Purified saponins as oral adjuvants
US6231858B1 (en) 1998-01-09 2001-05-15 Mochida Corporation Bolus for radiotherapy
AU3589899A (en) 1998-04-17 1999-11-08 Her Majesty The Queen In Right Of Canada As Represented By The Department Of Agriculture And Agri-Food Canada Process for recovery and purification of saponins and sapogenins from quinoa ((chenopodium quinoa))
GB2373743B (en) * 2001-03-27 2004-11-03 Membrane Extraction Tech Ltd Solvent exchange process
GB0525321D0 (en) * 2005-12-13 2006-01-18 Glaxosmithkline Biolog Sa Novel compositions
TWI457133B (zh) 2005-12-13 2014-10-21 Glaxosmithkline Biolog Sa 新穎組合物
CN102462718A (zh) 2010-11-19 2012-05-23 苏州宝泽堂医药科技有限公司 一种青阳参皂苷的提取方法
CN102232977A (zh) 2011-05-06 2011-11-09 南京泽朗医药科技有限公司 一种从商陆中提取总皂苷的方法
CN102351938B (zh) 2011-09-01 2012-09-26 安徽农业大学 一种高纯度茶皂素的制备方法

Also Published As

Publication number Publication date
WO2014016374A1 (en) 2014-01-30
BR112015001655B1 (pt) 2021-08-17
BR112015001655A2 (pt) 2017-07-04
CA2879709C (en) 2020-10-06
GB201213364D0 (en) 2012-09-12
PL2877479T3 (pl) 2019-06-28
CN104662031B (zh) 2017-11-03
HRP20190123T1 (hr) 2019-03-08
CY1121304T1 (el) 2020-05-29
EP2877479B1 (en) 2018-11-14
US20140030318A1 (en) 2014-01-30
ES2708783T3 (es) 2019-04-11
PT2877479T (pt) 2019-01-28
CN104662031A (zh) 2015-05-27
US9540416B2 (en) 2017-01-10
EP2877479A1 (en) 2015-06-03
JP6360830B2 (ja) 2018-07-18
JP2015522643A (ja) 2015-08-06
CA2879709A1 (en) 2014-01-30
HUE042179T2 (hu) 2019-06-28
TR201901100T4 (tr) 2019-02-21
DK2877479T3 (en) 2019-02-25
SI2877479T1 (sl) 2019-03-29

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