PL2804858T3 - Związki - inhibitory metaloenzymu - Google Patents
Związki - inhibitory metaloenzymuInfo
- Publication number
- PL2804858T3 PL2804858T3 PL13738427T PL13738427T PL2804858T3 PL 2804858 T3 PL2804858 T3 PL 2804858T3 PL 13738427 T PL13738427 T PL 13738427T PL 13738427 T PL13738427 T PL 13738427T PL 2804858 T3 PL2804858 T3 PL 2804858T3
- Authority
- PL
- Poland
- Prior art keywords
- inhibitor compounds
- metalloenzyme inhibitor
- metalloenzyme
- compounds
- inhibitor
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title 1
- 229940125956 metalloenzyme inhibitor Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6524—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having four or more nitrogen atoms as the only ring hetero atoms
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
- C12N9/0073—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14) with NADH or NADPH as one donor, and incorporation of one atom of oxygen 1.14.13
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Heart & Thoracic Surgery (AREA)
- Rheumatology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Reproductive Health (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Ophthalmology & Optometry (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261589076P | 2012-01-20 | 2012-01-20 | |
| EP13738427.7A EP2804858B1 (en) | 2012-01-20 | 2013-01-18 | Metalloenzyme inhibitor compounds |
| PCT/US2013/022313 WO2013109998A1 (en) | 2012-01-20 | 2013-01-18 | Metalloenzyme inhibitor compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2804858T3 true PL2804858T3 (pl) | 2020-06-29 |
Family
ID=48799718
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL13738427T PL2804858T3 (pl) | 2012-01-20 | 2013-01-18 | Związki - inhibitory metaloenzymu |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US10221160B2 (instruction) |
| EP (1) | EP2804858B1 (instruction) |
| JP (1) | JP6189865B2 (instruction) |
| KR (1) | KR102061137B1 (instruction) |
| CN (1) | CN104136427B (instruction) |
| AU (2) | AU2013209516A1 (instruction) |
| BR (1) | BR112014017751B1 (instruction) |
| CA (1) | CA2861339C (instruction) |
| DK (1) | DK2804858T3 (instruction) |
| EA (1) | EA026209B1 (instruction) |
| ES (1) | ES2774267T3 (instruction) |
| IN (1) | IN2014DN06792A (instruction) |
| PL (1) | PL2804858T3 (instruction) |
| WO (1) | WO2013109998A1 (instruction) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR102012015199A2 (pt) | 2011-06-19 | 2014-05-13 | Viamet Pharmaceuticals Inc | Compostos inibidores de metaloenzima |
| WO2013109998A1 (en) * | 2012-01-20 | 2013-07-25 | Viamet Pharmaceuticals, Inc. | Metalloenzyme inhibitor compounds |
| EA201691648A1 (ru) * | 2014-03-19 | 2017-01-30 | Ваймет Фармасьютикалс, Инк. | Способ получения противогрибковых соединений |
| CA2942927A1 (en) * | 2014-03-19 | 2015-09-24 | Viamet Pharmaceuticals, Inc. | Antifungal compound process |
| WO2015143180A1 (en) * | 2014-03-19 | 2015-09-24 | Viamet Pharmaceuticals, Inc. | Antifungal compound process |
| JP2017514790A (ja) * | 2014-03-19 | 2017-06-08 | ヴィアメット ファーマスーティカルズ，インコーポレイテッド | 抗真菌化合物の調製方法 |
| AU2015231226B2 (en) * | 2014-03-19 | 2019-04-04 | Mycovia Pharmaceuticals, Inc. | Antifungal compound process |
| WO2015143188A1 (en) | 2014-03-19 | 2015-09-24 | Viamet Pharmaceuticals, Inc. | 2-(2,4-difluorophenyl)-1,1-difluoro-1-(5-substituted-pyridin-2-yl)-3-(1h-tetrazol-1-yl)propan-2-ols and proceses for their preparation |
| AU2015231216B2 (en) * | 2014-03-19 | 2019-04-04 | Mycovia Pharmaceuticals, Inc. | Antifungal compound process |
| MX2016012060A (es) | 2014-03-19 | 2017-01-19 | Viamet Pharmaceuticals Inc | 2-(2,4-difluorofenil)-1,1-difluoro-1-(5-sustituido-piridin-2-il)- 3-(1h-tetrazol-1-il)propan-2-oles y procesos para su preparacion. |
| EP3119748A4 (en) * | 2014-03-19 | 2017-08-30 | Viamet Pharmaceuticals, Inc. | Antifungal compound process |
| US10196375B2 (en) | 2014-03-19 | 2019-02-05 | Mycovia Pharmaceuticals, Inc. | Antifungal compound process |
| BR112017018823A2 (pt) | 2015-03-19 | 2018-04-24 | Viamet Pharmaceuticals, Inc. | compostos antifúngicos e processos para a fabricação |
| PL3349586T3 (pl) | 2015-09-18 | 2021-05-31 | Mycovia Pharmaceuticals, Inc. | Sposób wytwarzania związku przeciwgrzybiczego |
| CN108779094B (zh) * | 2015-12-30 | 2021-11-16 | Nqp 1598公司 | 金属酶抑制剂化合物 |
| CA3046987A1 (en) | 2016-12-22 | 2018-06-28 | Calithera Biosciences, Inc. | Compositions and methods for inhibiting arginase activity |
| CN109666019B (zh) * | 2017-10-14 | 2021-04-06 | 朱允涛 | 一种氘代的氮唑醇类化合物及其制备方法和用途 |
| CN109810049B (zh) * | 2018-11-30 | 2021-01-15 | 深圳大学 | 一种含吡啶的化合物及其提取方法 |
| WO2021143811A1 (zh) * | 2020-01-17 | 2021-07-22 | 上海森辉医药有限公司 | 四氮唑类化合物的可药用盐及其结晶形式、制备方法和用途 |
| CN116528855A (zh) * | 2020-10-16 | 2023-08-01 | 米拉洛克斯有限责任公司 | 用于治疗癌症、阿尔茨海默病、血色沉着病和其它病症的金属酶抑制剂 |
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| GB8304282D0 (en) * | 1983-02-16 | 1983-03-23 | Pfizer Ltd | Antifungal agents |
| GB8305377D0 (en) | 1983-02-25 | 1983-03-30 | Pfizer Ltd | Antifungal agents |
| US4921475A (en) | 1983-08-18 | 1990-05-01 | Drug Delivery Systems Inc. | Transdermal drug patch with microtubes |
| US5087240A (en) | 1983-08-18 | 1992-02-11 | Drug Delivery Systems Inc. | Transdermal drug patch with conductive fibers |
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| AU4327585A (en) | 1984-06-21 | 1986-01-02 | Imperial Chemical Industries Plc | Antifungal azole compounds |
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| US5358939A (en) | 1992-06-25 | 1994-10-25 | Rohm And Haas Company | Fungicidal 2-aryl-2,2-disubstituted ethyl-1,2,4-triazoles |
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| GB9512961D0 (en) | 1995-06-26 | 1995-08-30 | Pfizer Ltd | Antifungal agents |
| GB9602080D0 (en) | 1996-02-02 | 1996-04-03 | Pfizer Ltd | Pharmaceutical compounds |
| IT1283911B1 (it) | 1996-02-05 | 1998-05-07 | Farmigea Spa | Soluzioni oftalmiche viscosizzate con polisaccaridi della gomma di tamarindo |
| US5800807A (en) | 1997-01-29 | 1998-09-01 | Bausch & Lomb Incorporated | Ophthalmic compositions including glycerin and propylene glycol |
| US6261547B1 (en) | 1998-04-07 | 2001-07-17 | Alcon Manufacturing, Ltd. | Gelling ophthalmic compositions containing xanthan gum |
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| WO2008064311A2 (en) | 2006-11-21 | 2008-05-29 | Viamet Pharmaceuticals, Inc. | Metallo-oxidoreductase inhibitors using metal binding moieties in combination with targeting moieties |
| US8221057B2 (en) | 2008-06-25 | 2012-07-17 | General Electric Company | Method, system and controller for establishing a wheel space temperature alarm in a turbomachine |
| KR20110048586A (ko) | 2008-09-03 | 2011-05-11 | 바이엘 크롭사이언스 아게 | 특정 녹병균을 구제하기 위한 살진균성 조성물의 용도 |
| CA2785898C (en) * | 2009-12-31 | 2018-07-03 | Viamet Pharmaceuticals, Inc. | Metalloenzyme inhibitor compounds |
| WO2011133875A2 (en) * | 2010-04-24 | 2011-10-27 | Viamet Pharmaceuticals, Inc. | Metalloenzyme inhibitor compounds |
| AU2011320565A1 (en) * | 2010-10-28 | 2013-05-23 | Innocrin Pharmaceuticals, Inc. | Metalloenzyme inhibitor compounds |
| ES2703498T3 (es) * | 2010-11-13 | 2019-03-11 | Innocrin Pharmaceuticals Inc | 1-(6,7-Bis(difluorometoxi)naftalen-2-il)-2-metil-1-(1H-1,2,3-triazol-4-il)propan-1-ol como inhibidor de CYP17 para el tratamiento de enfermedades dependientes de andrógenos como el cáncer de próstata |
| CA2820718A1 (en) * | 2010-12-13 | 2012-06-21 | Viamet Pharmaceuticals, Inc. | Metalloenzyme inhibitor compounds |
| EP2721023B1 (en) * | 2011-06-19 | 2018-08-08 | Viamet Pharmaceuticals (NC), Inc. | Metalloenzyme inhibitor compounds |
| BR102012015199A2 (pt) * | 2011-06-19 | 2014-05-13 | Viamet Pharmaceuticals Inc | Compostos inibidores de metaloenzima |
| WO2012177725A1 (en) | 2011-06-23 | 2012-12-27 | Viamet Pharmaceuticals, Inc. | Metalloenzyme inhibitor compounds |
| AU2012300275A1 (en) * | 2011-08-30 | 2014-03-06 | Innocrin Pharmaceuticals, Inc. | Metalloenzyme inhibitor compounds |
| ES2671387T3 (es) * | 2011-12-11 | 2018-06-06 | Viamet Pharmaceuticals (NC), Inc. | Compuestos inhibidores de metaloenzimas |
| WO2013109998A1 (en) * | 2012-01-20 | 2013-07-25 | Viamet Pharmaceuticals, Inc. | Metalloenzyme inhibitor compounds |
| MX2014008729A (es) * | 2012-01-20 | 2015-02-04 | Viamet Pharmaceuticals Inc | Compuestos inhibidores de metaloenzima. |
| CA2898615A1 (en) * | 2013-01-28 | 2014-07-31 | Viamet Pharmaceuticals, Inc. | Metalloenzyme inhibitor compounds |
| CN105431418B (zh) * | 2013-06-12 | 2019-02-05 | 北卡罗来纳维亚梅特制药公司 | 金属酶抑制剂化合物 |
| EP3131400A4 (en) * | 2014-04-15 | 2017-11-29 | Dow AgroSciences LLC | Metalloenzyme inhibitor compounds as fungicides |
| JP2017513848A (ja) * | 2014-04-15 | 2017-06-01 | ダウ アグロサイエンシィズ エルエルシー | 殺真菌剤としての金属酵素阻害剤化合物 |
| EP4311577A3 (en) * | 2016-12-29 | 2024-04-17 | Ji Xing Pharmaceuticals Hong Kong Limited | Metalloenzyme inhibitor compounds |
-
2013
- 2013-01-18 WO PCT/US2013/022313 patent/WO2013109998A1/en active Application Filing
- 2013-01-18 JP JP2014553491A patent/JP6189865B2/ja active Active
- 2013-01-18 BR BR112014017751-1A patent/BR112014017751B1/pt active IP Right Grant
- 2013-01-18 US US14/373,314 patent/US10221160B2/en active Active
- 2013-01-18 EP EP13738427.7A patent/EP2804858B1/en active Active
- 2013-01-18 AU AU2013209516A patent/AU2013209516A1/en not_active Abandoned
- 2013-01-18 ES ES13738427T patent/ES2774267T3/es active Active
- 2013-01-18 IN IN6792DEN2014 patent/IN2014DN06792A/en unknown
- 2013-01-18 PL PL13738427T patent/PL2804858T3/pl unknown
- 2013-01-18 CN CN201380010231.4A patent/CN104136427B/zh active Active
- 2013-01-18 DK DK13738427.7T patent/DK2804858T3/da active
- 2013-01-18 EA EA201491385A patent/EA026209B1/ru unknown
- 2013-01-18 KR KR1020147023020A patent/KR102061137B1/ko active Active
- 2013-01-18 CA CA2861339A patent/CA2861339C/en active Active
-
2017
- 2017-09-20 AU AU2017232080A patent/AU2017232080B2/en active Active
-
2019
- 2019-01-28 US US16/259,096 patent/US10526312B2/en active Active
-
2020
- 2020-01-06 US US16/735,094 patent/US11247981B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EA201491385A1 (ru) | 2015-02-27 |
| US20190169159A1 (en) | 2019-06-06 |
| EA026209B1 (ru) | 2017-03-31 |
| KR102061137B1 (ko) | 2019-12-31 |
| AU2017232080B2 (en) | 2019-02-14 |
| AU2017232080A1 (en) | 2017-10-12 |
| EP2804858A1 (en) | 2014-11-26 |
| JP2015504095A (ja) | 2015-02-05 |
| CA2861339C (en) | 2020-08-25 |
| JP6189865B2 (ja) | 2017-08-30 |
| US20150004666A1 (en) | 2015-01-01 |
| BR112014017751B1 (pt) | 2021-12-07 |
| CN104136427A (zh) | 2014-11-05 |
| WO2013109998A1 (en) | 2013-07-25 |
| EP2804858B1 (en) | 2019-12-25 |
| BR112014017751A8 (pt) | 2021-03-09 |
| CN104136427B (zh) | 2017-03-01 |
| AU2013209516A1 (en) | 2014-08-28 |
| EP2804858A4 (en) | 2015-07-29 |
| IN2014DN06792A (instruction) | 2015-05-22 |
| US11247981B2 (en) | 2022-02-15 |
| US20200247779A1 (en) | 2020-08-06 |
| DK2804858T3 (da) | 2020-03-16 |
| US10526312B2 (en) | 2020-01-07 |
| KR20140116939A (ko) | 2014-10-06 |
| CA2861339A1 (en) | 2013-07-25 |
| ES2774267T3 (es) | 2020-07-20 |
| US10221160B2 (en) | 2019-03-05 |
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