PL2467153T3 - Zastosowanie mimotopów epitopów alfa-synukleiny do leczenia chorób z ciałami Lewy'ego - Google Patents

Zastosowanie mimotopów epitopów alfa-synukleiny do leczenia chorób z ciałami Lewy'ego

Info

Publication number
PL2467153T3
PL2467153T3 PL10747562.6T PL10747562T PL2467153T3 PL 2467153 T3 PL2467153 T3 PL 2467153T3 PL 10747562 T PL10747562 T PL 10747562T PL 2467153 T3 PL2467153 T3 PL 2467153T3
Authority
PL
Poland
Prior art keywords
mimotopes
alpha
lewy body
body diseases
treating lewy
Prior art date
Application number
PL10747562.6T
Other languages
English (en)
Polish (pl)
Inventor
Markus Mandler
Harald Weninger
Radmila Santic
Christian Lahsnig
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of PL2467153T3 publication Critical patent/PL2467153T3/pl

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/0005Vertebrate antigens
    • A61K39/0007Nervous system antigens; Prions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04Linear peptides containing only normal peptide links
    • C07K7/06Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/60Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031Proteins
    • A61K2039/6081Albumin; Keyhole limpet haemocyanin [KLH]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Toxicology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Psychiatry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
PL10747562.6T 2009-08-21 2010-08-20 Zastosowanie mimotopów epitopów alfa-synukleiny do leczenia chorób z ciałami Lewy'ego PL2467153T3 (pl)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
AT0132409A AT508638B1 (de) 2009-08-21 2009-08-21 Verwendung von peptiden und polypeptiden zur behandlung und/oder prävention von synukleinopathien

Publications (1)

Publication Number Publication Date
PL2467153T3 true PL2467153T3 (pl) 2016-09-30

Family

ID=42940852

Family Applications (1)

Application Number Title Priority Date Filing Date
PL10747562.6T PL2467153T3 (pl) 2009-08-21 2010-08-20 Zastosowanie mimotopów epitopów alfa-synukleiny do leczenia chorób z ciałami Lewy'ego

Country Status (21)

Country Link
US (1) US8828942B2 (es)
EP (1) EP2467153B1 (es)
JP (2) JP2013502379A (es)
KR (2) KR20140141651A (es)
CN (1) CN102596224B (es)
AT (1) AT508638B1 (es)
AU (1) AU2010283948B2 (es)
BR (1) BR112012003800A2 (es)
CA (1) CA2771429A1 (es)
CY (1) CY1117582T1 (es)
DK (1) DK2467153T3 (es)
ES (1) ES2573662T3 (es)
HR (1) HRP20160594T1 (es)
HU (1) HUE027563T2 (es)
IL (1) IL218207A0 (es)
MX (1) MX2012002153A (es)
PL (1) PL2467153T3 (es)
PT (1) PT2467153E (es)
RU (1) RU2532351C2 (es)
SI (1) SI2467153T1 (es)
WO (1) WO2011020133A1 (es)

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RS53496B1 (sr) 2011-10-04 2015-02-27 Affiris Ag POSTUPAK ZA DETEKCIJU Aβ-SPECIFIČNIH ANTITELA U BIOLOŠKOM UZORKU
EP2659907A1 (en) * 2012-05-01 2013-11-06 Affiris AG Compositions
EP2659906A1 (en) * 2012-05-01 2013-11-06 Affiris AG Compositions
PT3071597T (pt) 2013-11-21 2020-10-08 Hoffmann La Roche Anticorpos anti-alfa-sinucleína e métodos de utilização
CN108472344A (zh) 2015-11-03 2018-08-31 阿费里斯股份公司 用于针对人患者中的自身抗原的疫苗接种方法
KR101726549B1 (ko) 2016-06-29 2017-04-12 정상문 모바일 실시간 시뮬레이션 게임에서의 터치 조작 방식
KR102087494B1 (ko) 2018-03-15 2020-03-10 정상문 모바일 실시간 시뮬레이션 게임에서 객체를 표시하는 방법
IL319030A (en) 2018-12-20 2025-04-01 Saiba AG CMV virus-like particles modified by fusion
WO2022024693A1 (ja) * 2020-07-29 2022-02-03 国立大学法人東北大学 シヌクレイノパチーを予防又は治療するために使用されるペプチド
JP2023536497A (ja) 2020-08-04 2023-08-25 エイシー イミューン ソシエテ アノニム 免疫原性化合物
US20240189407A1 (en) 2021-04-12 2024-06-13 Saiba AG Modified virus-like particles of bacteriophage ap205
EP4357354A1 (en) * 2021-06-18 2024-04-24 Sumitomo Pharma Co., Ltd. Epitope peptide of human alpha-synuclein and pharmaceutical composition including said peptide
IL314865A (en) 2022-02-09 2024-10-01 Ac Immune Sa Anti-alpha-synuclein therapeutic vaccines
EP4486388A1 (en) 2022-02-28 2025-01-08 Tridem Bioscience GmbH & Co KG A conjugate consisting of or comprising at least a ss-glucan or a mannan
AU2023223603A1 (en) 2022-02-28 2024-08-22 Tridem Bioscience Gmbh & Co Kg A CONJUGATE CONSISTING OF OR COMPRISING AT LEAST A ß-GLUCAN OR A MANNAN.

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007325595A (ja) * 2000-12-22 2007-12-20 Locomogene Inc 滑膜細胞タンパク質
CA2466841A1 (en) * 2001-11-21 2003-06-05 New York University Synthetic immunogenic but non-deposit-forming polypeptides and peptides homologous to amyloid .beta., prion protein, amylin, .alpha.-synuclein, or polyglutamine repeats for induction of an immune response thereto
TW200509968A (en) * 2002-11-01 2005-03-16 Elan Pharm Inc Prevention and treatment of synucleinopathic disease
US8697082B2 (en) * 2002-11-01 2014-04-15 Neotope Biosciences Limited Prevention and treatment of synucleinopathic and amyloidogenic disease
US8506959B2 (en) * 2002-11-01 2013-08-13 Neotope Biosciences Limited Prevention and treatment of synucleinopathic and amyloidogenic disease
US20080014194A1 (en) * 2003-10-31 2008-01-17 Elan Pharmaceuticals, Inc. Prevention and Treatment of Synucleinopathic and Amyloidogenic Disease
US7358331B2 (en) * 2003-05-19 2008-04-15 Elan Pharmaceuticals, Inc. Truncated fragments of alpha-synuclein in Lewy body disease
ES2640669T3 (es) * 2003-05-19 2017-11-03 Prothena Biosciences Limited Fragmentos truncados de alfa-sinucleína en enfermedad con cuerpos de lewy
WO2004113535A1 (ja) 2003-06-22 2004-12-29 Koji Sode 凝集抑制作用を有するシヌクレイン変異体
WO2006004066A1 (ja) * 2004-07-02 2006-01-12 Locomogene, Inc. S1-5を含有するタンパク質製剤
CN101052417A (zh) * 2004-08-09 2007-10-10 艾兰制药公司 突触核蛋白病以及淀粉样变性病的预防和治疗
EA013752B1 (ru) * 2004-08-09 2010-06-30 Элан Фармасьютикалз, Инк. Предупреждение и лечение синуклеинопатических и амилоидогенных заболеваний
CN101330923B (zh) * 2005-12-12 2015-01-07 Ac免疫有限公司 治疗性疫苗
CA2746778C (en) * 2008-12-19 2019-04-23 University Of Zurich Human anti-alpha-synuclein autoantibodies

Also Published As

Publication number Publication date
AU2010283948B2 (en) 2015-01-22
KR20120059562A (ko) 2012-06-08
WO2011020133A1 (en) 2011-02-24
KR101517447B1 (ko) 2015-05-28
AT508638B1 (de) 2011-08-15
BR112012003800A2 (pt) 2016-11-22
AT508638A1 (de) 2011-03-15
CN102596224B (zh) 2015-12-09
CY1117582T1 (el) 2017-04-26
US20120156234A1 (en) 2012-06-21
HK1170658A1 (zh) 2013-03-08
AU2010283948A1 (en) 2012-03-29
US8828942B2 (en) 2014-09-09
KR20140141651A (ko) 2014-12-10
JP5901714B2 (ja) 2016-04-13
HUE027563T2 (en) 2016-10-28
PT2467153E (pt) 2016-06-08
RU2012110582A (ru) 2013-09-27
EP2467153B1 (en) 2016-03-02
EP2467153A1 (en) 2012-06-27
ES2573662T3 (es) 2016-06-09
CN102596224A (zh) 2012-07-18
MX2012002153A (es) 2012-03-14
RU2532351C2 (ru) 2014-11-10
IL218207A0 (en) 2012-04-30
DK2467153T3 (en) 2016-06-06
CA2771429A1 (en) 2011-02-24
HRP20160594T1 (hr) 2016-07-29
JP2013502379A (ja) 2013-01-24
JP2015038078A (ja) 2015-02-26
SI2467153T1 (sl) 2016-07-29

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