PL2428561T3 - Prekursory komórek gwiaździstych wątroby - Google Patents

Prekursory komórek gwiaździstych wątroby

Info

Publication number
PL2428561T3
PL2428561T3 PL11189465T PL11189465T PL2428561T3 PL 2428561 T3 PL2428561 T3 PL 2428561T3 PL 11189465 T PL11189465 T PL 11189465T PL 11189465 T PL11189465 T PL 11189465T PL 2428561 T3 PL2428561 T3 PL 2428561T3
Authority
PL
Poland
Prior art keywords
cell precursors
hepatic stellate
stellate cell
hepatic
precursors
Prior art date
Application number
PL11189465T
Other languages
English (en)
Inventor
Hiroshi Kubota
Lola M. Reid
Original Assignee
Univ North Carolina Chapel Hill
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ North Carolina Chapel Hill filed Critical Univ North Carolina Chapel Hill
Publication of PL2428561T3 publication Critical patent/PL2428561T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0018—Culture media for cell or tissue culture
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/067—Hepatocytes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/067—Hepatocytes
    • C12N5/0672—Stem cells; Progenitor cells; Precursor cells; Oval cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56966—Animal cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/05—Inorganic components
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/05—Inorganic components
    • C12N2500/10—Metals; Metal chelators
    • C12N2500/20—Transition metals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/05—Inorganic components
    • C12N2500/10—Metals; Metal chelators
    • C12N2500/20—Transition metals
    • C12N2500/24—Iron; Fe chelators; Transferrin
    • C12N2500/25—Insulin-transferrin; Insulin-transferrin-selenium
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/30—Organic components
    • C12N2500/32—Amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/30—Organic components
    • C12N2500/36—Lipids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/30—Organic components
    • C12N2500/38—Vitamins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/90—Serum-free medium, which may still contain naturally-sourced components
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/11—Epidermal growth factor [EGF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/23—Interleukins [IL]
    • C12N2501/235—Leukemia inhibitory factor [LIF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/30—Hormones
    • C12N2501/33—Insulin
PL11189465T 2006-05-26 2007-05-24 Prekursory komórek gwiaździstych wątroby PL2428561T3 (pl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US80854806P 2006-05-26 2006-05-26
EP07797729.6A EP2029725B1 (en) 2006-05-26 2007-05-24 Hepatic stellate cell precursors and methods of isolating same
PCT/US2007/069645 WO2007140243A2 (en) 2006-05-26 2007-05-24 Hepatic stellate cell precursors and methods of isolating same
EP11189465.5A EP2428561B8 (en) 2006-05-26 2007-05-24 Hepatic stellate cell precursors

Publications (1)

Publication Number Publication Date
PL2428561T3 true PL2428561T3 (pl) 2019-05-31

Family

ID=38779344

Family Applications (2)

Application Number Title Priority Date Filing Date
PL07797729T PL2029725T3 (pl) 2006-05-26 2007-05-24 Prekursory gwiaździstej komórki wątrobowej i metody ich izolowania
PL11189465T PL2428561T3 (pl) 2006-05-26 2007-05-24 Prekursory komórek gwiaździstych wątroby

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PL07797729T PL2029725T3 (pl) 2006-05-26 2007-05-24 Prekursory gwiaździstej komórki wątrobowej i metody ich izolowania

Country Status (12)

Country Link
US (4) US7824911B2 (pl)
EP (2) EP2029725B1 (pl)
JP (1) JP5254221B2 (pl)
CN (1) CN101553564B (pl)
CA (2) CA2872716C (pl)
DK (2) DK2428561T3 (pl)
ES (2) ES2664375T3 (pl)
HU (2) HUE036729T2 (pl)
PL (2) PL2029725T3 (pl)
PT (2) PT2428561T (pl)
TW (1) TWI448554B (pl)
WO (1) WO2007140243A2 (pl)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2664375T3 (es) 2006-05-26 2018-04-19 The University Of North Carolina At Chapel Hill Precursores de células estrelladas hepáticas y métodos para aislarlos
US8338170B2 (en) 2008-04-21 2012-12-25 Viacyte, Inc. Methods for purifying endoderm and pancreatic endoderm cells derived from human embryonic stem cells
WO2012133954A1 (en) * 2011-03-31 2012-10-04 Kyoto University Novel cardiomyocyte marker
US9533013B2 (en) 2013-03-13 2017-01-03 University Of North Carolina At Chapel Hill Method of treating pancreatic and liver conditions by endoscopic-mediated (or laparoscopic-mediated) transplantation of stem cells into/onto bile duct walls of particular regions of the biliary tree
CN103743907B (zh) * 2013-07-24 2015-04-15 北京大学人民医院 测定造血干细胞移植后患者骨髓微循环环境评测的试剂盒、系统及方法
CN103555656A (zh) * 2013-10-24 2014-02-05 上海中医药大学附属龙华医院 同时分离肝星状细胞及成纤维母细胞的方法
US20180147242A1 (en) * 2015-03-18 2018-05-31 The University Of Tokyo Hepatocytes and hepatic non-parenchymal cells, and methods for preparation thereof
CN106947731A (zh) * 2017-02-21 2017-07-14 广州柏赛柯生物技术有限公司 一种肝星状细胞分离制备方法
WO2023086958A1 (en) * 2021-11-12 2023-05-19 Ambys Medicines, Inc. Methods of producing and using human hepatocytes and related compositions

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6069005A (en) 1991-08-07 2000-05-30 Albert Einstein College Of Medicine Of Yeshwa University Hapatoblasts and method of isolating same
CN1351656B (zh) * 1999-01-19 2012-02-29 查珀尔希尔北卡罗来纳大学 人肝脏祖先
US7456017B2 (en) * 1999-10-01 2008-11-25 University Of North Carolina At Chapel Hill Processes for clonal growth of hepatic progenitor cells
CN104630129A (zh) * 2002-03-15 2015-05-20 北卡罗来纳大学查伯山分校 原肝干细胞和近肝干细胞
ES2664375T3 (es) 2006-05-26 2018-04-19 The University Of North Carolina At Chapel Hill Precursores de células estrelladas hepáticas y métodos para aislarlos

Also Published As

Publication number Publication date
ES2701729T3 (es) 2019-02-25
US20080009057A1 (en) 2008-01-10
EP2029725B1 (en) 2018-01-03
CA2872716A1 (en) 2007-12-06
CA2872716C (en) 2017-12-05
US20120028353A1 (en) 2012-02-02
TWI448554B (zh) 2014-08-11
JP2009538152A (ja) 2009-11-05
TW200813224A (en) 2008-03-16
WO2007140243A3 (en) 2008-11-13
CA2688309A1 (en) 2007-12-06
EP2428561A1 (en) 2012-03-14
JP5254221B2 (ja) 2013-08-07
EP2029725A2 (en) 2009-03-04
US7824911B2 (en) 2010-11-02
PT2428561T (pt) 2019-01-10
PT2029725T (pt) 2018-04-12
EP2428561B8 (en) 2019-03-20
DK2029725T3 (en) 2018-03-26
US20170152472A1 (en) 2017-06-01
CA2688309C (en) 2015-02-17
EP2029725A4 (en) 2009-09-09
PL2029725T3 (pl) 2019-01-31
US10093895B2 (en) 2018-10-09
WO2007140243A2 (en) 2007-12-06
CN101553564A (zh) 2009-10-07
HUE036729T2 (hu) 2018-07-30
EP2428561B1 (en) 2018-09-26
US9416349B2 (en) 2016-08-16
US20150093762A1 (en) 2015-04-02
HUE040629T2 (hu) 2019-03-28
CN101553564B (zh) 2012-12-05
DK2428561T3 (en) 2019-01-21
ES2664375T3 (es) 2018-04-19

Similar Documents

Publication Publication Date Title
EP2005504A4 (en) ELECTROLYTE
GB2446273B (en) Chemically amplified resist composition
GB0720484D0 (en) Cells
EP2141990A4 (en) ACTIVE COMPOUNDS ON 11BETA-HSD1
EP2116535A4 (en) GLUCKINASE ACTIVATING SUBSTANCE
HK1139857A1 (en) Wrinkling-preventing and-modifying agent
PT2428561T (pt) Percursores de células hepáticas estreladas
EP2236594A4 (en) DISPOSAL AGENT OF A BIOLFILM
GB2447789B (en) Chemically amplified resist composition
EP2221057A4 (en) MEANS FOR IMPROVING THE SENSES
EP2062892A4 (en) AGENT ENHANCING HYPERTENSION
GB2447350B (en) Chemically amplified resist composition
ZA200900834B (en) Electrochemical actuator
PL1927646T3 (pl) Środek nawaniający o polepszonej trwałości
EP2204178A4 (en) LAXATIVE AGENT
EP2127540A4 (en) SKIN EMBELLISHMENT MEDIUM
EP2030629A4 (en) AGENT FOR IMPROVING LIPID METABOLISM
EP2168955A4 (en) SLEEP IMPROVEMENT AGENT
AU313341S (en) Pack
EP2060263A4 (en) AGENT FOR IMPROVING LIPID METABOLISM
GB0701321D0 (en) Agent
EP2172195A4 (en) MEANS OF CHOLESTEROL CONTROL
AU316603S (en) Stamp
TWI318598B (en) Mold structure
HK1101662A2 (en) Construction stamp