PL239917B1 - Kompozycja zawierająca cystatynę oraz jej zastosowanie w implantologii kostnej - Google Patents
Kompozycja zawierająca cystatynę oraz jej zastosowanie w implantologii kostnej Download PDFInfo
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- PL239917B1 PL239917B1 PL427909A PL42790918A PL239917B1 PL 239917 B1 PL239917 B1 PL 239917B1 PL 427909 A PL427909 A PL 427909A PL 42790918 A PL42790918 A PL 42790918A PL 239917 B1 PL239917 B1 PL 239917B1
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- cystatin
- poloxamer
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/252—Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/432—Inhibitors, antagonists
- A61L2300/434—Inhibitors, antagonists of enzymes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
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- Animal Behavior & Ethology (AREA)
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- Public Health (AREA)
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- Pharmacology & Pharmacy (AREA)
- Dermatology (AREA)
- Engineering & Computer Science (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Biomedical Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
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- Inorganic Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
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Abstract
Pierwszym przedmiotem wynalazku jest kompozycja implantologiczna zawierająca cystatynę, nośnik, substancję zobojętniającą, wodę dejonizowaną albo bufor, charakteryzuje się tym, że zawiera cystatynę o aktywności właściwej przynajmniej 10 jednostek inhibitorowych na miligram białka w ilości 0,02% (wagowo), substancję nośną w ilości od 15,0% do 20,0% (wagowo), i substancję zobojętniającą w ilości nie większej niż konieczna do uzyskania odpowiedniego pH, korzystnie wybraną z grupy zawierającej: NaOH albo TEA, i kompozycja zawiera wodę dejonizowaną albo bufor PBS w ilości do 100% (wagowo) masy kompozycji. Drugim przedmiotem wynalazku jest zastosowanie kompozycji implantologicznej do powlekania implantów albo do podawania miejscowego w celu wspomagania osseointegracji.
Claims (8)
- PL 239 917 B1Zastrzeżenia patentowe1. Kompozycja zawierająca cystatynę, nośnik, substancję zobojętniającą, wodę albo bufor, znamienna tym, że zawiera cystatynę o aktywności właściwej przynajmniej 10 jednostek inhibitorowych na miligram białka w ilości 0,02% (wagowo), substancję nośną w ilości od 15,0% do 20,0% (wagowo), i substancję zobojętniającą w ilości nie większej niż konieczna do uzyskania pH wynoszącego 7,40 ± 0,05, korzystnie wybraną z grupy zawierającej: NaOH albo TEA, i kompozycja zawiera wodę dejonizowaną albo bufor PBS w ilości do 100% (wagowo) masy kompozycji, i zawiera substancję zwiększającą właściwości adhezyjne w ilości nie większej niż 0,25% (wagowo) masy kompozycji, przy czym kompozycja ma postać żelu w temperaturze 37°C, przy czym substancję nośną stanowi poloksamer 407, przy czym substancja nośna stanowi także substancję żelującą.
- 2. Kompozycja wg. zastrz. od 1 do 2, znamienna tym, że substancję zwiększającą właściwości adhezyjne stanowi karbomer 974P albo karbomer 971P.
- 3. Kompozycja wg. zastrz. od 1 do 3, znamienna tym, że zawiera substancje pomocnicze.
- 4. Kompozycja wg. zastrz. od 1 do 4, znamienna tym, że substancje pomocnicze stanowią od 0% do 25% (wagowo) masy kompozycji.
- 5. Kompozycja wg. zastrz. od 1 do 5, znamienna tym, że substancje pomocnicze są wybrane z grupy zawierającej: parabeny (nipaginy), glicerol, glikol polioksyetylenowy-200, glikol propylenowy.
- 6. Kompozycja wg. zastrz. od 1 do 6, znamienna tym, że cystatyna jest pochodzenia zwierzęcego albo roślinnego albo ludzką rekombinowaną.
- 7. Kompozycja wg. zastrz. od 1 do 7, znamienna tym, że kompozycja ma postać płynną w temperaturze 20°C.
- 8. Kompozycja, jak zdefiniowano w zastrz. od 1 do 7, do zastosowania w powlekaniu implantów albo do podawania miejscowego w celu wspomagania osseointegracji.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL427909A PL239917B1 (pl) | 2018-11-28 | 2018-11-28 | Kompozycja zawierająca cystatynę oraz jej zastosowanie w implantologii kostnej |
| PCT/PL2019/050069 WO2020111960A1 (en) | 2018-11-28 | 2019-11-27 | An implantological composition comprising cystatin and its use in bone implantology |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL427909A PL239917B1 (pl) | 2018-11-28 | 2018-11-28 | Kompozycja zawierająca cystatynę oraz jej zastosowanie w implantologii kostnej |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PL427909A1 PL427909A1 (pl) | 2020-06-01 |
| PL239917B1 true PL239917B1 (pl) | 2022-01-24 |
Family
ID=70853368
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL427909A PL239917B1 (pl) | 2018-11-28 | 2018-11-28 | Kompozycja zawierająca cystatynę oraz jej zastosowanie w implantologii kostnej |
Country Status (2)
| Country | Link |
|---|---|
| PL (1) | PL239917B1 (pl) |
| WO (1) | WO2020111960A1 (pl) |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001056627A1 (en) * | 2000-01-12 | 2001-08-09 | Am-Pharma B.V. | Medical device coated with antimicrobial peptides |
| PL195665B1 (pl) * | 2000-06-13 | 2007-10-31 | Przed Farmaceutyczne Jelfa Sa | Środek farmaceutyczny w postaci żelu do stosowania miejscowego w leczeniu chorób przyzębia |
| PL218970B1 (pl) * | 2008-01-15 | 2015-02-27 | Akademia Medyczna Im Piastów Śląskich We Wrocławiu | Kompozycja farmaceutyczna do leczenia chorób skórnych |
| PL219098B1 (pl) * | 2008-08-28 | 2015-03-31 | Akademia Medyczna Im Piastów Śląskich We Wrocławiu | Kompozycja farmaceutyczna do leczenia chorób przyzębia |
-
2018
- 2018-11-28 PL PL427909A patent/PL239917B1/pl unknown
-
2019
- 2019-11-27 WO PCT/PL2019/050069 patent/WO2020111960A1/en active Application Filing
Also Published As
| Publication number | Publication date |
|---|---|
| WO2020111960A1 (en) | 2020-06-04 |
| PL427909A1 (pl) | 2020-06-01 |
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