PL2268823T3 - Wytwarzanie skwalenu z wykorzystaniem drożdży nadprodukujących skwalen - Google Patents

Wytwarzanie skwalenu z wykorzystaniem drożdży nadprodukujących skwalen

Info

Publication number
PL2268823T3
PL2268823T3 PL09786243T PL09786243T PL2268823T3 PL 2268823 T3 PL2268823 T3 PL 2268823T3 PL 09786243 T PL09786243 T PL 09786243T PL 09786243 T PL09786243 T PL 09786243T PL 2268823 T3 PL2268823 T3 PL 2268823T3
Authority
PL
Poland
Prior art keywords
squalene
hyper
production
producing yeasts
yeast
Prior art date
Application number
PL09786243T
Other languages
English (en)
Polish (pl)
Inventor
Michael Broeker
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41625158&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL2268823(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of PL2268823T3 publication Critical patent/PL2268823T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P5/00—Preparation of hydrocarbons or halogenated hydrocarbons
    • C12P5/02—Preparation of hydrocarbons or halogenated hydrocarbons acyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/113—Multiple emulsions, e.g. oil-in-water-in-oil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C12N1/16—Yeasts; Culture media therefor
    • C12N1/18—Baker's yeast; Brewer's yeast
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P5/00—Preparation of hydrocarbons or halogenated hydrocarbons
    • C12P5/007—Preparation of hydrocarbons or halogenated hydrocarbons containing one or more isoprene units, i.e. terpenes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Mycology (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Plant Pathology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Botany (AREA)
  • Virology (AREA)
  • Dispersion Chemistry (AREA)
  • Epidemiology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Enzymes And Modification Thereof (AREA)
PL09786243T 2008-08-28 2009-08-28 Wytwarzanie skwalenu z wykorzystaniem drożdży nadprodukujących skwalen PL2268823T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US19048608P 2008-08-28 2008-08-28
PCT/IB2009/006825 WO2010023551A2 (en) 2008-08-28 2009-08-28 Production of squalene from hyper-producing yeasts
EP09786243A EP2268823B1 (en) 2008-08-28 2009-08-28 Production of squalene from hyper-producing yeasts

Publications (1)

Publication Number Publication Date
PL2268823T3 true PL2268823T3 (pl) 2012-03-30

Family

ID=41625158

Family Applications (1)

Application Number Title Priority Date Filing Date
PL09786243T PL2268823T3 (pl) 2008-08-28 2009-08-28 Wytwarzanie skwalenu z wykorzystaniem drożdży nadprodukujących skwalen

Country Status (23)

Country Link
US (2) US11236366B2 (cg-RX-API-DMAC7.html)
EP (2) EP2369003B1 (cg-RX-API-DMAC7.html)
JP (3) JP4938911B2 (cg-RX-API-DMAC7.html)
KR (1) KR101443064B1 (cg-RX-API-DMAC7.html)
CN (1) CN102257149B (cg-RX-API-DMAC7.html)
AT (1) ATE513920T1 (cg-RX-API-DMAC7.html)
AU (1) AU2009286426B2 (cg-RX-API-DMAC7.html)
BR (1) BRPI0917716A2 (cg-RX-API-DMAC7.html)
CA (1) CA2735404C (cg-RX-API-DMAC7.html)
CY (1) CY1114687T1 (cg-RX-API-DMAC7.html)
DK (1) DK2268823T3 (cg-RX-API-DMAC7.html)
EA (1) EA028898B1 (cg-RX-API-DMAC7.html)
ES (2) ES2761697T3 (cg-RX-API-DMAC7.html)
HR (1) HRP20110671T1 (cg-RX-API-DMAC7.html)
IL (1) IL211435A (cg-RX-API-DMAC7.html)
MX (1) MX2011002279A (cg-RX-API-DMAC7.html)
NZ (1) NZ591876A (cg-RX-API-DMAC7.html)
PL (1) PL2268823T3 (cg-RX-API-DMAC7.html)
PT (1) PT2268823E (cg-RX-API-DMAC7.html)
RS (1) RS51999B (cg-RX-API-DMAC7.html)
SI (1) SI2268823T1 (cg-RX-API-DMAC7.html)
SM (1) SMT201100058B (cg-RX-API-DMAC7.html)
WO (1) WO2010023551A2 (cg-RX-API-DMAC7.html)

Families Citing this family (24)

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EA201071338A1 (ru) 2008-05-23 2012-01-30 Сибас Ойлз, Ллс Получение сквалена с применением дрожжей
EP2292741A1 (en) * 2009-08-26 2011-03-09 OrganoBalance GmbH Genetically modified organisms for the production of lipids
HUE034245T2 (en) 2009-11-23 2018-02-28 Nucelis Llc Methods and preparations for the preparation of squalene using yeast
MX352758B (es) 2010-05-12 2017-12-07 Novartis Ag Star Metodos mejorados para preparar escualeno.
CN102100260B (zh) * 2010-12-03 2013-07-31 滨州学院 酵母油脂及其制备方法和应用
CN102787140A (zh) * 2011-05-20 2012-11-21 罗盖特兄弟公司 从微藻制备与提取角鲨烯的工艺方法
CN102787074B (zh) 2011-05-20 2016-06-08 罗盖特兄弟公司 生产角鲨烯的微藻新菌株
FR2975705B1 (fr) 2011-05-27 2014-12-26 Roquette Freres Procede d'extraction du squalene a partir de microalgues
CN104159602B (zh) 2012-03-08 2017-10-24 葛兰素史密丝克莱恩生物有限公司 加强疫苗的含佐剂制剂
FR2989373B1 (fr) * 2012-04-16 2016-05-06 Roquette Freres Procede de raffinage du squalene produit par microalgues
KR102192410B1 (ko) * 2012-04-16 2020-12-17 로께뜨프레르 미세조류에 의해 생성된 스쿠알렌의 정련방법
AU2013311702A1 (en) 2012-09-06 2015-02-19 Novartis Ag Combination vaccines with serogroup B meningococcus and D/T/P
JP6440619B2 (ja) 2012-10-12 2018-12-19 グラクソスミスクライン バイオロジカルズ ソシエテ アノニム 混合ワクチン用の架橋されていない無細胞百日咳抗原
CA2894260A1 (en) 2012-12-18 2014-06-26 Glaxosmithkline Biologicals S.A. Conjugates for protecting against diphtheria and/or tetanus
EP2971049B1 (en) 2013-03-13 2017-03-01 Sanofi-Aventis Deutschland GmbH Production of squalene and/or sterol from cell suspensions of fermented yeast
GB2518927A (en) * 2013-05-21 2015-04-08 Univ Swansea The production of biomolecules using yeast
CN103849643A (zh) * 2014-03-11 2014-06-11 北京理工大学 一种利用蛋白支架提高酿酒酵母中鲨烯的合成方法
US10280406B2 (en) 2014-04-09 2019-05-07 Adeka Corporation Mutant enzyme and production method for terpenoid using said mutant enzyme
EP3225691B1 (en) * 2014-11-28 2020-10-28 Ajinomoto Co., Inc. Method for producing isoprenoid compound
ES2861806T3 (es) 2014-12-02 2021-10-06 Novartis Ag Fabricación de composiciones que contienen tensioactivo
CN104560731B (zh) * 2014-12-26 2018-10-09 中国科学院青岛生物能源与过程研究所 一种高产角鲨烯的类酵母菌及其应用
CN110373338B (zh) * 2019-08-15 2021-09-28 宜昌东阳光生化制药有限公司 酿酒酵母及其用途
CN111893049A (zh) * 2020-06-30 2020-11-06 厦门大学 一种过表达角鲨烯合成酶基因的裂殖壶菌基因工程菌株及其构建方法和应用
WO2025053947A1 (en) * 2023-09-07 2025-03-13 Avantor Performance Materials, Llc Synthetic triterpenes composition, method of production and applications thereof

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US5460949A (en) 1990-11-15 1995-10-24 Amoco Corporation Method and composition for increasing the accumulation of squalene and specific sterols in yeast
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DE19744212B4 (de) * 1997-09-30 2006-01-19 Schering Ag Verfahren zur Herstellung von Ergosterol und dessen Zwischenprodukten mittels rekombinanter Hefen
US20040235088A1 (en) 1997-09-30 2004-11-25 Schering Aktiengesellschaft Process for the production of ergosterol and its intermediate products using recombinant yeasts
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EA201071338A1 (ru) * 2008-05-23 2012-01-30 Сибас Ойлз, Ллс Получение сквалена с применением дрожжей
EP2292741A1 (en) 2009-08-26 2011-03-09 OrganoBalance GmbH Genetically modified organisms for the production of lipids

Also Published As

Publication number Publication date
NZ591876A (en) 2013-05-31
CA2735404A1 (en) 2010-03-04
PT2268823E (pt) 2011-09-01
SMT201100058B (it) 2012-01-18
AU2009286426B2 (en) 2013-08-22
IL211435A (en) 2014-03-31
CN102257149A (zh) 2011-11-23
JP4938911B2 (ja) 2012-05-23
US20220177928A1 (en) 2022-06-09
EP2268823A2 (en) 2011-01-05
EA201170381A1 (ru) 2011-08-30
WO2010023551A3 (en) 2010-04-29
MX2011002279A (es) 2011-04-21
JP2012500648A (ja) 2012-01-12
AU2009286426A1 (en) 2010-03-04
EA028898B1 (ru) 2018-01-31
EP2268823B1 (en) 2011-06-22
SI2268823T1 (sl) 2011-10-28
CN102257149B (zh) 2013-12-25
EP2369003A1 (en) 2011-09-28
CY1114687T1 (el) 2016-10-05
RS51999B (sr) 2012-04-30
WO2010023551A2 (en) 2010-03-04
CA2735404C (en) 2013-04-16
JP2012139225A (ja) 2012-07-26
DK2268823T3 (da) 2011-10-03
ES2366941T3 (es) 2011-10-26
KR101443064B1 (ko) 2014-09-19
JP2015061546A (ja) 2015-04-02
JP5930766B2 (ja) 2016-06-08
HK1152078A1 (en) 2012-02-17
EP2369003B1 (en) 2019-10-16
US20110243969A1 (en) 2011-10-06
ES2761697T3 (es) 2020-05-20
ATE513920T1 (de) 2011-07-15
IL211435A0 (en) 2011-05-31
KR20110049887A (ko) 2011-05-12
US11236366B2 (en) 2022-02-01
HRP20110671T1 (hr) 2011-11-30
BRPI0917716A2 (pt) 2019-09-03

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