PL2052273T3 - Obrazowanie lub spektroskopia metodą rezonansu magnetycznego 13C śmierci komórkowej - Google Patents

Obrazowanie lub spektroskopia metodą rezonansu magnetycznego 13C śmierci komórkowej

Info

Publication number
PL2052273T3
PL2052273T3 PL07808605T PL07808605T PL2052273T3 PL 2052273 T3 PL2052273 T3 PL 2052273T3 PL 07808605 T PL07808605 T PL 07808605T PL 07808605 T PL07808605 T PL 07808605T PL 2052273 T3 PL2052273 T3 PL 2052273T3
Authority
PL
Poland
Prior art keywords
imaging
spectroscopy
cell death
pyruvate
relates
Prior art date
Application number
PL07808605T
Other languages
English (en)
Inventor
Kevin M Brindle
Samuel Evan Day
Mikko Iivari Kettunen
Original Assignee
Ge Healthcare As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ge Healthcare As filed Critical Ge Healthcare As
Publication of PL2052273T3 publication Critical patent/PL2052273T3/pl

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/46—NMR spectroscopy
    • G01R33/465—NMR spectroscopy applied to biological material, e.g. in vitro testing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
    • A61B5/055—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/48—NMR imaging systems
    • G01R33/483—NMR imaging systems with selection of signals or spectra from particular regions of the volume, e.g. in vivo spectroscopy
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/48—NMR imaging systems
    • G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
    • G01R33/56—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
    • G01R33/5601—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution involving use of a contrast agent for contrast manipulation, e.g. a paramagnetic, super-paramagnetic, ferromagnetic or hyperpolarised contrast agent
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/48—NMR imaging systems
    • G01R33/4828—Resolving the MR signals of different chemical species, e.g. water-fat imaging

Landscapes

  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • High Energy & Nuclear Physics (AREA)
  • General Health & Medical Sciences (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • General Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Radiology & Medical Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Signal Processing (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Optics & Photonics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
PL07808605T 2006-08-18 2007-08-17 Obrazowanie lub spektroskopia metodą rezonansu magnetycznego 13C śmierci komórkowej PL2052273T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
NO20063702 2006-08-18
PCT/NO2007/000286 WO2008020764A1 (en) 2006-08-18 2007-08-17 13c-mr imaging or spectroscopy of cell death
EP07808605A EP2052273B1 (en) 2006-08-18 2007-08-17 13c-mr imaging or spectroscopy of cell death

Publications (1)

Publication Number Publication Date
PL2052273T3 true PL2052273T3 (pl) 2012-08-31

Family

ID=38690525

Family Applications (1)

Application Number Title Priority Date Filing Date
PL07808605T PL2052273T3 (pl) 2006-08-18 2007-08-17 Obrazowanie lub spektroskopia metodą rezonansu magnetycznego 13C śmierci komórkowej

Country Status (8)

Country Link
US (1) US8951500B2 (pl)
EP (1) EP2052273B1 (pl)
JP (1) JP5363320B2 (pl)
CN (1) CN101506679B (pl)
AT (1) ATE549638T1 (pl)
ES (1) ES2381380T3 (pl)
PL (1) PL2052273T3 (pl)
WO (1) WO2008020764A1 (pl)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010501483A (ja) * 2006-08-18 2010-01-21 ジーイー・ヘルスケア・アクスイェ・セルスカプ 乳酸塩及び過分極１３ｃ−ピルビン酸塩を含むイメージング剤
WO2008073842A1 (en) * 2006-12-08 2008-06-19 Molecular Image Inc. Methods for diagnosis and monitoring of neurologic diseases using magnetic resonance methods
GB0713074D0 (en) * 2007-07-05 2007-08-15 Univ London A method of hyperpolarising a magnetic resonance agent
CN102388317B (zh) * 2009-04-02 2015-11-25 通用电气健康护理有限公司 包含超极化13c丙酮酸盐的磁共振成像介质用于检测炎症或感染的用途
WO2012027274A2 (en) * 2010-08-23 2012-03-01 The Regents Of The University Of California Compositions and methods for imaging
US9452409B2 (en) 2011-04-22 2016-09-27 Vanderbilt University Para-hydrogen polarizer
WO2014118258A1 (en) 2013-01-31 2014-08-07 Bracco Imaging Spa Hyperpolarized esters as metabolic markers in mr
WO2015000838A1 (en) * 2013-07-01 2015-01-08 Bracco Imaging Spa Hyperpolarized 1-13c-1,1-bis(acetoxy(methyl))-2,2'-cyclopropane as metabolic marker for mr
EP2863229A1 (en) 2013-10-15 2015-04-22 Technische Universität München pH-biosensors based on compounds with pH-sensitive enolic groups for magnetic resonance imaging and spectroscopy and their uses

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4822816A (en) * 1987-04-10 1989-04-18 Oxycal Laboratories, Inc. Compositions and methods for administering vitamin C
US6278893B1 (en) * 1998-01-05 2001-08-21 Nycomed Imaging As Method of magnetic resonance imaging of a sample with ex vivo polarization of an MR imaging agent
CN1165301C (zh) * 1999-08-30 2004-09-08 奥克斯可尔实验室公司 组合物在制备治疗癌症的药物中的用途
ES2372058T3 (es) * 2004-07-30 2012-01-13 Ge Healthcare As Procedimiento de visualización de imágenes rm para la discriminación entre tejido sano y tumoral.
ES2422558T3 (es) * 2004-11-19 2013-09-12 Ge Healthcare As Metodo de obtención de imágenes cardiacas con el uso de 13C-piruvato hiperpolarizado

Also Published As

Publication number Publication date
JP5363320B2 (ja) 2013-12-11
CN101506679B (zh) 2013-03-06
US8951500B2 (en) 2015-02-10
CN101506679A (zh) 2009-08-12
WO2008020764A1 (en) 2008-02-21
US20100226859A1 (en) 2010-09-09
ATE549638T1 (de) 2012-03-15
JP2010501482A (ja) 2010-01-21
ES2381380T3 (es) 2012-05-25
EP2052273A1 (en) 2009-04-29
EP2052273B1 (en) 2012-03-14

Similar Documents

Publication Publication Date Title
PL2052273T3 (pl) Obrazowanie lub spektroskopia metodą rezonansu magnetycznego 13C śmierci komórkowej
PH12013502230A1 (en) Multispecific antibodies
MX2009008430A (es) Anticuerpos anti-robo4 y sus usos.
WO2008144522A8 (en) Tissue securing and sealing apparatus and related methods of use
WO2008124660A3 (en) Methods and compositions for the treatment of cancer
AU2016204346A1 (en) Methods and compositions for cell-proliferation-related disorders
MX2010006576A (es) Composiciones y metodos para producir isopreno.
TW200640924A (en) VEGF-R2 inhibitors and methods
SI2346864T1 (sl) Nove spojine, uporabne za zdravljenje degenerativnih in vnetnih bolezni
MX345909B (es) Anticuerpos anti-fgfr3 y métodos que los utilizan.
MX2007008137A (es) Triazoloftalazinas como inhibidores de pde2.
WO2009092108A3 (en) Biomarkers for the diagnosis and treatment of pancreatic cancer
NZ579478A (en) Epha3 antibodies for the treatment of solid tumors
PH12013502194A1 (en) Antibodies to egfl7 and methods for their use
TW200738751A (en) Anti-EphrinB2 antibodies and methods using same
WO2010141833A3 (en) Vital fluorochrome conjugates and methods of use
WO2009027388A3 (en) Imaging medium comprising hyperpolarised 13c-acetate and use thereof
MX2010002193A (es) Metodo de determinacion de actividad pdh y generacion de imagen para su uso en dicho metodo.
MX2010002950A (es) Metodos y composiciones para deteccion de ehrlichia chaffeensis (vlpt).
WO2011041701A3 (en) Inplantable contrast agents and methods
SG124371A1 (en) Methods and system for inspection of fabricated components
WO2008069976A3 (en) Compounds and methods for enzyme-mediated tumor imaging and therapy
TW200833751A (en) Method for preparing polyester nanocomposites
WO2007083287A3 (en) Test method for assessing irritation of skin
SG179067A1 (en) 13c-mr detection using hyperpolarised 13c-fructose