PL1963288T4 - Podstawione pochodne oksazolu - Google Patents
Podstawione pochodne oksazoluInfo
- Publication number
- PL1963288T4 PL1963288T4 PL06841029T PL06841029T PL1963288T4 PL 1963288 T4 PL1963288 T4 PL 1963288T4 PL 06841029 T PL06841029 T PL 06841029T PL 06841029 T PL06841029 T PL 06841029T PL 1963288 T4 PL1963288 T4 PL 1963288T4
- Authority
- PL
- Poland
- Prior art keywords
- alkyl
- optionally substituted
- aryl
- optionally
- attached
- Prior art date
Links
- 230000000202 analgesic effect Effects 0.000 title abstract 2
- 150000007978 oxazole derivatives Chemical class 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 7
- 125000003118 aryl group Chemical group 0.000 abstract 6
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- 150000007513 acids Chemical class 0.000 abstract 2
- 125000001072 heteroaryl group Chemical group 0.000 abstract 2
- 125000005842 heteroatom Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- -1 isonitrile amide Chemical class 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 102000051367 mu Opioid Receptors Human genes 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 108020001612 μ-opioid receptors Proteins 0.000 abstract 2
- 101100294115 Caenorhabditis elegans nhr-4 gene Proteins 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- AFBPFSWMIHJQDM-UHFFFAOYSA-N N-methylaniline Chemical compound CNC1=CC=CC=C1 AFBPFSWMIHJQDM-UHFFFAOYSA-N 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 230000002075 anti-alcohol Effects 0.000 abstract 1
- 230000001430 anti-depressive effect Effects 0.000 abstract 1
- 230000001139 anti-pruritic effect Effects 0.000 abstract 1
- 239000000935 antidepressant agent Substances 0.000 abstract 1
- 229940005513 antidepressants Drugs 0.000 abstract 1
- 239000003908 antipruritic agent Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 125000002485 formyl group Chemical class [H]C(*)=O 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 230000010534 mechanism of action Effects 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 229940125725 tranquilizer Drugs 0.000 abstract 1
- 239000003204 tranquilizing agent Substances 0.000 abstract 1
- 230000002936 tranquilizing effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/48—Nitrogen atoms not forming part of a nitro radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Addiction (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102005061429A DE102005061429A1 (de) | 2005-12-22 | 2005-12-22 | Substituierte Oxazol-Derivate |
| EP06841029A EP1963288B1 (de) | 2005-12-22 | 2006-12-19 | Substituierte oxazol-derivate mit analgetischer wirkung |
| PCT/EP2006/012222 WO2007079928A1 (de) | 2005-12-22 | 2006-12-19 | Substituierte oxazol-derivate mit analgetischer wirkung |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PL1963288T3 PL1963288T3 (pl) | 2012-01-31 |
| PL1963288T4 true PL1963288T4 (pl) | 2012-03-30 |
Family
ID=37814593
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL06841029T PL1963288T4 (pl) | 2005-12-22 | 2006-12-19 | Podstawione pochodne oksazolu |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US7608619B2 (pl) |
| EP (1) | EP1963288B1 (pl) |
| JP (1) | JP2009520718A (pl) |
| CN (1) | CN101384563B (pl) |
| AT (1) | ATE523501T1 (pl) |
| AU (1) | AU2006334744B2 (pl) |
| CA (1) | CA2634566A1 (pl) |
| CY (1) | CY1112176T1 (pl) |
| DE (1) | DE102005061429A1 (pl) |
| DK (1) | DK1963288T3 (pl) |
| ES (1) | ES2370660T3 (pl) |
| IL (1) | IL192269A0 (pl) |
| PL (1) | PL1963288T4 (pl) |
| PT (1) | PT1963288E (pl) |
| RU (1) | RU2424236C2 (pl) |
| SI (1) | SI1963288T1 (pl) |
| WO (1) | WO2007079928A1 (pl) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102005061430A1 (de) * | 2005-12-22 | 2007-07-05 | Grünenthal GmbH | Substituierte Imidazolin-Derivate |
| AR073841A1 (es) | 2008-03-27 | 2010-12-09 | Gruenenthal Chemie | Hidroximetilciclohexilaminas, medicamentos y uso de los mismos para la fabricacion de medicamentos. |
| PE20091657A1 (es) | 2008-03-27 | 2009-11-07 | Gruenenthal Chemie | Derivados de (hetero)aril-ciclohexano |
| CA2719743A1 (en) | 2008-03-27 | 2009-10-01 | Gruenenthal Gmbh | Substituted cyclohexyldiamines |
| CA2719736C (en) | 2008-03-27 | 2016-02-09 | Gruenenthal Gmbh | Spiro(5.5)undecane derivatives |
| KR20120075500A (ko) | 2008-03-27 | 2012-07-06 | 그뤼넨탈 게엠베하 | 치환된 4-아미노사이클로헥산 유도체 |
| WO2009118173A1 (de) | 2008-03-27 | 2009-10-01 | Grünenthal GmbH | Substituierte spirocyclische cyclohexan-derivate |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19525137C2 (de) * | 1995-07-11 | 2003-02-27 | Gruenenthal Gmbh | 6-Dimethylaminomethyl-1-phenyl-cyclohexanverbin -dungen als Zwischenprodukte zur Herstellung pharmazeutischer Wirkstoffe |
| DE19609847A1 (de) * | 1996-03-13 | 1997-09-18 | Gruenenthal Gmbh | Dimethyl-(3-aryl-but-3-enyl)-aminverbindungen als pharmazeutische Wirkstoffe |
| DE19732928C2 (de) * | 1997-07-31 | 2000-05-18 | Gruenenthal Gmbh | Verwendung substituierter Imidazolidin-2,4-dion-Verbindungen als Schmerzmittel |
| WO1999009829A1 (en) * | 1997-08-28 | 1999-03-04 | Eli Lilly And Company | Method for treating pain |
| US5952360A (en) * | 1997-08-28 | 1999-09-14 | Eli Lilly And Company | Method for treating neuropathic pain |
| DE19858593A1 (de) * | 1998-12-18 | 2000-06-21 | Merck Patent Gmbh | Sulfonyloxazolamine als therapeutische Wirkstoffe |
| EP1486490A1 (en) * | 2002-02-28 | 2004-12-15 | Takeda Chemical Industries, Ltd. | Azole compounds |
| TW200505446A (en) * | 2003-01-17 | 2005-02-16 | Fuj Isawa Pharmaceutical Co Ltd | Inhibitor of cox |
-
2005
- 2005-12-22 DE DE102005061429A patent/DE102005061429A1/de not_active Withdrawn
-
2006
- 2006-12-19 ES ES06841029T patent/ES2370660T3/es active Active
- 2006-12-19 PT PT06841029T patent/PT1963288E/pt unknown
- 2006-12-19 RU RU2008129625/04A patent/RU2424236C2/ru not_active IP Right Cessation
- 2006-12-19 JP JP2008546225A patent/JP2009520718A/ja active Pending
- 2006-12-19 AT AT06841029T patent/ATE523501T1/de active
- 2006-12-19 CA CA002634566A patent/CA2634566A1/en not_active Abandoned
- 2006-12-19 DK DK06841029.9T patent/DK1963288T3/da active
- 2006-12-19 SI SI200631150T patent/SI1963288T1/sl unknown
- 2006-12-19 CN CN2006800531790A patent/CN101384563B/zh not_active Expired - Fee Related
- 2006-12-19 PL PL06841029T patent/PL1963288T4/pl unknown
- 2006-12-19 EP EP06841029A patent/EP1963288B1/de not_active Not-in-force
- 2006-12-19 AU AU2006334744A patent/AU2006334744B2/en not_active Ceased
- 2006-12-19 WO PCT/EP2006/012222 patent/WO2007079928A1/de not_active Ceased
-
2008
- 2008-06-18 IL IL192269A patent/IL192269A0/en unknown
- 2008-06-20 US US12/143,519 patent/US7608619B2/en not_active Expired - Fee Related
-
2011
- 2011-12-06 CY CY20111101210T patent/CY1112176T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES2370660T3 (es) | 2011-12-21 |
| CN101384563B (zh) | 2012-06-27 |
| SI1963288T1 (sl) | 2011-12-30 |
| CY1112176T1 (el) | 2015-12-09 |
| WO2007079928A1 (de) | 2007-07-19 |
| CN101384563A (zh) | 2009-03-11 |
| EP1963288A1 (de) | 2008-09-03 |
| RU2008129625A (ru) | 2010-02-27 |
| JP2009520718A (ja) | 2009-05-28 |
| DK1963288T3 (da) | 2011-11-21 |
| AU2006334744B2 (en) | 2011-06-16 |
| DE102005061429A1 (de) | 2007-06-28 |
| AU2006334744A1 (en) | 2007-07-19 |
| PL1963288T3 (pl) | 2012-01-31 |
| ATE523501T1 (de) | 2011-09-15 |
| IL192269A0 (en) | 2008-12-29 |
| EP1963288B1 (de) | 2011-09-07 |
| PT1963288E (pt) | 2011-11-04 |
| RU2424236C2 (ru) | 2011-07-20 |
| HK1123297A1 (en) | 2009-06-12 |
| US7608619B2 (en) | 2009-10-27 |
| US20090069330A1 (en) | 2009-03-12 |
| CA2634566A1 (en) | 2007-07-19 |
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