PL1891446T3 - Sposób identyfikacji nowych związków oddziałujących z enzymami - Google Patents

Sposób identyfikacji nowych związków oddziałujących z enzymami

Info

Publication number
PL1891446T3
PL1891446T3 PL06763568T PL06763568T PL1891446T3 PL 1891446 T3 PL1891446 T3 PL 1891446T3 PL 06763568 T PL06763568 T PL 06763568T PL 06763568 T PL06763568 T PL 06763568T PL 1891446 T3 PL1891446 T3 PL 1891446T3
Authority
PL
Poland
Prior art keywords
identification
novel enzyme
interacting compounds
enzyme interacting
compounds
Prior art date
Application number
PL06763568T
Other languages
English (en)
Inventor
Gerard Drewes
Bernhard Kuester
Ulrich Kruse
Carsten Hopf
Dirk Eberhard
Marcus Bantscheff
Valerie Reader
David Middlemiss
Manfred Raida
Original Assignee
Cellzome Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP05012722A external-priority patent/EP1734367A1/en
Application filed by Cellzome Gmbh filed Critical Cellzome Gmbh
Publication of PL1891446T3 publication Critical patent/PL1891446T3/pl

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • C12Q1/485—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase involving kinase

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Microbiology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Cell Biology (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
PL06763568T 2005-06-14 2006-06-07 Sposób identyfikacji nowych związków oddziałujących z enzymami PL1891446T3 (pl)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP05012722A EP1734367A1 (en) 2005-06-14 2005-06-14 Process for the identification of novel enzyme interacting compounds
US71139905P 2005-08-25 2005-08-25
US78217006P 2006-03-14 2006-03-14
EP06763568.0A EP1891446B1 (en) 2005-06-14 2006-06-07 Process for the identification of novel enzyme interacting compounds
PCT/EP2006/062984 WO2006134056A1 (en) 2005-06-14 2006-06-07 Process for the identification of novel enzyme interacting compounds

Publications (1)

Publication Number Publication Date
PL1891446T3 true PL1891446T3 (pl) 2013-08-30

Family

ID=37038265

Family Applications (1)

Application Number Title Priority Date Filing Date
PL06763568T PL1891446T3 (pl) 2005-06-14 2006-06-07 Sposób identyfikacji nowych związków oddziałujących z enzymami

Country Status (6)

Country Link
US (1) US20090238808A1 (pl)
EP (1) EP1891446B1 (pl)
AU (1) AU2006259153B2 (pl)
CA (1) CA2611365C (pl)
PL (1) PL1891446T3 (pl)
WO (1) WO2006134056A1 (pl)

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EP1862802B1 (en) * 2006-06-01 2008-12-10 Cellzome Ag Methods for the identification of ZAP-70 interacting molecules and for the purification of ZAP-70
ATE414281T1 (de) 2006-08-03 2008-11-15 Cellzome Ag Verfahren zur identifizierung von molekülen die mit pi3k interagieren und verfahren zur reinigung von pi3k
JP5336375B2 (ja) 2006-08-30 2013-11-06 セルゾーム リミテッド キナーゼ阻害剤としてのトリアゾール誘導体
JP5279063B2 (ja) * 2007-05-25 2013-09-04 国立大学法人愛媛大学 Ｈｌａ−ａ２拘束性抗原ペプチドおよびその用途
DE602007007624D1 (de) * 2007-10-05 2010-08-19 Max Planck Gesellschaft Proteomweite Quantifizierung kleiner an zelluläre Zielproteine gebundener Moleküle
EP2058307A1 (en) 2007-11-12 2009-05-13 Cellzome Ag Methods for the identification of JAK kinase interacting molecules and for the purification of JAK kinases
MX2010005700A (es) 2007-11-27 2010-06-11 Cellzome Ltd Amino triazoles como inhibidores pi3k.
US20110111972A1 (en) 2008-02-04 2011-05-12 Cellzome Ag Selectivity profiling of pi3k interacting molecules against multiple targets
US8148677B2 (en) * 2008-02-05 2012-04-03 Thermo Finnigan Llc Peptide identification and quantitation by merging MS/MS spectra
US8703438B2 (en) * 2008-11-18 2014-04-22 The Regents Of The University Of California Ligand binding stabilization method for drug target identification
WO2010103094A1 (en) 2009-03-13 2010-09-16 Cellzome Limited PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS
EP2414337B1 (en) 2009-04-03 2013-05-01 Cellzome GmbH Methods for the identification of kinase interacting molecules and for the purification of kinase proteins
US20120040955A1 (en) 2009-04-14 2012-02-16 Richard John Harrison Fluoro substituted pyrimidine compounds as jak3 inhibitors
EP2432782A1 (en) 2009-05-20 2012-03-28 Cellzome Ag Methods for the identification of phosphatidylinositol kinase interacting molecules and for the purification of phosphatidylinositol kinase proteins
WO2010141596A2 (en) * 2009-06-02 2010-12-09 Marquette University Chemical proteomic assay for optimizing drug binding to target proteins
EP2464967B1 (en) * 2009-08-14 2013-06-12 Cellzome Ag Methods for the identification and characterization of hdac interacting compounds
EP2475648A1 (en) 2009-09-11 2012-07-18 Cellzome Limited Ortho substituted pyrimidine compounds as jak inhibitors
US9242987B2 (en) 2009-10-20 2016-01-26 Cellzome Limited Heterocyclyl pyrazolopyrimidine analogues as JAK inhibitors
KR101028875B1 (ko) 2010-02-12 2011-04-12 메디스커브 주식회사 세포 내에서 세포내 물질의 생리활성 기능을 조절하는 조절물질을 검출하는 방법
US9249129B2 (en) 2010-03-04 2016-02-02 Cellzome Limited Morpholino substituted urea derivatives as mTOR inhibitors
BR112012027803A2 (pt) 2010-04-30 2016-08-09 Cellzome Ltd compostos de pirazol como inibidores de jak
EP2588105A1 (en) 2010-07-01 2013-05-08 Cellzome Limited Triazolopyridines as tyk2 inhibitors
EP2596125A1 (en) 2010-07-19 2013-05-29 Cellzome Ag In vivo method for the evaluation of a compound-target interaction
EP2601527A1 (en) 2010-08-05 2013-06-12 Cellzome AG Methods for the identification of methyltransferase interacting molecules and for the purification of methyltransferase proteins
US9040545B2 (en) 2010-08-20 2015-05-26 Cellzome Limited Heterocyclyl pyrazolopyrimidine analogues as selective JAK inhibitors
AU2011328237A1 (en) 2010-11-09 2013-05-23 Cellzome Limited Pyridine compounds and aza analogues thereof as TYK2 inhibitors
WO2012084244A1 (en) * 2010-12-22 2012-06-28 Cellzome Ag A method for the evaluation of compound-target interactions across species
WO2012098006A1 (en) 2011-01-21 2012-07-26 Cellzome Ag Compounds and methods for the identification and characterization of hdac interacting compounds
WO2012123119A1 (en) 2011-03-17 2012-09-20 Cellzome Ag Methods for the identification and characterization of proteins interacting with histone tails and of compounds interacting with said proteins
JP2012197258A (ja) * 2011-03-23 2012-10-18 Tohoku Univ 個別化治療診断のためのマーカータンパク質絶対量の定量方法
EP2505659A1 (en) 2011-03-31 2012-10-03 Cellzome Ag Methods for the identification of dioxygenase interacting molecules and for the purification of dioxygenase proteins
WO2012143320A1 (en) 2011-04-18 2012-10-26 Cellzome Limited (7h-pyrrolo[2,3-d]pyrimidin-2-yl)amine compounds as jak3 inhibitors
WO2012150042A1 (en) 2011-05-04 2012-11-08 Cellzome Ag Compounds and methods for the identification of histone demethylase interacting molecules and for the purification of histone demethylase proteins
WO2012175201A1 (en) 2011-06-20 2012-12-27 Cellzome Ag Methods for the characterization of antibodies
CN103781780B (zh) 2011-07-28 2015-11-25 赛尔佐姆有限公司 作为jak抑制剂的杂环基嘧啶类似物
WO2013017480A1 (en) 2011-07-29 2013-02-07 Cellzome Limited Pyrazolo[4,3-c]pyridine derivatives as jak inhibitors
WO2013017479A1 (en) 2011-07-29 2013-02-07 Cellzome Limited Pyrazolo[4,3-c]pyridine derivatives as jak inhibitors
WO2013041605A1 (en) 2011-09-20 2013-03-28 Cellzome Limited Pyrazolo[4,3-c]pyridine derivatives as kinase inhibitors
ES2609606T3 (es) 2011-09-21 2017-04-21 Cellzome Limited Derivados de urea y carbamato de 2-morfolino-1,3,5-triazina como inhibidores de mTOR para el tratamiento de enfermedades inmunológicas o proliferativas
AU2012318590B2 (en) * 2011-10-04 2017-05-18 Expression Pathology, Inc. SRM/MRM assay for the ephrin type-A receptor 2 protein
BR112014008241A2 (pt) 2011-10-07 2017-04-18 Cellzome Ltd composto, composição farmacêutica, métodos para tratar, controlar, retardar ou prevenir doenças e distúrbios, e para preparar um composto, e, uso de um composto
EP2592154A1 (en) 2011-11-09 2013-05-15 Cellzome Ag Immobilization products and methods for the identification of histone demethylase interacting molecules and for the purification of histone demethylase proteins
CN104169272A (zh) 2011-12-23 2014-11-26 赛尔佐姆有限公司 作为激酶抑制剂的嘧啶-2,4-二胺衍生物
EP2855451B1 (en) 2012-05-24 2017-10-04 Cellzome Limited Heterocyclyl pyrimidine analogues as tyk2 inhibitors
WO2014168721A2 (en) * 2013-04-12 2014-10-16 Tufts Medical Center Methods and systems for designing and/or characterizing soluble lipidated ligand agents
WO2017118997A2 (en) * 2016-01-08 2017-07-13 Saxena Chaitanya Methods for determining protein targets of a ligand without ligand derivatization
WO2017127827A1 (en) 2016-01-22 2017-07-27 Tufts Medical Center Compounds and methods for treating inflammation
US11561226B2 (en) 2016-03-14 2023-01-24 Pierce Biotechnology Inc. Detection and quantification of AKT-mTOR pathway proteins
KR20190017928A (ko) 2016-06-10 2019-02-20 순-쳉 리 변이체 sh2 도메인에 의한 단백질 티로신 인산화 프로파일링 방법

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CA2403296A1 (en) 2000-04-10 2001-10-18 Benjamin F. Cravatt Proteomic analysis using activity-based probe libraries
CA2468457A1 (en) 2001-11-29 2003-06-12 Benjamin F. Cravatt Enzyme activity profiles
US20030148462A1 (en) * 2001-12-14 2003-08-07 President And Fellows Of Harvard College Dual inhibition of sister chromatid separation at metaphase
US20030186221A1 (en) 2002-04-02 2003-10-02 Lockhart David J. Phage display affinity filter and forward screen
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DK1644513T3 (da) * 2003-06-20 2011-10-17 Discoverx Corp Assay til detektion af proteinbinding

Also Published As

Publication number Publication date
EP1891446B1 (en) 2013-04-10
CA2611365A1 (en) 2006-12-21
EP1891446A1 (en) 2008-02-27
AU2006259153B2 (en) 2012-04-12
US20090238808A1 (en) 2009-09-24
CA2611365C (en) 2014-02-11
AU2006259153A1 (en) 2006-12-21
HK1115631A1 (en) 2008-12-05
WO2006134056A1 (en) 2006-12-21

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