PL1891446T3 - Sposób identyfikacji nowych związków oddziałujących z enzymami - Google Patents

Sposób identyfikacji nowych związków oddziałujących z enzymami

Info

Publication number
PL1891446T3
PL1891446T3 PL06763568T PL06763568T PL1891446T3 PL 1891446 T3 PL1891446 T3 PL 1891446T3 PL 06763568 T PL06763568 T PL 06763568T PL 06763568 T PL06763568 T PL 06763568T PL 1891446 T3 PL1891446 T3 PL 1891446T3
Authority
PL
Poland
Prior art keywords
identification
novel enzyme
interacting compounds
enzyme interacting
compounds
Prior art date
Application number
PL06763568T
Other languages
English (en)
Inventor
Gerard Drewes
Bernhard Kuester
Ulrich Kruse
Carsten Hopf
Dirk Eberhard
Marcus Bantscheff
Valerie Reader
David Middlemiss
Manfred Raida
Original Assignee
Cellzome Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP05012722A external-priority patent/EP1734367A1/en
Application filed by Cellzome Gmbh filed Critical Cellzome Gmbh
Publication of PL1891446T3 publication Critical patent/PL1891446T3/pl

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • C12Q1/485—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase involving kinase

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Urology & Nephrology (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
PL06763568T 2005-06-14 2006-06-07 Sposób identyfikacji nowych związków oddziałujących z enzymami PL1891446T3 (pl)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP05012722A EP1734367A1 (en) 2005-06-14 2005-06-14 Process for the identification of novel enzyme interacting compounds
US71139905P 2005-08-25 2005-08-25
US78217006P 2006-03-14 2006-03-14
EP06763568.0A EP1891446B1 (en) 2005-06-14 2006-06-07 Process for the identification of novel enzyme interacting compounds
PCT/EP2006/062984 WO2006134056A1 (en) 2005-06-14 2006-06-07 Process for the identification of novel enzyme interacting compounds

Publications (1)

Publication Number Publication Date
PL1891446T3 true PL1891446T3 (pl) 2013-08-30

Family

ID=37038265

Family Applications (1)

Application Number Title Priority Date Filing Date
PL06763568T PL1891446T3 (pl) 2005-06-14 2006-06-07 Sposób identyfikacji nowych związków oddziałujących z enzymami

Country Status (6)

Country Link
US (1) US20090238808A1 (pl)
EP (1) EP1891446B1 (pl)
AU (1) AU2006259153B2 (pl)
CA (1) CA2611365C (pl)
PL (1) PL1891446T3 (pl)
WO (1) WO2006134056A1 (pl)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101426927B (zh) * 2006-03-14 2012-05-23 塞尔卓姆股份公司 鉴定lrrk2相互作用分子和纯化lrrk2的方法
DE602006004196D1 (de) * 2006-06-01 2009-01-22 Cellzome Ag Verfahren zur Identifizierung von mit ZAP-70 wechselwirkenden Molekülen und zur ZAP-70-Reinigung
DE602006003651D1 (de) 2006-08-03 2008-12-24 Cellzome Ag Verfahren zur Identifizierung von Molekülen die mit PI3K interagieren und Verfahren zur Reinigung von PI3K
AU2007291190A1 (en) 2006-08-30 2008-03-06 Cellzome Limited Triazole derivatives as kinase inhibitors
JP5279063B2 (ja) * 2007-05-25 2013-09-04 国立大学法人愛媛大学 Ｈｌａ−ａ２拘束性抗原ペプチドおよびその用途
EP2045332B1 (en) 2007-10-05 2010-07-07 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Proteome-wide quantification of small molecule binding to cellular target proteins
EP2058307A1 (en) 2007-11-12 2009-05-13 Cellzome Ag Methods for the identification of JAK kinase interacting molecules and for the purification of JAK kinases
EP2222674B8 (en) 2007-11-27 2016-01-06 Cellzome Limited Amino triazoles as pi3k inhibitors
EP2245181B1 (en) 2008-02-04 2011-10-12 Cellzome Ag Selectivity profiling of pi3k interacting molecules against multiple targets
US8148677B2 (en) * 2008-02-05 2012-04-03 Thermo Finnigan Llc Peptide identification and quantitation by merging MS/MS spectra
US8703438B2 (en) * 2008-11-18 2014-04-22 The Regents Of The University Of California Ligand binding stabilization method for drug target identification
ES2529205T3 (es) 2009-03-13 2015-02-17 Cellzome Limited Derivados de pirimidina como inhibidores de mTOR
WO2010112210A1 (en) 2009-04-03 2010-10-07 Cellzome Ag Methods for the identification of kinase interacting molecules and for the purification of kinase proteins
EP2419423A1 (en) 2009-04-14 2012-02-22 Cellzome Limited Fluoro substituted pyrimidine compounds as jak3 inhibitors
WO2010133318A1 (en) 2009-05-20 2010-11-25 Cellzome Ag Methods for the identification of phosphatidylinositol kinase interacting molecules and for the purification of phosphatidylinositol kinase proteins
US20100304998A1 (en) * 2009-06-02 2010-12-02 Marquette University Chemical Proteomic Assay for Optimizing Drug Binding to Target Proteins
US20130071854A1 (en) * 2009-08-14 2013-03-21 Gerard Drewes Methods for the identification and characterization of hdac interacting compounds
US20120172385A1 (en) 2009-09-11 2012-07-05 Richard John Harrison Ortho substituted pyrimidine compounds as jak inhibitors
CA2775009A1 (en) 2009-10-20 2011-04-28 Cellzome Limited Heterocyclyl pyrazolopyrimidine analogues as jak inhibitors
KR101028875B1 (ko) 2010-02-12 2011-04-12 메디스커브 주식회사 세포 내에서 세포내 물질의 생리활성 기능을 조절하는 조절물질을 검출하는 방법
ES2535116T3 (es) 2010-03-04 2015-05-05 Cellzome Limited Derivados de urea sustituida con morfolino como inhibidores de mtor
SG184989A1 (en) 2010-04-30 2012-11-29 Cellzome Ltd Pyrazole compounds as jak inhibitors
WO2012000970A1 (en) 2010-07-01 2012-01-05 Cellzome Limited Triazolopyridines as tyk2 inhibitors
WO2012010240A1 (en) 2010-07-19 2012-01-26 Cellzome Ag In vivo method for the evaluation of a compound-target interaction
US20130210664A1 (en) 2010-08-05 2013-08-15 Cellzome Ag Methods for the Identification of Methyltransferase Interacting Molecules and for the Purification of Methyltransferase Proteins
US9040545B2 (en) 2010-08-20 2015-05-26 Cellzome Limited Heterocyclyl pyrazolopyrimidine analogues as selective JAK inhibitors
CA2815330A1 (en) 2010-11-09 2012-05-18 Cellzome Limited Pyridine compounds and aza analogues thereof as tyk2 inhibitors
US20140004530A1 (en) * 2010-12-22 2014-01-02 Cellzome Gmbh Method for the evaluation of compound-target interactions across species
EP2665829A1 (en) 2011-01-21 2013-11-27 Cellzome GmbH Compounds and methods for the identification and characterization of hdac interacting compounds
WO2012123119A1 (en) 2011-03-17 2012-09-20 Cellzome Ag Methods for the identification and characterization of proteins interacting with histone tails and of compounds interacting with said proteins
JP2012197258A (ja) * 2011-03-23 2012-10-18 Tohoku Univ 個別化治療診断のためのマーカータンパク質絶対量の定量方法
EP2505659A1 (en) 2011-03-31 2012-10-03 Cellzome Ag Methods for the identification of dioxygenase interacting molecules and for the purification of dioxygenase proteins
WO2012143320A1 (en) 2011-04-18 2012-10-26 Cellzome Limited (7h-pyrrolo[2,3-d]pyrimidin-2-yl)amine compounds as jak3 inhibitors
WO2012150042A1 (en) 2011-05-04 2012-11-08 Cellzome Ag Compounds and methods for the identification of histone demethylase interacting molecules and for the purification of histone demethylase proteins
WO2012175201A1 (en) 2011-06-20 2012-12-27 Cellzome Ag Methods for the characterization of antibodies
BR112014000360A2 (pt) 2011-07-28 2017-02-14 Cellzome Ltd análogos de heterociclil pirimidina como inibidores jak
WO2013017479A1 (en) 2011-07-29 2013-02-07 Cellzome Limited Pyrazolo[4,3-c]pyridine derivatives as jak inhibitors
WO2013017480A1 (en) 2011-07-29 2013-02-07 Cellzome Limited Pyrazolo[4,3-c]pyridine derivatives as jak inhibitors
JP2014531449A (ja) 2011-09-20 2014-11-27 セルゾーム リミティッド キナーゼ阻害剤としてのピラゾロ［４，３―ｃ］ピリジン誘導体
JP5995975B2 (ja) 2011-09-21 2016-09-21 セルゾーム リミテッド Ｍｔｏｒ阻害剤としてのモルホリノ置換尿素またはカルバメート誘導体
AU2012318590B2 (en) 2011-10-04 2017-05-18 Expression Pathology, Inc. SRM/MRM assay for the ephrin type-A receptor 2 protein
WO2013050508A1 (en) 2011-10-07 2013-04-11 Cellzome Limited Morpholino substituted bicyclic pyrimidine urea or carbamate derivatives as mtor inhibitors
EP2592154A1 (en) 2011-11-09 2013-05-15 Cellzome Ag Immobilization products and methods for the identification of histone demethylase interacting molecules and for the purification of histone demethylase proteins
WO2013092854A1 (en) 2011-12-23 2013-06-27 Cellzome Limited Pyrimidine-2,4-diamine derivatives as kinase inhibitors
CA2875990A1 (en) 2012-05-24 2013-11-28 Cellzome Limited Heterocyclyl pyrimidine analogues as tyk2 inhibitors
US10233219B2 (en) 2013-04-12 2019-03-19 Tufts Medical Center Methods and systems for designing and/or characterizing soluble lipidated ligand agents
WO2017118997A2 (en) * 2016-01-08 2017-07-13 Saxena Chaitanya Methods for determining protein targets of a ligand without ligand derivatization
CA3012190A1 (en) 2016-01-22 2017-07-27 Tufts Medical Center Compounds and methods for treating inflammation
CN108885215B (zh) 2016-03-14 2022-11-25 皮尔斯生物科技有限公司 AKT-mTOR通路蛋白的检测和量化
WO2017210801A1 (en) 2016-06-10 2017-12-14 Li shun-cheng Methods for protein tyrosine phosphorylation profiling with variant sh2 domains

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5536822A (en) 1994-03-09 1996-07-16 University Of Virginia Alumni Patents Foundation γ-phosphate linked adenosine 5' triphosphate sepharose
SE9602545L (sv) * 1996-06-25 1997-12-26 Michael Mecklenburg Metod för att diskriminera komplexa biologiska prover
US6242246B1 (en) * 1997-12-15 2001-06-05 Somalogic, Inc. Nucleic acid ligand diagnostic Biochip
US7300753B2 (en) * 1998-09-04 2007-11-27 John Rush Immunoaffinity isolation of modified peptides from complex mixtures
AU2196200A (en) * 1998-12-17 2000-07-03 Johns Hopkins University School Of Medicine, The Olfactory receptor expression libraries and methods of making and using them
GB9923146D0 (en) * 1999-09-30 1999-12-01 Imperial College Detector array
CA2400460C (en) * 2000-02-08 2009-01-06 The Regents Of The University Of Michigan Mapping of differential display of proteins
WO2001077684A2 (en) 2000-04-10 2001-10-18 The Scripps Research Institute Proteomic analysis using activity-based probe libraries
AU2002357764A1 (en) 2001-11-29 2003-06-17 The Scripps Research Institute Enzyme activity profiles
US20030148462A1 (en) * 2001-12-14 2003-08-07 President And Fellows Of Harvard College Dual inhibition of sister chromatid separation at metaphase
US20030186221A1 (en) 2002-04-02 2003-10-02 Lockhart David J. Phage display affinity filter and forward screen
AU2003258542A1 (en) * 2002-07-29 2004-02-23 Axxima Pharmaceuticals Ag Method for isolating atp binding proteins by means of immobolized protein inhibitors
DK1644513T3 (da) * 2003-06-20 2011-10-17 Discoverx Corp Assay til detektion af proteinbinding

Also Published As

Publication number Publication date
HK1115631A1 (en) 2008-12-05
EP1891446A1 (en) 2008-02-27
US20090238808A1 (en) 2009-09-24
AU2006259153A1 (en) 2006-12-21
CA2611365C (en) 2014-02-11
WO2006134056A1 (en) 2006-12-21
AU2006259153B2 (en) 2012-04-12
EP1891446B1 (en) 2013-04-10
CA2611365A1 (en) 2006-12-21

Similar Documents

Publication Publication Date Title
PL1891446T3 (pl) Sposób identyfikacji nowych związków oddziałujących z enzymami
IL242282B (en) Enzyme Inhibiting Compounds
PL1743882T3 (pl) Sposób do produkcji izocyjanianów
IL185419A0 (en) Improved process for the synthesis of enantiomeric indanylamine derivatives
EP1893570A4 (en) IMPROVED PROCESS FOR THE PREPARATION OF EZETIMIBE
PL1896426T3 (pl) Sposób syntezy związków organicznych
ZA200804264B (en) Process for the preparation of ferri-succinylcasein
EP1861408A4 (en) PROCESS FOR PRODUCING HYDROCHLOROSILANES
IL184715A0 (en) Process for the preparation of intermediates
SI1807395T1 (sl) Proces za sintezo N-alkoksiaminov
EP1940793A4 (en) METHOD FOR PRODUCING MONTELUCASTS
SI1891446T1 (sl) Postopek za identifikacijo novih spojin, ki vstopajo v interakcijo z encimi
IL187155A0 (en) Process for production of 4-biphenylazetidin-2-ones
GB0519758D0 (en) Novel process
ZA200601910B (en) Process for the preparation of organosilances
GB0500604D0 (en) Novel process
ZA200710066B (en) Process for production of 4-biphenylylazetidin-2-ones
IL189354A0 (en) Process for the production of anilines
GB0526474D0 (en) Novel process
GB0501253D0 (en) Process for the production of olefins
ZA200709621B (en) Process for the synthesis of organic compounds
IL185076A0 (en) Process for the prepartion of enantiomerically pure 1-substituted-3-aminoalcohols
TWI366559B (en) Process for the production of anilines
HU0500570D0 (en) Process for the preparation of (s)-(-)-amlodipine
GB0507164D0 (en) Novel process