PL1781604T3 - Sole bis(tiohydrazydoamidu) do leczenia nowotworów - Google Patents

Sole bis(tiohydrazydoamidu) do leczenia nowotworów

Info

Publication number
PL1781604T3
PL1781604T3 PL05762347T PL05762347T PL1781604T3 PL 1781604 T3 PL1781604 T3 PL 1781604T3 PL 05762347 T PL05762347 T PL 05762347T PL 05762347 T PL05762347 T PL 05762347T PL 1781604 T3 PL1781604 T3 PL 1781604T3
Authority
PL
Poland
Prior art keywords
thio
cancers
bis
salts
treatment
Prior art date
Application number
PL05762347T
Other languages
English (en)
Polish (pl)
Inventor
Elena Kostik
Farid Vaghefi
Guiqing Liang
Keizo Koya
Lijun Sun
Noriaki Tatsuta
Shoujun Chen
Takayo Inoue
Zhi-Qiang Xia
Original Assignee
Synta Pharmaceuticals Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synta Pharmaceuticals Corp filed Critical Synta Pharmaceuticals Corp
Publication of PL1781604T3 publication Critical patent/PL1781604T3/pl

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D305/00Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/16Amides, e.g. hydroxamic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C327/00Thiocarboxylic acids
    • C07C327/38Amides of thiocarboxylic acids
    • C07C327/56Amides of thiocarboxylic acids having nitrogen atoms of thiocarboxamide groups further bound to another hetero atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/02Systems containing only non-condensed rings with a three-membered ring
PL05762347T 2004-06-23 2005-06-20 Sole bis(tiohydrazydoamidu) do leczenia nowotworów PL1781604T3 (pl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US58259604P 2004-06-23 2004-06-23
US68136805P 2005-05-16 2005-05-16
PCT/US2005/021642 WO2006009940A1 (en) 2004-06-23 2005-06-20 Bis(thio-hydrazide amide) salts for treatment of cancers
EP05762347.2A EP1781604B1 (en) 2004-06-23 2005-06-20 Bis(thio-hydrazide amide) salts for treatment of cancers

Publications (1)

Publication Number Publication Date
PL1781604T3 true PL1781604T3 (pl) 2014-01-31

Family

ID=34993190

Family Applications (1)

Application Number Title Priority Date Filing Date
PL05762347T PL1781604T3 (pl) 2004-06-23 2005-06-20 Sole bis(tiohydrazydoamidu) do leczenia nowotworów

Country Status (22)

Country Link
US (5) US7385084B2 (US07795313-20100914-C00004.png)
EP (2) EP1781604B1 (US07795313-20100914-C00004.png)
JP (1) JP5362986B2 (US07795313-20100914-C00004.png)
KR (1) KR101313027B1 (US07795313-20100914-C00004.png)
CN (1) CN1993318B (US07795313-20100914-C00004.png)
AU (1) AU2005265202B2 (US07795313-20100914-C00004.png)
BR (1) BRPI0512526A (US07795313-20100914-C00004.png)
CA (1) CA2570698C (US07795313-20100914-C00004.png)
DK (1) DK1781604T3 (US07795313-20100914-C00004.png)
ES (1) ES2430373T3 (US07795313-20100914-C00004.png)
HK (1) HK1104526A1 (US07795313-20100914-C00004.png)
HR (1) HRP20131023T1 (US07795313-20100914-C00004.png)
IL (1) IL179632A (US07795313-20100914-C00004.png)
ME (1) ME01644B (US07795313-20100914-C00004.png)
NO (1) NO20070378L (US07795313-20100914-C00004.png)
NZ (1) NZ552159A (US07795313-20100914-C00004.png)
PL (1) PL1781604T3 (US07795313-20100914-C00004.png)
PT (1) PT1781604E (US07795313-20100914-C00004.png)
RS (1) RS52999B (US07795313-20100914-C00004.png)
RU (2) RU2406722C2 (US07795313-20100914-C00004.png)
TW (1) TWI389684B (US07795313-20100914-C00004.png)
WO (1) WO2006009940A1 (US07795313-20100914-C00004.png)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI252847B (en) * 2001-07-10 2006-04-11 Synta Pharmaceuticals Corp Synthesis of taxol enhancers
TWI297335B (en) 2001-07-10 2008-06-01 Synta Pharmaceuticals Corp Taxol enhancer compounds
TWI332943B (en) * 2001-07-10 2010-11-11 Synta Pharmaceuticals Corp Taxol enhancer compounds
TWI330079B (en) * 2003-01-15 2010-09-11 Synta Pharmaceuticals Corp Treatment for cancers
DK1781604T3 (da) 2004-06-23 2013-09-16 Synta Pharmaceuticals Corp Bis(thio-hydrazid-amid)-salte til behandling af cancere
EP1827410A2 (en) 2004-11-19 2007-09-05 Synta Pharmaceuticals Corporation Bis(thio-hydrazide amides) for increasing hsp70 expression
AU2006236534A1 (en) * 2005-04-15 2006-10-26 Synta Pharmaceuticals Corp. Methods of increasing natural killer cell activity for therapy
WO2006113695A1 (en) 2005-04-15 2006-10-26 Synta Pharmaceuticals Corp. Combination cancer therapy with bis(thiohydrazide) amide compounds
WO2006124736A2 (en) * 2005-05-16 2006-11-23 Synta Pharmaceuticals Corp. Synthesis of bis(thio-hydrazide amide) salts
EP1940375A1 (en) 2005-08-16 2008-07-09 Synta Pharmaceuticals Corporation Bis(thio-hydrazide amide) formulation
US20100310587A1 (en) * 2005-08-29 2010-12-09 Academia Sinica Immunomodulatory compositions
GB0607950D0 (en) * 2006-04-21 2006-05-31 Novartis Ag Organic compounds
JP2010501564A (ja) * 2006-08-21 2010-01-21 シンタ ファーマシューティカルズ コーポレーション 黒色腫を治療するためのビス(チオヒドラジドアミド)
WO2008024304A2 (en) * 2006-08-21 2008-02-28 Synta Pharmaceuticals Corp. Compounds for treatment of proliferative disorders
BRPI0716435A2 (pt) * 2006-08-21 2014-03-04 Synta Pharmaceuticals Corp Compostos para o tratamento de doenças proliferativas
AU2007288334A1 (en) * 2006-08-21 2008-02-28 Synta Pharmaceuticals Corp. Combination with bis(thiohydrazide amides) for treating cancer
WO2008024301A2 (en) * 2006-08-21 2008-02-28 Synta Pharmaceuticals Corp. Bis(thiohydrazide amides) for use in preventing or delaying the recurrence of melanoma
JP2010502616A (ja) * 2006-08-31 2010-01-28 シンタ ファーマシューティカルズ コーポレーション 癌を治療するためのビス(チオヒドラジドアミド)の組み合わせ
US9498528B2 (en) * 2006-09-13 2016-11-22 Genzyme Corporation Treatment of multiple sclerosis (MS)
TW200829543A (en) * 2006-09-15 2008-07-16 Synta Pharmaceuticals Corp Purification of bis(thiohydrazide amides)
US8618170B2 (en) * 2007-11-09 2013-12-31 Synta Pharmaceuticals Corp. Oral formulations of bis(thiohydrazide amides)
WO2009105257A1 (en) 2008-02-21 2009-08-27 Synta Pharmaceuticals Corp. Compounds for treating proliferative disorders
US8633323B2 (en) * 2008-03-31 2014-01-21 Synta Pharmaceuticals Corp. Process for preparing bis(thiohydrazide amides)
BRPI0919720A2 (pt) * 2008-10-22 2015-12-08 Synta Pharmaceuticals Corp complexos de metal de transição de compostos bis-[tio hidrazida amida
CN102256949B (zh) 2008-10-22 2014-09-24 辛塔医药品有限公司 双[硫代酰肼酰胺]化合物的过渡金属络合物
US8525776B2 (en) * 2008-10-27 2013-09-03 Lenovo (Singapore) Pte. Ltd Techniques for controlling operation of a device with a virtual touchscreen
EP2370402A2 (en) 2008-12-01 2011-10-05 Synta Pharmaceuticals Corp. Compounds for treating proliferative disorders
US8822532B2 (en) 2009-12-04 2014-09-02 Synta Pharmaceuticals Corp. Bis[thiohydrazide amide] compounds for treating leukemia
US8815945B2 (en) 2010-04-20 2014-08-26 Masazumi Nagai Use of bis [thiohydrazide amide] compounds such as elesclomol for treating cancers
EP2640372A1 (en) 2010-11-18 2013-09-25 Synta Pharmaceuticals Corp. Preselection of subjects for therapeutic treatment with elesclomol based on hypoxic status
JP2014534238A (ja) * 2011-11-10 2014-12-18 シンタ ファーマシューティカルズ コーポレーション 癌を治療するためのビス(チオヒドラジドアミド)化合物の投与
US20130149392A1 (en) 2011-12-12 2013-06-13 Synta Pharmaceuticals Corp. Method of treating non-small cell lung cancer with bis-(thiohydrazide)amide compounds
US20150057357A1 (en) * 2012-01-05 2015-02-26 The Board Of Trustees Of The Leland Stanford Junior University Bis (thiohydrazide amide) compounds for treating cancers

Family Cites Families (78)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2097737A5 (en) 1970-07-14 1972-03-03 Berlin Chemie Veb Virustatic 4-substd 1-acylthiosemicarbazides -from carboxylic acid - hydrazide and isothiocyanates or from carboxylic acid chloride and 4-
DE2037257A1 (en) 1970-07-28 1972-02-03 Farbwerke Hoechst AG, vorm. Meister Lucius & Brüning, 6000 Frankfurt Poly-(5-amino-1,3,4-thiadiazol-2-yl) derivs prepn - intermediates for drug and polymer prodn
GB1272920A (en) 1971-03-15 1972-05-03 Berlin Chemie Veb New thiosemicarbazides
US4012360A (en) 1973-12-03 1977-03-15 Ciba-Geigy Corporation Bis-salicyloyl-dicarboxylic acid dihydrazides as stabilizers for polyolefines
JPS5091056A (US07795313-20100914-C00004.png) 1973-12-17 1975-07-21
US4822777A (en) 1987-02-27 1989-04-18 Liposome Technology, Inc. Amphotericin B/cholesterol sulfate composition
JP2767241B2 (ja) 1987-04-15 1998-06-18 ロ−ム アンド ハ−ス コンパニ− 殺虫性のn−(場合により置換された)−n′−置換−n,n′−ジ置換ヒドラジン
US6013836A (en) 1992-02-28 2000-01-11 Rohm And Haas Company Insecticidal N'-substituted-N,N'-disubstitutedhydrazines
FR2697752B1 (fr) 1992-11-10 1995-04-14 Rhone Poulenc Rorer Sa Compositions antitumorales contenant des dérivés du taxane.
CH683965A5 (it) * 1993-02-19 1994-06-30 Limad Marketing Exp & Imp Composti della classe dei ftalidrazidici come sostanza attiva in agenti antinfiammatori ed antitossici.
US6537579B1 (en) 1993-02-22 2003-03-25 American Bioscience, Inc. Compositions and methods for administration of pharmacologically active compounds
US5439686A (en) 1993-02-22 1995-08-08 Vivorx Pharmaceuticals, Inc. Methods for in vivo delivery of substantially water insoluble pharmacologically active agents and compositions useful therefor
US6096331A (en) 1993-02-22 2000-08-01 Vivorx Pharmaceuticals, Inc. Methods and compositions useful for administration of chemotherapeutic agents
US6749868B1 (en) 1993-02-22 2004-06-15 American Bioscience, Inc. Protein stabilized pharmacologically active agents, methods for the preparation thereof and methods for the use thereof
US6753006B1 (en) 1993-02-22 2004-06-22 American Bioscience, Inc. Paclitaxel-containing formulations
CN1245156C (zh) 1993-02-22 2006-03-15 美国生物科学有限公司 用于体内传送生物制品的方法及用于该方法的组合物
US5665382A (en) 1993-02-22 1997-09-09 Vivorx Pharmaceuticals, Inc. Methods for the preparation of pharmaceutically active agents for in vivo delivery
US5916596A (en) 1993-02-22 1999-06-29 Vivorx Pharmaceuticals, Inc. Protein stabilized pharmacologically active agents, methods for the preparation thereof and methods for the use thereof
US5840746A (en) 1993-06-24 1998-11-24 Merck Frosst Canada, Inc. Use of inhibitors of cyclooxygenase in the treatment of neurodegenerative diseases
US5523325A (en) 1993-09-09 1996-06-04 Jacobson; Richard M. Amidrazones and their use as pesticides
EP0763014A1 (de) 1994-06-03 1997-03-19 Basf Aktiengesellschaft Carbamoylcarbonsäurehydrazide und ihre verwendung zur bekämpfung von schadpilzen
DE69604298T2 (de) 1995-09-22 2000-05-18 Bioimage A S Soeborg Varianten des grünen fluoreszenzproteins, gfp
US5739686A (en) 1996-04-30 1998-04-14 Naughton; Michael J. Electrically insulating cantilever magnetometer with mutually isolated and integrated thermometry, background elimination and null detection
US6235787B1 (en) 1997-06-30 2001-05-22 Hoffmann-La Roche Inc. Hydrazine derivatives
GB9727524D0 (en) 1997-12-31 1998-02-25 Pharmacia & Upjohn Spa Synergistic antitumor composition containing a biologically active ureido compound
TW479053B (en) 1998-10-19 2002-03-11 Agro Kanesho Co Ltd Hydrazineoxoacetamide derivatives and pesticides
ES2161594B1 (es) 1998-12-17 2003-04-01 Servier Lab Nuevos derivados de la hidrazida, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen.
RU2191015C2 (ru) * 1999-11-05 2002-10-20 Общество с ограниченной ответственностью "Центр бифункциональных иммуномодуляторов" Динатриевая соль n-(6-метил-2,4-диоксо-1,2,3,4-тетрагидро-5h-пиримидинсульфон)-n'- изоникотиноилгидразида, проявляющая антимикробную и иммунотропную активность, и лекарственное средство на ее основе
US6322303B1 (en) 2000-05-12 2001-11-27 David M. John Dunnage bag and method of making same
EP1164126A1 (de) 2000-06-16 2001-12-19 Basf Aktiengesellschaft Salicylsäurehydrazid-Derivate, Verfahren und Zwischenprodukte zu ihrer Herstellung, sie enthaltende Mittel und ihre Verwendung zur Bekämpfung von Schadpilzen
US6365745B1 (en) 2000-07-14 2002-04-02 Sumika Fine Chemicals Co., Ltd. Method for producing hydrazine derivative
JP2004532187A (ja) 2001-01-25 2004-10-21 ギルフォード ファーマシュウティカルズ インコーポレイテッド 三置換カルボサイクリックサイクロフィリン結合化合物とその用途
TWI231211B (en) 2001-05-01 2005-04-21 Abbott Lab Compositions and methods for enhancing the bioavailability of pharmaceutical agents
US20040235813A1 (en) 2001-05-03 2004-11-25 Erich Wanker Compounds that inhibit hsp90 and stimulate hsp70 and hsp40, useful in the prevention or treatment of diseases associated with protein aggregation and amyloid formation
US6602907B1 (en) 2001-06-08 2003-08-05 University Of Central Florida Treatment of breast cancer
TWI297335B (en) * 2001-07-10 2008-06-01 Synta Pharmaceuticals Corp Taxol enhancer compounds
TWI252847B (en) 2001-07-10 2006-04-11 Synta Pharmaceuticals Corp Synthesis of taxol enhancers
US6924312B2 (en) 2001-07-10 2005-08-02 Synta Pharmaceuticals Corp. Taxol enhancer compounds
TWI332943B (en) 2001-07-10 2010-11-11 Synta Pharmaceuticals Corp Taxol enhancer compounds
MY133406A (en) 2001-11-28 2007-11-30 Ipsen Pharma Sas 5-sulphanyl-4h-1,2,4-triazole derivatives and their use as a medicament
TW200408407A (en) 2001-11-30 2004-06-01 Dana Farber Cancer Inst Inc Methods and compositions for modulating the immune system and uses thereof
AU2006228035B2 (en) 2003-01-15 2010-02-18 Synta Pharmaceuticals Corp. Bis (thio-hydrazide amide) compounds for treating multi-drug resistant cancer
TWI330079B (en) 2003-01-15 2010-09-11 Synta Pharmaceuticals Corp Treatment for cancers
KR101166749B1 (ko) 2003-02-11 2012-07-27 베르날리스(캠브리지)리미티드 열쇼크 단백질 저해제로서의 이소옥사졸 화합물
KR100575251B1 (ko) 2003-03-03 2006-05-02 재단법인서울대학교산학협력재단 p38/JTV-1을 유효성분으로 하는 암 치료용 약학적조성물 및 암 치료용 약학적 조성물의 스크리닝 방법
KR100486693B1 (ko) * 2003-03-17 2005-05-03 삼성전자주식회사 금속 매립 방법
EP1493445A1 (en) 2003-07-04 2005-01-05 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Inhibition of stress-induced ligand-dependent EGFR activation
AR045595A1 (es) 2003-09-04 2005-11-02 Vertex Pharma Composiciones utiles como inhibidores de proteinas quinasas
KR100544347B1 (ko) 2003-12-11 2006-01-23 한국생명공학연구원 디아릴이소옥사졸계 화합물을 유효성분으로 함유하는 암 예방 및 치료용 약학적 조성물
BRPI0509172A (pt) 2004-03-26 2007-08-28 Amphora Discovery Corp pelo menos uma entidade quìmica, composição farmacêutica, métodos para tratar um paciente, para inibir pelo menos uma enzima que utiliza atp, e para tratar pelo menos uma doença, uso de pelo menos uma entidade quìmica, e, método para a fabricação de um medicamento
US7011923B2 (en) * 2004-04-07 2006-03-14 International Business Machines Corporation Negative photoresist and method of using thereof
DK1781604T3 (da) * 2004-06-23 2013-09-16 Synta Pharmaceuticals Corp Bis(thio-hydrazid-amid)-salte til behandling af cancere
US20060142393A1 (en) 2004-09-16 2006-06-29 Sherman Matthew L Bis(thio-hydrazide amides) for treatment of hyperplasia
WO2006062732A2 (en) 2004-11-19 2006-06-15 Synta Pharmaceuticals Corp. Compounds acting at the centrosome
EP1827410A2 (en) 2004-11-19 2007-09-05 Synta Pharmaceuticals Corporation Bis(thio-hydrazide amides) for increasing hsp70 expression
AU2006214164B2 (en) 2005-02-17 2010-12-09 Synta Pharmaceuticals Corp. Isoxazole combretastin derivatives for the treatment of disorders
WO2006113493A2 (en) 2005-04-15 2006-10-26 Synta Pharmaceuticals Corp. Methods of determining cancer prognosis via natural killer cell activity
WO2006113695A1 (en) 2005-04-15 2006-10-26 Synta Pharmaceuticals Corp. Combination cancer therapy with bis(thiohydrazide) amide compounds
AU2006236534A1 (en) 2005-04-15 2006-10-26 Synta Pharmaceuticals Corp. Methods of increasing natural killer cell activity for therapy
WO2006124736A2 (en) 2005-05-16 2006-11-23 Synta Pharmaceuticals Corp. Synthesis of bis(thio-hydrazide amide) salts
EP1940375A1 (en) 2005-08-16 2008-07-09 Synta Pharmaceuticals Corporation Bis(thio-hydrazide amide) formulation
EP2034996A2 (en) 2006-05-25 2009-03-18 Synta Pharmaceuticals Corporation Triazole compounds that modulate hsp90 activity
JP2010501564A (ja) 2006-08-21 2010-01-21 シンタ ファーマシューティカルズ コーポレーション 黒色腫を治療するためのビス(チオヒドラジドアミド)
AU2007288334A1 (en) 2006-08-21 2008-02-28 Synta Pharmaceuticals Corp. Combination with bis(thiohydrazide amides) for treating cancer
WO2008024298A1 (en) 2006-08-21 2008-02-28 Synta Pharmaceuticals Corp. Bis(thiohydrazide amides) for inhibiting angiogenesis
BRPI0716435A2 (pt) 2006-08-21 2014-03-04 Synta Pharmaceuticals Corp Compostos para o tratamento de doenças proliferativas
WO2008024301A2 (en) 2006-08-21 2008-02-28 Synta Pharmaceuticals Corp. Bis(thiohydrazide amides) for use in preventing or delaying the recurrence of melanoma
WO2008024302A2 (en) 2006-08-21 2008-02-28 Synta Pharmaceuticals Corp. Compounds for treating proliferative disorders
JP2010502616A (ja) 2006-08-31 2010-01-28 シンタ ファーマシューティカルズ コーポレーション 癌を治療するためのビス(チオヒドラジドアミド)の組み合わせ
AU2007294969A1 (en) 2006-09-11 2008-03-20 Synta Pharmaceuticals Corp. Bis (thiohydrazide amides) formulation
JP2010503674A (ja) 2006-09-14 2010-02-04 シンタ ファーマシューティカルズ コーポレーション 血管形成治療用化合物
TW200829543A (en) 2006-09-15 2008-07-16 Synta Pharmaceuticals Corp Purification of bis(thiohydrazide amides)
US20090093538A1 (en) 2007-01-03 2009-04-09 Synta Pharmaceuticals Corp Method for treating cancer
US8093425B2 (en) 2007-04-30 2012-01-10 Synta Pharmaceuticals Corp. Compounds for treating proliferative disorders
TW200922550A (en) 2007-08-07 2009-06-01 Synta Pharmaceuticals Corp Compounds for treating proliferative disorders
US8618170B2 (en) 2007-11-09 2013-12-31 Synta Pharmaceuticals Corp. Oral formulations of bis(thiohydrazide amides)
US8637704B2 (en) 2007-11-28 2014-01-28 Synta Pharmaceuticals Corp. Polymorphs of N-malonyl-bis(N′-methyl-N′-thiobenzoylhydrazide)
JP5091056B2 (ja) 2008-08-28 2012-12-05 三甲株式会社 密閉容器の蓋部シール構造

Also Published As

Publication number Publication date
US7579503B2 (en) 2009-08-25
DK1781604T3 (da) 2013-09-16
EP1781604A1 (en) 2007-05-09
CA2570698A1 (en) 2006-01-26
WO2006009940A1 (en) 2006-01-26
US7385084B2 (en) 2008-06-10
EP2305642A2 (en) 2011-04-06
RS52999B (en) 2014-02-28
JP2008504264A (ja) 2008-02-14
US8461208B2 (en) 2013-06-11
EP1781604B1 (en) 2013-08-07
CA2570698C (en) 2013-11-19
KR20070029259A (ko) 2007-03-13
CN1993318B (zh) 2012-10-03
RU2007101898A (ru) 2008-07-27
RU2010145056A (ru) 2012-05-20
EP2305642A3 (en) 2011-12-14
BRPI0512526A (pt) 2008-03-11
US8048925B2 (en) 2011-11-01
US20090281172A1 (en) 2009-11-12
RU2406722C2 (ru) 2010-12-20
IL179632A0 (en) 2007-05-15
PT1781604E (pt) 2013-10-15
JP5362986B2 (ja) 2013-12-11
NO20070378L (no) 2007-03-16
AU2005265202A1 (en) 2006-01-26
TWI389684B (zh) 2013-03-21
KR101313027B1 (ko) 2013-10-02
IL179632A (en) 2012-08-30
CN1993318A (zh) 2007-07-04
TW200612895A (en) 2006-05-01
US20080269340A1 (en) 2008-10-30
US7795313B2 (en) 2010-09-14
US20060135595A1 (en) 2006-06-22
US20100324143A1 (en) 2010-12-23
ES2430373T3 (es) 2013-11-20
US20120035266A1 (en) 2012-02-09
NZ552159A (en) 2009-12-24
AU2005265202B2 (en) 2009-07-23
HRP20131023T1 (hr) 2013-12-06
HK1104526A1 (en) 2008-01-18
ME01644B (me) 2014-09-20

Similar Documents

Publication Publication Date Title
HK1104526A1 (en) Bis(thio-hydrazide amide) salts for treatment of cancers
ZA200709395B (en) Synthesis of bis(thio-hydrazide amide) salts
IL188430A0 (en) Treatment of tumors
EP1924318A4 (en) SYNCHRONIZATION OF REPETITIVE THERAPEUTIC INTERVENTIONS
ZA200708703B (en) Combination cancer therapy with bis(thiohydrazide) amide compounds
HK1204476A1 (en) Compounds and methods for treatment of cancer
IL212985A0 (en) Therapeutic uses of inhibitors of rtp801
IL189156A0 (en) Bis(thio-hydrazide amide)formulation
IL188746A0 (en) Treatment of cancer
IL185546A0 (en) N - (n - sulfonylaminomethyl) cyclopropanecarboxamide derivatives useful for the treatment of pain
EP1838330A4 (en) TREATMENT OF SOLID TUMORS
EP2049139A4 (en) TREATMENT OF TUMORS EXPRESSING RAS
EP1968591A4 (en) TREATMENT OF SYNUCLEINOPATHIES
EP1867640A4 (en) MEANS FOR TREATING SOLID TUMORS
GB0520067D0 (en) Treatment of cancer
ZA200610440B (en) Bis(thio-hydrazide amide) salts for treatment of cancers
IL180709A0 (en) Treatment of tumours
ZA200708853B (en) Methods of treatment utilizing certain melatonin derivatives
GB0423273D0 (en) Treatment of cancer
GB0410379D0 (en) Treatment of cancer
ZA200703882B (en) Treatment of tumours
SI1583524T1 (sl) Bis(tio-hidrazid amidne) spojine za zdravljenje raka, ki je rezistenten na vec zdravil
GB0422225D0 (en) Treatment of cancer
IL180460A0 (en) Treatment of cancer
GB0420845D0 (en) Treatment of cancer