PL1697380T3 - Sposób wytwarzania 7-etylo-10-hydroksykamptotecyny - Google Patents

Sposób wytwarzania 7-etylo-10-hydroksykamptotecyny

Info

Publication number
PL1697380T3
PL1697380T3 PL04820383T PL04820383T PL1697380T3 PL 1697380 T3 PL1697380 T3 PL 1697380T3 PL 04820383 T PL04820383 T PL 04820383T PL 04820383 T PL04820383 T PL 04820383T PL 1697380 T3 PL1697380 T3 PL 1697380T3
Authority
PL
Poland
Prior art keywords
ethyl
hydroxycamptothecin
manufacturing
iodosobenzene
formula
Prior art date
Application number
PL04820383T
Other languages
English (en)
Inventor
Petr Dobrovolny
Original Assignee
Pliva Lachema As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pliva Lachema As filed Critical Pliva Lachema As
Publication of PL1697380T3 publication Critical patent/PL1697380T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
PL04820383T 2003-12-16 2004-12-14 Sposób wytwarzania 7-etylo-10-hydroksykamptotecyny PL1697380T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CZ20033442A CZ299593B6 (cs) 2003-12-16 2003-12-16 Zpusob výroby 7-ethyl-10-hydroxykamptothecinu
EP04820383A EP1697380B1 (en) 2003-12-16 2004-12-14 The method of manufacturing of 7-ethyl-10-hydroxycamptothecin
PCT/CZ2004/000085 WO2005058910A1 (en) 2003-12-16 2004-12-14 The method of manufacturing of 7-ethyl-10-hydroxycamptothecin

Publications (1)

Publication Number Publication Date
PL1697380T3 true PL1697380T3 (pl) 2007-10-31

Family

ID=34683186

Family Applications (1)

Application Number Title Priority Date Filing Date
PL04820383T PL1697380T3 (pl) 2003-12-16 2004-12-14 Sposób wytwarzania 7-etylo-10-hydroksykamptotecyny

Country Status (10)

Country Link
US (2) US7544801B2 (pl)
EP (1) EP1697380B1 (pl)
JP (1) JP4856549B2 (pl)
AT (1) ATE362478T1 (pl)
CZ (1) CZ299593B6 (pl)
DE (1) DE602004006533T2 (pl)
ES (1) ES2285573T3 (pl)
HR (1) HRP20070308T3 (pl)
PL (1) PL1697380T3 (pl)
WO (1) WO2005058910A1 (pl)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2523059A1 (en) 2003-05-12 2004-11-25 Scinopharm Taiwan, Ltd. Process for the preparation of 7-alkyl-10-hydroxy-20(s)-camptothecin
CZ299329B6 (cs) 2003-08-26 2008-06-18 Pliva-Lachema A.S. Zpusob výroby 7-ethyl-10-[ 4-(1-piperidino)-1-piperidino]karbonyloxykamptothecinu
CZ299593B6 (cs) 2003-12-16 2008-09-10 Pliva-Lachema A. S. Zpusob výroby 7-ethyl-10-hydroxykamptothecinu
ES2432553T3 (es) 2005-08-03 2013-12-04 Avra Laboratories Pvt. Ltd. Procedimiento de síntesis de intermedios clave para la producción de derivados de camptotecina
EP2881396A1 (en) 2013-12-03 2015-06-10 Synbias Pharma AG Method for the synthesis of irinotecan

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3894029A (en) * 1971-08-26 1975-07-08 Basf Ag Production of camptothecin and camptothecin-like compounds
JPS5198300A (en) * 1975-02-20 1976-08-30 Kanputoteshin oyobi sonoruijitaino seizoho
US4399282A (en) * 1979-07-10 1983-08-16 Kabushiki Kaisha Yakult Honsha Camptothecin derivatives
JPS5682843A (en) 1979-12-08 1981-07-06 Nippon Oil Co Ltd Wax emulsion
US4383431A (en) 1980-11-03 1983-05-17 The Perkin-Elmer Corporation Auto-zero system for pressure transducers
US4399276A (en) * 1981-01-09 1983-08-16 Kabushiki Kaisha Yakult Honsha 7-Substituted camptothecin derivatives
JPS5839685A (ja) * 1981-09-04 1983-03-08 Yakult Honsha Co Ltd 新規なカンプトテシン誘導体及びその製造法
US4473692A (en) 1981-09-04 1984-09-25 Kabushiki Kaisha Yakult Honsha Camptothecin derivatives and process for preparing same
JPS58154582A (ja) 1982-03-10 1983-09-14 Yakult Honsha Co Ltd 新規なカンプトテシン誘導体およびその製造法
JPS595188A (ja) * 1982-06-30 1984-01-12 Yakult Honsha Co Ltd １０−ヒドロキシカンプトテシンの製造法
JPS6019790A (ja) * 1983-07-14 1985-01-31 Yakult Honsha Co Ltd 新規なカンプトテシン誘導体
FR2560442B1 (fr) 1984-02-24 1987-08-07 Thomson Csf Dispositif de commutation et de limitation a ligne a fente, fonctionnant en hyperfrequences
FR2560315B1 (fr) 1984-02-29 1990-05-18 Dba Dispositif de rattrapage automatique de jeu pour embrayage
CA1332413C (en) * 1987-06-25 1994-10-11 Kabushiki Kaisha Yakult Honsha Camptothecin derivatives and process for preparing same
JPH0615547B2 (ja) * 1988-01-20 1994-03-02 株式会社ヤクルト本社 新規なカンプトテシン誘導体
JP2848958B2 (ja) * 1990-09-28 1999-01-20 スミスクライン・ビーチャム・コーポレイション 水溶性カンプトテシン類似体、方法および手段
GB9402934D0 (en) * 1994-02-16 1994-04-06 Erba Carlo Spa Camptothecin derivatives and process for their preparation
US5491237A (en) * 1994-05-03 1996-02-13 Glaxo Wellcome Inc. Intermediates in pharmaceutical camptothecin preparation
JPH0873461A (ja) * 1994-09-06 1996-03-19 Yakult Honsha Co Ltd 新規なカンプトテシン誘導体、その製造法および抗腫瘍剤
IL117684A (en) * 1995-04-07 2002-02-10 Pharmacia & Upjohn Inc Intermediates and Process for Production of History of Kempotocin (CPT-11) and Related Compounds
JP4094710B2 (ja) * 1997-11-06 2008-06-04 株式会社ヤクルト本社 新規なカンプトテシン誘導体
WO2000066125A1 (en) * 1999-04-29 2000-11-09 Aventis Pharma S.A. Method for treating cancer using camptothecin derivatives and 5-fluorouracil
AR027687A1 (es) * 2000-03-22 2003-04-09 Yakult Honsha Kk Procedimiento para preparar camptotecina
TWI245768B (en) * 2001-02-21 2005-12-21 Yakult Honsha Kk Process for synthesizing camptothecin related compound(s)
AU2003207369A1 (en) * 2002-02-18 2003-09-04 Dr. Reddy's Laboratories Limited A process for the preparation of 10-hydroxy-9-n,n-dimethylaminomethyl-5-(2'-fluoroethoxy)-20(s)-camptothecin hydrochloride
CA2523059A1 (en) * 2003-05-12 2004-11-25 Scinopharm Taiwan, Ltd. Process for the preparation of 7-alkyl-10-hydroxy-20(s)-camptothecin
CZ299329B6 (cs) 2003-08-26 2008-06-18 Pliva-Lachema A.S. Zpusob výroby 7-ethyl-10-[ 4-(1-piperidino)-1-piperidino]karbonyloxykamptothecinu
CZ299593B6 (cs) * 2003-12-16 2008-09-10 Pliva-Lachema A. S. Zpusob výroby 7-ethyl-10-hydroxykamptothecinu
US20050272757A1 (en) * 2004-06-04 2005-12-08 Phytogen Life Sciences Inc. Process to prepare camptothecin derivatives and novel intermediate and compounds thereof

Also Published As

Publication number Publication date
JP2007517778A (ja) 2007-07-05
HRP20070308T3 (en) 2007-09-30
DE602004006533D1 (de) 2007-06-28
US20090306387A1 (en) 2009-12-10
US7544801B2 (en) 2009-06-09
WO2005058910A1 (en) 2005-06-30
WO2005058910B1 (en) 2007-02-22
ES2285573T3 (es) 2007-11-16
DE602004006533T2 (de) 2008-01-31
US20070123552A1 (en) 2007-05-31
ATE362478T1 (de) 2007-06-15
CZ20033442A3 (cs) 2005-08-17
JP4856549B2 (ja) 2012-01-18
EP1697380B1 (en) 2007-05-16
EP1697380A1 (en) 2006-09-06
CZ299593B6 (cs) 2008-09-10
US8039626B2 (en) 2011-10-18

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