PL14366B1 - The method of obtaining basic bismuth salts of organic mercury compounds. - Google Patents
The method of obtaining basic bismuth salts of organic mercury compounds. Download PDFInfo
- Publication number
- PL14366B1 PL14366B1 PL14366A PL1436629A PL14366B1 PL 14366 B1 PL14366 B1 PL 14366B1 PL 14366 A PL14366 A PL 14366A PL 1436629 A PL1436629 A PL 1436629A PL 14366 B1 PL14366 B1 PL 14366B1
- Authority
- PL
- Poland
- Prior art keywords
- mercury compounds
- organic mercury
- basic bismuth
- obtaining basic
- salts
- Prior art date
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- 150000002731 mercury compounds Chemical class 0.000 title claims description 5
- 229940100892 mercury compounds Drugs 0.000 title claims description 5
- 150000001621 bismuth Chemical class 0.000 title claims description 4
- QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 claims description 4
- 229910052753 mercury Inorganic materials 0.000 claims description 4
- 239000011780 sodium chloride Substances 0.000 claims description 4
- 150000003839 salts Chemical class 0.000 claims description 3
- 230000002378 acidificating Effects 0.000 claims 1
- 125000005586 carbonic acid group Chemical group 0.000 claims 1
- 239000002253 acid Substances 0.000 description 5
- 238000002360 preparation method Methods 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- ZREIPSZUJIFJNP-UHFFFAOYSA-K Bismuth subsalicylate Chemical compound C1=CC=C2O[Bi](O)OC(=O)C2=C1 ZREIPSZUJIFJNP-UHFFFAOYSA-K 0.000 description 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-N acetic acid Substances CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- PPNKDDZCLDMRHS-UHFFFAOYSA-N dinitrooxybismuthanyl nitrate Chemical compound [Bi+3].[O-][N+]([O-])=O.[O-][N+]([O-])=O.[O-][N+]([O-])=O PPNKDDZCLDMRHS-UHFFFAOYSA-N 0.000 description 2
- OKKJLVBELUTLKV-UHFFFAOYSA-N methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 2
- 159000000000 sodium salts Chemical class 0.000 description 2
- 231100000614 Poison Toxicity 0.000 description 1
- 208000006379 Syphilis Diseases 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 229910052785 arsenic Inorganic materials 0.000 description 1
- CPELXLSAUQHCOX-UHFFFAOYSA-M bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 description 1
- PVEOYINWKBTPIZ-UHFFFAOYSA-N but-3-enoic acid Chemical compound OC(=O)CC=C PVEOYINWKBTPIZ-UHFFFAOYSA-N 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- PEDCQBHIVMGVHV-UHFFFAOYSA-N glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 150000002730 mercury Chemical class 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 230000001264 neutralization Effects 0.000 description 1
- 230000000607 poisoning Effects 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- KEAYESYHFKHZAL-UHFFFAOYSA-N sodium Chemical compound [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 230000001225 therapeutic Effects 0.000 description 1
Description
Stwierdzono, ze organiczne zwiazki rte¬ ciowe, które zawieraja grupy kwasne, a w których rtec nie tworzy polaczenia o cha¬ rakterze soli, daja sie latwo przeprowadzic w zasadowe sole bizmutowe. Zwiazki te o- trzymuje sie zapomoca wymiany rozpu¬ szczalnej soli zwiazków rteciowych z nor¬ malnemu lub zlozonemi solami bizmutowe¬ mu Otrzymane w ten sposób preparaty na¬ daja sie bardzo dobrze do leczenia, np. sy¬ filisu.W przeciwstawieniu do znanych z pa¬ tentu niemieckiego Nr 414191 soli rtecio¬ wych zlozonych kwasów bizmutylowych, o- trzymane wedlug niniejszego sposobu pre¬ paraty wykazuja slabsze wlasnosci truja¬ ce, przy conajmniej takim samym skutku leczniczym. W znanych preparatach rtec jest zwiazana w postaci jonu, podczas gdy w preparatach otrzymanych w mysl wyna¬ lazku jest ona zwiazana organicznie, two¬ rzac polaczenie zlozone, co pociaga za so¬ ba oslabienie dzialania trujacego.Przyklad I. 52,3 g sodowej soli kwa¬ su rteciowosalicylo-alliloamido-o-octowego, otrzymanego wedlug przykladu IV paten¬ tu niemieckiego Nr 423031, rozpuszcza sie w; 150 cm3 wody. Mieszajac energicznie, dodaje sie kroplami roztwór, zawierajacy 48,5 g azotanu bizmutowego, 48,5 g glice¬ ryny i 97 cm3 wody, a nastepnie mieszani¬ ne reakcyjna zobojetnia sie, dodajac 2-n lugu sodowego. Powstala biala zasadowa sól bizmutowa kwasu rteciowo-salicylo-alliloamido-o-octowego odsacza sie, prze¬ mywa wodalvalkdiolemi eterem i suszy w prozni. * -* * * Przyklad IL W ten sam sposób, jak wskazano w przykladzie I, otrzymuje sie zasadowa sól bizmutowa kwasu 4-rteciowo- allilooksy-3-acetyloaminoibenzeno - 1 - arsi- nowego, dzialajac roztworem 48,5 g azota¬ nu bizmutowego na 60 g soli sodowej kwa¬ su 4-rteciowo-allilooksy-3-acetylo-amino- benzeno-i-arsinowego, rozpuszczonego w 180 cm3 wody.Kwas allilo-oksy-acetyloaminobenzeno- arsinowy otrzymuje sie, dzialajac w alka¬ licznym roztworze bromkiem allilowym na kwas 3-acetyloamino-4-oksy-benzeno-7 -ar- sinowy. Kwas ten rozpuszcza sie dobrze w alkoholu metylowym i krystalizuje z wody w postaci bialych igielek. Wprowadzanie rteci odbywa sie tym samym sposobem, jak to produkcie wyjsciowym, wymienionym W przykladzie L PLIt has been found that organic mercury compounds which contain acid groups and in which mercury does not form a salt bond can easily be converted into basic bismuth salts. These compounds are maintained by exchanging the soluble salt of mercury compounds with normal or complex bismuth salts. The preparations obtained in this way are very suitable for the treatment of, for example, syphilis. German Patent No. 414191 of the mercury salts of the complex bismuthic acids, the preparations prepared according to the present process show less poisonous properties with at least the same therapeutic effect. In known preparations, mercury is bound in the form of an ion, while in the preparations obtained in accordance with the invention, it is bound organically, forming a complex connection, which entails a reduction in its poisoning effect. Example I. 52.3 g of sodium salt mercury-salicyl-allylamido-o-acetic acid obtained according to Example IV of German Patent No. 423031 is dissolved in 150 cm3 of water. While stirring vigorously, a solution containing 48.5 g of bismuth nitrate, 48.5 g of glycerin and 97 cm 3 of water is added dropwise, and then the reaction mixture becomes neutral by adding 2-n sodium liquor. The resulting white basic bismuth salt of mercury-salicyl-allylamide-o-acetic acid is filtered off, washed with water-alkydiol and ether and dried in a vacuum. * - * * * Example IL In the same manner as in Example 1, the basic bismuth salt of 4-mercury-allyloxy-3-acetylaminoibenzene-1-arsenic is obtained by treatment with a solution of 48.5 g of bismuth nitrate. per 60 g of sodium salt of 4-mercury-allyloxy-3-acetyl-amino-benzene-i-arsic acid dissolved in 180 cm3 of water. Allyl-oxy-acetylaminobenzene-arsinic acid is obtained by treating in an alkaline solution with bromide allylic acid to 3-acetylamino-4-oxy-benzene-7-aramino acid. This acid dissolves well in methyl alcohol and crystallizes from water in the form of white needles. The introduction of mercury is carried out in the same way as in the starting product mentioned in example L PL
Claims (1)
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL14366B1 true PL14366B1 (en) | 1931-10-31 |
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