PL14367B1 - The method of obtaining a readily soluble salt of 3-acetylamino-4-oxy-benzenarsinic acid. - Google Patents
The method of obtaining a readily soluble salt of 3-acetylamino-4-oxy-benzenarsinic acid. Download PDFInfo
- Publication number
- PL14367B1 PL14367B1 PL14367A PL1436730A PL14367B1 PL 14367 B1 PL14367 B1 PL 14367B1 PL 14367 A PL14367 A PL 14367A PL 1436730 A PL1436730 A PL 1436730A PL 14367 B1 PL14367 B1 PL 14367B1
- Authority
- PL
- Poland
- Prior art keywords
- acid
- oxy
- acetylamino
- benzenarsinic
- obtaining
- Prior art date
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- 239000002253 acid Substances 0.000 title claims description 8
- 150000003839 salts Chemical class 0.000 title claims description 8
- 239000011780 sodium chloride Substances 0.000 title claims description 8
- RTZKZFJDLAIYFH-UHFFFAOYSA-N diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 6
- CSCPPACGZOOCGX-UHFFFAOYSA-N acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 3
- 239000002904 solvent Substances 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- GEHJYWRUCIMESM-UHFFFAOYSA-L Sodium sulfite Chemical compound [Na+].[Na+].[O-]S([O-])=O GEHJYWRUCIMESM-UHFFFAOYSA-L 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 229910017253 AsO Inorganic materials 0.000 description 1
- 208000006379 Syphilis Diseases 0.000 description 1
- 125000001317 arsoryl group Chemical group *[As](*)(*)=O 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 230000000875 corresponding Effects 0.000 description 1
- 235000019621 digestibility Nutrition 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000001737 promoting Effects 0.000 description 1
- 235000010265 sodium sulphite Nutrition 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 230000001131 transforming Effects 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Description
Stwierdzono, ze kwas 3-acetyloamino- 4-oksy-benzenoarsinowy, stosowany przy leczeniu syfilisu, daje z oksyetyloamina do¬ brze krystalizujaca sól, latwo rozpuszcza¬ jaca sie w wodzie i wykazujaca w prze¬ ciwstawieniu do dotychczas znanych soli tego kwasu zalety, polegajace na lepszej przyswajalnosci i wiekszej trwalosci w roz¬ tworze, co posiada bardzo duze znaczenie w praktyce lekarskiej przedewszystkiem przy leczeniu dzieci. Nie jest koniecznem wyosobniac wytworzona sól, mozna ja u- zywac bezposrednio w postaci roztworu, otrzymanego prze2 zmieszanie skladników w wodzie, W celu zwiekszenia trwalosci jest korzystnie dodawac do roztworów male ilosci siarczynu sodowego.Przyklad. 275 g kwasu 3-acetyloami- no-4-oksybenzenoarsinowego zarabia sie 220 om3 wody na papke, zadaje 61 g oksy- etyloaminy i przeplókuje 20 cm3 wody. Po przyspieszeniu przemiany zapomoca ogrze¬ wania, celowo przez ogrzewanie az do tem¬ peratury wrzenia, przez co sprzyja sie roz¬ puszczeniu czesci skladowych, dodaje sie 9 g wegla odbarwiajacego i przesacza.Otrzymany przesacz (350 cm3) zadaje sie 70 cm3 acetonu, a nastepnie dodaje sie do powstalej mieszaniny, mieszajac, 350 cm3 alkoholu. Sól wykrystalizowuje w krótkimczasie. Po odsaczeniu i przemyciu alkoho¬ lem i eterem suszy sie ja w prózni.Otrzymamy zwiazek ó wzorze: OH I _NHCOCHz AsO(OHk • NH,CH%CH9OH przedstawia bialy proszek krystaliczny, latwo rozpuszclzajacy sie w 1,5 — 2 cze¬ sciach wody w temperaturze 35° C i trudno rozpuszczajacy sie w eterze i benzynie.Rozpuszczajac kwas 3-acetyloamino-4- oksy-benzenoansinowy razem z 2 czastecz¬ kami oksyetyloaminy otrzymuje sie odpo¬ wiednia sól dwiu-oksyetyloaminy. PLIt has been found that 3-acetylamino-4-oxy-benzenarsinic acid, used in the treatment of syphilis, gives oxyethylamine a salt that crystallizes well, dissolves easily in water and shows advantages over the previously known salts of this acid, consisting in better digestibility and stability in solution, which is of great importance in medical practice, especially in the treatment of children. It is not necessary to isolate the salt produced, it can be used directly as a solution obtained by mixing the ingredients in water. In order to increase the stability it is preferable to add a small amount of sodium sulphite to the solutions. 275 g of 3-acetylamino-4-oxybenzenarinoic acid is made into a mush with 220 ml of water, treated with 61 g of oxyethylamine and washed with 20 cm3 of water. After accelerating the transformation by heating, by heating it deliberately to the boiling point, thereby promoting the dissolution of the constituents, 9 g of decolorizing carbon and the effluent are added. The resulting effluent (350 cc) is added to 70 cc of acetone, and then 350 cm3 of alcohol are added to the mixture while stirring. The salt crystallizes out in a short time. After filtering off and washing with alcohol and ether, it is dried in a vacuum. We get the compound: OH I NHCOCHz AsO (OHk • NH, CH% CH9OH represents a white crystalline powder, easily dissolving in 1.5-2 parts of water at 35 ° C and difficult to dissolve in ether and gasoline. By dissolving 3-acetylamino-4-oxy-benzenansinic acid together with 2 molecules of oxyethylamine, the corresponding di-oxyethylamine salt is obtained. PL
Claims (4)
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL14367B1 true PL14367B1 (en) | 1931-10-31 |
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