PH27064A - Compounds for the reversal of multidrug resistance of cancer cells against cytotoxic drugs - Google Patents
Compounds for the reversal of multidrug resistance of cancer cells against cytotoxic drugs Download PDFInfo
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- PH27064A PH27064A PH41068A PH41068A PH27064A PH 27064 A PH27064 A PH 27064A PH 41068 A PH41068 A PH 41068A PH 41068 A PH41068 A PH 41068A PH 27064 A PH27064 A PH 27064A
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- Philippines
- Prior art keywords
- toremifene
- doxorubicin
- cells
- reversal
- mdr
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- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- 230000026683 transduction Effects 0.000 description 1
- 238000010361 transduction Methods 0.000 description 1
- ZEWQUBUPAILYHI-UHFFFAOYSA-N trifluoperazine Chemical compound C1CN(C)CCN1CCCN1C2=CC(C(F)(F)F)=CC=C2SC2=CC=CC=C21 ZEWQUBUPAILYHI-UHFFFAOYSA-N 0.000 description 1
- 229960002324 trifluoperazine Drugs 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/05—Phenols
- A61K31/06—Phenols the aromatic ring being substituted by nitro groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/397,551 US4990538A (en) | 1989-08-23 | 1989-08-23 | Use of toremifene and its metabolites for the reversal of multidrug resistance of cancer cells against cytotoxic drugs |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PH27064A true PH27064A (en) | 1993-02-01 |
Family
ID=23571649
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PH41068A PH27064A (en) | 1989-08-23 | 1990-08-23 | Compounds for the reversal of multidrug resistance of cancer cells against cytotoxic drugs |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US4990538A (hu) |
| EP (1) | EP0415623A3 (hu) |
| JP (1) | JP3186759B2 (hu) |
| KR (1) | KR0171893B1 (hu) |
| AU (1) | AU633954B2 (hu) |
| CA (1) | CA2023630C (hu) |
| HU (1) | HU215913B (hu) |
| IE (1) | IE67639B1 (hu) |
| NZ (1) | NZ234999A (hu) |
| PH (1) | PH27064A (hu) |
| ZA (1) | ZA906670B (hu) |
Families Citing this family (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5491173A (en) * | 1982-06-25 | 1996-02-13 | Orion-Yhtyma Oy | Tri-phenyl alkene derivatives and their preparation and use |
| US5114951A (en) * | 1989-04-11 | 1992-05-19 | Burroughs Wellcome Company | Agents for combating multiple drug resistance |
| US5162581A (en) * | 1989-05-29 | 1992-11-10 | Takaru Shuzo Co., Ltd. | Crystalline deoxyspergualin, process for its preparation and suppository containing the same |
| GB8914062D0 (en) * | 1989-06-19 | 1989-08-09 | Wellcome Found | Agents for potentiating the effects of antitumour agents and combating multiple drug resistance |
| GB8914040D0 (en) * | 1989-06-19 | 1989-08-09 | Wellcome Found | Agents for potentiating the effects of antitumour agents and combating multiple drug resistance |
| GB8914060D0 (en) * | 1989-06-19 | 1989-08-09 | Wellcome Found | Agents for potentiating the effects of antitumour agents and combating multiple drug resistance |
| GB8914061D0 (en) * | 1989-06-19 | 1989-08-09 | Wellcome Found | Agents for potentiating the effects of antitumour agents and combating multiple drug resistance |
| US5114919A (en) * | 1990-02-26 | 1992-05-19 | Merck & Co., Inc. | Adjuncts in cancer chemotherapy |
| ITRM910192A1 (it) * | 1990-04-03 | 1991-10-04 | American Cyanamid Co | Metodo per invertire la resistenza a bisantrene mediata da p-glicoproteine. |
| US5811447A (en) * | 1993-01-28 | 1998-09-22 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
| US6515009B1 (en) * | 1991-09-27 | 2003-02-04 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
| KR950700061A (ko) * | 1992-02-06 | 1995-01-16 | 스티븐 엘. 네스비트 | 테트라아릴에틸렌에 의한 다중 약물 내성의 역전(reversal of multi -drug resistance by tetraarylethylenes) |
| GB9207437D0 (en) * | 1992-04-03 | 1992-05-20 | Orion Yhtymae Oy | Topical administration of toremifene and its metabolites |
| US5770609A (en) * | 1993-01-28 | 1998-06-23 | Neorx Corporation | Prevention and treatment of cardiovascular pathologies |
| US6306421B1 (en) | 1992-09-25 | 2001-10-23 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
| US6251920B1 (en) | 1993-05-13 | 2001-06-26 | Neorx Corporation | Prevention and treatment of cardiovascular pathologies |
| US6395494B1 (en) * | 1993-05-13 | 2002-05-28 | Neorx Corporation | Method to determine TGF-β |
| US6093391A (en) * | 1992-10-08 | 2000-07-25 | Supratek Pharma, Inc. | Peptide copolymer compositions |
| US5840319A (en) * | 1992-10-08 | 1998-11-24 | Alakhov; Valery Yu | Biological agent compositions |
| AU5286693A (en) | 1992-10-27 | 1994-05-24 | Nippon Kayaku Kabushiki Kaisha | Use of non steroidal anti estrogens for autoimmune diseases |
| US5886049A (en) | 1992-10-27 | 1999-03-23 | Nippon Kayaku Kabushiki Kaisha | Remedy for autoimmune diseases |
| US5595722A (en) * | 1993-01-28 | 1997-01-21 | Neorx Corporation | Method for identifying an agent which increases TGF-beta levels |
| US5981568A (en) | 1993-01-28 | 1999-11-09 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
| US6491938B2 (en) | 1993-05-13 | 2002-12-10 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
| US6663881B2 (en) | 1993-01-28 | 2003-12-16 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
| US6197789B1 (en) | 1995-06-07 | 2001-03-06 | Neorx Corporation | Prevention and treatment of cardiovascular pathologies with tamoxifen analogues |
| DE69435137D1 (de) * | 1993-05-13 | 2008-10-16 | Poniard Pharmaceuticals Inc | Prävention und behandlung von pathologien, die mit einer abnormalen proliferationglatter muskelzellen verbunden sind |
| US5504074A (en) * | 1993-08-06 | 1996-04-02 | Children's Medical Center Corporation | Estrogenic compounds as anti-angiogenic agents |
| US5436243A (en) * | 1993-11-17 | 1995-07-25 | Research Triangle Institute Duke University | Aminoanthraquinone derivatives to combat multidrug resistance |
| US5432168A (en) * | 1993-12-27 | 1995-07-11 | University Of Manitoba | Method of treatment of hormone-unresponsive metastatic prostate cancer |
| US5650425A (en) * | 1994-04-04 | 1997-07-22 | Pharmos Corporation | Permanently ionic derivatives of steroid hormones and their antagonists |
| US5571687A (en) * | 1994-06-07 | 1996-11-05 | Duke University | Modulators of multidrug resistance transporters |
| US20030083733A1 (en) * | 1997-10-10 | 2003-05-01 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
| US20020091433A1 (en) * | 1995-04-19 | 2002-07-11 | Ni Ding | Drug release coated stent |
| US5837313A (en) * | 1995-04-19 | 1998-11-17 | Schneider (Usa) Inc | Drug release stent coating process |
| US6099562A (en) * | 1996-06-13 | 2000-08-08 | Schneider (Usa) Inc. | Drug coating with topcoat |
| US5767113A (en) * | 1995-05-10 | 1998-06-16 | The Salk Institute For Biological Studies | Compounds useful for concurrently activating glucocorticoid-induced response and reducing multidrug resistance |
| WO1998046588A2 (en) | 1997-04-11 | 1998-10-22 | Neorx Corporation | Compounds and therapies for the prevention of vascular and non-vascular pathologies |
| US20040092602A1 (en) * | 1998-05-07 | 2004-05-13 | Steiner Mitchell S. | Method for treatment and chemoprevention of prostate cancer |
| US6413533B1 (en) | 1998-05-07 | 2002-07-02 | The University Of Tennessee Research Corporation | Method for chemoprevention of prostate cancer |
| US6413535B1 (en) | 1998-05-07 | 2002-07-02 | The University Of Tennessee Research Corporation | Method for chemoprevention of prostate cancer |
| US20030130316A1 (en) * | 2000-03-20 | 2003-07-10 | Steiner Mitchell S. | Method for chemoprevention of prostate cancer |
| US20040186185A1 (en) * | 1998-05-07 | 2004-09-23 | Steiner Mitchell S. | Method for treatment and chemoprevention of prostate cancer |
| US6632447B1 (en) | 1998-05-07 | 2003-10-14 | The University Of Tennessee Research Corporation | Method for chemoprevention of prostate cancer |
| DE1003496T1 (de) * | 1998-05-07 | 2000-11-02 | Univ Tennessee Res Corp | Methode zur Vorbeugung von Prostatakrebs |
| AU1180900A (en) * | 1998-11-26 | 2000-06-13 | Teikoku Hormone Mfg. Co., Ltd. | Medicinal compositions for periodic administration |
| US6613083B2 (en) * | 2001-05-02 | 2003-09-02 | Eckhard Alt | Stent device and method |
| US20080249183A1 (en) * | 2001-11-29 | 2008-10-09 | Steiner Mitchell S | Treatment of androgen-deprivation induced osteoporosis |
| US20060270641A1 (en) * | 2005-05-31 | 2006-11-30 | Steiner Mitchell S | Method for chemoprevention of prostate cancer |
| CA2933579A1 (en) | 2013-12-11 | 2015-06-18 | University Of Massachusetts | Compositions and methods for treating disease using salmonella t3ss effector protein (sipa) |
| CA2971216A1 (en) | 2014-12-23 | 2016-06-30 | The Regents Of The University Of California | Methods for immunomodulation of cancer and infectious disease therapy |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0195015B1 (en) * | 1984-08-02 | 1992-05-13 | LABRIE, Fernand | Pharmaceutical composition for combination therapy of hormone dependent cancers |
-
1989
- 1989-08-23 US US07/397,551 patent/US4990538A/en not_active Expired - Lifetime
-
1990
- 1990-08-20 CA CA002023630A patent/CA2023630C/en not_active Expired - Lifetime
- 1990-08-20 AU AU61133/90A patent/AU633954B2/en not_active Ceased
- 1990-08-21 JP JP22092690A patent/JP3186759B2/ja not_active Expired - Fee Related
- 1990-08-21 NZ NZ234999A patent/NZ234999A/en unknown
- 1990-08-21 EP EP19900309119 patent/EP0415623A3/en not_active Withdrawn
- 1990-08-22 ZA ZA906670A patent/ZA906670B/xx unknown
- 1990-08-22 KR KR1019900012981A patent/KR0171893B1/ko not_active IP Right Cessation
- 1990-08-22 HU HU905276A patent/HU215913B/hu not_active IP Right Cessation
- 1990-08-22 IE IE304490A patent/IE67639B1/en not_active IP Right Cessation
- 1990-08-23 PH PH41068A patent/PH27064A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IE67639B1 (en) | 1996-04-17 |
| NZ234999A (en) | 1997-06-24 |
| US4990538A (en) | 1991-02-05 |
| KR910004185A (ko) | 1991-03-28 |
| AU6113390A (en) | 1991-02-28 |
| KR0171893B1 (ko) | 1999-02-01 |
| EP0415623A3 (en) | 1991-04-03 |
| AU633954B2 (en) | 1993-02-11 |
| JP3186759B2 (ja) | 2001-07-11 |
| JPH03163015A (ja) | 1991-07-15 |
| CA2023630A1 (en) | 1991-02-24 |
| CA2023630C (en) | 2002-02-19 |
| EP0415623A2 (en) | 1991-03-06 |
| HUT58511A (en) | 1992-03-30 |
| IE903044A1 (en) | 1991-02-27 |
| HU215913B (hu) | 1999-03-29 |
| ZA906670B (en) | 1991-06-26 |
| HU905276D0 (en) | 1991-02-28 |
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