KR910004185A - 세포독소 약제에 대항하는 암세포의 다약제 내성의 역전을 위한 화합물 및 그 사용 - Google Patents

세포독소 약제에 대항하는 암세포의 다약제 내성의 역전을 위한 화합물 및 그 사용 Download PDF

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KR910004185A
KR910004185A KR1019900012981A KR900012981A KR910004185A KR 910004185 A KR910004185 A KR 910004185A KR 1019900012981 A KR1019900012981 A KR 1019900012981A KR 900012981 A KR900012981 A KR 900012981A KR 910004185 A KR910004185 A KR 910004185A
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cytotoxin
compound
toremifene
compounds
cancer cells
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KR1019900012981A
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KR0171893B1 (ko
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르웰린 해리스 아드리안
베이꼬 맛티 캉가스 로오리
윌리엄 드그레고리오 마이클
Original Assignee
르웰린 해리스 아드리안
베이꼬 맛티 캉가스 로오리
윌리엄 드그레고리오 마이클
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A61K31/06—Phenols the aromatic ring being substituted by nitro groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

내용 없음.

Description

세포독소 약제에 대항하는 암세포의 다약제 내성의 역전을 위한 화합물 및 그 사용
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 24시간 노출후 CHO-k1() 및 CHO-Adr() 세포계 내에서 토레미펜의 농도 증가의 효과를 나타낸 그래프이다. (닫힌 기호는 AAG(2㎎/㎖)의 부재를 나타내고, 열린 기호는 AAG의 존재를 나타낸다.)

Claims (11)

  1. 적어도 하나의 세포독소 화합물을 사용한 암치료에 있어서, 상기 세포독소 화합물에 대한 암세포의 다약제 내성의 역전을 위한 토레미펜, N-데메틸토레미펜, 4-히드록시 토레미펜 또는 이들의 제약학적으로 허용가능한 비-독성 염의 사용.
  2. 제1항에 있어서, 토레미펜의 사용.
  3. 제1항 또는 제2항에 있어서, 세포독소 화합물이 알킬화제, 항핵분열제, 항대사물, 플라티늄 화합물 또는 항생제인 사용.
  4. 제3항에 있어서, 항생제가 안트라시클린 항생물질인 사용.
  5. 제4항에 있어서, 안트라시클린항생물질이 독소루비신인 사용.
  6. (a) 토레미펜. N-데메틸-토레미펜, 4-히드록시토레미펜 또는 이들의 제약학적으로 허용가능한 비-독성염. (b) (a) 이외의 세포독소 화합물 및, (c) 제약학적으로 허용가능한 담체 또는 희석제로 구성된 제약학적 상승 조성물.
  7. 제6항에 있어서, (b)가 제3항 또는 제4항에서 정의된 바와같은 세포독소화합물인 조성물.
  8. 제6항에 있어서, (b)가 독소루비신인 화합물.
  9. 암치료에 있어서 동시적, 별도의 또는 연속적 사용을 위해 조합된 제제로서, (a)토레미펜, N-데메틸토레미펜 또는 4-히드록시 토레미펜 또는 이들의 제약학적으로 허용가능한 비-독성 염, 및 (b) (a) 이외의 세포독소 화합물을 함유한 생성물.
  10. 제9항에 있어서, (b)가 제3항 또는 제4항에서 정의된 바와 같은 세포독소화합물인 생성물.
  11. 제10항에 있어서, (b)가 독소루비신인 생성물.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019900012981A 1989-08-23 1990-08-22 세포장해성 약물에 대항하는 암세포의 다약제 내성의 역전을 위한 화합물 및 그를 포함하는 제약학적 조성물 KR0171893B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US397551 1989-08-23
US07/397,551 US4990538A (en) 1989-08-23 1989-08-23 Use of toremifene and its metabolites for the reversal of multidrug resistance of cancer cells against cytotoxic drugs

Publications (2)

Publication Number Publication Date
KR910004185A true KR910004185A (ko) 1991-03-28
KR0171893B1 KR0171893B1 (ko) 1999-02-01

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KR1019900012981A KR0171893B1 (ko) 1989-08-23 1990-08-22 세포장해성 약물에 대항하는 암세포의 다약제 내성의 역전을 위한 화합물 및 그를 포함하는 제약학적 조성물

Country Status (11)

Country Link
US (1) US4990538A (ko)
EP (1) EP0415623A3 (ko)
JP (1) JP3186759B2 (ko)
KR (1) KR0171893B1 (ko)
AU (1) AU633954B2 (ko)
CA (1) CA2023630C (ko)
HU (1) HU215913B (ko)
IE (1) IE67639B1 (ko)
NZ (1) NZ234999A (ko)
PH (1) PH27064A (ko)
ZA (1) ZA906670B (ko)

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HU905276D0 (en) 1991-02-28
EP0415623A2 (en) 1991-03-06
ZA906670B (en) 1991-06-26
AU633954B2 (en) 1993-02-11
JP3186759B2 (ja) 2001-07-11
HUT58511A (en) 1992-03-30
IE67639B1 (en) 1996-04-17
CA2023630A1 (en) 1991-02-24
US4990538A (en) 1991-02-05
KR0171893B1 (ko) 1999-02-01
HU215913B (hu) 1999-03-29
EP0415623A3 (en) 1991-04-03
AU6113390A (en) 1991-02-28
IE903044A1 (en) 1991-02-27
NZ234999A (en) 1997-06-24
CA2023630C (en) 2002-02-19
PH27064A (en) 1993-02-01
JPH03163015A (ja) 1991-07-15

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