PH26816A - Diol-containing renin inhibitors - Google Patents

Diol-containing renin inhibitors Download PDF

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Publication number
PH26816A
PH26816A PH38698A PH38698A PH26816A PH 26816 A PH26816 A PH 26816A PH 38698 A PH38698 A PH 38698A PH 38698 A PH38698 A PH 38698A PH 26816 A PH26816 A PH 26816A
Authority
PH
Philippines
Prior art keywords
nhch
cad
phe
mmole
lower alkyl
Prior art date
Application number
PH38698A
Other languages
English (en)
Inventor
Richard Himmelsbach
John Cooke Hodges
James Stanley Kaltenbronn
Joseph Thomas Repine
Ila Sircar
William Chester Patt
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Priority to PH40714A priority Critical patent/PH27036A/en
Publication of PH26816A publication Critical patent/PH26816A/en

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04Linear peptides containing only normal peptide links
    • C07K7/06Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/38Drugs for disorders of the endocrine system of the suprarenal hormones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06Dipeptides
    • C07K5/06008Dipeptides with the first amino acid being neutral
    • C07K5/06078Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrrole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
PH38698A 1988-05-27 1989-05-25 Diol-containing renin inhibitors PH26816A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PH40714A PH27036A (en) 1988-05-27 1990-06-21 Process for the preparation of diol containing renin inhibitors

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US19999088A 1988-05-27 1988-05-27
US07/321,638 US5036053A (en) 1988-05-27 1989-03-15 Diol-containing renin inhibitors

Publications (1)

Publication Number Publication Date
PH26816A true PH26816A (en) 1992-11-05

Family

ID=26895354

Family Applications (1)

Application Number Title Priority Date Filing Date
PH38698A PH26816A (en) 1988-05-27 1989-05-25 Diol-containing renin inhibitors

Country Status (11)

Country Link
US (1) US5036053A (ja)
EP (1) EP0343654A3 (ja)
JP (1) JPH0267297A (ja)
KR (1) KR900018137A (ja)
AU (1) AU625456B2 (ja)
DK (1) DK258589A (ja)
FI (1) FI892521A (ja)
NO (1) NO892136L (ja)
NZ (1) NZ229281A (ja)
PH (1) PH26816A (ja)
PT (1) PT90659B (ja)

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US5227401A (en) * 1991-10-29 1993-07-13 G. D. Searle & Co. Ethynyl alanine amino diol compounds for treatment of hypertension
JP3208142B2 (ja) * 1992-02-13 2001-09-10 ワーナー−ランバート・コンパニー キラルなエチル(5−アミノ−1,2−ジヒドロ−2−メチル−3−フェニルピリド〔3,4−b〕ピラジン−7−イル)カーバメートの調製方法
US5972990A (en) * 1992-04-10 1999-10-26 Brigham And Women's Hospital, Inc. Methods for reducing risk of repeat myocardial infarction and increasing survival in heart attack victims
US5298505A (en) * 1992-08-14 1994-03-29 G. D. Searle & Co. Ethynyl alanine amino diol compounds having a piperazinyl-terminated group or a piperazinyl-alkylamino-terminated group for treatment of hypertension
US5373017A (en) * 1992-08-14 1994-12-13 G. D. Searle & Co. Imidazolyl/benzimidazolyl-terminated alkylamino ethynyl alanine amino diol compounds for treatment of hypertension
US5252591A (en) 1992-08-14 1993-10-12 G. D. Searle & Company Pyridinyl-terminated alkylamino ethynyl alanine amino diol compounds for treatment of hypertension
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US6410746B1 (en) * 1999-04-27 2002-06-25 Research Foundation Of State University Of New York, The Metal cataltsts and methods for making and using same
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AU2004315596B2 (en) 2003-08-29 2011-11-24 President And Fellows Of Harvard College Inhibitors of cellular necrosis
ATE546734T1 (de) 2003-12-05 2012-03-15 Cleveland Clinic Foundation Risikomarker für eine herzkreislaufkrankheit
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Also Published As

Publication number Publication date
DK258589A (da) 1989-11-28
AU625456B2 (en) 1992-07-09
FI892521A (fi) 1989-11-28
EP0343654A2 (en) 1989-11-29
FI892521A0 (fi) 1989-05-24
PT90659A (pt) 1989-11-30
US5036053A (en) 1991-07-30
JPH0267297A (ja) 1990-03-07
EP0343654A3 (en) 1991-05-29
DK258589D0 (da) 1989-05-26
NO892136D0 (no) 1989-05-26
AU3463389A (en) 1989-11-30
NO892136L (no) 1989-11-28
KR900018137A (ko) 1990-12-20
NZ229281A (en) 1991-11-26
PT90659B (pt) 1994-10-31

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