PH26317A - Modified release gemfibrozil composition - Google Patents
Modified release gemfibrozil composition Download PDFInfo
- Publication number
- PH26317A PH26317A PH39966A PH39966A PH26317A PH 26317 A PH26317 A PH 26317A PH 39966 A PH39966 A PH 39966A PH 39966 A PH39966 A PH 39966A PH 26317 A PH26317 A PH 26317A
- Authority
- PH
- Philippines
- Prior art keywords
- gemfibrozil
- granulation
- cellulose
- ing
- accord
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 39
- HEMJJKBWTPKOJG-UHFFFAOYSA-N Gemfibrozil Chemical compound CC1=CC=C(C)C(OCCCC(C)(C)C(O)=O)=C1 HEMJJKBWTPKOJG-UHFFFAOYSA-N 0.000 title claims abstract description 31
- 229960003627 gemfibrozil Drugs 0.000 title claims abstract description 30
- 238000005469 granulation Methods 0.000 claims abstract description 42
- 230000003179 granulation Effects 0.000 claims abstract description 42
- 238000009472 formulation Methods 0.000 claims abstract description 21
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 17
- 229920001577 copolymer Polymers 0.000 claims abstract description 14
- 239000000546 pharmaceutical excipient Substances 0.000 claims abstract description 11
- 239000001913 cellulose Substances 0.000 claims abstract description 10
- 229920002678 cellulose Polymers 0.000 claims abstract description 9
- 229920000642 polymer Polymers 0.000 claims abstract description 9
- 239000002245 particle Substances 0.000 claims abstract description 8
- 238000013268 sustained release Methods 0.000 claims abstract description 8
- 239000012730 sustained-release form Substances 0.000 claims abstract description 8
- 230000036961 partial effect Effects 0.000 claims abstract description 7
- 210000002784 stomach Anatomy 0.000 claims abstract description 7
- 230000000694 effects Effects 0.000 claims abstract description 5
- 239000012729 immediate-release (IR) formulation Substances 0.000 claims abstract description 4
- 235000010980 cellulose Nutrition 0.000 claims description 9
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims description 8
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims description 7
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims description 7
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims description 7
- 239000008108 microcrystalline cellulose Substances 0.000 claims description 7
- 229940016286 microcrystalline cellulose Drugs 0.000 claims description 7
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims description 7
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims description 6
- 229940048053 acrylate Drugs 0.000 claims description 6
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims description 6
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims description 6
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims description 6
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 6
- JIGUQPWFLRLWPJ-UHFFFAOYSA-N Ethyl acrylate Chemical compound CCOC(=O)C=C JIGUQPWFLRLWPJ-UHFFFAOYSA-N 0.000 claims description 4
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 claims description 4
- 239000004354 Hydroxyethyl cellulose Substances 0.000 claims description 4
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 4
- 229920013821 hydroxy alkyl cellulose Polymers 0.000 claims description 4
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 claims description 4
- PNJWIWWMYCMZRO-UHFFFAOYSA-N pent‐4‐en‐2‐one Natural products CC(=O)CC=C PNJWIWWMYCMZRO-UHFFFAOYSA-N 0.000 claims description 4
- 239000011734 sodium Substances 0.000 claims description 4
- 229910052708 sodium Inorganic materials 0.000 claims description 4
- BAPJBEWLBFYGME-UHFFFAOYSA-N acrylic acid methyl ester Natural products COC(=O)C=C BAPJBEWLBFYGME-UHFFFAOYSA-N 0.000 claims description 3
- SUPCQIBBMFXVTL-UHFFFAOYSA-N ethyl 2-methylprop-2-enoate Chemical compound CCOC(=O)C(C)=C SUPCQIBBMFXVTL-UHFFFAOYSA-N 0.000 claims description 3
- 235000015424 sodium Nutrition 0.000 claims description 2
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 description 6
- 239000000306 component Substances 0.000 description 6
- 239000004615 ingredient Substances 0.000 description 5
- 239000001856 Ethyl cellulose Substances 0.000 description 4
- 239000011248 coating agent Substances 0.000 description 4
- 238000000576 coating method Methods 0.000 description 4
- 235000019325 ethyl cellulose Nutrition 0.000 description 4
- 229920001249 ethyl cellulose Polymers 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- 229920001223 polyethylene glycol Polymers 0.000 description 4
- 229920003134 Eudragit® polymer Polymers 0.000 description 3
- VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 description 3
- 239000002202 Polyethylene glycol Substances 0.000 description 3
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 239000006185 dispersion Substances 0.000 description 3
- 230000003628 erosive effect Effects 0.000 description 3
- 239000011159 matrix material Substances 0.000 description 3
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 description 3
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 3
- 229940068968 polysorbate 80 Drugs 0.000 description 3
- 229920000053 polysorbate 80 Polymers 0.000 description 3
- 102220289725 rs778831047 Human genes 0.000 description 3
- 239000000454 talc Substances 0.000 description 3
- 229910052623 talc Inorganic materials 0.000 description 3
- 235000012222 talc Nutrition 0.000 description 3
- OVBFMEVBMNZIBR-UHFFFAOYSA-N -2-Methylpentanoic acid Natural products CCCC(C)C(O)=O OVBFMEVBMNZIBR-UHFFFAOYSA-N 0.000 description 2
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 2
- 229920006243 acrylic copolymer Polymers 0.000 description 2
- CJZGTCYPCWQAJB-UHFFFAOYSA-L calcium stearate Chemical compound [Ca+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CJZGTCYPCWQAJB-UHFFFAOYSA-L 0.000 description 2
- 239000008116 calcium stearate Substances 0.000 description 2
- 235000013539 calcium stearate Nutrition 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 229940071826 hydroxyethyl cellulose Drugs 0.000 description 2
- 239000000314 lubricant Substances 0.000 description 2
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
- 239000004014 plasticizer Substances 0.000 description 2
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 2
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 2
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 239000008213 purified water Substances 0.000 description 2
- 235000000346 sugar Nutrition 0.000 description 2
- LGJMUZUPVCAVPU-ANOYILKDSA-N (3s,8r,9s,10s,13r,14s,17r)-17-[(2r,5s)-5-ethyl-6-methylheptan-2-yl]-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-3-ol Chemical class C1CC2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CC[C@H](CC)C(C)C)[C@@]1(C)CC2 LGJMUZUPVCAVPU-ANOYILKDSA-N 0.000 description 1
- 239000005995 Aluminium silicate Substances 0.000 description 1
- 229920002785 Croscarmellose sodium Polymers 0.000 description 1
- 208000035150 Hypercholesterolemia Diseases 0.000 description 1
- HEFNNWSXXWATRW-UHFFFAOYSA-N Ibuprofen Chemical compound CC(C)CC1=CC=C(C(C)C(O)=O)C=C1 HEFNNWSXXWATRW-UHFFFAOYSA-N 0.000 description 1
- 239000006057 Non-nutritive feed additive Substances 0.000 description 1
- 229920002845 Poly(methacrylic acid) Polymers 0.000 description 1
- 235000021355 Stearic acid Nutrition 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 239000000783 alginic acid Substances 0.000 description 1
- 235000010443 alginic acid Nutrition 0.000 description 1
- 229920000615 alginic acid Polymers 0.000 description 1
- 229960001126 alginic acid Drugs 0.000 description 1
- 150000004781 alginic acids Chemical class 0.000 description 1
- 235000012211 aluminium silicate Nutrition 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- 229940111131 antiinflammatory and antirheumatic product propionic acid derivative Drugs 0.000 description 1
- 239000003613 bile acid Substances 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 229910000019 calcium carbonate Inorganic materials 0.000 description 1
- 235000010216 calcium carbonate Nutrition 0.000 description 1
- 229940106135 cellulose Drugs 0.000 description 1
- 229920002301 cellulose acetate Polymers 0.000 description 1
- 229940075614 colloidal silicon dioxide Drugs 0.000 description 1
- 229940000425 combination drug Drugs 0.000 description 1
- 230000002301 combined effect Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000013270 controlled release Methods 0.000 description 1
- 229960001681 croscarmellose sodium Drugs 0.000 description 1
- 235000010947 crosslinked sodium carboxy methyl cellulose Nutrition 0.000 description 1
- GXGAKHNRMVGRPK-UHFFFAOYSA-N dimagnesium;dioxido-bis[[oxido(oxo)silyl]oxy]silane Chemical compound [Mg+2].[Mg+2].[O-][Si](=O)O[Si]([O-])([O-])O[Si]([O-])=O GXGAKHNRMVGRPK-UHFFFAOYSA-N 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 210000004051 gastric juice Anatomy 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 229960001680 ibuprofen Drugs 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000006194 liquid suspension Substances 0.000 description 1
- 239000000391 magnesium silicate Substances 0.000 description 1
- 235000019359 magnesium stearate Nutrition 0.000 description 1
- 235000019793 magnesium trisilicate Nutrition 0.000 description 1
- 229940099273 magnesium trisilicate Drugs 0.000 description 1
- 229910000386 magnesium trisilicate Inorganic materials 0.000 description 1
- 125000005395 methacrylic acid group Chemical group 0.000 description 1
- 229920003146 methacrylic ester copolymer Polymers 0.000 description 1
- MYWUZJCMWCOHBA-VIFPVBQESA-N methamphetamine Chemical compound CN[C@@H](C)CC1=CC=CC=C1 MYWUZJCMWCOHBA-VIFPVBQESA-N 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 229920000058 polyacrylate Polymers 0.000 description 1
- 229920000447 polyanionic polymer Polymers 0.000 description 1
- 150000005599 propionic acid derivatives Chemical class 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 235000012239 silicon dioxide Nutrition 0.000 description 1
- 235000015500 sitosterol Nutrition 0.000 description 1
- 229940083492 sitosterols Drugs 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 239000003784 tall oil Substances 0.000 description 1
- 210000002438 upper gastrointestinal tract Anatomy 0.000 description 1
- 229920003176 water-insoluble polymer Polymers 0.000 description 1
- 238000005550 wet granulation Methods 0.000 description 1
- XOOUIPVCVHRTMJ-UHFFFAOYSA-L zinc stearate Chemical compound [Zn+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O XOOUIPVCVHRTMJ-UHFFFAOYSA-L 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
- A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Saccharide Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Hydrogenated Pyridines (AREA)
- Dental Preparations (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/305,082 US4927639A (en) | 1989-02-02 | 1989-02-02 | Modified release gemfibrozil composition |
Publications (1)
Publication Number | Publication Date |
---|---|
PH26317A true PH26317A (en) | 1992-04-29 |
Family
ID=23179253
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PH39966A PH26317A (en) | 1989-02-02 | 1990-01-30 | Modified release gemfibrozil composition |
Country Status (21)
Country | Link |
---|---|
US (1) | US4927639A (xx) |
EP (1) | EP0381219B1 (xx) |
JP (1) | JPH02240017A (xx) |
KR (1) | KR0137268B1 (xx) |
CN (1) | CN1053744A (xx) |
AT (1) | ATE88889T1 (xx) |
AU (1) | AU622751B2 (xx) |
CA (1) | CA2009135A1 (xx) |
DE (1) | DE69001488T2 (xx) |
DK (1) | DK0381219T3 (xx) |
ES (1) | ES2055177T3 (xx) |
FI (1) | FI900491A0 (xx) |
HU (1) | HU204192B (xx) |
IE (1) | IE900371L (xx) |
IL (1) | IL92994A (xx) |
MY (1) | MY104898A (xx) |
NO (1) | NO900484L (xx) |
NZ (1) | NZ232321A (xx) |
PH (1) | PH26317A (xx) |
PT (1) | PT93029A (xx) |
ZA (1) | ZA90776B (xx) |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5331756A (en) * | 1988-05-04 | 1994-07-26 | Rehrig International, Inc. | Basket wall with placard display assembly |
EP0462066A1 (en) * | 1990-06-15 | 1991-12-18 | Warner-Lambert Company | Amorphous gemfibrozil |
EP0462067A1 (en) * | 1990-06-15 | 1991-12-18 | Warner-Lambert Company | Gemfibrozil formulations |
EP0475894A1 (en) * | 1990-08-27 | 1992-03-18 | Warner-Lambert Company | Gemfibrozil formulations |
US5102668A (en) * | 1990-10-05 | 1992-04-07 | Kingaform Technology, Inc. | Sustained release pharmaceutical preparation using diffusion barriers whose permeabilities change in response to changing pH |
FR2671970B1 (fr) * | 1991-01-30 | 1995-06-23 | Wellcome Found | Comprimes dispersables dans l'eau. |
US5629016A (en) * | 1991-01-30 | 1997-05-13 | Glaxo Wellcome Inc. | Water-dispersible tablets |
US5492700A (en) * | 1991-11-26 | 1996-02-20 | Warner-Lambert Company | Process and composition for the development of controlled release gemfibrozil dosage form |
US5358723A (en) * | 1991-11-26 | 1994-10-25 | Warner-Lambert Company | Process and composition for the development of controlled release gemfibrozil dosage form |
WO1993010775A1 (en) * | 1991-11-26 | 1993-06-10 | Warner-Lambert Company | Process and composition for the development of controlled release gemfibrozil dosage form |
GB9215908D0 (en) * | 1992-07-27 | 1992-09-09 | Wellcome Found | Water dispersible tablets |
US5698226A (en) * | 1993-07-13 | 1997-12-16 | Glaxo Wellcome Inc. | Water-dispersible tablets |
DE4333190C2 (de) * | 1993-09-29 | 1996-05-30 | Korsatko Werner Univ Prof Dr E | Zerbeißtablette mit verzögerter Wirkstoff-Freisetzung |
US5451409A (en) * | 1993-11-22 | 1995-09-19 | Rencher; William F. | Sustained release matrix system using hydroxyethyl cellulose and hydroxypropyl cellulose polymer blends |
US6103262A (en) * | 1994-01-27 | 2000-08-15 | G. D. Searle & Company | Modified-release metronidazole compositions and methods for making and using same |
HU212428B (en) * | 1994-05-13 | 1996-06-28 | Egyt Gyogyszervegyeszeti Gyar | Process to prepare pharmaceutical compositions containing gemfibrozyl |
ATE321529T1 (de) * | 1996-09-30 | 2006-04-15 | Alza Corp | Dosierungsform für eine verzögerte und zunehmende wirkstoffsfreisetzung |
EP1690531A3 (en) * | 1996-09-30 | 2010-01-20 | Alza Corporation | Dosage form and method for administering drug |
US6919373B1 (en) | 1996-11-12 | 2005-07-19 | Alza Corporation | Methods and devices for providing prolonged drug therapy |
FR2758459B1 (fr) * | 1997-01-17 | 1999-05-07 | Pharma Pass | Composition pharmaceutique de fenofibrate presentant une biodisponibilite elevee et son procede de preparation |
US6814977B1 (en) | 1998-12-18 | 2004-11-09 | Abbott Laboratories | Formulations comprising lipid-regulating agents |
US6838091B2 (en) | 1998-12-18 | 2005-01-04 | Abbott Laboratories | Formulations comprising lipid-regulating agents |
US7014864B1 (en) | 1998-12-18 | 2006-03-21 | Abbott Laboratories | Formulations comprising lipid-regulating agents |
US6719999B2 (en) | 1999-03-31 | 2004-04-13 | Abbott Laboratories | Formulations comprising lipid-regulating agents |
US6465011B2 (en) | 1999-05-29 | 2002-10-15 | Abbott Laboratories | Formulations comprising lipid-regulating agents |
US6372251B2 (en) | 1999-06-11 | 2002-04-16 | Abbott Laboratories | Formulations comprising lipid-regulating agents |
TW200404544A (en) * | 2002-06-17 | 2004-04-01 | Kowa Co | Controlled release pharmaceutical composition |
US20050265955A1 (en) * | 2004-05-28 | 2005-12-01 | Mallinckrodt Inc. | Sustained release preparations |
PL1753398T3 (pl) * | 2004-06-10 | 2019-04-30 | Glatt Air Techniques Inc | Macierz o kontrolowanym uwalnianiu farmaceutycznej formulacji dawkowania |
FI125478B (fi) * | 2010-03-30 | 2015-10-30 | Pertti Neuvonen | Farmaseuttinen koostumus, joka sisältää gemfibrotsiiliä ja CYP2C8- ja/tai OATP-substraattilääkettä |
WO2016048826A1 (en) * | 2014-09-22 | 2016-03-31 | Amphenol InterCon Systems, Inc. | Interposer assembly and method |
PL4037666T3 (pl) | 2020-12-08 | 2024-08-19 | Ruminant Biotech Corp Limited | Ulepszenia w urządzeniach i sposobach dostarczania substancji zwierzętom |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4132753A (en) * | 1965-02-12 | 1979-01-02 | American Cyanamid Company | Process for preparing oral sustained release granules |
US4291016A (en) * | 1976-07-27 | 1981-09-22 | Sandoz Ltd. | Enteric coated mixture of 4-(2-hydroxy-3-isopropylamino-propoxy) indole and sodium lauryl sulphate |
US4195084A (en) * | 1977-01-07 | 1980-03-25 | Eli Lilly And Company | Taste-stable aqueous pharmaceutical suspension of tall oil sitosterols and a method for the preparation thereof |
IT1101649B (it) * | 1978-12-15 | 1985-10-07 | Lehner Ag | Composizione farmaceutica ad azione prolungata contenente acidi biliari |
JPS57171428A (en) * | 1981-04-13 | 1982-10-22 | Sankyo Co Ltd | Preparation of coated solid preparation |
JPS59193831A (ja) * | 1983-04-18 | 1984-11-02 | Sankyo Co Ltd | 腸溶性製剤の製造法 |
HU190619B (en) * | 1983-11-11 | 1986-09-29 | Bezzegh,Denes,Hu | Process for producing tablets with controlled dissolution of active ingredients |
CH658188A5 (de) * | 1984-03-23 | 1986-10-31 | Ciba Geigy Ag | Lagerstabile schnellzerfallende pharmazeutische presslinge. |
JPS6144811A (ja) * | 1984-08-10 | 1986-03-04 | Ss Pharmaceut Co Ltd | 徐放性ジクロフエナクナトリウム製剤 |
DE3678644D1 (de) * | 1985-08-16 | 1991-05-16 | Procter & Gamble | Wirkstoffpartikel mit sowohl kontinuierlicher als auch schneller freisetzung. |
US4778676A (en) * | 1985-12-20 | 1988-10-18 | Warner-Lambert Company | Confectionery delivery system for actives |
US4716033A (en) * | 1986-03-27 | 1987-12-29 | Warner-Lambert Company | Medicament adsorbates with surfactant and their preparation |
US4816264A (en) * | 1986-06-06 | 1989-03-28 | Warner-Lambert Company | Sustained release formulations |
IT1200178B (it) * | 1986-07-23 | 1989-01-05 | Alfa Farmaceutici Spa | Formulazioni galeniche a cessione programmata contenenti farmaci ad attivita' antiflogistica |
US4814354A (en) * | 1986-09-26 | 1989-03-21 | Warner-Lambert Company | Lipid regulating agents |
AU1422388A (en) * | 1987-01-27 | 1988-08-10 | Warner-Lambert Company | Lipid regulating compositions |
-
1989
- 1989-02-02 US US07/305,082 patent/US4927639A/en not_active Expired - Fee Related
-
1990
- 1990-01-08 IL IL9299490A patent/IL92994A/en not_active IP Right Cessation
- 1990-01-12 MY MYPI90000054A patent/MY104898A/en unknown
- 1990-01-30 PH PH39966A patent/PH26317A/en unknown
- 1990-01-31 NZ NZ232321A patent/NZ232321A/xx unknown
- 1990-01-31 FI FI900491A patent/FI900491A0/fi not_active Application Discontinuation
- 1990-02-01 IE IE900371A patent/IE900371L/xx unknown
- 1990-02-01 AT AT90102022T patent/ATE88889T1/de active
- 1990-02-01 DE DE9090102022T patent/DE69001488T2/de not_active Expired - Fee Related
- 1990-02-01 ES ES90102022T patent/ES2055177T3/es not_active Expired - Lifetime
- 1990-02-01 PT PT93029A patent/PT93029A/pt unknown
- 1990-02-01 CA CA002009135A patent/CA2009135A1/en not_active Abandoned
- 1990-02-01 ZA ZA90776A patent/ZA90776B/xx unknown
- 1990-02-01 JP JP2020552A patent/JPH02240017A/ja active Pending
- 1990-02-01 DK DK90102022.2T patent/DK0381219T3/da active
- 1990-02-01 KR KR1019900001170A patent/KR0137268B1/ko not_active IP Right Cessation
- 1990-02-01 HU HU90638A patent/HU204192B/hu not_active IP Right Cessation
- 1990-02-01 NO NO90900484A patent/NO900484L/no unknown
- 1990-02-01 AU AU48992/90A patent/AU622751B2/en not_active Ceased
- 1990-02-01 EP EP90102022A patent/EP0381219B1/en not_active Expired - Lifetime
- 1990-02-02 CN CN90100781A patent/CN1053744A/zh active Pending
Also Published As
Publication number | Publication date |
---|---|
AU4899290A (en) | 1990-08-09 |
KR0137268B1 (ko) | 1998-04-25 |
ATE88889T1 (de) | 1993-05-15 |
PT93029A (pt) | 1990-08-31 |
US4927639A (en) | 1990-05-22 |
KR900012604A (ko) | 1990-09-01 |
HU204192B (en) | 1991-12-30 |
NZ232321A (en) | 1991-02-26 |
AU622751B2 (en) | 1992-04-16 |
DE69001488T2 (de) | 1993-08-26 |
CN1053744A (zh) | 1991-08-14 |
FI900491A0 (fi) | 1990-01-31 |
IL92994A0 (en) | 1990-09-17 |
EP0381219B1 (en) | 1993-05-05 |
NO900484L (no) | 1990-08-03 |
DE69001488D1 (de) | 1993-06-09 |
JPH02240017A (ja) | 1990-09-25 |
IE900371L (en) | 1990-08-02 |
EP0381219A3 (en) | 1990-12-05 |
MY104898A (en) | 1994-06-30 |
HUT52950A (en) | 1990-09-28 |
NO900484D0 (no) | 1990-02-01 |
DK0381219T3 (da) | 1993-06-01 |
CA2009135A1 (en) | 1990-08-02 |
EP0381219A2 (en) | 1990-08-08 |
ZA90776B (en) | 1991-10-30 |
HU900638D0 (en) | 1990-04-28 |
ES2055177T3 (es) | 1994-08-16 |
IL92994A (en) | 1994-04-12 |
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