PH21319A - 8-alkylthio-2-piperazion-pyrimido (5,4-d) pyrimidines - Google Patents

8-alkylthio-2-piperazion-pyrimido (5,4-d) pyrimidines

Info

Publication number
PH21319A
PH21319A PH32439A PH32439A PH21319A PH 21319 A PH21319 A PH 21319A PH 32439 A PH32439 A PH 32439A PH 32439 A PH32439 A PH 32439A PH 21319 A PH21319 A PH 21319A
Authority
PH
Philippines
Prior art keywords
group
acid addition
addition salts
compounds
alkyl group
Prior art date
Application number
PH32439A
Other languages
English (en)
Inventor
Roch Dr Josef
Heckel Dr Armin
Nickl Dr Josef
Mueller Dr Erich
Narr Dr Berthold
Weisenberger Dr Johannes
Zimmermann Dr Rainer
Original Assignee
Thomae Gmbh Dr K
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Thomae Gmbh Dr K filed Critical Thomae Gmbh Dr K
Publication of PH21319A publication Critical patent/PH21319A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
PH32439A 1984-06-22 1985-06-21 8-alkylthio-2-piperazion-pyrimido (5,4-d) pyrimidines PH21319A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19843423092 DE3423092A1 (de) 1984-06-22 1984-06-22 Neue 8-alkylthio-2-piperazino-pyrimido(5,4-d) pyrimidine, ihre herstellung und diese verbindungen enthaltende arzneimittel

Publications (1)

Publication Number Publication Date
PH21319A true PH21319A (en) 1987-09-28

Family

ID=6238919

Family Applications (1)

Application Number Title Priority Date Filing Date
PH32439A PH21319A (en) 1984-06-22 1985-06-21 8-alkylthio-2-piperazion-pyrimido (5,4-d) pyrimidines

Country Status (19)

Country Link
US (1) US4714698A (fi)
EP (1) EP0167817B1 (fi)
JP (1) JPH0694465B2 (fi)
KR (1) KR920007435B1 (fi)
AT (1) ATE46511T1 (fi)
AU (1) AU579869B2 (fi)
CA (1) CA1241325A (fi)
DE (2) DE3423092A1 (fi)
DK (1) DK282285A (fi)
ES (1) ES8604590A1 (fi)
FI (1) FI80455C (fi)
GR (1) GR851467B (fi)
IE (1) IE58432B1 (fi)
IL (1) IL75596A0 (fi)
NO (1) NO161620C (fi)
NZ (1) NZ212515A (fi)
PH (1) PH21319A (fi)
PT (1) PT80670B (fi)
ZA (1) ZA854683B (fi)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH075594B2 (ja) * 1986-03-25 1995-01-25 三井石油化学工業株式会社 新規ピリドピリミジン誘導体
GB8719368D0 (en) * 1987-08-15 1987-09-23 Wellcome Found Heterocyclic compounds
US4885300A (en) * 1988-03-03 1989-12-05 Ortho Pharmaceutical Corporation 4-Substituted pyrazolo[3,4-D]pyrimidine derivatives
DE4325900A1 (de) * 1993-08-02 1995-02-09 Thomae Gmbh Dr K Trisubstituierte Pyrimido [5,4-d] pyrimidine zur Modulation der Multidrugresistenz, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
TW414798B (en) * 1994-09-07 2000-12-11 Thomae Gmbh Dr K Pyrimido (5,4-d) pyrimidines, medicaments comprising these compounds, their use and processes for their preparation
DE19608653A1 (de) * 1996-03-06 1997-09-11 Thomae Gmbh Dr K Pyrimido[5,4-d]pyrimidine, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung
WO2006074147A2 (en) 2005-01-03 2006-07-13 Myriad Genetics, Inc. Nitrogen containing bicyclic compounds and therapeutical use thereof
US8309562B2 (en) * 2003-07-03 2012-11-13 Myrexis, Inc. Compounds and therapeutical use thereof
WO2005003100A2 (en) 2003-07-03 2005-01-13 Myriad Genetics, Inc. 4-arylamino-quinazolines as activators of caspases and inducers of apoptosis
US8258145B2 (en) * 2005-01-03 2012-09-04 Myrexis, Inc. Method of treating brain cancer
US20100234347A1 (en) * 2006-05-24 2010-09-16 Boehringer Ingelheim Internationl Gmbh Substituted Pteridines substituted with a Four-Membered Heterocycle

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1116676B (de) * 1955-03-14 1961-11-09 Thomae Gmbh Dr K Verfahren zur Herstellung von Pyrimido [5, 4-d] pyrimidinen
US3031450A (en) * 1959-04-30 1962-04-24 Thomae Gmbh Dr K Substituted pyrimido-[5, 4-d]-pyrimidines
US3322755A (en) * 1964-03-10 1967-05-30 Boehringer Sohn Ingelheim Basic-substituted 1, 2, 3, 4-tetrahydropyrimido [5, 4-d]-pyrimidines
GB1190419A (en) * 1966-08-16 1970-05-06 Yamanouchi Pharma Co Ltd Substituted Pyrimido-Pyrimidines and a process for the preparation thereof
DE2926804A1 (de) * 1979-07-03 1981-01-22 Thomae Gmbh Dr K Neue 2-(perhydro-1,4-diazino)-pyrimido- eckige klammer auf 5,4-d eckige klammer zu pyrimidine, deren herstellung und verwendung als arzneimittel
EP0023559B1 (de) * 1979-07-03 1984-09-19 Dr. Karl Thomae GmbH 2-(Perhydro-1,4-diazino)-pyrimido(5,4-d)pyrimidine, ihre Herstellung und diese Verbindungen enthaltenden Arzneimittel
DE3049207A1 (de) * 1980-12-27 1982-07-29 Dr. Karl Thomae Gmbh, 7950 Biberach Neue trisubstituierte pyrimido (5,4-d) pyrimidine, ihre herstellung und ihre verwendung als arzneimittel

Also Published As

Publication number Publication date
DE3573119D1 (en) 1989-10-26
EP0167817A1 (de) 1986-01-15
NZ212515A (en) 1988-10-28
JPH0694465B2 (ja) 1994-11-24
KR920007435B1 (ko) 1992-09-01
AU4396885A (en) 1986-01-02
PT80670A (de) 1985-07-01
FI80455B (fi) 1990-02-28
FI852445L (fi) 1985-12-23
ATE46511T1 (de) 1989-10-15
GR851467B (fi) 1985-11-25
AU579869B2 (en) 1988-12-15
NO161620B (no) 1989-05-29
ZA854683B (en) 1987-02-25
EP0167817B1 (de) 1989-09-20
JPS6115883A (ja) 1986-01-23
DK282285D0 (da) 1985-06-21
IL75596A0 (en) 1985-10-31
PT80670B (de) 1987-05-08
DK282285A (da) 1985-12-23
IE58432B1 (en) 1993-09-22
KR860000287A (ko) 1986-01-27
FI80455C (fi) 1990-06-11
FI852445A0 (fi) 1985-06-20
ES8604590A1 (es) 1986-02-01
NO161620C (no) 1989-09-06
DE3423092A1 (de) 1986-01-02
ES544417A0 (es) 1986-02-01
NO852514L (no) 1985-12-23
IE851545L (en) 1985-12-22
US4714698A (en) 1987-12-22
CA1241325A (en) 1988-08-30

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