PH18391A - Chemical process for the synthesis of macrolide antibiotics - Google Patents
Chemical process for the synthesis of macrolide antibioticsInfo
- Publication number
- PH18391A PH18391A PH28203A PH28203A PH18391A PH 18391 A PH18391 A PH 18391A PH 28203 A PH28203 A PH 28203A PH 28203 A PH28203 A PH 28203A PH 18391 A PH18391 A PH 18391A
- Authority
- PH
- Philippines
- Prior art keywords
- synthesis
- chemical process
- macrolide antibiotics
- fluoroerythomycins
- anhydroerythromycin
- Prior art date
Links
- 230000015572 biosynthetic process Effects 0.000 title 1
- 238000001311 chemical methods and process Methods 0.000 title 1
- 239000003120 macrolide antibiotic agent Substances 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Natural products O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 abstract 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
- 150000001204 N-oxides Chemical class 0.000 abstract 1
- 230000003115 biocidal effect Effects 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 239000007795 chemical reaction product Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 239000011737 fluorine Substances 0.000 abstract 1
- 230000011987 methylation Effects 0.000 abstract 1
- 238000007069 methylation reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT25345/81A IT1195299B (it) | 1981-11-27 | 1981-11-27 | Procedimento chimico di sintesi per la preparazione di antibiotici macrolidici |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PH18391A true PH18391A (en) | 1985-06-21 |
Family
ID=11216419
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PH28203A PH18391A (en) | 1981-11-27 | 1982-11-26 | Chemical process for the synthesis of macrolide antibiotics |
Country Status (13)
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1163796B (it) * | 1983-07-18 | 1987-04-08 | Pierrel Spa | Procedimento per la preparazione di (8s)-8-fluoroeritromicina |
| IT1196041B (it) * | 1984-03-08 | 1988-11-10 | Pierrel Spa | Emichetali di (8s)-8-fluoroeritromicine,il procedimento per la loro preparazione e le formulazioni adatte alla somministrazione orale che contengono i prodotti |
| DE3424525A1 (de) * | 1984-07-04 | 1986-01-16 | Kernforschungsanlage Jülich GmbH, 5170 Jülich | Verfahren zur herstellung von (pfeil hoch)1(pfeil hoch)(pfeil hoch)8(pfeil hoch)f-alkyl- und arylverbindungen durch halogenaustausch |
| JPS6185378A (ja) * | 1984-10-02 | 1986-04-30 | Daikin Ind Ltd | ８−フルオロエリスロノライド誘導体の製法 |
| US4876245A (en) * | 1986-12-22 | 1989-10-24 | Daikin Industries Ltd. | Fluorine-containing macrolide compounds and their use |
| MA21697A1 (fr) * | 1988-12-19 | 1990-07-01 | Dow Agrosciences Llc | Composes de macrolides. |
| US5591606A (en) * | 1992-11-06 | 1997-01-07 | Dowelanco | Process for the production of A83543 compounds with Saccharopolyspora spinosa |
| AU685107B2 (en) * | 1993-03-12 | 1998-01-15 | Dow Agrosciences Llc | New A83543 compounds and process for production thereof |
| US5393743A (en) * | 1993-07-06 | 1995-02-28 | Abbott Laboratories | Erythromycin derivatives |
| US5552533A (en) * | 1994-09-14 | 1996-09-03 | Alliedsignal Inc. | Preparation of (8S)-8-fluoroerythromycins with N-F fluorinating agents |
| US6001981A (en) * | 1996-06-13 | 1999-12-14 | Dow Agrosciences Llc | Synthetic modification of Spinosyn compounds |
| EP1718698A1 (fr) * | 2004-02-24 | 2006-11-08 | Arkema France | Composition reticulee comprenant un copolymere sequence triblocs, son procede d obtention et ses utilisations |
| WO2011080739A2 (en) | 2009-12-29 | 2011-07-07 | Yeda Research And Development Co. Ltd. | Synergistic antibiotic combinations and derivatives |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2812323A (en) * | 1954-11-03 | 1957-11-05 | Lilly Co Eli | Des-n-methyl erythromycin |
| US3674773A (en) * | 1970-10-06 | 1972-07-04 | Abbott Lab | Erythromycin derivatives |
| CA1169375A (en) * | 1981-01-09 | 1984-06-19 | Luciano Toscano | Semisynthetic macrolidic antibiotics, microbiological process for their preparation and related microorganism, novel intermediate compounds for their preparation and related pharmaceutical compositions containing them |
-
1981
- 1981-11-27 IT IT25345/81A patent/IT1195299B/it active
-
1982
- 1982-11-19 DE DE8282201476T patent/DE3266578D1/de not_active Expired
- 1982-11-19 AT AT82201476T patent/ATE15805T1/de not_active IP Right Cessation
- 1982-11-19 EP EP82201476A patent/EP0080763B1/en not_active Expired
- 1982-11-22 US US06/443,580 patent/US4514562A/en not_active Expired - Lifetime
- 1982-11-26 CH CH6889/82A patent/CH660596A5/it not_active IP Right Cessation
- 1982-11-26 PH PH28203A patent/PH18391A/en unknown
- 1982-11-26 BE BE0/209580A patent/BE895155A/fr unknown
- 1982-11-26 KR KR8205343A patent/KR880001566B1/ko not_active Expired
- 1982-11-26 CA CA000416447A patent/CA1209987A/en not_active Expired
- 1982-11-26 FR FR8219865A patent/FR2517311B1/fr not_active Expired
- 1982-11-26 FI FI824084A patent/FI75835C/fi not_active IP Right Cessation
- 1982-11-27 JP JP57208363A patent/JPS58109496A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| CH660596A5 (it) | 1987-05-15 |
| FI824084A0 (fi) | 1982-11-26 |
| EP0080763B1 (en) | 1985-09-25 |
| JPH0312077B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1991-02-19 |
| BE895155A (fr) | 1983-03-16 |
| FR2517311A1 (fr) | 1983-06-03 |
| JPS58109496A (ja) | 1983-06-29 |
| ATE15805T1 (de) | 1985-10-15 |
| EP0080763A1 (en) | 1983-06-08 |
| FI824084L (fi) | 1983-05-28 |
| FI75835B (fi) | 1988-04-29 |
| IT1195299B (it) | 1988-10-12 |
| DE3266578D1 (en) | 1985-10-31 |
| IT8125345A0 (it) | 1981-11-27 |
| FR2517311B1 (fr) | 1987-12-24 |
| CA1209987A (en) | 1986-08-19 |
| FI75835C (fi) | 1988-08-08 |
| KR880001566B1 (ko) | 1988-08-22 |
| US4514562A (en) | 1985-04-30 |
| KR840002413A (ko) | 1984-07-02 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE3266578D1 (en) | Chemical process for the synthesis of macrolide antibiotics | |
| AU2203388A (en) | Chemical conversion process | |
| AU8096187A (en) | Novel azole derivative, process for producing thereof and agriculture and horticultural chemical composition containing the same | |
| YU39431B (en) | Process for the manufacture of 13-halo and 13-deoxy derivatives of compounds of the macrolide series, isolated from the fermentation broth of streptomyces avermilitis | |
| ATA399781A (de) | Vorrichtung zur verhinderung der verdrehung eines flexiblen schlauchgurtes in einem schlauchgurtfoerderer | |
| AU3026492A (en) | Endothermic reaction apparatus | |
| GB2182038B (en) | Preparation of 2,3,6,3',4'-o-acetylsucrose | |
| YU2085A (en) | Process for obtaining new antibiotic acetyl eritromycin stearate | |
| AU587308B2 (en) | Process for the production of synthesis gas | |
| AU547481B2 (en) | Process for generating synthesis gas | |
| PT86364A (en) | Process for producing antibiotic a10255 complex | |
| AU544425B2 (en) | Catalytic reaction process | |
| AU4489289A (en) | Process for selective manufacture of 2,6-dialkylnaphthalenes | |
| AU584396B2 (en) | Process for L-sugar synthesis | |
| GB2106511B (en) | Process for preparing oxygen-containing organic compounds from synthesis gas | |
| AU525800B2 (en) | Effecting subsurface, controlled, accelerated chemical reactions | |
| HUP9601976A3 (en) | 4-fluoralkyl benzoylguanidines, process for producing them and pharmaceutical compositions containing these compounds | |
| AU7021391A (en) | Chemical compound containing alkali metals or alkaline earth metals, catalyst containing the compound and reaction process using the catalyst | |
| AU4968997A (en) | 13-membered ring macrolide compounds, medicine containing the same, and process for producing the same | |
| GB2111111B (en) | An arrangement for a door-leaf, preferably intended as a fire-proof door, and a process for producing such an arrangement | |
| JPS57193496A (en) | N-acetylneuraminic acid derivative | |
| AU573467B2 (en) | Reaction products of mercapto-functional monohydric alcohols and vinyl silanes, and nco-functional compounds therefrom | |
| HUT46077A (en) | Process for the microbiological production of 9alpha-hydroxy-4-androsten-3,17-dione | |
| DE3276154D1 (en) | Catalytic composition and process for producing 1,2-dichloroethane | |
| YU39853B (en) | Process for the recycling of non-reacted 1,2-dichloroethane in the decomposition of 1,2-dichloroethane |