PH12677A - Ring substituted 4-exe-and 4-thioxo-hexahydro-4h-pyrazino-(2,1-a)isoquinoline derivatives - Google Patents

Ring substituted 4-exe-and 4-thioxo-hexahydro-4h-pyrazino-(2,1-a)isoquinoline derivatives

Info

Publication number
PH12677A
PH12677A PH17513A PH17513A PH12677A PH 12677 A PH12677 A PH 12677A PH 17513 A PH17513 A PH 17513A PH 17513 A PH17513 A PH 17513A PH 12677 A PH12677 A PH 12677A
Authority
PH
Philippines
Prior art keywords
pyrazino
exe
thioxo
hexahydro
ring substituted
Prior art date
Application number
PH17513A
Other languages
English (en)
Inventor
H Thomas
J Seubert
R Peklke
P Andrews
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of PH12677A publication Critical patent/PH12677A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
PH17513A 1974-08-28 1975-08-28 Ring substituted 4-exe-and 4-thioxo-hexahydro-4h-pyrazino-(2,1-a)isoquinoline derivatives PH12677A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2441261A DE2441261A1 (de) 1974-08-28 1974-08-28 Ringsubstituierte pyrazino-isochinolin-derivat und verfahren zu ihrer herstellung

Publications (1)

Publication Number Publication Date
PH12677A true PH12677A (en) 1979-07-11

Family

ID=5924323

Family Applications (1)

Application Number Title Priority Date Filing Date
PH17513A PH12677A (en) 1974-08-28 1975-08-28 Ring substituted 4-exe-and 4-thioxo-hexahydro-4h-pyrazino-(2,1-a)isoquinoline derivatives

Country Status (22)

Country Link
US (1) US4051243A (fr)
JP (1) JPS5168595A (fr)
AT (1) AT350055B (fr)
BE (1) BE832735A (fr)
CH (3) CH617934A5 (fr)
DD (1) DD121789A5 (fr)
DE (1) DE2441261A1 (fr)
DK (1) DK386175A (fr)
EG (1) EG12384A (fr)
ES (1) ES440509A1 (fr)
FI (1) FI752411A (fr)
FR (1) FR2282891A1 (fr)
GB (1) GB1479235A (fr)
IE (1) IE42218B1 (fr)
IL (1) IL47975A (fr)
LU (1) LU73263A1 (fr)
NL (1) NL7510173A (fr)
NO (1) NO752939L (fr)
OA (1) OA05094A (fr)
PH (1) PH12677A (fr)
SE (1) SE7509473L (fr)
ZA (1) ZA755480B (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4113867A (en) * 1973-12-17 1978-09-12 Merck Patent Gesellschaft Mit Beschrankter Haftung 2-acyl-4-oxo-pyrazino-isoquinoline derivatives and process for the preparation thereof
US4196291A (en) * 1973-12-17 1980-04-01 Merck Patent Gesellschaft Mit Beschraenkter Haftung 2-Acyl-4-oxo-pyrazino-isoquinoline derivatives and process for the preparation thereof
US4120961A (en) * 1974-08-28 1978-10-17 E. Merck Ring substituted pyrazino-isoquinoline derivatives and their preparation
FR2520740A1 (fr) * 1982-01-29 1983-08-05 Sanofi Sa Procede pour la preparation d'acyl-2-hexahydro-1,3,4,6,7,11b-2h-pyrazino (2,1-a) isoquinoleinones-4 et intermediaires
US4517187A (en) * 1982-10-18 1985-05-14 Pennwalt Corporation 1,3,4,6,7-11b-Hexahydro-7-phenyl-2H-pyrazino[2,1-a]isoquinolines methods of preparation, and use as antidepressants
EP0134984B1 (fr) * 1983-07-16 1988-07-13 Beecham Group Plc Dérivés de la benzazépine et de la benzoxazépine
US4772705A (en) * 1985-07-25 1988-09-20 Pennwalt Corporation Processes for the preparation of trans 1,3,4,6,7,11b-hexahydro-7-aryl-2H-pyrazinol[2,1-a]isoquinolines
US20040131560A1 (en) * 2002-10-04 2004-07-08 The Procter & Gamble Company Oral compositions and use thereof
UA95093C2 (uk) * 2005-12-07 2011-07-11 Нікомед Фарма Ас Спосіб одержання кальцієвмісної сполуки
TWI519508B (zh) * 2007-06-12 2016-02-01 Achaogen Inc 抗菌劑
CN101691367B (zh) * 2009-08-31 2013-07-24 中国人民解放军第二军医大学 具有抗真菌活性的哌嗪并[2,1-a]异喹啉类化合物或其盐类
US20220227765A1 (en) * 2019-08-28 2022-07-21 Ferro Therapeutics, Inc. Pyrido-indole analogues as gpx4 inhibitors

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2362539C2 (de) * 1973-12-17 1986-05-07 Merck Patent Gmbh, 6100 Darmstadt 2-Acyl-4-oxo-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isochinoline, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel

Also Published As

Publication number Publication date
ATA663375A (de) 1978-10-15
BE832735A (nl) 1976-02-25
CH617934A5 (fr) 1980-06-30
CH623584A5 (fr) 1981-06-15
SE7509473L (sv) 1976-03-01
ES440509A1 (es) 1977-06-01
IL47975A (en) 1980-05-30
DD121789A5 (fr) 1976-08-20
IE42218B1 (en) 1980-07-02
AU8410675A (en) 1977-02-24
IL47975A0 (en) 1975-11-25
LU73263A1 (fr) 1977-04-15
DE2441261A1 (de) 1976-03-18
CH624113A5 (fr) 1981-07-15
DK386175A (da) 1976-02-29
ZA755480B (en) 1976-07-28
OA05094A (fr) 1981-01-31
NL7510173A (nl) 1976-03-02
NO752939L (fr) 1976-03-02
EG12384A (en) 1980-03-31
FR2282891A1 (fr) 1976-03-26
JPS5168595A (en) 1976-06-14
GB1479235A (en) 1977-07-06
FI752411A (fr) 1976-02-29
US4051243A (en) 1977-09-27
AT350055B (de) 1979-05-10
FR2282891B1 (fr) 1980-03-28
IE42218L (en) 1976-02-28

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