PH12022550167A1 - High concentration anti-c5 formulations - Google Patents
High concentration anti-c5 formulationsInfo
- Publication number
- PH12022550167A1 PH12022550167A1 PH1/2022/550167A PH12022550167A PH12022550167A1 PH 12022550167 A1 PH12022550167 A1 PH 12022550167A1 PH 12022550167 A PH12022550167 A PH 12022550167A PH 12022550167 A1 PH12022550167 A1 PH 12022550167A1
- Authority
- PH
- Philippines
- Prior art keywords
- formulations
- high concentration
- concentration anti
- cemdisiran
- ahus
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39591—Stabilisation, fragmentation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Dermatology (AREA)
- Endocrinology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962888086P | 2019-08-16 | 2019-08-16 | |
| PCT/US2020/046314 WO2021034639A1 (en) | 2019-08-16 | 2020-08-14 | High concentration anti-c5 formulations |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PH12022550167A1 true PH12022550167A1 (en) | 2023-05-08 |
Family
ID=72560889
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PH1/2022/550167A PH12022550167A1 (en) | 2019-08-16 | 2020-08-14 | High concentration anti-c5 formulations |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US20210046182A1 (enExample) |
| EP (1) | EP4013784A1 (enExample) |
| JP (2) | JP7813222B2 (enExample) |
| KR (1) | KR20220047826A (enExample) |
| CN (1) | CN116782876A (enExample) |
| AU (1) | AU2020334880A1 (enExample) |
| BR (1) | BR112022002831A2 (enExample) |
| CA (1) | CA3145621A1 (enExample) |
| CL (1) | CL2022000340A1 (enExample) |
| CO (1) | CO2022001097A2 (enExample) |
| IL (1) | IL290034A (enExample) |
| JO (1) | JOP20220030A1 (enExample) |
| MX (1) | MX2022001896A (enExample) |
| PH (1) | PH12022550167A1 (enExample) |
| WO (1) | WO2021034639A1 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT2970974T (pt) | 2013-03-14 | 2017-11-29 | Alnylam Pharmaceuticals Inc | Composições de irna de componente do complemento c5 e métodos para a sua utilização |
| CN112545886A (zh) | 2015-03-10 | 2021-03-26 | 里珍纳龙药品有限公司 | 无菌刺穿系统和方法 |
| IL263481B2 (en) | 2016-06-14 | 2024-06-01 | Regeneron Pharma | Anti-c5 antibodies and uses thereof |
| CA3055583A1 (en) | 2017-05-05 | 2018-11-08 | Regeneron Pharmaceuticals, Inc. | Auto-injector |
| AU2018383751B2 (en) | 2017-12-13 | 2025-05-08 | Regeneron Pharmaceuticals, Inc. | Anti-C5 antibody combinations and uses thereof |
| EP4423271A2 (en) | 2021-10-28 | 2024-09-04 | Regeneron Pharmaceuticals, Inc. | Crispr/cas-related methods and compositions for knocking out c5 |
| USD1007676S1 (en) | 2021-11-16 | 2023-12-12 | Regeneron Pharmaceuticals, Inc. | Wearable autoinjector |
| AR130041A1 (es) * | 2022-07-27 | 2024-10-30 | Cephalon Llc | Formulaciones de anticuerpos anti-tl1a |
| CN119894931A (zh) * | 2022-07-27 | 2025-04-25 | 赛福伦有限责任公司 | 用于治疗溃疡性结肠炎和克罗恩病的抗tl1a抗体 |
| JP2025536552A (ja) * | 2022-10-28 | 2025-11-07 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | 抗Ｃ５抗体／Ｃ５ ｉＲＮＡ合剤および併用療法 |
| WO2024259313A1 (en) | 2023-06-16 | 2024-12-19 | Regeneron Pharamceuticals, Inc. | Medical device packaging and related methods |
| CN116712390B (zh) * | 2023-08-04 | 2023-11-14 | 上海览屹医药科技有限公司 | 一种高浓度高稳定性的抗体制剂及其制备方法 |
| TW202529831A (zh) | 2023-10-02 | 2025-08-01 | 美商再生元醫藥公司 | 藥物遞輸裝置安全系統 |
| CN118460651B (zh) * | 2024-07-10 | 2025-03-18 | 凯莱英医药集团（天津）股份有限公司 | 制备Cemdisiran的方法 |
| CN119454939A (zh) * | 2024-11-28 | 2025-02-18 | 北海康成(苏州)生物制药有限公司 | 一种欧莫扑拜单抗原液及其制备方法 |
| US20260221053A1 (en) | 2025-01-29 | 2026-07-30 | Regeneron Pharmaceuticals, Inc. | Drug delivery devices, safety systems, training devices, and methods of use thereof |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US5981501A (en) | 1995-06-07 | 1999-11-09 | Inex Pharmaceuticals Corp. | Methods for encapsulating plasmids in lipid bilayers |
| CA2289702C (en) | 1997-05-14 | 2008-02-19 | Inex Pharmaceuticals Corp. | High efficiency encapsulation of charged therapeutic agents in lipid vesicles |
| CA2489174C (en) | 2002-07-10 | 2013-02-05 | Thomas Tuschl | Rna-interference by single-stranded rna molecules |
| ITMI20021527A1 (it) | 2002-07-11 | 2004-01-12 | Consiglio Nazionale Ricerche | Anticorpi anti componente c5 del complemento e loro uso |
| JP2009525986A (ja) * | 2006-02-03 | 2009-07-16 | メディミューン，エルエルシー | タンパク質製剤 |
| JP5419709B2 (ja) | 2007-01-09 | 2014-02-19 | ワイス・エルエルシー | 抗ｉｌ−１３抗体製剤およびその使用 |
| EP2279254B1 (en) | 2008-04-15 | 2017-07-05 | Protiva Biotherapeutics Inc. | Novel lipid formulations for nucleic acid delivery |
| PY09026846A (es) | 2008-08-05 | 2015-09-01 | Novartis Ag | Composiciones y métodos para anticuerpos que se dirigen a la proteína de complemento c5 |
| PE20120359A1 (es) | 2009-03-06 | 2012-04-13 | Genentech Inc | Formulacion con anticuerpo |
| KR20220038506A (ko) | 2009-06-10 | 2022-03-28 | 알닐람 파마슈티칼스 인코포레이티드 | 향상된 지질 조성물 |
| PT2970974T (pt) | 2013-03-14 | 2017-11-29 | Alnylam Pharmaceuticals Inc | Composições de irna de componente do complemento c5 e métodos para a sua utilização |
| WO2015103438A2 (en) * | 2014-01-02 | 2015-07-09 | Genelux Corporation | Oncolytic virus adjunct therapy with agents that increase virus infectivity |
| EA201691481A1 (ru) | 2014-03-20 | 2017-02-28 | Инфларкс Гмбх | ИНГИБИТОРЫ C5a ДЛЯ ЛЕЧЕНИЯ ВИРУСНОЙ ПНЕВМОНИИ |
| WO2017055966A1 (en) | 2015-10-01 | 2017-04-06 | Pfizer Inc. | Low viscosity antibody compositions |
| CN109328197A (zh) | 2016-06-07 | 2019-02-12 | 诺华股份有限公司 | 用于治疗具有补体c5多态性的患者的抗c5抗体 |
| IL263481B2 (en) | 2016-06-14 | 2024-06-01 | Regeneron Pharma | Anti-c5 antibodies and uses thereof |
| JP7275027B2 (ja) * | 2016-10-06 | 2023-05-17 | アムジェン インコーポレイテッド | 粘度低下タンパク質医薬製剤 |
| ES2965486T3 (es) * | 2017-07-27 | 2024-04-15 | Alexion Pharma Inc | Formulaciones de anticuerpos anti-C5 de alta concentración |
| JP7518764B2 (ja) * | 2017-10-26 | 2024-07-18 | アレクシオン ファーマシューティカルズ， インコーポレイテッド | 発作性夜間ヘモグロビン尿症（ＰＮＨ）および非典型溶血性尿毒症症候群（ａＨＵＳ）の処置のための抗Ｃ５抗体の投薬量および投与 |
| AU2018383751B2 (en) * | 2017-12-13 | 2025-05-08 | Regeneron Pharmaceuticals, Inc. | Anti-C5 antibody combinations and uses thereof |
-
2020
- 2020-08-14 WO PCT/US2020/046314 patent/WO2021034639A1/en not_active Ceased
- 2020-08-14 BR BR112022002831A patent/BR112022002831A2/pt unknown
- 2020-08-14 JO JOP/2022/0030A patent/JOP20220030A1/ar unknown
- 2020-08-14 CN CN202080069383.1A patent/CN116782876A/zh active Pending
- 2020-08-14 CA CA3145621A patent/CA3145621A1/en active Pending
- 2020-08-14 PH PH1/2022/550167A patent/PH12022550167A1/en unknown
- 2020-08-14 EP EP20775090.2A patent/EP4013784A1/en active Pending
- 2020-08-14 MX MX2022001896A patent/MX2022001896A/es unknown
- 2020-08-14 KR KR1020227008645A patent/KR20220047826A/ko active Pending
- 2020-08-14 JP JP2022509593A patent/JP7813222B2/ja active Active
- 2020-08-14 US US16/993,434 patent/US20210046182A1/en active Pending
- 2020-08-14 AU AU2020334880A patent/AU2020334880A1/en active Pending
-
2022
- 2022-01-23 IL IL290034A patent/IL290034A/en unknown
- 2022-02-02 CO CONC2022/0001097A patent/CO2022001097A2/es unknown
- 2022-02-09 CL CL2022000340A patent/CL2022000340A1/es unknown
-
2025
- 2025-09-12 JP JP2025151837A patent/JP2026003133A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CA3145621A1 (en) | 2021-02-25 |
| US20210046182A1 (en) | 2021-02-18 |
| AU2020334880A1 (en) | 2022-03-24 |
| JP7813222B2 (ja) | 2026-02-12 |
| BR112022002831A2 (pt) | 2022-06-28 |
| WO2021034639A4 (en) | 2021-04-15 |
| CN116782876A (zh) | 2023-09-19 |
| CO2022001097A2 (es) | 2022-03-08 |
| JOP20220030A1 (ar) | 2023-01-30 |
| JP2022544589A (ja) | 2022-10-19 |
| EP4013784A1 (en) | 2022-06-22 |
| JP2026003133A (ja) | 2026-01-09 |
| WO2021034639A1 (en) | 2021-02-25 |
| CL2022000340A1 (es) | 2022-10-07 |
| MX2022001896A (es) | 2022-06-02 |
| IL290034A (en) | 2022-03-01 |
| KR20220047826A (ko) | 2022-04-19 |
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