PH12020550766A1 - Synp61, a primate retinal pigment epithelium cell-specific promoter - Google Patents
Synp61, a primate retinal pigment epithelium cell-specific promoterInfo
- Publication number
- PH12020550766A1 PH12020550766A1 PH12020550766A PH12020550766A PH12020550766A1 PH 12020550766 A1 PH12020550766 A1 PH 12020550766A1 PH 12020550766 A PH12020550766 A PH 12020550766A PH 12020550766 A PH12020550766 A PH 12020550766A PH 12020550766 A1 PH12020550766 A1 PH 12020550766A1
- Authority
- PH
- Philippines
- Prior art keywords
- retinal pigment
- nucleic acid
- pigment epithelium
- synp61
- specific promoter
- Prior art date
Links
- 241000288906 Primates Species 0.000 title abstract 4
- 210000003583 retinal pigment epithelium Anatomy 0.000 title abstract 4
- 150000007523 nucleic acids Chemical class 0.000 abstract 6
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 3
- 108020004707 nucleic acids Proteins 0.000 abstract 3
- 102000039446 nucleic acids Human genes 0.000 abstract 3
- 108090000623 proteins and genes Proteins 0.000 abstract 3
- 101100243022 Mus musculus Pcnt gene Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70571—Receptors; Cell surface antigens; Cell surface determinants for neuromediators, e.g. serotonin receptor, dopamine receptor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
- A61K48/0058—Nucleic acids adapted for tissue specific expression, e.g. having tissue specific promoters as part of a contruct
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14141—Use of virus, viral particle or viral elements as a vector
- C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/008—Vector systems having a special element relevant for transcription cell type or tissue specific enhancer/promoter combination
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Biophysics (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Physics & Mathematics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Ophthalmology & Optometry (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Neurology (AREA)
- Immunology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP17204746 | 2017-11-30 | ||
| PCT/EP2018/082872 WO2019106027A1 (en) | 2017-11-30 | 2018-11-28 | SynP61, A PRIMATE RETINAL PIGMENT EPITHELIUM CELL-SPECIFIC PROMOTER |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PH12020550766A1 true PH12020550766A1 (en) | 2021-05-10 |
Family
ID=60543414
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PH12020550766A PH12020550766A1 (en) | 2017-11-30 | 2020-05-28 | Synp61, a primate retinal pigment epithelium cell-specific promoter |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US20230193314A1 (https=) |
| EP (1) | EP3717509A1 (https=) |
| JP (1) | JP7390290B2 (https=) |
| KR (1) | KR20200091435A (https=) |
| CN (1) | CN111527102A (https=) |
| AU (1) | AU2018376544B2 (https=) |
| BR (1) | BR112020010775A2 (https=) |
| CA (1) | CA3083404A1 (https=) |
| CR (1) | CR20200235A (https=) |
| IL (1) | IL274885A (https=) |
| MX (1) | MX2020005648A (https=) |
| PH (1) | PH12020550766A1 (https=) |
| RU (1) | RU2020121390A (https=) |
| SG (1) | SG11202005002QA (https=) |
| WO (1) | WO2019106027A1 (https=) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2010011467A (es) | 2008-04-18 | 2011-02-15 | Novartis Forschungsstiftung | Novedosas herramientas y metodos terapeuticos para tratar la ceguera. |
| US10941417B2 (en) | 2015-04-30 | 2021-03-09 | Friedrich Miescher Institute For Biomedical Research | Promoter for the specific expression of genes in Müller cells |
| US10857241B2 (en) | 2015-09-15 | 2020-12-08 | Friedrich Miescher Institute For Biomedical Research | Therapeutical tools and methods for treating blindness by targeting photoreceptors |
| WO2017064642A1 (en) | 2015-10-14 | 2017-04-20 | Fredrich Miescher Institute For Biomedical Research | Promoter for the specific expression of genes in retinal endothelial cells |
| EP3383440B1 (en) | 2015-12-03 | 2021-06-30 | Friedrich Miescher Institute for Biomedical Research | Synp162, a promoter for the specific expression of genes in rod photoreceptors |
| EP3383439B1 (en) | 2015-12-03 | 2019-09-25 | Friedrich Miescher Institute for Biomedical Research | Synp161, a promoter for the specific expression of genes in rod photoreceptors |
| ES2909444T3 (es) | 2015-12-03 | 2022-05-06 | Friedrich Miescher Institute For Biomedical Res | Synp159, un promotor para la expresión específica de genes en los fotorreceptores de los bastones |
| WO2017093934A1 (en) | 2015-12-03 | 2017-06-08 | Friedrich Miescher Institute For Biomedical Research | Synp160, a promoter for the specific expression of genes in rod photoreceptors |
| RU2766353C2 (ru) | 2016-11-02 | 2022-03-15 | Фридрих Мишер Инститьют Фор Байомедикал Рисерч | Synp198, промотор для специфической экспрессии генов в ганглионарных клетках сетчатки, избирательных в отношении направления |
| WO2018146588A1 (en) | 2017-02-08 | 2018-08-16 | Friedrich Miescher Institute For Biomedical Research | Synp88, a promoter for the specific expression of genes in retinal ganglion cells |
| MX2020005033A (es) | 2017-11-15 | 2020-10-28 | Friedrich Miescher Institute For Biomedical Res | Promotor especifico de las celulas del epitelio pigmentario retinal en primates. |
| SG11202005024QA (en) | 2017-11-30 | 2020-06-29 | Friedrich Miescher Institute For Biomedical Res | Synpiii, a promoter for the specific expression of genes in retinal pigment epithelium |
| US20220154211A1 (en) * | 2019-02-25 | 2022-05-19 | Novartis Ag | Compositions and methods to treat bietti crystalline dystrophy |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7309487B2 (en) * | 2004-02-09 | 2007-12-18 | George Inana | Methods and compositions for detecting and treating retinal diseases |
| EP3105334B1 (en) * | 2014-02-11 | 2019-07-03 | Friedrich Miescher Institute for Biomedical Research | Müller cell-specific promoter |
| MX2020005033A (es) * | 2017-11-15 | 2020-10-28 | Friedrich Miescher Institute For Biomedical Res | Promotor especifico de las celulas del epitelio pigmentario retinal en primates. |
-
2018
- 2018-11-28 CN CN201880084798.9A patent/CN111527102A/zh active Pending
- 2018-11-28 BR BR112020010775-1A patent/BR112020010775A2/pt not_active IP Right Cessation
- 2018-11-28 RU RU2020121390A patent/RU2020121390A/ru unknown
- 2018-11-28 MX MX2020005648A patent/MX2020005648A/es unknown
- 2018-11-28 SG SG11202005002QA patent/SG11202005002QA/en unknown
- 2018-11-28 WO PCT/EP2018/082872 patent/WO2019106027A1/en not_active Ceased
- 2018-11-28 JP JP2020529473A patent/JP7390290B2/ja active Active
- 2018-11-28 US US16/768,055 patent/US20230193314A1/en not_active Abandoned
- 2018-11-28 CA CA3083404A patent/CA3083404A1/en active Pending
- 2018-11-28 KR KR1020207018368A patent/KR20200091435A/ko not_active Ceased
- 2018-11-28 EP EP18833620.0A patent/EP3717509A1/en not_active Withdrawn
- 2018-11-28 CR CR20200235A patent/CR20200235A/es unknown
- 2018-11-28 AU AU2018376544A patent/AU2018376544B2/en not_active Ceased
-
2020
- 2020-05-24 IL IL274885A patent/IL274885A/en unknown
- 2020-05-28 PH PH12020550766A patent/PH12020550766A1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US20230193314A1 (en) | 2023-06-22 |
| CR20200235A (es) | 2020-10-19 |
| RU2020121390A (ru) | 2021-12-30 |
| BR112020010775A2 (pt) | 2020-11-24 |
| CA3083404A1 (en) | 2019-06-06 |
| SG11202005002QA (en) | 2020-06-29 |
| MX2020005648A (es) | 2020-10-14 |
| JP2021503933A (ja) | 2021-02-15 |
| AU2018376544B2 (en) | 2022-06-16 |
| IL274885A (en) | 2020-07-30 |
| WO2019106027A1 (en) | 2019-06-06 |
| RU2020121390A3 (https=) | 2022-02-03 |
| EP3717509A1 (en) | 2020-10-07 |
| AU2018376544A1 (en) | 2020-06-11 |
| JP7390290B2 (ja) | 2023-12-01 |
| CN111527102A (zh) | 2020-08-11 |
| KR20200091435A (ko) | 2020-07-30 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PH12020550757A1 (en) | Primate retinal pigment epithelium cell-specific promoter | |
| PH12020550766A1 (en) | Synp61, a primate retinal pigment epithelium cell-specific promoter | |
| PH12020550748A1 (en) | Synpiii, a promoter for the specific expression of genes in retinal pigment epithelium | |
| WO2018146588A8 (en) | Synp88, a promoter for the specific expression of genes in retinal ganglion cells | |
| IN2012DN01652A (https=) | ||
| EP4678754A3 (en) | A modified mglur6 promoter and methods of use | |
| MX2015017110A (es) | Integracion dirigida. | |
| PH12018500155A1 (en) | Recombinant orf virus vector | |
| NZ592082A (en) | Promoters for recombinant viral expression | |
| MX2020005324A (es) | Microorganismo modificado geneticamente para producir acido 3-hidroxidadipico, acido alfa-hidromuconico y/o acido adipico, y metodo de produccion para tales productos quimicos. | |
| MX2012015139A (es) | Polipéptido que tiene o que ayuda en la actividad de degradación del material de carbohidratos y usos del mismo. | |
| MX2012015142A (es) | Polipeptidos que tiene actividad beta-glucosidasa y usos del mismo. | |
| WO2013164793A3 (en) | Viral vectors for the treatment of retinal dystrophy | |
| PH12017502240A1 (en) | Recombinant microorganism for improved production of alanine | |
| WO2014202622A3 (en) | Rasamsonia gene and use thereof | |
| PH12021550256A1 (en) | Novel crispr-associated protein and use thereof | |
| NZ705575A (en) | Recombinant clostridium botulinum neurotoxins | |
| EP3760713A3 (en) | Lipase variants and polynucleotides encoding same | |
| WO2019098671A3 (ko) | 재조합 미생물 및 이를 이용한 개미산 제조 방법 | |
| IN2014DN10111A (https=) | ||
| PH12020551191A1 (en) | Oligodendrocyte-specific promoter, mirna specific to plp1 gene, vector including said promoter and/or mirna, and pharmaceutical composition including said vector | |
| MX2022006748A (es) | Composiciones de acidos nucleicos. | |
| EP4582089A3 (en) | Particle-mediated delivery of biologics | |
| MX2011005074A (es) | Una fitasa escherichia coli no-k12 termotolerante y su produccion. | |
| IN2015DN01042A (https=) |