WO2019098671A3 - 재조합 미생물 및 이를 이용한 개미산 제조 방법 - Google Patents

재조합 미생물 및 이를 이용한 개미산 제조 방법 Download PDF

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WO2019098671A3
WO2019098671A3 PCT/KR2018/013894 KR2018013894W WO2019098671A3 WO 2019098671 A3 WO2019098671 A3 WO 2019098671A3 KR 2018013894 W KR2018013894 W KR 2018013894W WO 2019098671 A3 WO2019098671 A3 WO 2019098671A3
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Prior art keywords
formic acid
production
recombinant microorganism
same
microorganism
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PCT/KR2018/013894
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English (en)
French (fr)
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WO2019098671A2 (ko
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김용환
장정호
전병욱
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울산과학기술원
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Priority to US16/495,680 priority Critical patent/US11230703B2/en
Publication of WO2019098671A2 publication Critical patent/WO2019098671A2/ko
Publication of WO2019098671A3 publication Critical patent/WO2019098671A3/ko

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0008—Oxidoreductases (1.) acting on the aldehyde or oxo group of donors (1.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0093—Oxidoreductases (1.) acting on CH or CH2 groups (1.17)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y117/00—Oxidoreductases acting on CH or CH2 groups (1.17)
    • C12Y117/01—Oxidoreductases acting on CH or CH2 groups (1.17) with NAD+ or NADP+ as acceptor (1.17.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/07—Bacillus

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

본 발명은 FDH1α(formate dehydrogenase 1 alpha subunit)를 코딩하는 내인성 유전자가 결실되고, FDH1을 코딩하는 외인성 유전자가 도입된, 개미산을 생산하기 위한 재조합 미생물 및 상기 미생물을 이용하여 개미산을 생산하는 방법에 관한 것이다.
PCT/KR2018/013894 2017-11-15 2018-11-14 재조합 미생물 및 이를 이용한 개미산 제조 방법 WO2019098671A2 (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US16/495,680 US11230703B2 (en) 2017-11-15 2018-11-14 Recombinant microorganism and method for production of formic acid by using same

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020170152507A KR101976691B1 (ko) 2017-11-15 2017-11-15 재조합 미생물 및 이를 이용한 개미산 제조 방법
KR10-2017-0152507 2017-11-15

Publications (2)

Publication Number Publication Date
WO2019098671A2 WO2019098671A2 (ko) 2019-05-23
WO2019098671A3 true WO2019098671A3 (ko) 2019-07-11

Family

ID=66539776

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PCT/KR2018/013894 WO2019098671A2 (ko) 2017-11-15 2018-11-14 재조합 미생물 및 이를 이용한 개미산 제조 방법

Country Status (3)

Country Link
US (1) US11230703B2 (ko)
KR (1) KR101976691B1 (ko)
WO (1) WO2019098671A2 (ko)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0817796D0 (en) 2008-09-29 2008-11-05 Convatec Inc wound dressing
KR102011415B1 (ko) * 2018-10-26 2019-08-16 한국에너지기술연구원 로도박터 에스투아리(Rhodobacter aestuarii)에서 유래한 신규 이산화탄소 환원 효소 및 이의 용도
US11771819B2 (en) 2019-12-27 2023-10-03 Convatec Limited Low profile filter devices suitable for use in negative pressure wound therapy systems
US11331221B2 (en) 2019-12-27 2022-05-17 Convatec Limited Negative pressure wound dressing
KR102527339B1 (ko) * 2021-01-06 2023-04-28 울산과학기술원 일산화탄소 탈수소효소 및 포름산 탈수소효소를 이용한 개미산의 제조 방법
KR102682441B1 (ko) * 2021-04-12 2024-07-05 울산과학기술원 유전자 재조합 포름산 탈수소효소 또는 고정화된 유전자 재조합 포름산 탈수소효소 및 그들을 이용한 개미산의 제조 방법
WO2023181065A1 (en) * 2022-03-20 2023-09-28 Fertis India Pvt. Ltd. Genetic modification of endophytic/ epiphytic/rhizospheric microbes for improved co2 fixation for crops
WO2024121870A1 (en) * 2022-12-09 2024-06-13 Fertis India Pvt. Ltd. Genetic modification of microbes for production of carbon-containing non-nitrogen compounds

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015064517A1 (ja) * 2013-10-28 2015-05-07 国立大学法人岐阜大学 ギ酸脱水素酵素とその利用
KR101524340B1 (ko) * 2012-10-12 2015-06-04 광운대학교 산학협력단 재조합 미생물, 이로부터 발현된 재조합 포름산 탈수소효소를 이용한 포름산의 제조방법
KR101655939B1 (ko) * 2014-09-18 2016-09-08 광운대학교 산학협력단 메탄올 자화균을 이용하여 이산화탄소로부터 개미산을 합성하는 방법
WO2017119731A1 (ko) * 2016-01-06 2017-07-13 주식회사 씨원켐 Co 수화효소 및 이를 이용한 개미산의 제조방법

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GB0605890D0 (en) * 2006-03-24 2006-05-03 Bioconversion Technologies Ltd Enhancemeny Of Microbial Ethanol Production

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KR101524340B1 (ko) * 2012-10-12 2015-06-04 광운대학교 산학협력단 재조합 미생물, 이로부터 발현된 재조합 포름산 탈수소효소를 이용한 포름산의 제조방법
WO2015064517A1 (ja) * 2013-10-28 2015-05-07 国立大学法人岐阜大学 ギ酸脱水素酵素とその利用
KR101655939B1 (ko) * 2014-09-18 2016-09-08 광운대학교 산학협력단 메탄올 자화균을 이용하여 이산화탄소로부터 개미산을 합성하는 방법
WO2017119731A1 (ko) * 2016-01-06 2017-07-13 주식회사 씨원켐 Co 수화효소 및 이를 이용한 개미산의 제조방법

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Title
JANG, JUNGHO ET AL.: "Bioelectrochemical conversion of C02 to value added product formate using engineered Methylobacterium extorquens", SCIENTIFIC REPORTS, vol. 8, no. 7211, 8 May 2018 (2018-05-08), pages 1 - 7, XP055619044 *
KENNEDY, CALEB J. ET AL.: "Systems-level engineering of nonfermentative metabolism in yeast", GENETICS, vol. 183, 19 June 2009 (2009-06-19) - September 2009 (2009-09-01), pages 385 - 397, XP055619054 *
LAUKEL, MARKUS ET AL.: "The tungsten-containing formate dehydrogenase from Methylobacterium extorquens AM 1: purification and proper ties", EUROPEAN JOURNAL OF BIOCHEMISTRY, vol. 270, no. 2, 19 December 2002 (2002-12-19) - January 2003 (2003-01-01), pages 325 - 333, XP055619050 *

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Publication number Publication date
WO2019098671A2 (ko) 2019-05-23
US11230703B2 (en) 2022-01-25
US20200095620A1 (en) 2020-03-26
KR101976691B1 (ko) 2019-05-09

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