PH12016500581A1 - Tyrosine hydroxylase inhibitors for treating intestinal hyperpermeability - Google Patents

Tyrosine hydroxylase inhibitors for treating intestinal hyperpermeability

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Publication number
PH12016500581A1
PH12016500581A1 PH12016500581A PH12016500581A PH12016500581A1 PH 12016500581 A1 PH12016500581 A1 PH 12016500581A1 PH 12016500581 A PH12016500581 A PH 12016500581A PH 12016500581 A PH12016500581 A PH 12016500581A PH 12016500581 A1 PH12016500581 A1 PH 12016500581A1
Authority
PH
Philippines
Prior art keywords
disease
treating intestinal
syndrome
intestinal hyperpermeability
tyrosine hydroxylase
Prior art date
Application number
PH12016500581A
Other languages
English (en)
Inventor
Hoffman Steven
Original Assignee
Hoffman Steven
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffman Steven filed Critical Hoffman Steven
Publication of PH12016500581A1 publication Critical patent/PH12016500581A1/en

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    • A61K31/215Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/223Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of alpha-aminoacids
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    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
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    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/195Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
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PH12016500581A 2013-10-22 2016-03-30 Tyrosine hydroxylase inhibitors for treating intestinal hyperpermeability PH12016500581A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361894261P 2013-10-22 2013-10-22
US14/062,165 US20150111878A1 (en) 2013-10-22 2013-10-24 Compositions and methods for treating intestinal hyperpermeability
PCT/US2014/061590 WO2015061328A2 (en) 2013-10-22 2014-10-21 Compositions and methods for treating intestinal hyperpermeability

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PH12016500581A1 true PH12016500581A1 (en) 2016-06-20

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PH12016500581A PH12016500581A1 (en) 2013-10-22 2016-03-30 Tyrosine hydroxylase inhibitors for treating intestinal hyperpermeability
PH12020550046A PH12020550046A1 (en) 2013-10-22 2020-02-06 Tyrosine hydroxylase inhibitors for treating intestinal hyperpermeability
PH12020550047A PH12020550047A1 (en) 2013-10-22 2020-02-06 Tyrosine hydroxylase inhibitors for treating intestinal hyperpermeability

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PH12020550046A PH12020550046A1 (en) 2013-10-22 2020-02-06 Tyrosine hydroxylase inhibitors for treating intestinal hyperpermeability
PH12020550047A PH12020550047A1 (en) 2013-10-22 2020-02-06 Tyrosine hydroxylase inhibitors for treating intestinal hyperpermeability

Country Status (16)

Country Link
US (1) US20150111878A1 (https=)
EP (3) EP3238707B1 (https=)
JP (3) JP2016538254A (https=)
KR (1) KR20160093000A (https=)
CN (2) CN105848652A (https=)
AU (2) AU2014340303B2 (https=)
CA (1) CA2925324A1 (https=)
DK (1) DK3238707T3 (https=)
ES (1) ES2865505T3 (https=)
IL (2) IL244707B (https=)
MX (1) MX2016004920A (https=)
PH (3) PH12016500581A1 (https=)
PL (1) PL3238707T3 (https=)
PT (1) PT3238707T (https=)
RS (1) RS61806B1 (https=)
WO (1) WO2015061328A2 (https=)

Families Citing this family (18)

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Publication number Priority date Publication date Assignee Title
US9763903B2 (en) 2013-10-22 2017-09-19 Steven Hoffman Compositions and methods for treating intestinal hyperpermeability
US10751313B2 (en) 2013-10-22 2020-08-25 Yamo Pharmaceuticals Llc Compositions and methods for treating autism
US9326962B2 (en) 2013-10-22 2016-05-03 Steven Hoffman Compositions and methods for treating intestinal hyperpermeability
US10813901B2 (en) 2013-10-22 2020-10-27 Yamo Pharmaceuticals Llc Compositions and methods for treating autism
KR20180015126A (ko) * 2015-04-14 2018-02-12 스티븐 호프만 자폐증을 치료하기 위한 조성물 및 방법
US20170181993A1 (en) * 2015-12-28 2017-06-29 Steven Hoffman Methods of Treating Amyotrophic Lateral Sclerosis and Symptoms
EP3518918A4 (en) * 2016-09-28 2020-04-22 Eiger Biopharmaceuticals, Inc. METHOD AND PHARMACEUTICAL COMPOSITIONS FOR TREATING NON-ALCOHOLIC STEATOHEPATITIS
JP6978122B2 (ja) 2017-03-31 2021-12-08 アキシャル セラピューティクス,インク. 自閉症および関連障害の治療および予防のための腸管選択的隔離剤
CN110769855A (zh) * 2017-04-21 2020-02-07 史蒂文·霍夫曼 用于治疗视网膜病变的组合物和方法
EP3431491A1 (en) * 2017-07-18 2019-01-23 Centre National De La Recherche Scientifique Methods for purifying proteins having a tubulin carboxypeptidase activity and peptidic based inhibitors thereof
BR112020001074A2 (pt) 2017-07-19 2020-07-14 Hoffman Technologies, Inc. composição
CN111655243A (zh) * 2018-01-29 2020-09-11 乔纳森·萨克纳-伯恩斯坦 在人类神经系统疾病中调节多巴胺的方法
EP3823593A4 (en) * 2018-07-19 2022-04-20 Yamo Pharmaceuticals LLC COMPOSITIONS AND METHODS FOR THE TREATMENT OF AUTISM
WO2020018291A1 (en) 2018-07-19 2020-01-23 Yamo Pharmaceuticals Llc Compositions and methods for treating autism
WO2020231909A1 (en) * 2019-05-11 2020-11-19 Steven Hoffman Compositions and methods for treating bile acid associated diseases
PH12021552866A1 (en) 2019-05-14 2022-11-07 Tyme Inc Compositions and methods for treating cancer
US10905698B1 (en) 2020-05-14 2021-02-02 Tyme, Inc. Methods of treating SARS-COV-2 infections
IL319533A (en) * 2022-09-16 2025-05-01 Francis Peter Halas A low-dose sustained-release preparation for the relief of symptoms caused by elevated levels of dopamine and norepinephrine

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU3783799A (en) * 1998-05-05 1999-11-23 Jose Pozuelo Compositions and methods for treating particular chemical addictions and mental illnesses
GB201020032D0 (en) * 2010-11-25 2011-01-12 Sigmoid Pharma Ltd Composition
WO2012123819A1 (en) * 2011-03-15 2012-09-20 Optinose As Et Al Nasal delivery

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