PH12015501204B1 - Tobacco specific nitrosamine reduction in plants - Google Patents
Tobacco specific nitrosamine reduction in plantsInfo
- Publication number
- PH12015501204B1 PH12015501204B1 PH1/2015/501204A PH12015501204A PH12015501204B1 PH 12015501204 B1 PH12015501204 B1 PH 12015501204B1 PH 12015501204 A PH12015501204 A PH 12015501204A PH 12015501204 B1 PH12015501204 B1 PH 12015501204B1
- Authority
- PH
- Philippines
- Prior art keywords
- seq
- mutant
- naturally occurring
- plants
- polynucleotide
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01H—NEW PLANTS OR NON-TRANSGENIC PROCESSES FOR OBTAINING THEM; PLANT REPRODUCTION BY TISSUE CULTURE TECHNIQUES
- A01H5/00—Angiosperms, i.e. flowering plants, characterised by their plant parts; Angiosperms characterised otherwise than by their botanic taxonomy
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
- A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
- A24B15/18—Treatment of tobacco products or tobacco substitutes
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
- A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
- A24B15/18—Treatment of tobacco products or tobacco substitutes
- A24B15/24—Treatment of tobacco products or tobacco substitutes by extraction; Tobacco extracts
- A24B15/241—Extraction of specific substances
- A24B15/245—Nitrosamines
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
- A24B3/00—Preparing tobacco in the factory
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8216—Methods for controlling, regulating or enhancing expression of transgenes in plant cells
- C12N15/8218—Antisense, co-suppression, viral induced gene silencing [VIGS], post-transcriptional induced gene silencing [PTGS]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
- C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A40/00—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production
- Y02A40/10—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production in agriculture
- Y02A40/146—Genetically Modified [GMO] plants, e.g. transgenic plants
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Cell Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nutrition Science (AREA)
- Virology (AREA)
- Botany (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physiology (AREA)
- Developmental Biology & Embryology (AREA)
- Environmental Sciences (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Manufacture Of Tobacco Products (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12198966 | 2012-12-21 | ||
| PCT/EP2013/077532 WO2014096283A2 (en) | 2012-12-21 | 2013-12-19 | Tobacco specific nitrosamine reduction in plants |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PH12015501204A1 PH12015501204A1 (en) | 2015-08-17 |
| PH12015501204B1 true PH12015501204B1 (en) | 2022-07-15 |
Family
ID=47559184
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PH1/2015/501204A PH12015501204B1 (en) | 2012-12-21 | 2013-12-19 | Tobacco specific nitrosamine reduction in plants |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US10563215B2 (https=) |
| EP (1) | EP2935588B1 (https=) |
| JP (1) | JP6693747B2 (https=) |
| KR (1) | KR102253223B1 (https=) |
| CN (1) | CN105247053B (https=) |
| AP (1) | AP2015008563A0 (https=) |
| CA (1) | CA2894955C (https=) |
| MX (2) | MX2015008084A (https=) |
| PH (1) | PH12015501204B1 (https=) |
| RU (1) | RU2735254C2 (https=) |
| WO (1) | WO2014096283A2 (https=) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9980509B2 (en) | 2013-04-05 | 2018-05-29 | R.J. Reynolds Tobacco Company | Modification of bacterial profile of tobacco |
| CA2952534A1 (en) * | 2014-06-25 | 2015-12-30 | Philip Morris Products S.A. | Modulation of nitrate content in plants |
| GB201501941D0 (en) * | 2015-02-05 | 2015-03-25 | British American Tobacco Co | Method |
| WO2016179356A1 (en) * | 2015-05-05 | 2016-11-10 | North Carolina State University | Methods and compositions for reducing the tobacco specific nitrosamine nnk in tobacco |
| WO2017156535A1 (en) * | 2016-03-11 | 2017-09-14 | Altria Client Services Llc | Compositions and methods for producing tobacco plants and products having reduced or eliminated suckers |
| AR112465A1 (es) | 2017-07-31 | 2019-10-30 | Reynolds Tobacco Co R | Métodos y composiciones para la edición de genes de base viral en plantas |
| AR115023A1 (es) | 2018-03-28 | 2020-11-18 | Philip Morris Products Sa | Modulación del contenido de azúcar reductor en una planta |
| AR115022A1 (es) | 2018-03-28 | 2020-11-18 | Philip Morris Products Sa | Modulación del contenido de aminoácidos en una planta |
| GB201812603D0 (en) | 2018-08-02 | 2018-09-19 | British American Tobacco Investments Ltd | Method |
| US11976286B2 (en) | 2018-12-30 | 2024-05-07 | Philip Morris Products S.A. | Modulation of nitrate levels in plants via mutation of nitrate reductase |
| US12344853B2 (en) * | 2019-06-05 | 2025-07-01 | University Of Kentucky Research Foundation | bZIP transcription factors regulate conversion of nicotine to nornicotine and reduce levels of tobacco specific (TSNA) precursors |
| CN110499388B (zh) * | 2019-09-29 | 2023-03-24 | 云南省烟草农业科学研究院 | 鉴别烟草抗斑萎病位点rtsw等位基因类型的共显性标记引物组、鉴别方法及其应用 |
| JP2022552638A (ja) | 2019-10-01 | 2022-12-19 | フィリップ・モーリス・プロダクツ・ソシエテ・アノニム | 植物における糖およびアミノ酸含有量の調節（ｓｕｌｔｒ３） |
| JP7659547B2 (ja) | 2019-10-01 | 2025-04-09 | フィリップ・モーリス・プロダクツ・ソシエテ・アノニム | 植物における還元糖含有量の調節（ｉｎｖ） |
| CN111690661A (zh) * | 2020-06-01 | 2020-09-22 | 云南省烟草农业科学研究院 | 一种烟草NtbHLH13基因突变体及分子鉴定方法和应用 |
| US20240368615A1 (en) | 2021-09-10 | 2024-11-07 | Philip Morris Products S.A. | Modulating alkaloid profiles in nicotiana tabacum |
| WO2023117661A1 (en) | 2021-12-20 | 2023-06-29 | Philip Morris Products S.A. | Increasing anatabine in tobacco leaf by regulating methyl putrescine oxidase |
| WO2023117701A1 (en) | 2021-12-21 | 2023-06-29 | Philip Morris Products S.A. | Modulation of nicotine production by alteration of nicotinamidase expression or function in plants |
| KR20240112979A (ko) | 2021-12-27 | 2024-07-19 | 니뽄 다바코 산교 가부시키가이샤 | 담배 식물 |
| JP2025533986A (ja) | 2022-10-13 | 2025-10-09 | フィリップ・モーリス・プロダクツ・ソシエテ・アノニム | Ｎｔｐ２を調節することによって葉バイオマスおよび窒素利用効率を増加させる |
| EP4658670A1 (en) | 2023-02-02 | 2025-12-10 | Philip Morris Products S.A. | Modulation of genes coding for lysine ketoglutarate reductase |
| JP2026506774A (ja) | 2023-02-02 | 2026-02-26 | フィリップ・モーリス・プロダクツ・ソシエテ・アノニム | 糖トランスポーターの調節 |
| CN121335615A (zh) | 2023-06-29 | 2026-01-13 | 菲利普莫里斯生产公司 | 编码谷氨酸脱氢酶的基因的调节 |
| CN117025627B (zh) * | 2023-06-29 | 2024-11-01 | 中国烟草总公司郑州烟草研究院 | 烟草氯离子通道蛋白NtCLC13及其编码基因和应用 |
| CN117025626B (zh) * | 2023-06-29 | 2025-02-14 | 中国烟草总公司郑州烟草研究院 | 烟草硝酸盐转运蛋白NtNPF7.4及其编码基因、基因编辑载体和应用 |
| CN120944912A (zh) * | 2025-09-17 | 2025-11-14 | 河南省农业科学院烟草研究所 | NtGCN1基因及其在调控烟叶氯离子含量中的应用 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5810020A (en) | 1993-09-07 | 1998-09-22 | Osmotek, Inc. | Process for removing nitrogen-containing anions and tobacco-specific nitrosamines from tobacco products |
| US6202649B1 (en) | 1996-12-02 | 2001-03-20 | Regent Court Technologies | Method of treating tobacco to reduce nitrosamine content, and products produced thereby |
| US6586661B1 (en) * | 1997-06-12 | 2003-07-01 | North Carolina State University | Regulation of quinolate phosphoribosyl transferase expression by transformation with a tobacco quinolate phosphoribosyl transferase nucleic acid |
| EA002448B1 (ru) | 1997-06-20 | 2002-04-25 | Риджент Корт Текнолоджиз | Способ обработки табака для снижения содержания нитрозоаминов и продукты, полученные этим способом |
| US7700834B2 (en) * | 2001-11-13 | 2010-04-20 | U.S. Smokless Tobacco Company | Nicotiana nucleic acid molecules and uses thereof |
| RU2191529C1 (ru) | 2001-12-21 | 2002-10-27 | Романенко Александр Павлович | Устройство для курения |
| KR100730631B1 (ko) * | 2003-05-06 | 2007-06-20 | 니뽄 다바코 산교 가부시키가이샤 | 재생 담배재의 제조방법 |
| JP4160868B2 (ja) * | 2003-07-10 | 2008-10-08 | 日本たばこ産業株式会社 | 葉タバコ中のニトロソアミン含量の低減方法 |
| EA200600449A1 (ru) * | 2003-08-19 | 2006-08-25 | ТВЕНТИ СЕКОНД СЕНЧУРИ ЛИМИТИД, эЛэЛСи | Табачное изделие (варианты), способ его изготовления (варианты), трансгенное растение табака, способы повышения содержания никотина, редуцирующих сахаров и уровня биосинтеза алкалоидов в растении и способ изготовления восстановленного табака |
| EP2338905B1 (en) | 2005-02-23 | 2017-11-29 | North Carolina State University | Alteration of tobacco alkaloid content through modification of specific cytochrome p450 genes |
| CA2666383C (en) | 2006-10-13 | 2015-12-22 | North Carolina State University | Alteration of tobacco alkaloid content through modification of specific cytochrome p450 genes |
| RU2324737C1 (ru) * | 2006-10-18 | 2008-05-20 | Институт цитологии и генетики Сибирского отделения Российской академии наук (СО РАН) | Способ получения трансгенных растений табака с повышенным содержанием пролина |
| US20110214199A1 (en) | 2007-06-06 | 2011-09-01 | Monsanto Technology Llc | Genes and uses for plant enhancement |
| US8124851B2 (en) | 2007-11-12 | 2012-02-28 | North Carolina State University | Alteration of tobacco alkaloid content through modification of specific cytochrome P450 genes |
| PL2231861T3 (pl) | 2007-12-13 | 2015-04-30 | Philip Morris Products Sa | Rośliny transgeniczne modyfikowane w celu zmniejszenia transportu kadmu, produkty pochodne i metody związane |
| WO2009091518A2 (en) | 2008-01-15 | 2009-07-23 | Monsanto Technology, Llc | Isolated novel nucleic acid and protein molecules from corn and methods of using those molecules to generate transgenic plant with enhanced agronomic traits |
| KR20120126061A (ko) * | 2009-10-22 | 2012-11-20 | 재단법인 작물유전체기능연구사업단 | 향상된 수확량 관련 형질을 갖는 식물 및 이의 제조 방법 |
| US9247706B2 (en) | 2010-01-15 | 2016-02-02 | North Carolina State University | Compositions and methods for minimizing nornicotine synthesis in tobacco |
| CN103228671B (zh) | 2010-09-03 | 2017-08-15 | 菲利普莫里斯产品有限公司 | 植物中的重金属减少 |
-
2013
- 2013-12-19 PH PH1/2015/501204A patent/PH12015501204B1/en unknown
- 2013-12-19 AP AP2015008563A patent/AP2015008563A0/xx unknown
- 2013-12-19 KR KR1020157018188A patent/KR102253223B1/ko active Active
- 2013-12-19 EP EP13817681.3A patent/EP2935588B1/en active Active
- 2013-12-19 RU RU2015126909A patent/RU2735254C2/ru active
- 2013-12-19 JP JP2015548608A patent/JP6693747B2/ja active Active
- 2013-12-19 MX MX2015008084A patent/MX2015008084A/es unknown
- 2013-12-19 CA CA2894955A patent/CA2894955C/en active Active
- 2013-12-19 CN CN201380073174.4A patent/CN105247053B/zh active Active
- 2013-12-19 WO PCT/EP2013/077532 patent/WO2014096283A2/en not_active Ceased
- 2013-12-19 US US14/653,924 patent/US10563215B2/en active Active
-
2015
- 2015-06-19 MX MX2019001598A patent/MX2019001598A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2894955A1 (en) | 2014-06-26 |
| CA2894955C (en) | 2023-10-31 |
| US20150315603A1 (en) | 2015-11-05 |
| EP2935588A2 (en) | 2015-10-28 |
| WO2014096283A3 (en) | 2014-08-14 |
| EP2935588B1 (en) | 2026-03-25 |
| CN105247053B (zh) | 2020-07-31 |
| JP2016508032A (ja) | 2016-03-17 |
| CN105247053A (zh) | 2016-01-13 |
| MX2015008084A (es) | 2016-03-31 |
| JP6693747B2 (ja) | 2020-05-13 |
| MX2019001598A (es) | 2019-07-01 |
| RU2015126909A (ru) | 2017-01-27 |
| KR102253223B1 (ko) | 2021-05-21 |
| PH12015501204A1 (en) | 2015-08-17 |
| RU2735254C2 (ru) | 2020-10-29 |
| WO2014096283A2 (en) | 2014-06-26 |
| KR20150096451A (ko) | 2015-08-24 |
| US10563215B2 (en) | 2020-02-18 |
| AP2015008563A0 (en) | 2015-06-30 |
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