PH12014501062B1 - Immediate release 4-methyl-3-[[4-(3-pyridinyl )-2-pyrimidinyl ]amino]-n-[5-(4-methyl-1h-1midazol-1yl)-3-(trifluoromethyl)phenyl]benzamide formulation - Google Patents
Immediate release 4-methyl-3-[[4-(3-pyridinyl )-2-pyrimidinyl ]amino]-n-[5-(4-methyl-1h-1midazol-1yl)-3-(trifluoromethyl)phenyl]benzamide formulationInfo
- Publication number
- PH12014501062B1 PH12014501062B1 PH1/2014/501062A PH12014501062A PH12014501062B1 PH 12014501062 B1 PH12014501062 B1 PH 12014501062B1 PH 12014501062 A PH12014501062 A PH 12014501062A PH 12014501062 B1 PH12014501062 B1 PH 12014501062B1
- Authority
- PH
- Philippines
- Prior art keywords
- methyl
- pyridinyl
- pyrimidinyl
- trifluoromethyl
- phenyl
- Prior art date
Links
- KXDAEFPNCMNJSK-UHFFFAOYSA-N Benzamide Chemical compound NC(=O)C1=CC=CC=C1 KXDAEFPNCMNJSK-UHFFFAOYSA-N 0.000 title 2
- 238000009472 formulation Methods 0.000 title 1
- 239000012729 immediate-release (IR) formulation Substances 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 title 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 title 1
- HHZIURLSWUIHRB-UHFFFAOYSA-N nilotinib Chemical compound C1=NC(C)=CN1C1=CC(NC(=O)C=2C=C(NC=3N=C(C=CN=3)C=3C=NC=CC=3)C(C)=CC=2)=CC(C(F)(F)F)=C1 HHZIURLSWUIHRB-UHFFFAOYSA-N 0.000 abstract 2
- 229920000642 polymer Polymers 0.000 abstract 2
- 239000007909 solid dosage form Substances 0.000 abstract 2
- 239000005536 L01XE08 - Nilotinib Substances 0.000 abstract 1
- 239000011248 coating agent Substances 0.000 abstract 1
- 238000000576 coating method Methods 0.000 abstract 1
- 230000003111 delayed effect Effects 0.000 abstract 1
- 229960001346 nilotinib Drugs 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
- A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161559281P | 2011-11-14 | 2011-11-14 | |
| PCT/US2012/064610 WO2013074432A1 (en) | 2011-11-14 | 2012-11-12 | Immediate release 4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]-n-[5-(4-methyl- 1h-imidazol-1-yl)-3-(trifluoromethyl)phenyl] benzamide formulation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PH12014501062A1 PH12014501062A1 (en) | 2014-06-23 |
| PH12014501062B1 true PH12014501062B1 (en) | 2018-04-20 |
Family
ID=47324402
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PH1/2014/501062A PH12014501062B1 (en) | 2011-11-14 | 2012-11-12 | Immediate release 4-methyl-3-[[4-(3-pyridinyl )-2-pyrimidinyl ]amino]-n-[5-(4-methyl-1h-1midazol-1yl)-3-(trifluoromethyl)phenyl]benzamide formulation |
Country Status (23)
| Country | Link |
|---|---|
| EP (1) | EP2779995A1 (enExample) |
| JP (1) | JP6275645B2 (enExample) |
| KR (1) | KR20140093230A (enExample) |
| CN (1) | CN103930094A (enExample) |
| AR (1) | AR088844A1 (enExample) |
| BR (1) | BR112014011518A2 (enExample) |
| CA (1) | CA2855503A1 (enExample) |
| CL (1) | CL2014001247A1 (enExample) |
| CO (1) | CO6960546A2 (enExample) |
| EA (1) | EA201490960A1 (enExample) |
| GT (1) | GT201400094A (enExample) |
| HK (1) | HK1197025A1 (enExample) |
| IL (1) | IL232480A0 (enExample) |
| IN (1) | IN2014DN03416A (enExample) |
| MA (1) | MA35636B1 (enExample) |
| MX (1) | MX2014005874A (enExample) |
| PE (1) | PE20141337A1 (enExample) |
| PH (1) | PH12014501062B1 (enExample) |
| SG (2) | SG10201707768RA (enExample) |
| TN (1) | TN2014000177A1 (enExample) |
| TW (1) | TWI574690B (enExample) |
| WO (1) | WO2013074432A1 (enExample) |
| ZA (1) | ZA201402756B (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2792360A1 (en) | 2013-04-18 | 2014-10-22 | IP Gesellschaft für Management mbH | (1aR,12bS)-8-cyclohexyl-11-fluoro-N-((1-methylcyclopropyl)sulfonyl)-1a-((3-methyl-3,8-diazabicyclo[3.2.1]oct-8-yl)carbonyl)-1,1a,2,2b-tetrahydrocyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxamide for use in treating HCV |
| CZ2017821A3 (cs) | 2017-12-20 | 2019-07-03 | Zentiva, K.S. | Léková forma obsahující krystalický nilotinib |
| JP7378279B2 (ja) * | 2019-11-18 | 2023-11-13 | 日本化薬株式会社 | ニロチニブを有効成分とする医薬錠剤及びその製造方法 |
| JP7489849B2 (ja) * | 2020-07-20 | 2024-05-24 | 日本化薬株式会社 | ニロチニブ錠剤 |
| JP7776274B2 (ja) * | 2021-07-19 | 2025-11-26 | 日本化薬株式会社 | ニロチニブ錠剤およびその製造方法 |
| JP7776275B2 (ja) * | 2021-07-26 | 2025-11-26 | 日本化薬株式会社 | ニロチニブ錠剤およびその製造方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0215676D0 (en) * | 2002-07-05 | 2002-08-14 | Novartis Ag | Organic compounds |
| GT200600315A (es) | 2005-07-20 | 2007-03-19 | Formas cristalinas de 4-metilo-n-[3-(4-metilo-imidazol-1-ilo)-5-trifluorometilo-fenilo]-3-(4-pyridina-3-ilo-pirimidina-2-iloamino)-benzamida | |
| GT200600316A (es) | 2005-07-20 | 2007-04-02 | Sales de 4-metilo-n-(3-(4-metilo-imidazol-1-ilo)-5-trifluorometilo-fenilo)-3-(4-piridina-3-ilo-pirimidina-2-iloamino)- benzamida. | |
| EP1923053A1 (en) * | 2006-09-27 | 2008-05-21 | Novartis AG | Pharmaceutical compositions comprising nilotinib or its salt |
| US20100136097A1 (en) * | 2008-12-02 | 2010-06-03 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Systems for modulating inflammation |
| WO2012164578A1 (en) * | 2011-06-02 | 2012-12-06 | Hetero Research Foundation | Compositions and methods for preparing immediate release formulations of nilotinib |
-
2012
- 2012-11-12 AR ARP120104259A patent/AR088844A1/es unknown
- 2012-11-12 CN CN201280055937.8A patent/CN103930094A/zh active Pending
- 2012-11-12 WO PCT/US2012/064610 patent/WO2013074432A1/en not_active Ceased
- 2012-11-12 CA CA2855503A patent/CA2855503A1/en not_active Abandoned
- 2012-11-12 JP JP2014541363A patent/JP6275645B2/ja not_active Expired - Fee Related
- 2012-11-12 HK HK14110470.2A patent/HK1197025A1/xx unknown
- 2012-11-12 BR BR112014011518A patent/BR112014011518A2/pt not_active IP Right Cessation
- 2012-11-12 EP EP12798500.0A patent/EP2779995A1/en not_active Withdrawn
- 2012-11-12 PH PH1/2014/501062A patent/PH12014501062B1/en unknown
- 2012-11-12 EA EA201490960A patent/EA201490960A1/ru unknown
- 2012-11-12 PE PE2014000672A patent/PE20141337A1/es not_active Application Discontinuation
- 2012-11-12 KR KR1020147012521A patent/KR20140093230A/ko not_active Ceased
- 2012-11-12 SG SG10201707768RA patent/SG10201707768RA/en unknown
- 2012-11-12 SG SG11201401476TA patent/SG11201401476TA/en unknown
- 2012-11-12 MX MX2014005874A patent/MX2014005874A/es unknown
- 2012-11-12 IN IN3416DEN2014 patent/IN2014DN03416A/en unknown
- 2012-11-13 TW TW101142278A patent/TWI574690B/zh not_active IP Right Cessation
-
2014
- 2014-04-15 ZA ZA2014/02756A patent/ZA201402756B/en unknown
- 2014-04-25 TN TNP2014000177A patent/TN2014000177A1/en unknown
- 2014-05-05 IL IL232480A patent/IL232480A0/en unknown
- 2014-05-07 MA MA36991A patent/MA35636B1/fr unknown
- 2014-05-13 CL CL2014001247A patent/CL2014001247A1/es unknown
- 2014-05-14 GT GT201400094A patent/GT201400094A/es unknown
- 2014-05-14 CO CO14103891A patent/CO6960546A2/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PE20141337A1 (es) | 2014-10-16 |
| EP2779995A1 (en) | 2014-09-24 |
| SG11201401476TA (en) | 2014-10-30 |
| WO2013074432A1 (en) | 2013-05-23 |
| MA35636B1 (fr) | 2014-11-01 |
| IL232480A0 (en) | 2014-06-30 |
| AU2012339829B2 (en) | 2016-05-12 |
| GT201400094A (es) | 2017-09-28 |
| JP2014533283A (ja) | 2014-12-11 |
| NZ623844A (en) | 2016-09-30 |
| TWI574690B (zh) | 2017-03-21 |
| AR088844A1 (es) | 2014-07-10 |
| CO6960546A2 (es) | 2014-05-30 |
| BR112014011518A2 (pt) | 2017-05-16 |
| JP6275645B2 (ja) | 2018-02-07 |
| KR20140093230A (ko) | 2014-07-25 |
| AU2012339829A1 (en) | 2014-05-29 |
| CN103930094A (zh) | 2014-07-16 |
| TW201325594A (zh) | 2013-07-01 |
| CL2014001247A1 (es) | 2014-10-17 |
| SG10201707768RA (en) | 2017-10-30 |
| EA201490960A1 (ru) | 2014-08-29 |
| HK1197025A1 (en) | 2015-01-02 |
| CA2855503A1 (en) | 2013-05-23 |
| IN2014DN03416A (enExample) | 2015-06-26 |
| PH12014501062A1 (en) | 2014-06-23 |
| ZA201402756B (en) | 2015-04-29 |
| MX2014005874A (es) | 2014-06-23 |
| TN2014000177A1 (en) | 2015-09-30 |
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